{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T19:54:57Z","timestamp":1781812497706,"version":"3.54.5"},"reference-count":13,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Thiamine has been utilized for metabolic resuscitation in septic shock (SS), but optimal thiamine dosing remains unknown. The purpose of this study was to assess variable thiamine dosing in critically ill patients with SS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>This retrospective, cohort study included SS patients on high-dose (HD &gt;500\u2009mg\/d) or low-dose (LD \u2264500\u2009mg\/d) thiamine for 72 hours without an alternative indication. The primary endpoint was to evaluate the impact of HD or LD thiamine on vasopressor alive-and-free days.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>\n                      The analysis included 87 patients who received HD thiamine and 65 patients who received LD thiamine. The mean thiamine dose was 1.485.6\u2009mg\/d in the HD group and 323.8\u2009mg\/d in the LD group. The HD group more often utilized 30\u2009mL\/kg of intravenous fluid resuscitation (89%\n                      <jats:italic toggle=\"yes\">vs.<\/jats:italic>\n                      82%) and hydrocortisone at 300\u2009mg\/d (69%\n                      <jats:italic toggle=\"yes\">vs.<\/jats:italic>\n                      58%). Results found vasopressor alive-and-free days to be 17.13 in the HD group and 14.84 days in the LD group. No statistically discernible differences were found between the groups in 28-day mortality, intensive care unit length of stay, vasopressor free days, percentage decrease in lactate or serum creatinine, need for additional vasopressor(s), or hospital length of stay, although some of the observed differences are believed to be clinically meaningful.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Relevance:<\/jats:title>\n                    <jats:p>Patients with SS who received HD thiamine had no statistically discernible differences in vasopressor alive-and-free days or intensive care unit length of stay as compared to the LD thiamine group. Larger, prospective, randomized trials are warranted to further investigate HD thiamine in critically ill patients with SS.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/shk.0000000000002739","type":"journal-article","created":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T17:00:14Z","timestamp":1761843614000},"page":"211-217","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of Variable Thiamine Dosing Strategies in Critically Ill Patients with Septic Shock"],"prefix":"10.1097","volume":"65","author":[{"given":"Arilyn","family":"Maier","sequence":"first","affiliation":[{"name":"Department of Pharmacy, UNC Health Rex, Raleigh, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Kolar","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, UNC Medical Center, Chapel Hill, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Shible","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, UNC Health Rex, Raleigh, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler","family":"Merritt","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Duke University Hospital, Durham, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R","family":"Jiroutek","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical & Clinical Sciences, Campbell University, Buies Creek, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Mullaney","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, UNC Health Rex, Raleigh, North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tia","family":"Collier","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Erlanger Health, Chattanooga, Tennessee"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","published-online":{"date-parts":[[2025,10,16]]},"reference":[{"issue":"11","key":"R1-20260618","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1515\/cclm-2017-0054","article-title":"R. 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