{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T14:44:52Z","timestamp":1708008292941},"reference-count":14,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Nucl Med"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>A 37-year-old woman with pheochromocytoma underwent presurgical FDG PET\/CT. Despite her usual antiadrenergic medication consisting in 25 mg of carvedilol, PET\/CT demonstrated intense and widespread FDG uptake in brown adipose tissue (BAT). No BAT FDG uptake was detectable on a repeated examination after specific preparation consisting in 40 mg propranolol and 5 mg diazepam. We therefore recommend this propranolol-diazepam preparation in patients with pheochromocytoma referred for PET\/CT. Carvedilol\u2014classically prescribed to alleviate effects of adrenergic overstimulation\u2014seems ineffective on BAT. This observation questions the benefit of carvedilol to reduce \u03b23-adrenoreceptor\u2013mediated effects, not only in BAT, but also in other tissues.<\/jats:p>","DOI":"10.1097\/rlu.0000000000002170","type":"journal-article","created":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T17:55:24Z","timestamp":1529430924000},"page":"604-605","source":"Crossref","is-referenced-by-count":2,"title":["Failure of Classical \u03b2-Blocker Carvedilol to Deactivate Brown Adipose Tissue in a Patient With Pheochromocytoma"],"prefix":"10.1097","volume":"43","author":[{"given":"Ioannis","family":"Tsechelidis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"El Darazi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raoul","family":"Muteganya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"Weyts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serge","family":"Goldman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"bib1-20230925","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/s13139-014-0276-2","article-title":"Perirenal (18)F-FDG uptake in a patient with a pheochromocytoma","volume":"48","year":"2014","journal-title":"Nucl Med Mol Imaging"},{"key":"bib2-20230925","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s12149-007-0096-x","article-title":"Brown adipose tissue demonstrating intense FDG uptake in a patient with mediastinal pheochromocytoma","volume":"22","year":"2008","journal-title":"Ann Nucl Med"},{"key":"bib3-20230925","doi-asserted-by":"crossref","first-page":"300","DOI":"10.2214\/AJR.08.1166","article-title":"Adrenal pheochromocytoma with surrounding brown fat stimulation","volume":"192","year":"2009","journal-title":"AJR Am J Roentgenol"},{"key":"bib4-20230925","first-page":"446","article-title":"The effect of catecholamines on the glucose uptake in brown adipose tissue demonstrated by 18F-FDG PET\/CT in a patient with adrenal pheochromocytoma","volume":"35","year":"2007","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"bib5-20230925","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1097\/RLU.0000000000001819","article-title":"18F-FDG PET\/CT of brown adipose tissue hyperactivation associated with pregnancy and paraganglioma","volume":"42","year":"2017","journal-title":"Clin Nucl Med"},{"key":"bib6-20230925","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/S0022-2275(20)37695-1","article-title":"Fat cell adrenergic receptors and the control of white and brown fat cell function","volume":"34","year":"1993","journal-title":"J Lipid Res"},{"key":"bib7-20230925","doi-asserted-by":"crossref","first-page":"C969","DOI":"10.1152\/ajpcell.1994.267.4.C969","article-title":"Coexisting beta-adrenoceptor subtypes: significance for thermogenic process in brown fat cells","volume":"267","year":"1994","journal-title":"Am J Physiol"},{"key":"bib8-20230925","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00210-003-0860-y","article-title":"Comparative pharmacology of human beta-adrenergic receptor subtypes\u2014characterization of stably transfected receptors in CHO cells","volume":"369","year":"2004","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"bib9-20230925","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/0040-6031(94)02010-L","article-title":"Thermogenic effect of two \u03b2-adrenoceptor blocking drugs, propranolol and carvedilol, on skeletal muscle in rats. 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