{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:12:58Z","timestamp":1786119178246,"version":"build-2736575974"},"reference-count":33,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,7]]},"DOI":"10.1097\/shk.0b013e31818bb7a1","type":"journal-article","created":{"date-parts":[[2009,6,9]],"date-time":"2009-06-09T03:18:46Z","timestamp":1244517526000},"page":"55-61","source":"Crossref","is-referenced-by-count":28,"title":["NITRIC OXIDE MEDIATES LUNG VASCULAR PERMEABILITY AND LYMPH-BORNE IL-6 AFTER AN INTESTINAL ISCHEMIC INSULT"],"prefix":"10.1097","volume":"32","author":[{"given":"Ana Cristina","family":"Breithaupt-Faloppa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana Beatriz","family":"Vitoretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando Rodrigues","family":"Coelho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana Lino","family":"dos Santos Franco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helori Vanni","family":"Domingos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lia Siguemi","family":"Sudo-Hayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Martins","family":"Oliveira-Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wothan Tavares","family":"de Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-9-20210213","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1053\/crad.2001.0889","article-title":"Acute respiratory distress syndrome: imaging of the injured lung.","volume":"57","author":"Desai","year":"2002","journal-title":"Clin Radiol"},{"key":"R2-9-20210213","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0002-9610(01)00846-7","article-title":"Role of integrins and intracellular adhesion molecule-1 in lung injury after intestinal ischemia-reperfusion.","volume":"183","author":"Kuzu","year":"2002","journal-title":"Am J Surg"},{"key":"R3-9-20210213","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1097\/00075198-200104000-00007","article-title":"Role of the gut lymphatic system in multiple organ failure.","volume":"7","author":"Deitch","year":"2001","journal-title":"Curr Opin Crit Care"},{"key":"R4-9-20210213","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1097\/01.shk.0000157303.76749.9b","article-title":"Lymphatic system as a path underlying the spread of lung and gut injury after intestinal ischemia\/reperfusion in rats.","volume":"23","author":"Cavriani","year":"2005","journal-title":"Shock"},{"key":"R5-9-20210213","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/01.shk.0000238068.84826.52","article-title":"Lymphatic thoracic duct ligation modulates the serum levels of IL-1beta and IL-10 after intestinal ischemia\/reperfusion in rats with the involvement of tumor necrosis factor alpha and nitric oxide.","volume":"27","author":"Cavriani","year":"2007","journal-title":"Shock"},{"key":"R6-9-20210213","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1097\/shk.0b013e318053621d","article-title":"Lymphatic-borne IL-1beta and the inducible isoform of nitric oxide synthase trigger the bronchial hyporesponsiveness after intestinal ischemia\/reperfusion in rats.","volume":"28","author":"Coelho","year":"2007","journal-title":"Shock"},{"key":"R7-9-20210213","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ejphar.2004.04.048","article-title":"Lung microvascular permeability and neutrophil recruitment are differently regulated by nitric oxide in a rat model of intestinal ischemia-reperfusion.","volume":"494","author":"Cavriani","year":"2004","journal-title":"Eur J Pharmacol"},{"key":"R8-9-20210213","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/00024382-200202000-00003","article-title":"A nitric oxide scavenger protects against pulmonary inflammation following hemorrhagic shock.","volume":"17","author":"Hierholzer","year":"2002","journal-title":"Shock"},{"key":"R9-9-20210213","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/00024382-200208000-00014","article-title":"Role of induced nitric oxide in the initiation of the inflammatory response after postischemic injury.","volume":"18","author":"Cuzzocrea","year":"2002","journal-title":"Shock"},{"key":"R10-9-20210213","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0039-6060(98)70153-9","article-title":"Intestinal reperfusion-induced pulmonary edema is related to increased pulmonary inducible nitric oxide synthase activity.","volume":"124","author":"Turnage","year":"1998","journal-title":"Surgery"},{"key":"R11-9-20210213","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1006\/jsre.1999.5795","article-title":"Sustained nitric oxide production via l-arginine administration ameliorates effects of intestinal ischemia-reperfusion.","volume":"89","author":"Ward","year":"2000","journal-title":"J Surg Res"},{"key":"R12-9-20210213","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.niox.2004.04.002","article-title":": A novel potent inhibitor of inducible nitric oxide inhibitor, ONO-1714, reduces intestinal ischemia-reperfusion injury in rats.","volume":"10","author":"Naito","year":"2004","journal-title":"Nitric Oxide"},{"key":"R13-9-20210213","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0891-5849(02)00844-4","article-title":"Dual role of inducible nitric oxide synthase in acute asbestos-induced lung injury.","volume":"33","author":"Dorger","year":"2002","journal-title":"Free Radic Biol Med"},{"key":"R14-9-20210213","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1097\/01.CCM.0000165445.48350.4F","article-title":"Pulmonary oxidant stress in murine sepsis is due to inflammatory cell nitric oxide.","volume":"33","author":"Razavi","year":"2005","journal-title":"Crit Care Med"},{"key":"R15-9-20210213","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.resp.2006.06.005","article-title":": Endothelial nitric oxide synthase mediates protective effects of hypoxic preconditioning in lungs.","volume":"155","author":"Kaminski","year":"2007","journal-title":"Respir Physiol Neurobiol"},{"key":"R16-9-20210213","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1097\/00000658-199204000-00009","article-title":"Cytokine serum level during severe sepsis in human IL-6 as a marker of severity.","volume":"215","author":"Damas","year":"1992","journal-title":"Ann Surg"},{"key":"R17-9-20210213","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1006\/jsre.1994.1121","article-title":"Intragraft expression of messenger RNA for interleukin-6 and tumor necrosis factor-alpha is a predictor of rat small intestine transplant rejection.","volume":"57","author":"Farmer","year":"1994","journal-title":"J Surg Res"},{"key":"R18-9-20210213","first-page":"1097","article-title":"Intratracheal injection of endotoxin and cytokines. II. Interleukin-6 and transforming growth factor beta inhibit acute inflammation.","volume":"138","author":"Ulich","year":"1991","journal-title":"Am J Pathol"},{"key":"R19-9-20210213","doi-asserted-by":"crossref","first-page":"C343","DOI":"10.1152\/ajpcell.2001.280.2.C343","article-title":"Essential role for IL-6 in postresuscitation inflammation in hemorrhagic shock.","volume":"280","author":"Meng","year":"2001","journal-title":"Am J Physiol Cell Physiol"},{"key":"R20-9-20210213","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/00024382-200014010-00008","article-title":"Distinct effects of systemic infusion of G-CSF vs. IL-6 on lung and liver inflammation and injury in hemorrhagic shock.","volume":"14","author":"Meng","year":"2000","journal-title":"Shock"},{"key":"R21-9-20210213","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1111\/j.1600-6143.2004.00368.x","article-title":"Exogenous IL-6 inhibits acute inflammatory responses and prevents ischemia\/reperfusion injury after intestinal transplantation.","volume":"4","author":"Kimizuka","year":"2004","journal-title":"Am J Transplant"},{"key":"R22-9-20210213","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1164\/rccm.200712-1777OC","article-title":"Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsis.","volume":"177","author":"Yende","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"R23-9-20210213","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1007\/s00595-004-2847-9","article-title":"Lung injury after intestinal ischemia-reperfusion may be avoided by the reduced absorption of locally produced cytokines.","volume":"34","author":"Narita","year":"2004","journal-title":"Surg Today"},{"key":"R24-9-20210213","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1097\/00000658-199904000-00005","article-title":"Intestinal cytokine response after gut ischemia: role of gut barrier failure.","volume":"229","author":"Grotz","year":"1999","journal-title":"Ann Surg"},{"key":"R25-9-20210213","doi-asserted-by":"crossref","first-page":"C227","DOI":"10.1152\/ajpcell.00112.2001","article-title":"Reactive species mechanisms of cellular hypoxia-reoxygenation injury.","volume":"282","author":"Li","year":"2002","journal-title":"Am J Physiol Cell Physiol"},{"key":"R26-9-20210213","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/0090-6980(88)90009-3","article-title":"PAF increases vascular permeability in selected tissues: effect of BN-52021 and L-655, 240.","volume":"36","author":"Sirois","year":"1988","journal-title":"Prostaglandins"},{"key":"R27-9-20210213","first-page":"176","article-title":"The inflammatory responses of rats depleted of lymphocytes or with an artificial obstruction of the thoracic duct.","volume":"61","author":"Sudo","year":"1980","journal-title":"Br J Exp Pathol"},{"key":"R28-9-20210213","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0022-1759(01)00408-2","article-title":"Endothelial cell culture: protocol to obtain and cultivate human umbilical endothelial cells.","volume":"254","author":"Marin","year":"2001","journal-title":"J Immunol Methods"},{"key":"R29-9-20210213","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/0741-5214(93)90264-M","article-title":"Multiple organ dysfunction after mesenteric artery revascularization.","volume":"18","author":"Harward","year":"1993","journal-title":"J Vasc Surg"},{"key":"R30-9-20210213","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1097\/SHK.0b013e318173edd1","article-title":"Mesenteric lymph duct ligation improves survival in a lethal shock model.","volume":"30","author":"Badami","year":"2008","journal-title":"Shock"},{"key":"R31-9-20210213","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1097\/01.shk.0000133592.55400.83","article-title":"The role of lymph factors in lung injury, bone marrow suppression, and endothelial cell dysfunction in a primate model of trauma-hemorrhagic shock.","volume":"22","author":"Deitch","year":"2004","journal-title":"Shock"},{"key":"R32-9-20210213","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.surg.2003.12.012","article-title":"A study of the biologic activity of trauma-hemorrhagic shock mesenteric lymph over time and the relative role of cytokines.","volume":"136","author":"Davidson","year":"2004","journal-title":"Surgery"},{"key":"R33-9-20210213","first-page":"L611","article-title":"Interleukin-6 production in hemorrhagic shock is accompanied by neutrophil recruitment and lung injury.","volume":"275","author":"Hierholzer","year":"1998","journal-title":"Am J Physiol"}],"container-title":["Shock"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/SHK.0b013e31818bb7a1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T17:55:35Z","timestamp":1786038935000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00024382-200907000-00009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,7]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1097\/shk.0b013e31818bb7a1","relation":{},"ISSN":["1073-2322"],"issn-type":[{"value":"1073-2322","type":"print"}],"subject":[],"published":{"date-parts":[[2009,7]]}}}