{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:06:21Z","timestamp":1786118781831,"version":"build-2736575974"},"reference-count":60,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,3]]},"DOI":"10.1097\/scs.0b013e3180336047","type":"journal-article","created":{"date-parts":[[2007,3,26]],"date-time":"2007-03-26T03:47:17Z","timestamp":1174880837000},"page":"336-346","source":"Crossref","is-referenced-by-count":19,"title":["Postoperative Anti-Tgf-\u03b22 Antibody Therapy Improves Intracranial Volume and Craniofacial Growth in Craniosynostotic Rabbits"],"prefix":"10.1097","volume":"18","author":[{"given":"Mark P.","family":"Mooney","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Wolfgang","family":"Losken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amr M.","family":"Moursi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyn M.","family":"Shand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory M.","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chris","family":"Curry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lillian","family":"Ho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"Burrows","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric J.","family":"Stelnicki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph E.","family":"Losee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynne A.","family":"Opperman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael I.","family":"Siegel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R5-19-20210208","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1597\/1545-1569_1994_031_0008_doasor_2.3.co_2","article-title":"Development of a strain of rabbits with congenital simple nonsyndromic coronal suture synostosis. Part II: Somatic and craniofacial growth patterns.","volume":"31","author":"Mooney","year":"1994","journal-title":"Cleft Palate Craniofac J"},{"key":"R8-19-20210208","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1159\/000120913","article-title":"Intracranial hypertension after cranial vault decompression for craniosynostosis.","volume":"22","author":"Campbell","year":"1995","journal-title":"Pediatr Neurosurg"},{"key":"R9-19-20210208","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s003810050220","article-title":"A rabbit model of human familial, nonsyndromic unicoronal suture synostosis. II. Intracranial contents, intracranial volume, and intracranial pressure.","volume":"14","author":"Mooney","year":"1998","journal-title":"Childs Nerv Syst"},{"key":"R10-19-20210208","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1097\/00001665-199903000-00003","article-title":"Increased intracranial pressure after coronal suturectomy in craniosynostotic rabbits.","volume":"10","author":"Mooney","year":"1999","journal-title":"J Craniofac Surg"},{"key":"R12-19-20210208","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1097\/01.PRS.0000101056.33534.F0","article-title":"Intracranial pressure changes in craniosynostotic rabbits.","volume":"113","author":"Fellows-Mayle","year":"2004","journal-title":"Plast Reconstr Surg"},{"key":"R13-19-20210208","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1097\/00006534-199209000-00003","article-title":"Intracranial pressure and intracranial volume in children with craniosynostosis.","volume":"90","author":"Gault","year":"1992","journal-title":"Plast Reconstr Surg"},{"key":"R14-19-20210208","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1159\/000121038","article-title":"Incidence of increased intracranial pressure after early surgical treatment of syndromic craniosynostosis.","volume":"24","author":"Pollack","year":"1996","journal-title":"Pediatr Neurosurg"},{"key":"R15-19-20210208","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1597\/1545-1569_1998_035_0167_mssaii_2.3.co_2","article-title":"Multiple suture synostosis and increased intracranial pressure following repair of single suture, nonsyndromal craniosynostosis.","volume":"35","author":"Hudgins","year":"1998","journal-title":"Cleft Palate Craniofac J"},{"key":"R16-19-20210208","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1097\/00001665-199805000-00010","article-title":"Intracranial volume in craniosynostotic rabbits.","volume":"9","author":"Mooney","year":"1998","journal-title":"J Craniofac Surg"},{"key":"R17-19-20210208","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ymthe.2005.02.027","article-title":"Noggin improves bone healing elicited by muscle stem cells expressing inducible BMP4.","volume":"12","author":"Peng","year":"2005","journal-title":"Mol Ther"},{"key":"R18-19-20210208","first-page":"867","article-title":"The subarachnoid spaces in craniosynostosis.","volume":"30","author":"Chadduck","year":"1992","journal-title":"Neurosurgery"},{"key":"R19-19-20210208","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/s00381-004-1107-z","article-title":"Age-related changes in lateral ventricle morphology in craniosynostotic rabbits using magnetic resonance imaging.","volume":"21","author":"Fellows-Mayle","year":"2005","journal-title":"Childs Nerv Syst"},{"key":"R22-19-20210208","doi-asserted-by":"crossref","first-page":"476","DOI":"10.3171\/jns.1995.83.3.0476","article-title":"Prognosis for mental function in scaphocephaly.","volume":"83","author":"Arnaud","year":"1995","journal-title":"J Neurosurg"},{"key":"R24-19-20210208","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1597\/1545-1569_2003_040_0486_enbicr_2.0.co_2","article-title":"Early neuromotor behavior in craniosynostotic rabbits.","volume":"40","author":"Mitchell","year":"2003","journal-title":"Cleft Palate Craniofac J"},{"key":"R31-19-20210208","doi-asserted-by":"crossref","first-page":"2032","DOI":"10.1097\/01.PRS.0000056839.94034.47","article-title":"Management of craniosynostosis.","volume":"111","author":"Panchal","year":"2003","journal-title":"Plast Reconstr Surg"},{"key":"R33-19-20210208","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1097\/00006534-199508000-00005","article-title":"Twenty-year experience with early surgery for craniosynostosis: II. The craniofacial synostosis syndromes and pansynostosis-results and unsolved problems.","volume":"96","author":"McCarthy","year":"1995","journal-title":"Plast Reconstr Surg"},{"key":"R34-19-20210208","doi-asserted-by":"crossref","first-page":"646","DOI":"10.3349\/ymj.2001.42.6.646","article-title":"The pathogenesis of craniosynostosis in the fetus.","volume":"42","author":"Warren","year":"2001","journal-title":"Yonsei Med J"},{"key":"R35-19-20210208","doi-asserted-by":"crossref","first-page":"715","DOI":"10.3171\/jns.1974.41.6.0715","article-title":"Recurrent and multiple suture closures after craniectomy for craniosynostosis.","volume":"41","author":"Norwood","year":"1974","journal-title":"J Neurosurg"},{"key":"R36-19-20210208","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1227\/00006123-199010000-00006","article-title":"Radical osteoclastic craniectomy in sagittal synostosis.","volume":"27","author":"Hassler","year":"1990","journal-title":"Neurosurgery"},{"key":"R37-19-20210208","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1097\/00001665-199211000-00009","article-title":"Prevention of cranial reossification after surgical craniectomy.","volume":"3","author":"Fatah","year":"1992","journal-title":"J Craniofac Surg"},{"key":"R38-19-20210208","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1097\/00001665-199304000-00006","article-title":"Calvarial deformity regeneration following subtotal craniectomy for craniosynostosis: a case report and theoretical implications.","volume":"4","author":"Drake","year":"1993","journal-title":"J Craniofac Surg"},{"key":"R39-19-20210208","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1054\/bjps.2002.3923","article-title":"Pediatric transcranial surgery: a review of 114 consecutive procedures.","volume":"55","author":"Kirkpatrick","year":"2002","journal-title":"Br J Plast Surg"},{"key":"R40-19-20210208","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1597\/1545-1569_2001_038_0533_tfoacs_2.0.co_2","article-title":"The faith of a coronal suture grafted onto midline synostosis inducing dura and deprived from tensile stress.","volume":"38","author":"Mommaerts","year":"2001","journal-title":"Cleft Palate Craniofac J"},{"key":"R41-19-20210208","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1159\/000028706","article-title":"Pancraniosynostosis after surgery for single sutural craniosynostosis.","volume":"29","author":"Greene","year":"1998","journal-title":"Pediatr Neurosurg"},{"key":"R42-19-20210208","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1597\/1545-1569_2001_038_0206_cocssu_2.0.co_2","article-title":"Correction of coronal suture synostosis using suture and dura mater allografts in rabbits with familial craniosynostosis.","volume":"38","author":"Mooney","year":"2001","journal-title":"Cleft Palate Craniofac J"},{"key":"R44-19-20210208","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1097\/00001665-200303000-00003","article-title":"Clinical outcome in cranioplasty: critical review in long-term follow-up.","volume":"14","author":"Moreira-Gonzalez","year":"2003","journal-title":"J Craniofac Surg"},{"key":"R45-19-20210208","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/00006534-199708000-00003","article-title":"A longitudinal, statistical study of reoperation rates in craniosynostosis.","volume":"100","author":"Williams","year":"1997","journal-title":"Plast Reconstr Surg"},{"key":"R46-19-20210208","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1093\/hmg\/6.10.1647","article-title":"Craniosynostosis: genes and mechanisms.","volume":"6","author":"Wilkie","year":"1997","journal-title":"Hum Mol Genet"},{"key":"R47-19-20210208","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1056\/NEJM199608223350804","article-title":"Overexpression of an osteogenic morphogen in fibrodysplasia ossificans progressiva.","volume":"335","author":"Shafritz","year":"1996","journal-title":"N Engl J Med"},{"key":"R50-19-20210208","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1517\/14712598.4.3.279","article-title":"Cytokine therapy for craniosynostosis.","volume":"4","author":"Mooney","year":"2004","journal-title":"Expert Opin Biol Ther"},{"key":"R52-19-20210208","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ajmg.a.10750","article-title":"TGF beta\/Smad signaling system and its pathologic correlates.","volume":"116","author":"Cohen","year":"2003","journal-title":"Am J Med Genet A"},{"key":"R53-19-20210208","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1097\/00006534-199702000-00002","article-title":"Immunolocalization of transforming growth factor beta 1, beta 2, and beta 3 and insulin-like growth factor I in premature cranial suture fusion.","volume":"99","author":"Roth","year":"1997","journal-title":"Plast Reconstr Surg"},{"key":"R54-19-20210208","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1359\/jbmr.1997.12.3.301","article-title":"TGF-beta 1, TGF-beta 2, and TGF-beta 3 exhibit distinct patterns of expression during cranial suture formation and obliteration in vivo and in vitro.","volume":"12","author":"Opperman","year":"1997","journal-title":"J Bone Miner Res"},{"key":"R55-19-20210208","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1097\/00006534-200206000-00028","article-title":"Craniosynostosis and altered patterns of fetal TGF-beta expression induced by intrauterine constraint.","volume":"109","author":"Kirschner","year":"2002","journal-title":"Plast Reconstr Surg"},{"key":"R57-19-20210208","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1097\/01.PRS.0000143578.41666.2C","article-title":"Quantitative transcriptional analysis of fusing and nonfusing cranial suture complexes in mice.","volume":"114","author":"Nacamuli","year":"2004","journal-title":"Plast Reconstr Surg"},{"key":"R58-19-20210208","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/ng1511","article-title":"A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2.","volume":"37","author":"Loeys","year":"2005","journal-title":"Nat Genet"},{"key":"R59-19-20210208","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1597\/1545-1569_2003_040_0225_dotgfa_2.0.co_2","article-title":"Delivery of transforming growth factor-beta2-perturbing antibody in a collagen vehicle inhibits cranial suture fusion in calvarial organ culture.","volume":"40","author":"Moursi","year":"2003","journal-title":"Cleft Palate Craniofac J"},{"key":"R60-19-20210208","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1597\/1545-1569_1997_034_0330_elotgf_2.3.co_2","article-title":"Elevated levels of transforming growth factors beta 2 and beta 3 in lambdoid sutures from children with persistent plagiocephaly.","volume":"34","author":"Lin","year":"1997","journal-title":"Cleft Palate Craniofac J"},{"key":"R61-19-20210208","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1359\/jbmr.1997.12.3.311","article-title":"Studies in cranial suture biology: I Part, increased immunoreactivity for TGF-beta isoforms (beta 1, beta 2, and beta 3) during rat cranial suture fusion.","volume":"12","author":"Roth","year":"1997","journal-title":"J Bone Miner Res"},{"key":"R62-19-20210208","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1097\/00006534-199805000-00001","article-title":"Studies in cranial suture biology: up-regulation of transforming growth factor-beta1 and basic fibroblast growth factor mRNA correlates with posterior frontal cranial suture fusion in the rat.","volume":"101","author":"Most","year":"1998","journal-title":"Plast Reconstr Surg"},{"key":"R63-19-20210208","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1097\/00000637-200105000-00015","article-title":"Toward an understanding of nonsyndromic craniosynostosis: altered patterns of TGF-beta receptor and FGF receptor expression induced by intrauterine head constraint.","volume":"46","author":"Hunenko","year":"2001","journal-title":"Ann Plast Surg"},{"key":"R64-19-20210208","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1002\/ar.a.10113","article-title":"Rescue of coronal suture fusion using transforming growth factor-beta 3 (Tgf-beta 3) in rabbits with delayed-onset craniosynostosis.","volume":"274","author":"Chong","year":"2003","journal-title":"Anat Rec A Discov Mol Cell Evol Biol"},{"key":"R65-19-20210208","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1597\/02-140.1","article-title":"Transforming growth factor-beta isoform expression in the perisutural tissues of craniosynostotic rabbits.","volume":"41","author":"Poisson","year":"2004","journal-title":"Cleft Palate Craniofac J"},{"key":"R66-19-20210208","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1097\/00006534-200208000-00022","article-title":"Adenovirus-mediated transmission of a dominant negative transforming growth factor-beta receptor inhibits in vitro mouse cranial suture fusion.","volume":"110","author":"Mehrara","year":"2002","journal-title":"Plast Reconstr Surg"},{"key":"R67-19-20210208","first-page":"164","article-title":"Cranial suture obliteration is induced by removal of transforming growth factor (TGF)-beta 3 activity and prevented by removal of TGF-beta 2 activity from fetal rat calvaria in vitro.","volume":"19","author":"Opperman","year":"1999","journal-title":"J Craniofac Genet Dev Biol"},{"key":"R68-19-20210208","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1097\/01.PRS.0000117363.43699.5B","article-title":"Mechanisms of murine cranial suture patency mediated by a dominant negative transforming growth factor-beta receptor adenovirus.","volume":"113","author":"Song","year":"2004","journal-title":"Plast Reconstr Surg"},{"key":"R69-19-20210208","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1002\/ar.10094","article-title":"Transforming growth factor-beta 3(Tgf-beta3) in a collagen gel delays fusion of the rat posterior interfrontal suture in vivo.","volume":"267","author":"Opperman","year":"2002","journal-title":"Anat Rec"},{"key":"R71-19-20210208","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0094-1298(20)32662-6","article-title":"Bone and cartilage tissue engineering.","volume":"26","author":"Boyan","year":"1999","journal-title":"Clin Plast Surg"},{"key":"R72-19-20210208","doi-asserted-by":"crossref","first-page":"12025","DOI":"10.1073\/pnas.192291499","article-title":"Engineering growing tissues.","volume":"99","author":"Alsberg","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R73-19-20210208","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1177\/10454411010120010501","article-title":"Craniofacial tissue engineering.","volume":"12","author":"Alsberg","year":"2001","journal-title":"Crit Rev Oral Biol Med"},{"key":"R74-19-20210208","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1177\/154405910508401204","article-title":"Biological approaches to bone regeneration by gene therapy.","volume":"84","author":"Franceschi","year":"2005","journal-title":"J Dent Res"},{"key":"R77-19-20210208","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.archoralbio.2005.08.008","article-title":"Sustained delivery of bioactive cytokine using a dense collagen gel vehicle collagen gel delivery of bioactive cytokine.","volume":"51","author":"Premaraj","year":"2006","journal-title":"Arch Oral Biol"},{"key":"R78-19-20210208","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1159\/000240527","article-title":"Growth and development of the rabbit brain.","volume":"21","author":"Harel","year":"1972","journal-title":"Biol Neonate"},{"key":"R79-19-20210208","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1597\/1545-1569_1995_032_0235_gotcvi_2.3.co_2","article-title":"Growth of the cranial vault in rabbits with congenital coronal suture synostosis.","volume":"32","author":"Burrows","year":"1995","journal-title":"Cleft Palate Craniofac J"},{"key":"R80-19-20210208","first-page":"19","article-title":"Craniofacial disorders caused by mutations in homeobox genes MSX1 and MSX2.","volume":"20","author":"Cohen","year":"2000","journal-title":"J Craniofac Genet Dev Biol"},{"key":"R81-19-20210208","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1242\/dev.124.13.2659","article-title":"TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes.","volume":"124","author":"Sanford","year":"1997","journal-title":"Development"},{"key":"R82-19-20210208","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1097\/01.PRS.0000117362.33347.43","article-title":"TGF-beta1, FGF-2, and receptor mRNA expression in suture mesenchyme and dura versus underlying brain in fusing and nonfusing mouse cranial sutures.","volume":"113","author":"Gosain","year":"2004","journal-title":"Plast Reconstr Surg"},{"key":"R83-19-20210208","first-page":"2863","article-title":"Craniosynostosis.","volume":"69","author":"Kabbani","year":"2004","journal-title":"Am Fam Physician"},{"key":"R84-19-20210208","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1097\/00001665-199507000-00003","article-title":"Interaction of craniofacial dysmorphology, growth, and prediction of surgical outcome.","volume":"6","author":"Dufresne","year":"1995","journal-title":"J Craniofac Surg"},{"key":"R86-19-20210208","first-page":"961","article-title":"Craniosynostosis; a modification in surgical treatment.","volume":"40","author":"Anderson","year":"1956","journal-title":"Surgery"}],"container-title":["Journal of Craniofacial Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00001665-200703000-00019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T16:34:31Z","timestamp":1786034071000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00001665-200703000-00019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3]]},"references-count":60,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007]]}},"URL":"https:\/\/doi.org\/10.1097\/scs.0b013e3180336047","relation":{},"ISSN":["1049-2275"],"issn-type":[{"value":"1049-2275","type":"print"}],"subject":[],"published":{"date-parts":[[2007,3]]}}}