{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T20:27:45Z","timestamp":1783024065062,"version":"3.54.6"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:p>\n                    AL cardiac amyloidosis (CA) is challenging to diagnose due to limitations of biopsy and conventional imaging. Endomyocardial biopsy (EMB) can yield false negatives, and\n                    <jats:sup>99m<\/jats:sup>\n                    Tc-pyrophosphate scintigraphy is less reliable for AL amyloidosis. We report a 56-year-old man with progressive dyspnea, palpitations, and macroglossia, in whom echocardiography revealed hypertrophic cardiomyopathy with reduced ejection fraction. Cardiac MRI, bone marrow biopsy (BMB), and EMB were inconclusive, while PYP scintigraphy was equivocal.\n                    <jats:sup>68<\/jats:sup>\n                    Ga-FAPI-46 PET\/CT demonstrated intense myocardial uptake, prompting a repeat BMB confirming AL amyloidosis. This case underscores the emerging role of FAPI PET\/CT in clarifying diagnosis after an equivocal workup, enabling targeted therapy.\n                  <\/jats:p>","DOI":"10.1097\/rlu.0000000000006325","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T17:00:38Z","timestamp":1770051638000},"page":"e689-e691","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Bridging Diagnostic Gaps in AL Cardiac Amyloidosis"],"prefix":"10.1097","volume":"51","author":[{"given":"Srinivas Ananth","family":"Kumar","sequence":"first","affiliation":[{"name":"Nuclear Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harish","family":"Goyal","sequence":"additional","affiliation":[{"name":"Nuclear Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A Shaheer","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Cardiology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashanth","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"Nuclear Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dhanapathi","family":"Halanaik","sequence":"additional","affiliation":[{"name":"Nuclear Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,1,21]]},"reference":[{"key":"R1-20260702","doi-asserted-by":"crossref","first-page":"94","DOI":"10.62347\/ZBRQ1229","article-title":"Diagnostic challenges in cardiac amyloidosis: a case report of negative initial endomyocardial biopsy","volume":"17","author":"Mojahedi","year":"2025","journal-title":"Int J Physiol Pathophysiol Pharmacol"},{"key":"R2-20260702","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1751-7133.2009.00115.x","article-title":"An unusual case of biopsy-negative amyloid cardiomyopathy","volume":"16","author":"George","year":"2010","journal-title":"Congest Heart Fail"},{"key":"R3-20260702","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s11936-023-00976-7","article-title":"A review of current and evolving imaging techniques in cardiac amyloidosis","volume":"25","author":"Khedraki","year":"2023","journal-title":"Curr Treat Options Cardiovasc Med"},{"key":"R4-20260702","first-page":"19","article-title":"The use of PYP scan for evaluation of ATTR cardiac amyloidosis at a tertiary medical centre","volume":"29","author":"Dower","year":"2022","journal-title":"Br J Cardiol"},{"key":"R5-20260702","doi-asserted-by":"crossref","first-page":"e25582","DOI":"10.1097\/MD.0000000000025582","article-title":"False positive technetium-99m pyrophosphate scintigraphy in a patient with cardiac amyloidosis light chain: case report","volume":"100","author":"Zeng","year":"2021","journal-title":"Medicine (Baltimore)"},{"key":"R6-20260702","doi-asserted-by":"crossref","first-page":"e621","DOI":"10.1097\/RLU.0000000000005821","article-title":"First clinical application of 99m Tc-FAPI-46 as an available radiotracer to evaluate the cardiac remodeling process : a case report","volume":"50","author":"Raeisi","year":"2025","journal-title":"Clin Nucl Med"},{"key":"R7-20260702","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s11886-025-02230-x","article-title":"68Ga-FAPI-04 PET\/CT for the assessment of light-chain cardiac amyloidosis: a promising risk- stratification imaging modality","volume":"27","author":"Zheng","year":"2025","journal-title":"Curr Cardiol Rep"},{"key":"R8-20260702","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1016\/j.jcmg.2022.06.004","article-title":"Feasibility of 68Ga-labeled fibroblast activation protein inhibitor PET\/CT in light-chain cardiac amyloidosis","volume":"15","author":"Wang","year":"2022","journal-title":"JACC Cardiovasc Imaging"},{"key":"R9-20260702","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.jcmg.2024.10.001","article-title":"Molecular stratification of light-chain cardiac amyloidosis with 18F-Florbetapir and 68Ga-FAPI-04 for enhanced prognostic precision","volume":"18","author":"Wang","year":"2025","journal-title":"JACC Cardiovasc Imaging"},{"key":"R10-20260702","doi-asserted-by":"crossref","first-page":"e020358","DOI":"10.1161\/JAHA.120.020358","article-title":"Amyloid deposits and fibrosis on left ventricular endomyocardial biopsy correlate with extracellular volume in cardiac amyloidosis","volume":"10","author":"Pucci","year":"2021","journal-title":"J Am Heart Assoc"},{"key":"R11-20260702","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1016\/j.jcmg.2022.08.019","article-title":"Fibroblast activation: a novel mechanism of heart failure in light chain cardiac amyloidosis?","volume":"15","author":"Dorbala","year":"2022","journal-title":"JACC Cardiovasc 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PET\/CT"],"short-title":[],"issued":{"date-parts":[[2026,1,21]]},"references-count":12,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.1097\/rlu.0000000000006325","relation":{},"ISSN":["0363-9762","1536-0229"],"issn-type":[{"value":"0363-9762","type":"print"},{"value":"1536-0229","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,21]]},"assertion":[{"value":"2025-09-23","name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-28","name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}}]}}