{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:10:36Z","timestamp":1787166636489,"version":"build-2736575974"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Nucl Med"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Purpose<\/jats:title>\n                  <jats:p>Cancer treatments with axillary or pelvic lymph nodes dissection and radiation place patients at lifelong risk for the development of secondary lymphedema. Our aim was to evaluate the role of stress lymphoscintigraphy for early detection and management of secondary lymphedema.<\/jats:p>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Stress lymphoscintigraphy was performed within 1 year after surgery and the completion of chemotherapy and radiation treatments. All patients were classified by the International Society of Lymphology clinical stages from 0 to 3. A dose of 50 MBq of 99mTc-HSA-nanocolloidal in 0.4mL was injected intradermally at the first and fourth intermetacarpal spaces on the hand, for the upper limb with edema, or at the first intermetatarsal space and at the lateral malleolus for lower extremities. Two planar static scans at rest were acquired immediately after tracer injection. Stress scans were acquired after weight lifting for upper extremity or stepping for 2 minutes for lower-extremity edema. After that, the patients underwent prolonged muscular exercise limited by symptoms, and later scans were acquired at 60 minutes to visualize regional lymph nodes and the effects of sustained muscular exercise. Transport Index was evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Five patterns of lymphoscintigraphy were observed. In our experience, patients with types I to III pattern benefit from an exercise program as a first-line treatment. Patterns IVand V seem to be predictive of lymphedema.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The abnormal patterns found may provide the basis for earlier complex physical therapy or microsurgical treatment of lymphatic disorders in patients resulting in improved outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/rlu.0000000000001963","type":"journal-article","created":{"date-parts":[[2017,12,30]],"date-time":"2017-12-30T08:13:28Z","timestamp":1514621608000},"page":"155-161","source":"Crossref","is-referenced-by-count":23,"title":["Stress Lymphoscintigraphy for Early Detection and Management of Secondary Limb Lymphedema"],"prefix":"10.1097","volume":"43","author":[{"given":"Girolamo","family":"Tartaglione","sequence":"first","affiliation":[{"name":"From the *Department of Nuclear Medicine, Cristo Re Hospital, Rome; \u2020Department of Plastic and Reconstructive Surgery, Center for Surgical Treatment of Lymphedema, University Cattolica del Sacro Cuore\u2013A. Gemelli Hospital, Rome; \u2021Oncological Rehabilitation, Istituto Dermopatico dell'Immacolata, IDI-IRCCS, Rome; \u00a7Department of Nuclear Medicine, Imaging and Clinical Pathology, Rovigo Hospital, Rovigo, Italy; and \u2225Department of Radiology, University of Southern California, Los Angeles, CA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Visconti","sequence":"additional","affiliation":[{"name":"From the *Department of Nuclear Medicine, Cristo Re Hospital, Rome; \u2020Department of Plastic and Reconstructive Surgery, Center for Surgical Treatment of Lymphedema, University Cattolica del Sacro Cuore\u2013A. Gemelli Hospital, Rome; \u2021Oncological Rehabilitation, Istituto Dermopatico dell'Immacolata, IDI-IRCCS, Rome; \u00a7Department of Nuclear Medicine, Imaging and Clinical Pathology, Rovigo Hospital, Rovigo, Italy; and \u2225Department of Radiology, University of Southern California, Los Angeles, CA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Bartoletti","sequence":"additional","affiliation":[{"name":"From the *Department of Nuclear Medicine, Cristo Re Hospital, Rome; \u2020Department of Plastic and Reconstructive Surgery, Center for Surgical Treatment of Lymphedema, University Cattolica del Sacro Cuore\u2013A. Gemelli Hospital, Rome; \u2021Oncological Rehabilitation, Istituto Dermopatico dell'Immacolata, IDI-IRCCS, Rome; \u00a7Department of Nuclear Medicine, Imaging and Clinical Pathology, Rovigo Hospital, Rovigo, Italy; and \u2225Department of Radiology, University of Southern California, Los Angeles, CA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Gentileschi","sequence":"additional","affiliation":[{"name":"From the *Department of Nuclear Medicine, Cristo Re Hospital, Rome; \u2020Department of Plastic and Reconstructive Surgery, Center for Surgical Treatment of Lymphedema, University Cattolica del Sacro Cuore\u2013A. Gemelli Hospital, Rome; \u2021Oncological Rehabilitation, Istituto Dermopatico dell'Immacolata, IDI-IRCCS, Rome; \u00a7Department of Nuclear Medicine, Imaging and Clinical Pathology, Rovigo Hospital, Rovigo, Italy; and \u2225Department of Radiology, University of Southern California, Los Angeles, CA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marzia","family":"Salgarello","sequence":"additional","affiliation":[{"name":"From the *Department of Nuclear Medicine, Cristo Re Hospital, Rome; \u2020Department of Plastic and Reconstructive Surgery, Center for Surgical Treatment of Lymphedema, University Cattolica del Sacro Cuore\u2013A. Gemelli Hospital, Rome; \u2021Oncological Rehabilitation, Istituto Dermopatico dell'Immacolata, IDI-IRCCS, Rome; \u00a7Department of Nuclear Medicine, Imaging and Clinical Pathology, Rovigo Hospital, Rovigo, Italy; and \u2225Department of Radiology, University of Southern California, Los Angeles, CA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domenico","family":"Rubello","sequence":"additional","affiliation":[{"name":"From the *Department of Nuclear Medicine, Cristo Re Hospital, Rome; \u2020Department of Plastic and Reconstructive Surgery, Center for Surgical Treatment of Lymphedema, University Cattolica del Sacro Cuore\u2013A. Gemelli Hospital, Rome; \u2021Oncological Rehabilitation, Istituto Dermopatico dell'Immacolata, IDI-IRCCS, Rome; \u00a7Department of Nuclear Medicine, Imaging and Clinical Pathology, Rovigo Hospital, Rovigo, Italy; and \u2225Department of Radiology, University of Southern California, Los Angeles, CA."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick M.","family":"Colletti","sequence":"additional","affiliation":[{"name":"From the *Department of Nuclear Medicine, Cristo Re Hospital, Rome; \u2020Department of Plastic and Reconstructive Surgery, Center for Surgical Treatment of Lymphedema, University Cattolica del Sacro Cuore\u2013A. Gemelli Hospital, Rome; \u2021Oncological Rehabilitation, Istituto Dermopatico dell'Immacolata, IDI-IRCCS, Rome; \u00a7Department of Nuclear Medicine, Imaging and Clinical Pathology, Rovigo Hospital, Rovigo, Italy; and \u2225Department of Radiology, University of Southern California, Los Angeles, CA."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"bib2-20231021","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1245\/s10434-017-5982-4","article-title":"Considerations for clinicians in the diagnosis, prevention, and treatment of breast cancer\u2013related lymphedema: recommendations from a multidisciplinary expert ASBrS panel: part 1: definitions, assessments, education, and future directions","volume":"24","year":"2017","journal-title":"Ann Surg Oncol"},{"key":"bib3-20231021","first-page":"1","article-title":"The diagnosis and treatment of peripheral lymphedema: 2013 consensus document of the International Society of 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