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The following review seeks to summarize the various immunopathogenic mechanisms that may cause these features of Lyme disease and suggests a series of approaches based on the most likely underlying mechanism(s).<\/jats:p>","DOI":"10.1097\/rhu.0000000000002139","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T11:01:57Z","timestamp":1728903717000},"page":"315-325","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Proposed Immunopathogenetic Mechanisms Underlying Lyme Arthritis"],"prefix":"10.1097","volume":"30","author":[{"given":"Leonard H.","family":"Sigal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"bib1-20250802","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/art.1780200102","article-title":"Lyme arthritis: an epidemic of oligoarticular arthritis in children and adults in three Connecticut communities","volume":"20","year":"1977","journal-title":"Arthritis Rheum"},{"key":"bib2-20250802","doi-asserted-by":"crossref","first-page":"685","DOI":"10.7326\/0003-4819-86-6-685","article-title":"Erythema chronicum migrans and Lyme arthritis. 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