{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,26]],"date-time":"2024-07-26T18:33:12Z","timestamp":1722018792472},"reference-count":8,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Clin Nucl Med"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>\u03b2-Lactam antibiotics are proconvulsive. In laboratory animals, this effect seems to be predominantly mediated through inhibition of GABA-A receptors, but it has not been demonstrated in humans in vivo. We report images of a [<jats:sup>11<\/jats:sup>C]Ro15-4513 PET from a 40-year-old man who had completed a 1-week course of flucloxacillin before it. Relative to healthy controls, the participant had significantly lower mean gray matter binding. These novel data suggest that, in humans, the proconvulsive effect of \u03b2-lactam antibiotics is mediated via either competition for the same benzodiazepine-binding site as [<jats:sup>11<\/jats:sup>C]Ro15-4513 or downregulation of GABA-A receptor expression.<\/jats:p>","DOI":"10.1097\/rlu.0000000000002811","type":"journal-article","created":{"date-parts":[[2019,11,4]],"date-time":"2019-11-04T19:20:08Z","timestamp":1572895208000},"page":"981-982","source":"Crossref","is-referenced-by-count":2,"title":["Decreased GABA-A Receptor Binding in Association With \u03b2-Lactam Antibiotic Use"],"prefix":"10.1097","volume":"44","author":[{"given":"Anthime","family":"Flaus","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela Alexandra","family":"Ria\u00f1o Barros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rainer","family":"Hinz","sequence":"additional","affiliation":[{"name":"Wolfson Molecular Imaging Centre, University of Manchester, Manchester"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James F.","family":"Myers","sequence":"additional","affiliation":[{"name":"Centre for Neuroscience, Department of Medicine, Imperial College London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Lingford-Hughes","sequence":"additional","affiliation":[{"name":"Neuropsychopharmacology Unit, Department of Medicine, Imperial College London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias J.","family":"Koepp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Hammers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colm Joseph","family":"McGinnity","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2019,10,31]]},"reference":[{"key":"bib1-20230925","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1111\/j.1365-2125.2011.03991.x","article-title":"Neurotoxic effects associated with antibiotic use: management considerations","volume":"72","year":"2011","journal-title":"Br J Clin Pharmacol"},{"key":"bib2-20230925","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1007\/s10096-005-0021-y","article-title":"Neurotoxicity induced by beta-lactam antibiotics: from bench to bedside","volume":"24","year":"2005","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"bib3-20230925","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/S0028-3908(03)00188-6","article-title":"Evidence for the involvement of GABA(A) receptor blockade in convulsions induced by cephalosporins","volume":"45","year":"2003","journal-title":"Neuropharmacology"},{"key":"bib4-20230925","doi-asserted-by":"crossref","first-page":"3014","DOI":"10.1111\/j.1476-5381.1995.tb15957.x","article-title":"Dual mechanisms of GABAA response inhibition by beta-lactam antibiotics in the pyramidal neurones of the rat cerebral cortex","volume":"116","year":"1995","journal-title":"Br J Pharmacol"},{"key":"bib5-20230925","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.mcn.2014.10.001","article-title":"Block of GABAA receptor ion channel by penicillin: electrophysiological and modeling insights toward the mechanism","volume":"63","year":"2014","journal-title":"Mol Cell Neurosci"},{"key":"bib6-20230925","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.neuroimage.2016.12.038","article-title":"Test-retest reproducibility of quantitative binding measures of [11C]Ro15-4513, a PET ligand for GABA A receptors containing alpha5 subunits","volume":"152","year":"2017","journal-title":"Neuroimage"},{"key":"bib7-20230925","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1038\/jcbfm.2011.177","article-title":"Characterisation of the contribution of the GABA-benzodiazepine \u03b11 receptor subtype to [11C]Ro15-4513 PET images","volume":"32","year":"2012","journal-title":"J Cereb Blood Flow Metab"},{"key":"bib8-20230925","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.neuroimage.2013.04.015","article-title":"Quantification of opioid receptor availability following spontaneous epileptic seizures: correction of [11C]diprenorphine PET data for the partial-volume effect","volume":"79","year":"2013","journal-title":"Neuroimage"}],"container-title":["Clinical Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/RLU.0000000000002811","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T05:00:40Z","timestamp":1695618040000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/RLU.0000000000002811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,31]]},"references-count":8,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019]]}},"URL":"https:\/\/doi.org\/10.1097\/rlu.0000000000002811","relation":{},"ISSN":["1536-0229","0363-9762"],"issn-type":[{"value":"1536-0229","type":"electronic"},{"value":"0363-9762","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10,31]]}}}