{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T22:52:18Z","timestamp":1752101538439},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Nucl Med"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>In this case of suspected sphenoid wing meningioma, <jats:sup>68<\/jats:sup>Ga-DOTATATE PET\/CT showed a somatostatin receptor (SSR)\u2013expressing tumor with extension to the nasopharynx and SSR-expressing cervical lymph nodes. Subsequent biopsy from the nasopharynx revealed an Epstein-Barr virus (EBV)\u2013associated, undifferentiated World Health Organization type 3 nasopharyngeal carcinoma (NPC), a potential clinical pitfall due to the reported high SSR expression of this tumor subtype. In consideration of the high target-to-background contrast, SSR ligands might be superior to <jats:sup>18<\/jats:sup>F-FDG for EBV-associated NPC PET imaging, particularly at the skull base. Somatostatin receptor ligands might furthermore offer interesting theranostic possibilities for patients with advanced\/extensive EBV-associated NPC.<\/jats:p>","DOI":"10.1097\/rlu.0000000000001985","type":"journal-article","created":{"date-parts":[[2018,2,4]],"date-time":"2018-02-04T22:59:27Z","timestamp":1517785167000},"page":"287-288","source":"Crossref","is-referenced-by-count":16,"title":["68Ga-DOTATATE PET\/CT Reveals Epstein-Barr Virus\u2013Associated Nasopharyngeal Carcinoma in a Case of Suspected Sphenoid Wing Meningioma"],"prefix":"10.1097","volume":"43","author":[{"given":"Marcus","family":"Unterrainer","sequence":"first","affiliation":[{"name":"From the Departments of *Nuclear Medicine and \u2020Radiation Oncology, University Hospital, LMU Munich; \u2021German Cancer Consortium (DKTK), Partner Site Munich, Munich; and German Cancer Research Center (DKFZ), Heidelberg; \u00a7Clinical Cooperation Group \u201cPersonalized Radiotherapy in Head and Neck Cancer\u201d Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Heath GmbH, Neuherberg; and \u2225Department of Radiology, University Hospital, LMU Munich, Munich, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelius","family":"Maihoefer","sequence":"additional","affiliation":[{"name":"From the Departments of *Nuclear Medicine and \u2020Radiation Oncology, University Hospital, LMU Munich; \u2021German Cancer Consortium (DKTK), Partner Site Munich, Munich; and German Cancer Research Center (DKFZ), Heidelberg; \u00a7Clinical Cooperation Group \u201cPersonalized Radiotherapy in Head and Neck Cancer\u201d Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Heath GmbH, Neuherberg; and \u2225Department of Radiology, University Hospital, LMU Munich, Munich, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clemens C.","family":"Cyran","sequence":"additional","affiliation":[{"name":"From the Departments of *Nuclear Medicine and \u2020Radiation Oncology, University Hospital, LMU Munich; \u2021German Cancer Consortium (DKTK), Partner Site Munich, Munich; and German Cancer Research Center (DKFZ), Heidelberg; \u00a7Clinical Cooperation Group \u201cPersonalized Radiotherapy in Head and Neck Cancer\u201d Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Heath GmbH, Neuherberg; and \u2225Department of Radiology, University Hospital, LMU Munich, Munich, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Bartenstein","sequence":"additional","affiliation":[{"name":"From the Departments of *Nuclear Medicine and \u2020Radiation Oncology, University Hospital, LMU Munich; \u2021German Cancer Consortium (DKTK), Partner Site Munich, Munich; and German Cancer Research Center (DKFZ), Heidelberg; \u00a7Clinical Cooperation Group \u201cPersonalized Radiotherapy in Head and Neck Cancer\u201d Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Heath GmbH, Neuherberg; and \u2225Department of Radiology, University Hospital, LMU Munich, Munich, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maximilian","family":"Niyazi","sequence":"additional","affiliation":[{"name":"From the Departments of *Nuclear Medicine and \u2020Radiation Oncology, University Hospital, LMU Munich; \u2021German Cancer Consortium (DKTK), Partner Site Munich, Munich; and German Cancer Research Center (DKFZ), Heidelberg; \u00a7Clinical Cooperation Group \u201cPersonalized Radiotherapy in Head and Neck Cancer\u201d Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Heath GmbH, Neuherberg; and \u2225Department of Radiology, University Hospital, LMU Munich, Munich, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie Lisa","family":"Albert","sequence":"additional","affiliation":[{"name":"From the Departments of *Nuclear Medicine and \u2020Radiation Oncology, University Hospital, LMU Munich; \u2021German Cancer Consortium (DKTK), Partner Site Munich, Munich; and German Cancer Research Center (DKFZ), Heidelberg; \u00a7Clinical Cooperation Group \u201cPersonalized Radiotherapy in Head and Neck Cancer\u201d Helmholtz Zentrum M\u00fcnchen, German Research Center for Environmental Heath GmbH, Neuherberg; and \u2225Department of Radiology, University Hospital, LMU Munich, Munich, Germany."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"bib1-20230925","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1093\/neuonc\/nox112","article-title":"PET imaging in patients with meningioma\u2014report of the RANO\/PET group","volume":"19","year":"2017","journal-title":"Neuro Oncol"},{"key":"bib2-20230925","doi-asserted-by":"crossref","first-page":"e383","DOI":"10.1016\/S1470-2045(16)30321-7","article-title":"EANO guidelines for the diagnosis and treatment of meningiomas","volume":"17","year":"2016","journal-title":"Lancet Oncol"},{"key":"bib3-20230925","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.2967\/jnumed.117.191932","article-title":"Improved detection of transosseous meningiomas using 68Ga-DOTATATE PET\/CT compared with contrast-enhanced MRI","volume":"58","year":"2017","journal-title":"J Nucl Med"},{"key":"bib4-20230925","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/1748-717X-4-56","article-title":"[68Ga]-DOTATOC-PET\/CT for meningioma IMRT treatment planning","volume":"4","year":"2009","journal-title":"Radiat Oncol"},{"key":"bib5-20230925","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1385\/MO:22:2:113","article-title":"Involvement of the Epstein-Barr virus in the nasopharyngeal carcinoma pathogenesis","volume":"22","year":"2005","journal-title":"Med Oncol"},{"key":"bib6-20230925","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1097\/RLU.0b013e31817dec00","article-title":"Somatostatin receptor scintigraphy in nasopharyngeal carcinoma","volume":"33","year":"2008","journal-title":"Clin Nucl Med"},{"key":"bib7-20230925","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1007\/s00428-002-0693-y","article-title":"Somatostatin receptors in nasopharyngeal carcinoma","volume":"441","year":"2002","journal-title":"Virchows Arch"},{"key":"bib8-20230925","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1007\/s00259-013-2442-7","article-title":"68Ga-DOTA0-Tyr3-octreotide positron emission tomography in head and neck squamous cell carcinoma","volume":"40","year":"2013","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"bib9-20230925","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1097\/RLU.0000000000001793","article-title":"Epidural metastases from follicular thyroid cancer mimicking meningiomas in 68Ga-DOTATATE PET","volume":"42","year":"2017","journal-title":"Clin Nucl Med"},{"key":"bib10-20230925","first-page":"1538","article-title":"Somatostatin receptor\u2013targeted radionuclide therapy for progressive meningioma: benefit linked to 68Ga-DOTATATE\/-TOC uptake","volume":"18","year":"2016","journal-title":"Neuro Oncol"}],"container-title":["Clinical Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/00003072-201804000-00020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T05:01:11Z","timestamp":1695618071000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00003072-201804000-00020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1097\/rlu.0000000000001985","relation":{},"ISSN":["1536-0229","0363-9762"],"issn-type":[{"value":"1536-0229","type":"electronic"},{"value":"0363-9762","type":"print"}],"subject":[],"published":{"date-parts":[[2018,4]]}}}