{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:45:52Z","timestamp":1787010352061,"version":"build-2736575974"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"9","license":[{"start":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T00:00:00Z","timestamp":1687478400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Clin Nucl Med"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      This study aimed to explore the imaging value of\n                      <jats:sup>68<\/jats:sup>\n                      Ga-FAPI-04 PET\/CT in synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome and compare it with that of\n                      <jats:sup>99m<\/jats:sup>\n                      Tc-MDP bone scan.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Nineteen participants with SAPHO syndrome underwent\n                      <jats:sup>68<\/jats:sup>\n                      Ga-FAPI-04 PET\/CT and\n                      <jats:sup>99m<\/jats:sup>\n                      Tc-MDP bone scan. Demographic data and clinical features were recorded, SAPHO imaging features were analyzed, and the osteoarticular lesion detection rate in both methods was calculated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      This prospective study recruited 4 men and 15 women aged 52.4 \u00b1 8.6 years. The anterior chest wall was involved in all participants (100%). Palmoplantar pustulosis was the most common (36.8%) skin symptom.\n                      <jats:sup>99m<\/jats:sup>\n                      Tc-MDP bone scan and\n                      <jats:sup>68<\/jats:sup>\n                      Ga-FAPI-04 PET\/CT together detected 84 osteoarticular lesions, of which 91.7% (77\/84) were detected by the former and 96.4% (81\/84) by the latter. Furthermore,\n                      <jats:sup>68<\/jats:sup>\n                      Ga-FAPI-04 PET\/CT detected 5 cases of knee and hip joint synovitis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      <jats:sup>68<\/jats:sup>\n                      Ga-FAPI-04 PET\/CT was more sensitive than\n                      <jats:sup>99m<\/jats:sup>\n                      Tc-MDP bone scan when evaluating osteoarticular lesions in SAPHO syndrome and could also evaluate synovial lesions.\n                      <jats:sup>68<\/jats:sup>\n                      Ga-FAPI-04 PET\/CT could be a good imaging method for SAPHO syndrome but requires further verification in a more extensive research cohort.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/rlu.0000000000004752","type":"journal-article","created":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T13:18:08Z","timestamp":1687612688000},"page":"768-774","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":14,"title":["Prospective Comparison of the Imaging Value of 99mTc-MDP Bone Scan and 68Ga-FAPI-04 PET\/CT in Synovitis, Acne, Pustulosis, Hyperostosis, and Osteitis Syndrome"],"prefix":"10.1097","volume":"48","author":[{"given":"Tingting","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyuan","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingxue","family":"Shu","sequence":"additional","affiliation":[{"name":"Department of 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