{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T18:10:17Z","timestamp":1789063817972,"version":"build-2803163510"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Secondary ameloblastic carcinoma is a rare malignant odontogenic tumor arising through malignant transformation of a pre-existing ameloblastoma and may involve complex craniofacial compartments. When the skull base is involved, management requires integration of oncologic resection with reconstructive strategies that ensure durable intracranial-extracranial separation and structural stability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case Presentation:<\/jats:title>\n                    <jats:p>A 27-year-old male with a 13-year history of recurrent mandibular ameloblastoma presented with extensive craniofacial progression involving the temporal bone, masticator and infratemporal spaces, orbit, parotid region, and skull base, with regional lymph node metastases. Radical en bloc craniofacial resection with modified radical neck dissection was performed, including focal dural excision to achieve margin control. Proximal vascular control was achieved through elective external carotid artery ligation, which substantially limited nearby ipsilateral recipient-vessel options for immediate free tissue transfer. Cranial base integrity was restored using multilayer vascularized pericranial-galeal reconstruction reinforced with a dural substitute. Adjuvant radiotherapy (72\u00a0Gy) was administered. At 42-month follow-up, the patient remains disease-free, with preserved functional status and stable craniofacial contour.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Adherence to foundational reconstructive principles\u2014including vascularized tissue coverage and multilayer dural repair\u2014is integral to radical craniofacial resection. In selected defects with constrained recipient-vessel options, regional vascularized reconstruction may provide durable intracranial protection and preserve functional outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/sap.0000000000004841","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T14:40:59Z","timestamp":1786027259000},"page":"405-411","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":0,"title":["Secondary Ameloblastic Carcinoma With Craniofacial and Skull Base Invasion"],"prefix":"10.1097","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-4799-4278","authenticated-orcid":false,"given":"Federico","family":"Sacasa","sequence":"first","affiliation":[{"name":"Faculty of Medical Sciences, National Autonomous University of Nicaragua (UNAN-Le\u00f3n), Le\u00f3n, Nicaragua"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Eugenia","family":"Lara","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Imaging, Hospital Militar Escuela Dr. Alejandro D\u00e1vila Bola\u00f1os, Managua, Nicaragua"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melina","family":"Quezada","sequence":"additional","affiliation":[{"name":"Department of Pathology, Hospital Monte Espa\u00f1a, Managua, Nicaragua"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Surgery, Hospital Vivian Pellas, Managua, Nicaragua"},{"name":"Department of Head and Neck Surgery, Hospital Monte Espa\u00f1a, Managua, Nicaragua"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2026,8,6]]},"reference":[{"key":"R1-20260910","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s12105-021-01404-7","article-title":"Update from the 5th 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