{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T17:26:54Z","timestamp":1778779614287,"version":"3.51.4"},"reference-count":28,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec>\n            <jats:title>Background:<\/jats:title>\n            <jats:p>Several studies have illustrated the efficacy of pregabalin in decreasing postoperative opioid use in adults undergoing orthognathic surgery. We aimed to study the effects of a single dose of preoperative pregabalin on total opioid consumption after orthognathic surgery in individuals with cleft lip and palate.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods:<\/jats:title>\n            <jats:p>This is a retrospective cohort study of consecutive patients who underwent Le Fort I midface advancement between June 2012 and July 2019. All patients had a diagnosis of cleft lip and palate. The treatment group received a 1-time preoperative dose of pregabalin; the control group did not. Total morphine milligram equivalent (MME) consumption was calculated by adding intraoperative and postoperative opioid use during admission.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results:<\/jats:title>\n            <jats:p>Twenty-three patients were included in this study; 12 patients received pregabalin. The pregabalin group had significantly lower total opioid consumption (total MME 70.95 MME; interquartile range [IQR]: 24.65\u2013150.17) compared to the control group (138.00 MME; IQR: 105.00\u2013232.48) (MU\u200a=\u200a31.00, <jats:italic toggle=\"yes\">P<\/jats:italic>\u200a=\u200a0.031). The difference in mean pain scores in the treatment group (3.21\u200a\u00b1\u200a2.03) and the control group (3.71\u200a\u00b1\u200a2.95) was not statistically significant (<jats:italic toggle=\"yes\">P<\/jats:italic>\u200a=\u200a0.651, 95% confidence interval \u22121.75 to 2.75).<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions:<\/jats:title>\n            <jats:p>A 1-time preoperative dose of pregabalin before orthognathic surgery in patients with cleft lip and palate reduced total opioid consumption during admission without increasing patient pain. A single preemptive dose of pregabalin should be considered an effective adjunct to pain management protocols in patients undergoing orthognathic surgery.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/scs.0000000000007109","type":"journal-article","created":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T06:00:53Z","timestamp":1600840853000},"page":"517-520","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":6,"title":["Effects of Single-Dose Preoperative Pregabalin on Postoperative Pain and Opioid Consumption in Cleft Orthognathic Surgery"],"prefix":"10.1097","volume":"32","author":[{"given":"Abdullah M.","family":"Said","sequence":"first","affiliation":[{"name":"Division of Plastic & Reconstructive Surgery, Department of Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ema","family":"Zubovic","sequence":"additional","affiliation":[{"name":"Division of Plastic & Reconstructive Surgery, Department of Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Austin Y.","family":"Ha","sequence":"additional","affiliation":[{"name":"Division of Plastic & Reconstructive Surgery, Department of Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary B.","family":"Skolnick","sequence":"additional","affiliation":[{"name":"Division of Plastic & Reconstructive Surgery, Department of Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sybill D.","family":"Naidoo","sequence":"additional","affiliation":[{"name":"Division of Plastic & Reconstructive Surgery, Department of Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacob","family":"AuBuchon","sequence":"additional","affiliation":[{"name":"Division of Pain Management, Department of Anesthesiology, Washington University School of Medicine in St. Louis, St. Louis, MO."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamlesh B.","family":"Patel","sequence":"additional","affiliation":[{"name":"Division of Plastic & Reconstructive Surgery, Department of Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","published-online":{"date-parts":[[2020,9,23]]},"reference":[{"key":"R1-20250803","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1097\/SCS.0000000000005536","article-title":"Complications following orthognathic surgery for patients with cleft lip\/palate","volume":"30","author":"Hwang","year":"2019","journal-title":"J Craniofac Surg"},{"key":"R2-20250803","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1378\/chest.116.6.1519","article-title":"Maxillomandibular advancement surgery in a site-specific treatment approach for obstructive sleep apnea in 50 consecutive 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