{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:34:31Z","timestamp":1790937271261,"version":"4.1.0"},"reference-count":51,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Opinion in Infectious Diseases"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1097\/qco.0b013e328332c54d","type":"journal-article","created":{"date-parts":[[2009,10,25]],"date-time":"2009-10-25T03:00:36Z","timestamp":1256439636000},"page":"574-582","source":"Crossref","is-referenced-by-count":21,"title":["New approaches for quantitating the inhibition of HIV-1 replication by antiviral drugs in vitro and in vivo"],"prefix":"10.1097","volume":"22","author":[{"given":"Moira A","family":"McMahon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F","family":"Siliciano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-10-20091025","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1001\/jama.300.5.555","volume":"300","author":"Hammer","year":"2008","journal-title":"JAMA"},{"key":"R2-10-20091025","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1056\/NEJM199709113371101","volume":"337","author":"Hammer","year":"1997","journal-title":"N Engl J Med"},{"key":"R3-10-20091025","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1056\/NEJM199709113371102","volume":"337","author":"Gulick","year":"1997","journal-title":"N Engl J Med"},{"key":"R4-10-20091025","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/387188a0","volume":"387","author":"Perelson","year":"1997","journal-title":"Nature"},{"key":"R5-10-20091025","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/387183a0","volume":"387","author":"Chun","year":"1997","journal-title":"Nature"},{"key":"R6-10-20091025","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1126\/science.278.5341.1295","volume":"278","author":"Finzi","year":"1997","journal-title":"Science"},{"key":"R7-10-20091025","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1126\/science.278.5341.1291","volume":"278","author":"Wong","year":"1997","journal-title":"Science"},{"key":"R8-10-20091025","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1001\/jama.282.17.1627","volume":"282","author":"Dornadula","year":"1999","journal-title":"JAMA"},{"key":"R9-10-20091025","doi-asserted-by":"crossref","first-page":"4531","DOI":"10.1128\/JCM.41.10.4531-4536.2003","volume":"41","author":"Palmer","year":"2003","journal-title":"J Clin Microbiol"},{"key":"R10-10-20091025","doi-asserted-by":"crossref","first-page":"9403","DOI":"10.1073\/pnas.0903107106","volume":"106","author":"Dinoso","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R11-10-20091025","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1128\/AAC.37.5.1095","volume":"37","author":"Japour","year":"1993","journal-title":"Antimicrob Agents Chemother"},{"key":"R12-10-20091025","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1128\/AAC.36.11.2423","volume":"36","author":"Schinazi","year":"1992","journal-title":"Antimicrob Agents Chemother"},{"key":"R13-10-20091025","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1128\/AAC.34.6.1061","volume":"34","author":"Schinazi","year":"1990","journal-title":"Antimicrob Agents Chemother"},{"key":"R14-10-20091025","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1093\/jnci\/81.8.577","volume":"81","author":"Weislow","year":"1989","journal-title":"J Natl Cancer Inst"},{"key":"R15-10-20091025","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1128\/AAC.38.1.23","volume":"38","author":"Kellam","year":"1994","journal-title":"Antimicrob Agents Chemother"},{"key":"R16-10-20091025","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0165-6147(00)01615-1","volume":"22","author":"Ferguson","year":"2001","journal-title":"Trends Pharmacol Sci"},{"key":"R17-10-20091025","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1128\/AAC.37.4.875","volume":"37","author":"Schinazi","year":"1993","journal-title":"Antimicrob Agents Chemother"},{"key":"R18-10-20091025","doi-asserted-by":"crossref","first-page":"5653","DOI":"10.1073\/pnas.90.12.5653","volume":"90","author":"Tisdale","year":"1993","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R19-10-20091025","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1128\/AAC.37.6.1390","volume":"37","author":"Gao","year":"1993","journal-title":"Antimicrob Agents Chemother"},{"key":"R20-10-20091025","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1128\/AAC.44.9.2475-2484.2000","volume":"44","author":"Bacheler","year":"2000","journal-title":"Antimicrob Agents Chemother"},{"key":"R21-10-20091025","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1128\/CMR.00017-07","volume":"20","author":"Dykes","year":"2007","journal-title":"Clin Microbiol Rev"},{"key":"R22-10-20091025","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.virusres.2007.12.021","volume":"134","author":"Martinez-Picado","year":"2008","journal-title":"Virus Res"},{"key":"R23-10-20091025","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1128\/AAC.44.4.920-928.2000","volume":"44","author":"Petropoulos","year":"2000","journal-title":"Antimicrob Agents Chemother"},{"key":"R24-10-20091025","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1128\/JVI.78.4.1718-1729.2004","volume":"78","author":"Zhang","year":"2004","journal-title":"J Virol"},{"key":"R25-10-20091025","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1038\/nm1777","volume":"14","author":"Shen","year":"2008","journal-title":"Nat Med"},{"key":"R26-10-20091025","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1056\/NEJMoa067710","volume":"356","author":"McMahon","year":"2007","journal-title":"N Engl J Med"},{"key":"R27-10-20091025","doi-asserted-by":"crossref","first-page":"31289","DOI":"10.1074\/jbc.C800188200","volume":"283","author":"McMahon","year":"2008","journal-title":"J Biol Chem"},{"key":"R28-10-20091025","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0960-894X(96)00594-X","volume":"7","author":"Bisacchi","year":"1997","journal-title":"Bioorg Med Chem Lit"},{"key":"R29-10-20091025","doi-asserted-by":"crossref","first-page":"2365","DOI":"10.1097\/QAD.0b013e3282f1e769","volume":"21","author":"Jain","year":"2007","journal-title":"AIDS"},{"key":"R30-10-20091025","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1097\/QAD.0b013e3282ffde91","volume":"22","author":"Sasadeusz","year":"2008","journal-title":"AIDS"},{"key":"R31-10-20091025","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1097\/QAD.0b013e3282f08bae","volume":"21","author":"Soriano","year":"2007","journal-title":"AIDS"},{"key":"R32-10-20091025","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1097\/QAD.0b013e3282f82b96","volume":"22","author":"Soriano","year":"2008","journal-title":"AIDS"},{"key":"R33-10-20091025","doi-asserted-by":"crossref","first-page":"34218","DOI":"10.1074\/jbc.M806797200","volume":"283","author":"Tchesnokov","year":"2008","journal-title":"J Biol Chem"},{"key":"R34-10-20091025","doi-asserted-by":"crossref","first-page":"5452","DOI":"10.1074\/jbc.M707834200","volume":"283","author":"Domaoal","year":"2008","journal-title":"J Biol Chem"},{"key":"R35-10-20091025","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1128\/AAC.01313-07","volume":"52","author":"Lin","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"key":"R36-10-20091025","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nchembio806","volume":"2","author":"Chong","year":"2006","journal-title":"Nat Chem Biol"},{"key":"R37-10-20091025","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.chom.2008.07.008","volume":"4","author":"Lisco","year":"2008","journal-title":"Cell Host Microb"},{"key":"R38-10-20091025","doi-asserted-by":"crossref","first-page":"21496","DOI":"10.1074\/jbc.M109.024026","volume":"284","author":"Tchesnokov","year":"2009","journal-title":"J Biol Chem"},{"key":"R39-10-20091025","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1086\/522523","volume":"196","author":"Zuckerman","year":"2007","journal-title":"J Infect Dis"},{"key":"R40-10-20091025","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1056\/NEJMoa062607","volume":"356","author":"Nagot","year":"2007","journal-title":"N Engl J Med"},{"key":"R41-10-20091025","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1097\/COH.0b013e3282fbaaba","volume":"3","author":"la Porte","year":"2008","journal-title":"Curr Opin HIV AIDS"},{"key":"R42-10-20091025","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/0022-5193(76)90169-7","volume":"59","author":"Chou","year":"1976","journal-title":"J Theor Biol"},{"key":"R43-10-20091025","first-page":"iv","volume":"40","author":"Hill","year":"1910","journal-title":"J Physiol (Lond)"},{"key":"R44-10-20091025","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1126\/science.2467383","volume":"243","author":"Larder","year":"1989","journal-title":"Science"},{"key":"R45-10-20091025","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1126\/science.7824947","volume":"267","author":"Coffin","year":"1995","journal-title":"Science"},{"key":"R46-10-20091025","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/373117a0","volume":"373","author":"Wei","year":"1995","journal-title":"Nature"},{"key":"R47-10-20091025","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1038\/13410","volume":"5","author":"Grossman","year":"1999","journal-title":"Nat Med"},{"key":"R48-10-20091025","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1086\/512619","volume":"195","author":"Kuritzkes","year":"2007","journal-title":"J Infect Dis"},{"key":"R49-10-20091025","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1097\/QAI.0b013e318157131c","volume":"46","author":"Markowitz","year":"2007","journal-title":"J Acquir Immune Defic Syndr"},{"key":"R50-10-20091025","doi-asserted-by":"crossref","first-page":"4832","DOI":"10.1073\/pnas.0711372105","volume":"105","author":"Sedaghat","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R51-10-20091025","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1097\/QAI.0b013e31802b4956","volume":"43","author":"Markowitz","year":"2006","journal-title":"J Acquir Immune Defic Syndr"}],"container-title":["Current Opinion in Infectious Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/QCO.0b013e328332c54d","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:02:26Z","timestamp":1786039346000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001432-200912000-00010"}},"subtitle":[""],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":51,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.1097\/qco.0b013e328332c54d","relation":{},"ISSN":["0951-7375"],"issn-type":[{"value":"0951-7375","type":"print"}],"subject":[],"published":{"date-parts":[[2009,12]]}}}