{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T13:47:38Z","timestamp":1785764858087,"version":"3.56.0"},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Heterotopic ossification (HO) within the gastrointestinal tract is extremely rare, and its association with low-grade appendiceal mucinous neoplasm (LAMN) and pseudomyxoma peritonei (PMP) is exceptional. We report a rare case of LAMN with visceral HO and PMP, highlighting its clinical features, pathological findings, and postoperative outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation:<\/jats:title>\n                    <jats:p>A 55-year-old female presented with progressive abdominal distension over 4 months. Imaging suggested an ovarian mass with ascites. Intraoperatively, gelatinous material filled the peritoneal cavity, with findings consistent with PMP. The patient underwent total abdominal hysterectomy, bilateral salpingo-oophorectomy, omentectomy, appendectomy, and right hemicolectomy. Histopathology confirmed LAMN with ovarian involvement, dystrophic calcification, and foci of mature ossification within the appendix. The patient declined adjuvant chemotherapy but remained under surveillance. At 12\u00a0months follow-up, she remains asymptomatic with no radiological evidence of recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>Visceral HO is an uncommon phenomenon, possibly involving epithelial\u2013mesenchymal transition (EMT) and bone morphogenetic protein pathways. While EMT is theoretically linked to aggressive tumor biology, the clinical course in this case has been indolent.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The coexistence of LAMN, PMP, and HO underscores the complex biology of mucinous appendiceal tumors. While HO represents a rare pathological differentiation, long-term surveillance is required to determine its true prognostic significance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/rc9.0000000000000075","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:01:57Z","timestamp":1768395717000},"page":"226-229","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Low-grade appendiceal mucinous neoplasm with heterotopic ossification and pseudomyxoma peritonei: a case report"],"prefix":"10.1097","volume":"138","author":[{"given":"Samuel Addisu","family":"Abera","sequence":"first","affiliation":[{"name":"Department of Pathology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2664-9452","authenticated-orcid":false,"given":"Suleiman Ayalew","family":"Belay","sequence":"additional","affiliation":[{"name":"Department of Dermatovenerology, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohannis Derbew","family":"Molla","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ermias Teklehaimanot","family":"Yefter","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meron Berhanu","family":"Hailemeskel","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misganew Abere","family":"Worku","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"R1-20260803","doi-asserted-by":"crossref","first-page":"1084\u201391","DOI":"10.2106\/JBJS.H.00792","article-title":"Heterotopic ossification in high-energy wartime extremity injuries: prevalence and risk factors","volume":"91","author":"Forsberg","year":"2009","journal-title":"J Bone Joint Surg Am"},{"key":"R2-20260803","doi-asserted-by":"crossref","first-page":"689\u201397","DOI":"10.5435\/00124635-200911000-00003","article-title":"Heterotopic ossification following traumatic brain injury and spinal cord 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