{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T14:36:39Z","timestamp":1785162999561,"version":"3.55.0"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Nucl Med"],"published-print":{"date-parts":[[2018,5]]},"abstract":"<jats:sec>\n            <jats:title>Objective<\/jats:title>\n            <jats:p>The evaluation of therapy response of patients with deep mycosis is a major challenge. The aim of this study was to assess the severity of disease at admission and evaluate treatment response of patients with paracoccidioidomycosis using <jats:sup>67<\/jats:sup>Ga scintigraphy.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Subjects and Methods<\/jats:title>\n            <jats:p>Seventy-three patients with fully active disease were enrolled. A scoring system based on clinicoradiological and serological evaluation and <jats:sup>67<\/jats:sup>Ga scan was devised. Pretherapy <jats:sup>67<\/jats:sup>Ga score of 73 patients was compared with clinicoradiological and serological scores. A subgroup of 23 patients was followed up during treatment, and the rates of improvement of their clinicoradiological, serological, and <jats:sup>67<\/jats:sup>Ga scores during treatment were compared at 3 time points (fully active phase, after clinical improvement, and clinically inactive disease).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>The correlations between scores before therapy were statistically significant. <jats:sup>67<\/jats:sup>Ga score correlated with clinical score (<jats:italic toggle=\"yes\">r<\/jats:italic> = 0.47, <jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001). Serological score correlated with both <jats:sup>67<\/jats:sup>Ga and clinical scores (<jats:italic toggle=\"yes\">r<\/jats:italic> = 0.32, <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.006, and <jats:italic toggle=\"yes\">r<\/jats:italic> = 0.25, <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.034, respectively). Concerning evaluation of therapy response, clinicoradiological, serological, and <jats:sup>67<\/jats:sup>Ga scores decreased significantly after therapy (<jats:italic toggle=\"yes\">P<\/jats:italic> &lt; 0.001). Notably, <jats:sup>67<\/jats:sup>Ga score was the single one to become negative in most patients at the end of treatment (20 of 23 patients compared with 7 on clinicoradiological evaluation and 10 on serology, <jats:italic toggle=\"yes\">P<\/jats:italic> = 0.003).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>In patients with paracoccidioidomycosis, pretherapy <jats:sup>67<\/jats:sup>Ga scintigraphy correlates with disease severity. Serial <jats:sup>67<\/jats:sup>Ga scans seem to be helpful in evaluating the response to therapy.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/rlu.0000000000002017","type":"journal-article","created":{"date-parts":[[2018,3,7]],"date-time":"2018-03-07T19:52:29Z","timestamp":1520452349000},"page":"305-310","source":"Crossref","is-referenced-by-count":5,"title":["67Ga Scintigraphy for Assessment of Disease Severity and Treatment Response in Patients With Paracoccidioidomycosis"],"prefix":"10.1097","volume":"43","author":[{"given":"Lilian Yuri Itaya","family":"Yamaga","sequence":"first","affiliation":[{"name":"From the *Department of Imaging, Hospital Israelita Albert Einstein; and \u2020Laboratory of Dermatology and Immunodeficiencies, Departments of \u2021Radiology, and \u00a7Infectious and Parasitic Diseases, S\u00e3o Paulo University Faculty of Medicine, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gil","family":"Benard","sequence":"additional","affiliation":[{"name":"From the *Department of Imaging, Hospital Israelita Albert Einstein; and \u2020Laboratory of Dermatology and Immunodeficiencies, Departments of \u2021Radiology, and \u00a7Infectious and Parasitic Diseases, S\u00e3o Paulo University Faculty of Medicine, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoco","family":"Watanabe","sequence":"additional","affiliation":[{"name":"From the *Department of Imaging, Hospital Israelita Albert Einstein; and \u2020Laboratory of Dermatology and Immunodeficiencies, Departments of \u2021Radiology, and \u00a7Infectious and Parasitic Diseases, S\u00e3o Paulo University Faculty of Medicine, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Buarque de Gusm\u00e3o","family":"Funari","sequence":"additional","affiliation":[{"name":"From the *Department of Imaging, Hospital Israelita Albert Einstein; and \u2020Laboratory of Dermatology and Immunodeficiencies, Departments of \u2021Radiology, and \u00a7Infectious and Parasitic Diseases, S\u00e3o Paulo University Faculty of Medicine, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fausto Haruki","family":"Hironaka","sequence":"additional","affiliation":[{"name":"From the *Department of Imaging, Hospital Israelita Albert Einstein; and \u2020Laboratory of Dermatology and Immunodeficiencies, Departments of \u2021Radiology, and \u00a7Infectious and Parasitic Diseases, S\u00e3o Paulo University Faculty of Medicine, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Alberto","family":"Buchpighel","sequence":"additional","affiliation":[{"name":"From the *Department of Imaging, Hospital Israelita Albert Einstein; and \u2020Laboratory of Dermatology and Immunodeficiencies, Departments of \u2021Radiology, and \u00a7Infectious and Parasitic Diseases, S\u00e3o Paulo University Faculty of Medicine, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Aparecida","family":"Shikanai-Yasuda","sequence":"additional","affiliation":[{"name":"From the *Department of Imaging, Hospital Israelita Albert Einstein; and \u2020Laboratory of Dermatology and Immunodeficiencies, Departments of \u2021Radiology, and \u00a7Infectious and Parasitic Diseases, S\u00e3o Paulo University Faculty of Medicine, S\u00e3o Paulo, Brazil."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"bib2-20231021","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1590\/0037-8682-0230-2017","article-title":"Brazilian guidelines for the clinical management of paracoccidioidomycosis","volume":"50","year":"2017","journal-title":"Rev Soc Bras Med Trop"},{"key":"bib3-20231021","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1080\/mmy.40.4.411.417","article-title":"Randomized therapeutic trial with itraconazole, ketoconazole and sulfadiazine in paracoccidioidomycosis","volume":"40","year":"2002","journal-title":"Med Mycol"},{"key":"bib4-20231021","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1055\/s-2008-1063857","article-title":"Pulmonary paracoccidioidomycosis","volume":"29","year":"2008","journal-title":"Semin Respir Crit Care Med"},{"key":"bib5-20231021","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1086\/377538","article-title":"Residual pulmonary abnormalities in adult patients with chronic paracoccidioidomycosis: prolonged follow-up after itraconazole therapy","volume":"37","year":"2003","journal-title":"Clin Infect Dis"},{"key":"bib6-20231021","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1590\/S0036-46651991000400005","article-title":"Paracoccidioidomycosis: radiologic and pulmonary study in 58 cases","volume":"33","year":"1991","journal-title":"Rev Inst Med Trop Sao Paulo"},{"key":"bib7-20231021","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1099\/0022-1317-49-1-37","article-title":"Evaluation of tests for antibody response in the follow-up of patients with acute and chronic forms of paracoccidioidomycosis","volume":"49","year":"2000","journal-title":"J Med Microbiol"},{"key":"bib8-20231021","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1007\/BF00256555","article-title":"Gallium-67 imaging in the diagnosis of blastomycosis","volume":"13","year":"1987","journal-title":"Eur J Nucl Med"},{"key":"bib9-20231021","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1007\/s00259-003-1172-7","article-title":"The role of gallium-67 scan in defining the extent of disease in an endemic deep mycosis, paracoccidioidomycosis: a predominantly multifocal disease","volume":"30","year":"2003","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"bib10-20231021","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S0001-2998(05)80227-2","article-title":"The current role of gallium imaging in infection","volume":"24","year":"1994","journal-title":"Semin Nucl Med"},{"key":"bib11-20231021","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/0002-9343(83)90516-8","article-title":"Treatment of coccidioidomycosis with ketoconazole: an evaluation utilizing a new scoring system","volume":"74","year":"1983","journal-title":"Am J Med"},{"key":"bib12-20231021","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1007\/s40336-014-0092-9","article-title":"SPECT\/CT in infection and inflammation","volume":"2","year":"2014","journal-title":"Clin Transl Imaging"},{"key":"bib13-20231021","doi-asserted-by":"crossref","first-page":"W403","DOI":"10.2214\/AJR.06.0587","article-title":"Monitoring treatment responses in patients with pulmonary TB using serial lung gallium-67 scintigraphy","volume":"188","year":"2007","journal-title":"AJR Am J Roentgenol"},{"key":"bib14-20231021","first-page":"673","article-title":"Diagnostic value of gallium and bone scans in evaluation of extrapulmonary coccidioidal lesions","volume":"121","year":"1980","journal-title":"Am Rev Respir Dis"},{"key":"bib15-20231021","doi-asserted-by":"crossref","first-page":"441","DOI":"10.6061\/clinics\/2013(04)02","article-title":"The lung in paracoccidioidomycosis: new insights into old problems","volume":"68","year":"2013","journal-title":"Clinics (Sao Paulo)"},{"key":"bib16-20231021","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s11046-007-9047-2","article-title":"Neoplasia and paracoccidioidomycosis","volume":"165","year":"2008","journal-title":"Mycopathologia"},{"key":"bib17-20231021","first-page":"356","article-title":"Association between paracoccidioidomycosis and cancer","volume":"36","year":"2010","journal-title":"J Bras Pneumol"},{"key":"bib18-20231021","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2214\/ajr.173.1.10397100","article-title":"Chronic pulmonary paracoccidioidomycosis (South American blastomycosis): high-resolution CT findings in 41 patients","volume":"173","year":"1999","journal-title":"AJR Am J Roentgenol"},{"key":"bib19-20231021","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/BF00437631","article-title":"Pathology of the human pulmonary paracoccidioidomycosis","volume":"92","year":"1985","journal-title":"Mycopathologia"},{"key":"bib20-20231021","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1590\/S0036-46651991000400006","article-title":"The sensitivity, specificity and efficiency values of some serological tests used in the diagnosis of paracoccidioidomycosis","volume":"33","year":"1991","journal-title":"Rev Inst Med Trop Sao Paulo"},{"key":"bib21-20231021","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/j.1439-0507.2008.01687.x","article-title":"Is the geographical origin of a Paracoccidioides brasiliensis isolate important for antigen production for regional diagnosis of paracoccidioidomycosis?","volume":"53","year":"2010","journal-title":"Mycoses"},{"key":"bib22-20231021","doi-asserted-by":"crossref","first-page":"e2986","DOI":"10.1371\/journal.pntd.0002986","article-title":"Serology of paracoccidioidomycosis due to Paracoccidioides lutzii","volume":"8","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"bib23-20231021","doi-asserted-by":"crossref","first-page":"e3174","DOI":"10.1371\/journal.pntd.0003174","article-title":"Serological diagnosis of paracoccidioidomycosis: high rate of inter-laboratorial variability among medical mycology reference centers","volume":"8","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"bib24-20231021","first-page":"381","article-title":"Acompanhamento terap\u00eautico da paracoccidiodomicose por imagens com 67-Ga","volume":"6","year":"1994","journal-title":"Arq Bras Med"},{"key":"bib25-20231021","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1590\/S0036-46651992000200005","article-title":"Aspectos radiol\u00f3gicos tor\u00e1cicos n paracoccidioidomicose","volume":"34","year":"1992","journal-title":"Rev Inst Med Trop S\u00e3o Paulo"},{"key":"bib26-20231021","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1007\/s00259-007-0585-0","article-title":"Double-phase 18F-FDG PET-CT for determination of pulmonary tuberculoma activity","volume":"35","year":"2008","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"bib27-20231021","first-page":"180","article-title":"Potential role of 18F-FDG PET\/CT in patients with fungal infections","volume":"203","year":"2014","journal-title":"Am J Radiol"}],"container-title":["Clinical Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/00003072-201805000-00001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T04:52:15Z","timestamp":1697863935000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00003072-201805000-00001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":26,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1097\/rlu.0000000000002017","relation":{},"ISSN":["1536-0229","0363-9762"],"issn-type":[{"value":"1536-0229","type":"electronic"},{"value":"0363-9762","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]}}}