{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T19:31:09Z","timestamp":1772739069804,"version":"3.50.1"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,11]]},"DOI":"10.1097\/shk.0b013e31804f5898","type":"journal-article","created":{"date-parts":[[2007,6,22]],"date-time":"2007-06-22T08:04:12Z","timestamp":1182499452000},"page":"564-569","source":"Crossref","is-referenced-by-count":9,"title":["SEPSIS AFFECTS CARDIAC EXPRESSION OF MULTIDRUG RESISTANCE PROTEIN 5 (MRP5, ABCC5), AN ABC-TYPE CGMP EXPORT PUMP"],"prefix":"10.1097","volume":"28","author":[{"given":"Konrad","family":"Meissner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfram","family":"Kessler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henriette E. U.","family":"Meyer zu Schwabedissen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Schuster","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kay","family":"Saalfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Grube","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Buck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Jedlitschky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Maier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Traeger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00f6rg","family":"Mostertz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Homuth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus-Dieter","family":"Heidecke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Lehmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heyo K.","family":"Kroemer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-10-20210213","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1186\/cc2917","article-title":"Severe sepsis epidemiology: sampling, selection, and society.","volume":"8","author":"Linde-Zwirble","year":"2004","journal-title":"Crit Care"},{"key":"R2-10-20210213","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1186\/cc1822","article-title":"Clinical review: myocardial depression in sepsis and septic shock.","volume":"6","author":"Court","year":"2002","journal-title":"Crit Care"},{"key":"R3-10-20210213","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1097\/01.CCM.0000163398.79679.66","article-title":"Tumor necrosis factor-alpha-induced caspase activation mediates endotoxin-related cardiac dysfunction.","volume":"33","author":"Carlson","year":"2005","journal-title":"Crit Care Med"},{"key":"R4-10-20210213","doi-asserted-by":"crossref","first-page":"3111","DOI":"10.1097\/00003246-200008000-00088","article-title":"Myocardial depression versus myocardial destruction: integrating the multiple mechanisms of myocardial dysfunction during sepsis.","volume":"28","author":"Giroir","year":"2000","journal-title":"Crit Care Med"},{"key":"R5-10-20210213","first-page":"R265","article-title":"Role of nitric oxide and cGMP in human septic serum-induced depression of cardiac myocyte contractility.","volume":"276","author":"Kumar","year":"1999","journal-title":"Am J Physiol"},{"key":"R6-10-20210213","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1096\/fasebj.14.5.805","article-title":"Nitric oxide reduces vascular smooth muscle cell elastase activity through cGMP-mediated suppression of ERK phosphorylation and AML1B nuclear partitioning.","volume":"14","author":"Mitani","year":"2000","journal-title":"FASEB J"},{"key":"R7-10-20210213","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1096\/fj.00-0538com","article-title":"Cardiac phosphodiesterase 5 (cGMP-specific) modulates beta-adrenergic signaling in vivo and is down-regulated in heart failure.","volume":"15","author":"Senzaki","year":"2001","journal-title":"FASEB J"},{"key":"R8-10-20210213","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1161\/CIRCULATIONAHA.105.577627","article-title":"Type 5 phosphodiesterase inhibition: the focus shifts to the heart.","volume":"112","author":"Semigran","year":"2005","journal-title":"Circulation"},{"key":"R9-10-20210213","doi-asserted-by":"crossref","first-page":"12944","DOI":"10.1074\/jbc.M404706200","article-title":"Phosphodiesterase-5 inhibitor sildenafil preconditions adult cardiac myocytes against necrosis and apoptosis. Essential role of nitric oxide signaling.","volume":"280","author":"Das","year":"2005","journal-title":"J Biol Chem"},{"key":"R10-10-20210213","first-page":"3537","article-title":"Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines.","volume":"57","author":"Kool","year":"1997","journal-title":"Cancer Res"},{"key":"R11-10-20210213","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1124\/dmd.105.003780","article-title":"Tissue distribution and hepatic and renal ontogeny of the multidrug resistance-associated protein (MRP) family in mice.","volume":"33","author":"Maher","year":"2005","journal-title":"Drug Metab Dispos"},{"key":"R12-10-20210213","doi-asserted-by":"crossref","first-page":"30069","DOI":"10.1074\/jbc.M005463200","article-title":"The multidrug resistance protein 5 functions as an ATP-dependent export pump for cyclic nucleotides.","volume":"275","author":"Jedlitschky","year":"2000","journal-title":"J Biol Chem"},{"key":"R13-10-20210213","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1016\/S0002-9440(10)63513-4","article-title":"P, Meissner K, Vogelgesang S, Heydrich B, Eckel L, Bohm M, Warzok R, Kerb R, Brinkmann U, Schaeffeler E,.et al.: Expression and localization of the multidrug resistance protein 5 (MRP5\/ABCC5), a cellular export pump for cyclic nucleotides, in human heart.","volume":"163","year":"2003","journal-title":"Am J Pathol"},{"key":"R14-10-20210213","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1097\/01.shk.0000126906.52367.dd","article-title":"Cecal ligation and puncture versus colon ascendens stent peritonitis: two distinct animal models for polymicrobial sepsis.","volume":"21","author":"Maier","year":"2004","journal-title":"Shock"},{"key":"R15-10-20210213","doi-asserted-by":"crossref","first-page":"2979","DOI":"10.1073\/pnas.95.6.2979","article-title":"HL-1 cells: a cardiac muscle cell line that contracts and retains phenotypic characteristics of the adult cardiomyocyte.","volume":"95","author":"Claycomb","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R16-10-20210213","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1128\/IAI.66.5.2300-2309.1998","article-title":"Essential role of gamma interferon in survival of colon ascendens stent peritonitis, a novel murine model of abdominal sepsis.","volume":"66","author":"Zantl","year":"1998","journal-title":"Infect Immun"},{"key":"R17-10-20210213","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal Biochem"},{"key":"R18-10-20210213","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1471-2199-7-3","article-title":"The RIN: an RNA integrity number for assigning integrity values to RNA measurements.","volume":"7","author":"Schroeder","year":"2006","journal-title":"BMC Mol Biol"},{"key":"R19-10-20210213","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1016\/S0022-5347(05)65141-5","article-title":"Immunolocalization of multidrug resistance protein 5 in the human genitourinary system.","volume":"167","author":"Nies","year":"2002","journal-title":"J Urol"},{"key":"R20-10-20210213","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1124\/dmd.32.7.734","article-title":"Lipopolysaccharide-mediated regulation of hepatic transporter mRNA levels in rats.","volume":"32","author":"Cherrington","year":"2004","journal-title":"Drug Metab Dispos"},{"key":"R21-10-20210213","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1515\/BC.2004.029","article-title":"Enhanced expression of basolateral multidrug resistance protein isoforms MRP3 and MRP5 in rat liver by LPS.","volume":"385","author":"Donner","year":"2004","journal-title":"Biol Chem"},{"key":"R22-10-20210213","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1097\/00024382-200014020-00017","article-title":"Intraabdominal sepsis down-regulates transcription of sodium taurocholate cotransporter and multidrug resistance-associated protein in rats.","volume":"14","author":"Kim","year":"2000","journal-title":"Shock"},{"key":"R23-10-20210213","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1097\/01.CCM.0000240229.98275.07","article-title":"Sepsis-induced cholestasis, steatosis, hepatocellular injury, and impaired hepatocellular regeneration are enhanced in interleukin-6 \/ mice.","volume":"34","author":"Deutschman","year":"2006","journal-title":"Crit Care Med"},{"key":"R24-10-20210213","doi-asserted-by":"crossref","first-page":"H2020","DOI":"10.1152\/ajpheart.01105.2003","article-title":"Regulation of rat pial arteriolar smooth muscle relaxation in vivo through multidrug resistance protein 5-mediated cGMP efflux.","volume":"286","author":"Xu","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"R25-10-20210213","first-page":"H193","article-title":"Relationship between plasma NOx and cardiac and vascular dysfunction after LPS injection in anesthetized dogs.","volume":"274","author":"Forfia","year":"1998","journal-title":"Am J Physiol"},{"key":"R26-10-20210213","doi-asserted-by":"crossref","first-page":"H800","DOI":"10.1152\/ajpheart.00701.2005","article-title":"Cellular and molecular mechanisms underlying LPS-associated myocyte impairment.","volume":"290","author":"Tavener","year":"2006","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"R27-10-20210213","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1161\/01.CIR.97.14.1382","article-title":"Pathophysiologically relevant concentrations of tumor necrosis factor-alpha promote progressive left ventricular dysfunction and remodeling in rats.","volume":"97","author":"Bozkurt","year":"1998","journal-title":"Circulation"},{"key":"R28-10-20210213","doi-asserted-by":"crossref","first-page":"R600","DOI":"10.1152\/ajpregu.00182.2004","article-title":"Signaling for myocardial depression in hemorrhagic shock: roles of Toll-like receptor 4 and p55 TNF-alpha receptor.","volume":"288","author":"Meng","year":"2005","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"R29-10-20210213","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1164\/ajrccm.163.1.2003109","article-title":"Caspase inhibition prevents cardiac dysfunction and heart apoptosis in a rat model of sepsis.","volume":"163","author":"Neviere","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"R30-10-20210213","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1097\/01.CCM.0000199070.46812.21","article-title":"Role of inducible nitric oxide synthase in the reduced responsiveness of the myocardium to catecholamines in a hyperdynamic, murine model of septic shock.","volume":"34","author":"Barth","year":"2006","journal-title":"Crit Care Med"}],"container-title":["Shock"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.lww.com\/00024382-200711000-00010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T01:40:33Z","timestamp":1618278033000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00024382-200711000-00010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007]]}},"URL":"https:\/\/doi.org\/10.1097\/shk.0b013e31804f5898","relation":{},"ISSN":["1073-2322"],"issn-type":[{"value":"1073-2322","type":"print"}],"subject":[],"published":{"date-parts":[[2007,11]]}}}