{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:04:42Z","timestamp":1785852282070,"version":"3.56.0"},"reference-count":45,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Nucl Med"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      To evaluate the preventive effect of parotid gland (PG) massage for PG damage during the\n                      <jats:sup>131<\/jats:sup>\n                      I therapy, we prospectively investigated the serum amylase value and salivary gland scintigraphy (SGS) after\n                      <jats:sup>131<\/jats:sup>\n                      I therapy.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      One hundred patients with thyroidectomized differentiated thyroid cancer who underwent high-dose\n                      <jats:sup>131<\/jats:sup>\n                      I therapy were enrolled in the clinical trial and randomized into 2 groups (PG massage group and nonmassage group). The serum amylase value was obtained before and 24 hours after\n                      <jats:sup>131<\/jats:sup>\n                      I therapy, and the SGSs were also taken just before and at 8 months after the\n                      <jats:sup>131<\/jats:sup>\n                      I therapy. Change in serum amylase value and SGS was compared between PG massage and nonmassage groups.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The difference value of serum amylase was significantly lower in PG massage group than in nonmassage group (\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0052). Worsening of PG function on SGS was observed in 43 (45.3%) of the 95 patients. The incidence rate of PG abnormality on F\/U SGS was significantly lower in PG massage group than in nonmassage group (odds ratio, 0.3704;\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0195). In the multiple regression analysis, PG massage significantly affected the abnormality on the 8-month F\/U SGS (\n                      <jats:italic toggle=\"yes\">r<\/jats:italic>\n                      <jats:sub>partial<\/jats:sub>\n                      = \u22120.2741,\n                      <jats:italic toggle=\"yes\">P<\/jats:italic>\n                      = 0.0090) after adjusting for clinical variables (age, sex, TNM stage, TSH preparation methods for the\n                      <jats:sup>131<\/jats:sup>\n                      I therapy, and\n                      <jats:sup>131<\/jats:sup>\n                      I dose).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      PG gland massage significantly reduced the incidence rates of salivary gland dysfunction on the 8-month F\/U SGS and the level of the serological marker of salivary gland destruction after\n                      <jats:sup>131<\/jats:sup>\n                      I therapy. Therefore, PG gland massage could alleviate salivary gland damage related to\n                      <jats:sup>131<\/jats:sup>\n                      I therapy.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/rlu.0000000000002602","type":"journal-article","created":{"date-parts":[[2019,5,6]],"date-time":"2019-05-06T16:38:09Z","timestamp":1557160689000},"page":"625-633","source":"Crossref","is-referenced-by-count":22,"title":["The Preventive Effect of Parotid Gland Massage on Salivary Gland Dysfunction During High-Dose Radioactive Iodine Therapy for Differentiated Thyroid Cancer"],"prefix":"10.1097","volume":"44","author":[{"given":"Seung Hyun","family":"Son","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Hee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Hoon","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Do-Hoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chae Moon","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju Hye","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin Young","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang-Woo","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaetae","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byeong-Cheol","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2019,5,3]]},"reference":[{"key":"bib1-20230925","doi-asserted-by":"crossref","first-page":"260","DOI":"10.3389\/fendo.2017.00260","article-title":"Redifferentiation of radioiodine refractory differentiated thyroid cancer for reapplication of I-131 therapy","volume":"8","year":"2017","journal-title":"Front Endocrinol (Lausanne)"},{"key":"bib2-20230925","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1007\/s12149-017-1188-x","article-title":"I-131 biokinetics of remnant normal thyroid tissue and residual thyroid cancer in patients with differentiated thyroid cancer: comparison between recombinant human TSH administration and thyroid hormone withdrawal","volume":"31","year":"2017","journal-title":"Ann Nucl Med"},{"key":"bib3-20230925","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1097\/MNM.0000000000000636","article-title":"Clinical outcomes of low-dose and high-dose postoperative radioiodine therapy in patients with intermediate-risk differentiated thyroid cancer","volume":"38","year":"2017","journal-title":"Nucl Med Commun"},{"key":"bib4-20230925","first-page":"1680464","article-title":"Personalized medicine based on theranostic radioiodine molecular imaging for differentiated thyroid cancer","volume":"2016","year":"2016","journal-title":"Biomed Res Int"},{"key":"bib5-20230925","first-page":"362","article-title":"False-positive uptake on radioiodine whole-body scintigraphy: physiologic and pathologic variants unrelated to thyroid cancer","volume":"2","year":"2012","journal-title":"Am J Nucl Med Mol Imaging"},{"key":"bib6-20230925","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1152\/physrev.2000.80.3.1083","article-title":"Molecular analysis of the sodium\/iodide symporter: impact on thyroid and extrathyroid pathophysiology","volume":"80","year":"2000","journal-title":"Physiol Rev"},{"key":"bib7-20230925","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1089\/105072503321582060","article-title":"Radioactive iodine and the salivary glands","volume":"13","year":"2003","journal-title":"Thyroid"},{"key":"bib8-20230925","doi-asserted-by":"crossref","first-page":"392","DOI":"10.7150\/thno.3722","article-title":"Sodium iodide symporter for nuclear molecular imaging and gene therapy: from bedside to bench and back","volume":"2","year":"2012","journal-title":"Theranostics"},{"key":"bib9-20230925","doi-asserted-by":"crossref","first-page":"576","DOI":"10.7326\/0003-4819-120-7-199404010-00008","article-title":"Peripheral facial nerve palsy after high-dose radioiodine therapy in patients with papillary thyroid carcinoma","volume":"120","year":"1994","journal-title":"Ann Intern Med"},{"key":"bib10-20230925","first-page":"755","article-title":"Sialadenitis following I-131 therapy for thyroid carcinoma: concise communication","volume":"25","year":"1984","journal-title":"J Nucl Med"},{"key":"bib11-20230925","first-page":"485","article-title":"The salivary and thyroid glands. 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