{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:43:50Z","timestamp":1787064230854,"version":"build-2736575974"},"reference-count":23,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,3]]},"abstract":"\n Objective:<\/jats:title>\n Contrast-enhanced imaging, including magnetic resonance imaging and, more recently, contrast-enhanced digital mammography (CEM), is indicated for the precise diagnosis of invasive lobular carcinoma (ILC). The aim of our study was to further validate the use of CEM for evaluation of extent of disease in ILC cases, with digital breast tomosynthesis (DBT) as an adjunct.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n A retrospective, institutional review board approved study was conducted in a tertiary medical center. All CEM examinations performed on ILC patients between 2017 and 2023 were reread by 2 dedicated breast radiologists. Clinical data and pathology reports were retrieved from electronic medical records. The longest diameter of the enhancing lesion was correlated to pathology findings. In addition, for each case, the readers provided brief commentary on the added value of DBT.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n \n Twenty-four CEM examinations were evaluated. The subjects in the study cohort were on average older than expected for ILC patients (74 vs 63\u2009years) and were unable to undergo breast magnetic resonance imaging due to advanced age and comorbidities. Three subjects were treated with neoadjuvant therapy and thus were excluded from the correlation to pathology analysis. Enhancing lesions, ranging from 4\u201375\u2009mm, strongly correlated to pathology results, with statistical significance. This was demonstrated for mass and nonmass lesions (\n r<\/jats:italic>\n \u2009=\u20090.94,\n P<\/jats:italic>\n \u2009<\u20090.001 and\n r<\/jats:italic>\n \u2009=\u20090.99,\n P<\/jats:italic>\n \u2009=\u20090.002, respectively). For most lesions (17\/24, 71%), readers remarked that the addition of DBT allowed for improved characterization of lesion margins, mainly detecting architectural distortion.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions:<\/jats:title>\n When compared with the pathology findings, ILC was accurately diagnosed and assessed using CEM. The addition of DBT was reported by the interpreting radiologists as a valuable adjunct for margin analysis.<\/jats:p>\n <\/jats:sec>","DOI":"10.1097\/rct.0000000000001663","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:07Z","timestamp":1729641607000},"page":"258-264","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["Contrast-Enhanced Digital Mammography for the Diagnosis and Determination of Extent of Disease in Invasive Lobular Carcinoma: Our Experience and Literature Review"],"prefix":"10.1097","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6912-4368","authenticated-orcid":false,"given":"Margaret","family":"Johansson Lipinski","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tal","family":"Friehmann","sequence":"additional","affiliation":[{"name":"Department of Radiology, Breast Imaging, Rabin Medical Center\u2014Beilinson Hospital, Petach Tikva, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shlomit","family":"Tamir","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eli","family":"Atar","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8930-6932","authenticated-orcid":false,"given":"Ahuva","family":"Grubstein","sequence":"additional","affiliation":[{"name":"Department of Radiology, Breast Imaging, Rabin Medical Center\u2014Beilinson Hospital, Petach Tikva, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,10,10]]},"reference":[{"key":"bib1-20250415","first-page":"746","article-title":"Invasive lobular carcinoma: a review of imaging modalities with special focus on pathology concordance","volume":"11","author":"Pereslucha","year":"2023","journal-title":"Healthcare (Basel)"},{"key":"bib2-20250415","first-page":"1046","article-title":"Clinical characteristics of different histologic types of breast cancer","volume":"93","author":"Li","year":"2005","journal-title":"Br J Cancer"},{"key":"bib3-20250415","first-page":"165","article-title":"Invasive lobular carcinoma of the breast: spectrum of mammographic, US, and MR imaging findings","volume":"29","author":"Lopez","year":"2009","journal-title":"Radiographics"},{"key":"bib4-20250415","first-page":"519","article-title":"Breast MR imaging for extent of disease assessment in patients with newly diagnosed breast cancer","volume":"21","author":"Brasic","year":"2013","journal-title":"Magn Reson Imaging Clin N Am"},{"key":"bib5-20250415","first-page":"520","article-title":"Breast MRI: state of the art","volume":"292","author":"Mann","year":"2019","journal-title":"Radiology"},{"key":"bib6-20250415","first-page":"1307","article-title":"Breast MRI: guidelines from the European Society of Breast Imaging","volume":"18","author":"Mann","year":"2008","journal-title":"Eur Radiol"},{"key":"bib7-20250415","first-page":"541","article-title":"Breast MR imaging in newly diagnosed breast cancer","volume":"55","author":"Gupta","year":"2017","journal-title":"Radiol Clin North Am"},{"key":"bib8-20250415","first-page":"269","article-title":"High prevalence of MRI-detected contralateral and ipsilateral malignant findings in patients with invasive ductolobular breast cancer: impact on surgical management","volume":"16","author":"El Sharouni","year":"2016","journal-title":"Clin Breast Cancer"},{"key":"bib9-20250415","first-page":"1","article-title":"Role of magnetic resonance imaging in the preoperative staging and work-up of patients affected by invasive lobular carcinoma or invasive ductolobular carcinoma","volume":"2018","author":"Selvi","year":"2018","journal-title":"Biomed Res Int"},{"key":"bib10-20250415","first-page":"531","article-title":"Who may benefit from preoperative breast MRI? 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