{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T10:57:52Z","timestamp":1794394672114,"version":"4.9.0"},"reference-count":11,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Clin Nucl Med"],"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>A 14-year-old boy presented with severe, nonintentional weight loss, fatigue, and cough. Investigations were notable for raised inflammatory markers and significantly elevated serum immunoglobulin G4 (IgG4). <jats:sup>18<\/jats:sup>F-FDG PET\/CT was obtained for assessment of disease involvement and extent, to exclude differential diagnoses and to guide biopsy. The study demonstrated extensive FDG-avid nodal disease and multisystem organ involvement. Excisional biopsy of a right inguinal lymph node demonstrated reactive changes with numerous IgG4-positive plasma cells consistent with IgG4-related disease. He was commenced on immunosuppressive therapy with consequent weight restoration and symptom resolution.<\/jats:p>","DOI":"10.1097\/rlu.0000000000005151","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T18:34:56Z","timestamp":1709836496000},"page":"e364-e366","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":2,"title":["18F-FDG PET\/CT in Pediatric Immunoglobulin G4\u2013Related Disease"],"prefix":"10.1097","volume":"49","author":[{"given":"Karan","family":"Singh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva Alina","family":"Wegner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Marsden","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Sydney Children's Hospital Network"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davinder Singh","family":"Grewal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,3,1]]},"reference":[{"key":"bib1-20250621","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s12969-016-0079-3","article-title":"IgG4-related disease: a systematic review of this unrecognized disease in pediatrics","volume":"14","year":"2016","journal-title":"Pediatr Rheumatol Online J"},{"key":"bib2-20250621","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1038\/modpathol.2012.72","article-title":"Consensus statement on the pathology of IgG4-related disease","volume":"25","year":"2012","journal-title":"Mod Pathol"},{"key":"bib3-20250621","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/S0140-6736(14)60720-0","article-title":"IgG4-related disease","volume":"385","year":"2015","journal-title":"Lancet"},{"key":"bib4-20250621","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/art.41120","article-title":"The 2019 American College of Rheumatology\/European League Against Rheumatism classification criteria for IgG4-related disease","volume":"72","year":"2020","journal-title":"Arthritis Rheumatol"},{"key":"bib5-20250621","doi-asserted-by":"crossref","first-page":"e125","DOI":"10.1097\/RLU.0000000000003358","article-title":"FDG-avid pulmonary nodules and tracheobronchial mural inflammation in IgG4-related disease","volume":"46","year":"2021","journal-title":"Clin Nucl Med"},{"key":"bib6-20250621","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1080\/14397595.2020.1859710","article-title":"The 2020 Revised Comprehensive Diagnostic (RCD) criteria for IgG4-RD","volume":"31","year":"2021","journal-title":"Mod Rheumatol"},{"key":"bib7-20250621","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.autrev.2014.08.013","article-title":"The clinical spectrum of IgG4-related disease","volume":"13","year":"2014","journal-title":"Autoimmun Rev"},{"key":"bib8-20250621","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1007\/s00259-014-2729-3","article-title":"Characterizing IgG4-related disease with 18F-FDG PET\/CT: a prospective cohort study","volume":"41","year":"2014","journal-title":"Eur J Nucl Med Mol Imaging"},{"key":"bib9-20250621","first-page":"155","article-title":"IgG4-related disease: the utility of 18F-FDG PET\/CT in diagnosis and treatment","volume":"18","year":"2015","journal-title":"Hell J Nucl Med"},{"key":"bib10-20250621","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.crad.2011.10.011","article-title":"Utility of FDG PET\/CT in IgG4-related systemic disease","volume":"67","year":"2012","journal-title":"Clin Radiol"},{"key":"bib11-20250621","doi-asserted-by":"crossref","first-page":"20210105","DOI":"10.1259\/bjr.20210105","article-title":"18F-FDG PET\/CT manifestations of IgG4-related disease","volume":"94","year":"2021","journal-title":"Br J Radiol"}],"container-title":["Clinical Nuclear Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/RLU.0000000000005151","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T19:01:53Z","timestamp":1750532513000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/RLU.0000000000005151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,1]]},"references-count":11,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.1097\/rlu.0000000000005151","relation":{},"ISSN":["1536-0229","0363-9762"],"issn-type":[{"value":"1536-0229","type":"electronic"},{"value":"0363-9762","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3,1]]}}}