{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:00:25Z","timestamp":1790283625619,"version":"4.1.0"},"reference-count":17,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"10","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":["Clin Nucl Med"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n          <jats:p>\n                           <jats:sup>18<\/jats:sup>F-labeled THK5351 PET can visualize ongoing astrogliosis by estimating monoamine oxidase B levels and can be used as an adjunct for diagnosing neurodegenerative disorders. Little has been reported on multiple system atrophy (MSA) in the differential diagnosis of parkinsonian syndromes. Here, we present <jats:sup>18<\/jats:sup>F-THK5351 images in typical cases of MSA-P (parkinsonian type) and MSA-C (cerebellar type), showing intense <jats:sup>18<\/jats:sup>F-THK5351 uptake in the lateral-posterior part of the putamen (MSA-P) and in the pons and middle cerebellar peduncles (MSA-C). Hence, this study illustrates the possible utility of <jats:sup>18<\/jats:sup>F-THK5351 PET as an adjunct for diagnosing MSA-P and MSA-C by imaging ongoing astrogliosis.<\/jats:p>","DOI":"10.1097\/rlu.0000000000005347","type":"journal-article","created":{"date-parts":[[2024,7,24]],"date-time":"2024-07-24T10:09:40Z","timestamp":1721815780000},"page":"e503-e505","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Clinical Application of 18F-THK5351 PET to Image Ongoing Astrogliosis in MSA-P and MSA-C"],"prefix":"10.1097","volume":"49","author":[{"given":"Soichiro","family":"Kondo","sequence":"first","affiliation":[{"name":"Department of Neurology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Ishibashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Ishii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Iwata","sequence":"additional","affiliation":[{"name":"Department of Neurology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoko","family":"Ihara","sequence":"additional","affiliation":[{"name":"Department of Neurology"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2024,7,20]]},"reference":[{"key":"bib1-20250621","doi-asserted-by":"crossref","first-page":"e523","DOI":"10.1097\/RLU.0000000000001868","article-title":"Potential use of 18F-THK5351 PET to identify Wallerian degeneration of the pyramidal tract caused by cerebral infarction","volume":"42","year":"2017","journal-title":"Clin Nucl Med"},{"key":"bib2-20250621","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1097\/RLU.0000000000002564","article-title":"Monoamine oxidase B binding of 18F-THK5351 to visualize glioblastoma and associated gliosis: an autopsy-confirmed case","volume":"44","year":"2019","journal-title":"Clin Nucl Med"},{"key":"bib3-20250621","doi-asserted-by":"crossref","first-page":"e98","DOI":"10.1097\/RLU.0000000000002751","article-title":"18F-THK5351 PET can identify astrogliosis in multiple sclerosis plaques","volume":"45","year":"2020","journal-title":"Clin Nucl Med"},{"key":"bib4-20250621","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1186\/s12880-020-00481-4","article-title":"Relationship between the temporal course of astrogliosis and symptom improvement in cerebral infarction: report of a case monitored using 18F-THK5351 positron emission tomography","volume":"20","year":"2020","journal-title":"BMC Med 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Int"},{"key":"bib11-20250621","doi-asserted-by":"crossref","first-page":"249","DOI":"10.3389\/fnagi.2019.00249","article-title":"PET imaging of astrogliosis and tau facilitates diagnosis of parkinsonian syndromes","volume":"11","year":"2019","journal-title":"Front Aging Neurosci"},{"key":"bib12-20250621","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1002\/mds.29143","article-title":"Middle cerebellar peduncle in early stage of multiple system atrophy: a THK5351 PET study","volume":"37","year":"2022","journal-title":"Mov Disord"},{"key":"bib13-20250621","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1093\/brain\/awf117","article-title":"Progression and prognosis in multiple system atrophy: an analysis of 230 Japanese patients","volume":"125","year":"2002","journal-title":"Brain"},{"key":"bib14-20250621","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1097\/RLU.0000000000004815","article-title":"Detailed assessment of 18F-THK5351 distribution pattern in the midbrain: comparison with progressive supranuclear palsy and corticobasal syndrome","volume":"48","year":"2023","journal-title":"Clin Nucl Med"},{"key":"bib15-20250621","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1365-2990.2011.01234.x","article-title":"The neuropathology, pathophysiology and genetics of multiple system atrophy","volume":"38","year":"2012","journal-title":"Neuropathol Appl Neurobiol"},{"key":"bib16-20250621","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1093\/jnen\/nly080","article-title":"Converging patterns of alpha-synuclein pathology in multiple system atrophy","volume":"77","year":"2018","journal-title":"J Neuropathol Exp Neurol"},{"key":"bib17-20250621","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1007\/s00702-021-02383-3","article-title":"Neuropathology of multiple system atrophy: Kurt Jellinger\u2019s legacy","volume":"128","year":"2021","journal-title":"J Neural Transm (Vienna)"}],"container-title":["Clinical 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