{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T20:14:12Z","timestamp":1780517652249,"version":"3.54.1"},"reference-count":10,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Clin Nucl Med"],"published-print":{"date-parts":[[2021,5]]},"abstract":"Abstract<\/jats:title>\n A 60-year-old woman with surgically confirmed immunoglobulin G4\u2013related sclerosing cholangitis underwent 18<\/jats:sup>F-FDG PET\/CT due to significantly elevated serum CA-19-9 level, which revealed a hypermetabolic lesion in the residual liver. 68<\/jats:sup>Ga-FAPI PET\/MR was performed to further evaluate whether the FDG-avid lesion is a malignant tumor. Astonishingly, diffuse intense radioactivity was revealed throughout the liver, suggesting involvement of active immunoglobulin G4\u2013related sclerosing cholangitis, but nonfocal elevated 68<\/jats:sup>Ga-FAPI accumulation in the FDG-avid lesion indicated postoperative change. From this case, we speculated that FAPI imaging could be used for evaluation of chronic liver disease because fibroblast activation protein has a profibrogenic role in chronic liver injury.<\/jats:p>","DOI":"10.1097\/rlu.0000000000003552","type":"journal-article","created":{"date-parts":[[2021,2,27]],"date-time":"2021-02-27T06:58:02Z","timestamp":1614409082000},"page":"419-421","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":20,"title":["Immunoglobulin G4\u2013Related Sclerosing Cholangitis Revealed by 68Ga-FAPI PET\/MR"],"prefix":"10.1097","volume":"46","author":[{"given":"Chunxia","family":"Qin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiwei","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuqiang","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"bib1-20250621","doi-asserted-by":"crossref","first-page":"801","DOI":"10.2967\/jnumed.119.227967","article-title":"68Ga-FAPI PET\/CT: tracer uptake in 28 different kinds of cancer","volume":"60","year":"2019","journal-title":"J Nucl Med"},{"key":"bib2-20250621","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s00259-020-04940-6","article-title":"Usefulness of [68Ga]Ga-DOTA-FAPI-04 PET\/CT in patients presenting with inconclusive [18F]FDG PET\/CT findings","volume":"48","year":"2021","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"bib3-20250621","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1136\/annrheumdis-2020-217408","article-title":"Disentangling inflammatory from fibrotic disease activity by fibroblast activation protein imaging","volume":"79","year":"2020","journal-title":"Ann Rheum Dis"},{"key":"bib4-20250621","article-title":"Fibroblast activation protein targeted PET\/CT with 68Ga-FAPI for imaging IgG4-related disease: comparison to 18F-FDG PET\/CT","year":"2020","journal-title":"J Nucl Med"},{"key":"bib5-20250621","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1097\/RLU.0000000000002919","article-title":"Recurrent immunoglobulin G4\u2013related disease shown on 18F-FDG and 68Ga-FAPI PET\/CT","volume":"45","year":"2020","journal-title":"Clin Nucl Med"},{"key":"bib6-20250621","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1097\/BOR.0b013e328341347b","article-title":"Pathological features of IgG4-related sclerosing disease","volume":"23","year":"2011","journal-title":"Curr Opin Rheumatol"},{"key":"bib7-20250621","doi-asserted-by":"crossref","first-page":"386","DOI":"10.2967\/jnumed.118.215913","article-title":"68Ga-FAPI PET\/CT: biodistribution and preliminary dosimetry estimate of 2 DOTA-containing FAP-targeting agents in patients with various cancers","volume":"60","year":"2019","journal-title":"J Nucl Med"},{"key":"bib8-20250621","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1002\/hep.20853","article-title":"Fibroblast activation protein increases apoptosis, cell adhesion, and migration by the LX-2 human stellate cell line","volume":"42","year":"2005","journal-title":"Hepatology"},{"key":"bib9-20250621","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2741\/4706","article-title":"Fibroblast activation protein in liver fibrosis","volume":"24","year":"2019","journal-title":"Front Biosci (Landmark Ed)"},{"key":"bib10-20250621","doi-asserted-by":"crossref","first-page":"e430","DOI":"10.1097\/RLU.0000000000003015","article-title":"68Ga-FAPI PET\/CT in assessment of liver nodules in a cirrhotic patient","volume":"45","year":"2020","journal-title":"Clin Nucl Med"}],"container-title":["Clinical Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/RLU.0000000000003552","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T21:03:17Z","timestamp":1750539797000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/RLU.0000000000003552"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.1097\/rlu.0000000000003552","relation":{},"ISSN":["1536-0229","0363-9762"],"issn-type":[{"value":"1536-0229","type":"electronic"},{"value":"0363-9762","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]}}}