{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T20:55:48Z","timestamp":1764276948894},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Nucl Med"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>T-cell large granular lymphocytic leukemia is a rare form of leukemia, caused by clonal proliferation of cytotoxic T-cells, characterized by modest lymphocytosis and cytopenias of other lineage with hepatosplenomegaly and relatively rare lymph nodal involvement. Involvement of other organs is extremely rare. It is predominantly an indolent disease and most of patients remain asymptomatic for a long period. We present a rare case of aggressive form (CD56 positive) of large granular lymphocytic leukemia with atypical presentations mimicking pleural malignancy on <jats:sup>18<\/jats:sup>F-FDG PET\/CT.<\/jats:p>","DOI":"10.1097\/rlu.0000000000002425","type":"journal-article","created":{"date-parts":[[2019,1,23]],"date-time":"2019-01-23T20:29:55Z","timestamp":1548275395000},"page":"e296-e297","source":"Crossref","is-referenced-by-count":2,"title":["Atypical Presentation of T-Cell Large Granular Lymphocytic Leukemia Mimicking Pleural Malignancy on 18F-FDG PET\/CT"],"prefix":"10.1097","volume":"44","author":[{"given":"Raja","family":"Senthil","sequence":"first","affiliation":[{"name":"Nuclear Medicine and PET\/CT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arun","family":"Visakh R.","sequence":"additional","affiliation":[{"name":"Nuclear Medicine and PET\/CT"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thara","family":"Pratap","sequence":"additional","affiliation":[{"name":"Radiology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pushpa","family":"Mahadevan","sequence":"additional","affiliation":[{"name":"Pathology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V P","family":"Gangadharan","sequence":"additional","affiliation":[{"name":"Medical Oncology, VPS Lakeshore Hospital, Kochi, India."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"bib1-20230925","doi-asserted-by":"crossref","first-page":"545","DOI":"10.3348\/kjr.2016.17.4.545","article-title":"Multidetector CT findings and differential diagnoses of malignant pleural mesothelioma and metastatic pleural diseases in Korea","volume":"17","year":"2016","journal-title":"Korean J Radiol"},{"key":"bib2-20230925","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1634\/theoncologist.9-3-247","article-title":"T-cell large granular lymphocyte leukemia and related disorders","volume":"9","year":"2004","journal-title":"Oncologist"},{"key":"bib3-20230925","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0037-1963(03)00135-5","article-title":"Survival signals in leukemic large granular lymphocytes","volume":"40","year":"2003","journal-title":"Semin Hematol"},{"key":"bib4-20230925","doi-asserted-by":"crossref","first-page":"e68","DOI":"10.4081\/cp.2012.e68","article-title":"Asymptomatic T-cell large granular lymphocyte leukemia with an unusual immunophenotype","volume":"2","year":"2012","journal-title":"Clin Pract"},{"key":"bib5-20230925","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1182\/blood.V82.1.1.bloodjournal8211","article-title":"Clonal diseases of large granular lymphocytes","volume":"82","year":"1993","journal-title":"Blood"},{"key":"bib6-20230925","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1111\/j.1365-2141.1992.tb06458.x","article-title":"A distinct large granular lymphocyte (LGL)\/NK-associated (NKa) abnormality characterized by membrane CD4 and CD8 coexpression. 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