{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:00:10Z","timestamp":1791806410992,"version":"4.3.4"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,2]]},"DOI":"10.1097\/shk.0b013e3181ae8155","type":"journal-article","created":{"date-parts":[[2010,1,9]],"date-time":"2010-01-09T07:00:32Z","timestamp":1263020432000},"page":"197-204","source":"Crossref","is-referenced-by-count":38,"title":["RON RECEPTOR TYROSINE KINASE NEGATIVELY REGULATES TNF\u03b1 PRODUCTION IN ALVEOLAR MACROPHAGES BY INHIBITING NF-\u03baB ACTIVITY AND ADAM17 PRODUCTION"],"prefix":"10.1097","volume":"33","author":[{"given":"Nikolaos M.","family":"Nikolaidis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerilyn K.","family":"Gray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devikala","family":"Gurusamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Fox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D.","family":"Stuart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Huber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan E.","family":"Waltz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-12-20210213","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0065-2776(08)60432-0","article-title":"Inflammatory mediators, cytokines, and adhesion molecules in pulmonary inflammation and injury.","volume":"62","author":"Lukacs","year":"1996","journal-title":"Adv Immunol"},{"issue":"1","key":"R2-12-20210213","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/1357-4310(95)80019-0","article-title":"The role of cytokines and adhesion molecules in the development of inflammatory injury.","volume":"1","author":"Shanley","year":"1995","journal-title":"Mol Med Today"},{"issue":"Suppl 1","key":"R3-12-20210213","doi-asserted-by":"crossref","first-page":"103S","DOI":"10.1378\/chest.116.suppl_1.103S","article-title":"Chemokines in lung injury: Thomas A. Neff Lecture.","volume":"116","author":"Strieter","year":"1999","journal-title":"Chest"},{"issue":"3","key":"R4-12-20210213","first-page":"489","article-title":"Macrophage-derived cytokines amplify immune complex-triggered O2 responses by rat alveolar macrophages.","volume":"130","author":"Warren","year":"1988","journal-title":"Am J Pathol"},{"issue":"4","key":"R5-12-20210213","first-page":"316","article-title":"Pulmonary failure following lower torso ischemia: clinical evidence for a remote effect of reperfusion injury.","volume":"61","author":"Fantini","year":"1995","journal-title":"Am Surg"},{"issue":"1","key":"R7-12-20210213","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2567.2005.02143.x","article-title":"The intriguing biology of the tumour necrosis factor\/tumour necrosis factor receptor superfamily: players, rules and the games.","volume":"115","author":"Hehlgans","year":"2005","journal-title":"Immunology"},{"issue":"4","key":"R8-12-20210213","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1172\/JCI116351","article-title":"3rd: Tumor necrosis factor-alpha blockade prevents neutrophil CD18 receptor upregulation and attenuates acute lung injury in porcine sepsis without inhibition of neutrophil oxygen radical generation.","volume":"91","author":"Windsor","year":"1993","journal-title":"J Clin Invest"},{"issue":"4","key":"R9-12-20210213","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1053\/joca.1998.0221","article-title":"Regulation of tumor necrosis factor-alpha and tumor necrosis factor converting enzyme in human osteoarthritis.","volume":"7","author":"Amin","year":"1999","journal-title":"Osteoarthritis Cartilage"},{"issue":"15","key":"R10-12-20210213","doi-asserted-by":"crossref","first-page":"3524","DOI":"10.1002\/j.1460-2075.1994.tb06659.x","article-title":"RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP.","volume":"13","author":"Gaudino","year":"1994","journal-title":"Embo J"},{"issue":"11","key":"R11-12-20210213","doi-asserted-by":"crossref","first-page":"3160","DOI":"10.1182\/blood.V83.11.3160.3160","article-title":"Molecular cloning of a novel receptor tyrosine kinase gene, STK, derived from enriched hematopoietic stem cells.","volume":"83","author":"Iwama","year":"1994","journal-title":"Blood"},{"issue":"9","key":"R12-12-20210213","doi-asserted-by":"crossref","first-page":"3394","DOI":"10.1182\/blood.V86.9.3394.bloodjournal8693394","article-title":": Terminal differentiation of murine resident peritoneal macrophages is characterized by expression of the STK protein tyrosine kinase, a receptor for macrophage-stimulating protein.","volume":"86","author":"Iwama","year":"1995","journal-title":"Blood"},{"issue":"4","key":"R13-12-20210213","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/aja.1002040405","article-title":"Restricted expression of the ron gene encoding the macrophage stimulating protein receptor during mouse development.","volume":"204","author":"Quantin","year":"1995","journal-title":"Dev Dyn"},{"issue":"48","key":"R14-12-20210213","doi-asserted-by":"crossref","first-page":"30526","DOI":"10.1074\/jbc.272.48.30526","article-title":"Functional characterization of domains contained in hepatocyte growth factor-like protein.","volume":"272","author":"Waltz","year":"1997","journal-title":"J Biol Chem"},{"issue":"3","key":"R15-12-20210213","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1097\/01.shk.0000239755.82711.89","article-title":"The Ron receptor tyrosine kinase regulates acute lung injury and suppresses nuclear factor kappaB activation.","volume":"27","author":"Lentsch","year":"2007","journal-title":"Shock"},{"issue":"1","key":"R16-12-20210213","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1165\/rcmb.2005-0093OC","article-title":"Gene expression profiles of Mst1r-deficient mice during nickel-induced acute lung injury.","volume":"34","author":"Mallakin","year":"2006","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"4","key":"R17-12-20210213","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1172\/JCI11881","article-title":"Ron-mediated cytoplasmic signaling is dispensable for viability but is required to limit inflammatory responses.","volume":"108","author":"Waltz","year":"2001","journal-title":"J Clin Invest"},{"issue":"5","key":"R18-12-20210213","first-page":"1365","article-title":"Expression of ADAMs (a disintegrin and metalloproteases) and TIMP-3 (tissue inhibitor of metalloproteinase-3) in human prostatic adenocarcinomas.","volume":"23","author":"Karan","year":"2003","journal-title":"Int J Oncol"},{"issue":"18","key":"R19-12-20210213","doi-asserted-by":"crossref","first-page":"9162","DOI":"10.1158\/0008-5472.CAN-06-0283","article-title":": Therapeutic implications of a human neutralizing antibody to the macrophage-stimulating protein receptor tyrosine kinase (RON), a c-MET family member.","volume":"66","author":"O'Toole","year":"2006","journal-title":"Cancer Res"},{"issue":"4","key":"R20-12-20210213","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1172\/JCI119214","article-title":"Role of macrophage-stimulating protein and its receptor, RON tyrosine kinase, in ciliary motility.","volume":"99","author":"Sakamoto","year":"1997","journal-title":"J Clin Invest"},{"issue":"7","key":"R21-12-20210213","doi-asserted-by":"crossref","first-page":"3815","DOI":"10.4049\/jimmunol.164.7.3815","article-title":"Regulation of the RON receptor tyrosine kinase expression in macrophages: blocking the RON gene transcription by endotoxin-induced nitric oxide.","volume":"164","author":"Wang","year":"2000","journal-title":"J Immunol"},{"issue":"4","key":"R22-12-20210213","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1165\/ajrcmb.18.4.2978","article-title":"Macrophage-stimulating protein and its receptor in non-small-cell lung tumors: induction of receptor tyrosine phosphorylation and cell migration.","volume":"18","author":"Willett","year":"1998","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"2","key":"R23-12-20210213","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/jlb.46.2.119","article-title":"MH-S, a murine alveolar macrophage cell line: morphological, cytochemical, and functional characteristics.","volume":"46","author":"Mbawuike","year":"1989","journal-title":"J Leukoc Biol"},{"issue":"4","key":"R24-12-20210213","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1002\/jlb.57.4.562","article-title":"Phenotypic and functional heterogeneity of the murine alveolar macrophage-derived cell line MH-S.","volume":"57","author":"Sankaran","year":"1995","journal-title":"J Leukoc Biol"},{"issue":"3","key":"R25-12-20210213","doi-asserted-by":"crossref","first-page":"L379","DOI":"10.1152\/ajplung.00010.2008","article-title":"Animal models of acute lung injury.","volume":"295","author":"Matute-Bello","year":"2008","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"1","key":"R26-12-20210213","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1165\/ajrcmb.26.1.4621","article-title":": The role of the receptor tyrosine kinase Ron in nickel-induced acute lung injury.","volume":"26","author":"McDowell","year":"2002","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"4","key":"R27-12-20210213","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/sj.bjp.0706751","article-title":"Macrophage-stimulating protein differently affects human alveolar macrophages from smoker and non-smoker patients: evaluation of respiratory burst, cytokine release and NF-kappaB pathway.","volume":"148","author":"Gunella","year":"2006","journal-title":"Br J Pharmacol"},{"issue":"6","key":"R28-12-20210213","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/sj.bjp.0704356","article-title":"Macrophage stimulating protein (MSP) evokes superoxide anion production by human macrophages of different origin.","volume":"134","author":"Brunelleschi","year":"2001","journal-title":"Br J Pharmacol"},{"issue":"9","key":"R29-12-20210213","doi-asserted-by":"crossref","first-page":"4950","DOI":"10.4049\/jimmunol.161.9.4950","article-title":"Activation of the RON receptor tyrosine kinase inhibits inducible nitric oxide synthase (iNOS) expression by murine peritoneal exudate macrophages: phosphatidylinositol-3 kinase is required for RON-mediated inhibition of iNOS expression.","volume":"161","author":"Chen","year":"1998","journal-title":"J Immunol"},{"issue":"12","key":"R30-12-20210213","doi-asserted-by":"crossref","first-page":"6606","DOI":"10.4049\/jimmunol.163.12.6606","article-title":"Negative regulation of macrophage activation in response to IFN-gamma and lipopolysaccharide by the STK\/RON receptor tyrosine kinase.","volume":"163","author":"Liu","year":"1999","journal-title":"J Immunol"},{"issue":"3","key":"R31-12-20210213","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.4049\/jimmunol.172.3.1825","article-title":"Macrophage-stimulating protein, the ligand for the stem cell-derived tyrosine kinase\/RON receptor tyrosine kinase, inhibits IL-12 production by primary peritoneal macrophages stimulated with IFN-gamma and lipopolysaccharide.","volume":"172","author":"Morrison","year":"2004","journal-title":"J Immunol"},{"issue":"5","key":"R32-12-20210213","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1053\/jhep.2002.36822","article-title":"Deletion of the Ron receptor tyrosine kinase domain in mice provides protection from endotoxin-induced acute liver failure.","volume":"36","author":"Leonis","year":"2002","journal-title":"Hepatology"},{"issue":"5","key":"R33-12-20210213","doi-asserted-by":"crossref","first-page":"L1037","DOI":"10.1152\/ajplung.2001.281.5.L1037","article-title":"Transcriptional mechanisms of acute lung injury.","volume":"281","author":"Fan","year":"2001","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"4","key":"R34-12-20210213","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.4049\/jimmunol.157.4.1630","article-title":"In vivo antioxidant treatment suppresses nuclear factor-kappa B activation and neutrophilic lung inflammation.","volume":"157","author":"Blackwell","year":"1996","journal-title":"J Immunol"},{"issue":"12","key":"R35-12-20210213","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1161\/01.CIR.100.12.1330","article-title":"Inhibition of NF-kappaB activation by pyrrolidine dithiocarbamate prevents in vivo expression of proinflammatory genes.","volume":"100","author":"Liu","year":"1999","journal-title":"Circulation"},{"issue":"4","key":"R36-12-20210213","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/S0026-895X(24)23027-3","article-title":"Pyrrolidine dithiocarbamate prevents I-kappaB degradation and reduces microvascular injury induced by lipopolysaccharide in multiple organs.","volume":"55","author":"Liu","year":"1999","journal-title":"Mol Pharmacol"},{"issue":"9","key":"R37-12-20210213","doi-asserted-by":"crossref","first-page":"4570","DOI":"10.4049\/jimmunol.160.9.4570","article-title":"TNF-alpha convertase enzyme from human arthritis-affected cartilage: isolation of cDNA by differential display, expression of the active enzyme, and regulation of TNF-alpha.","volume":"160","author":"Patel","year":"1998","journal-title":"J Immunol"},{"issue":"1-2","key":"R38-12-20210213","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0378-1119(99)00155-9","article-title":"cDNA cloning of mouse tumor necrosis factor-alpha converting enzyme (TACE) and partial analysis of its promoter.","volume":"233","author":"Mizui","year":"1999","journal-title":"Gene"}],"container-title":["Shock"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.lww.com\/00024382-201002000-00012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,16]],"date-time":"2025-02-16T16:20:16Z","timestamp":1739722816000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00024382-201002000-00012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1097\/shk.0b013e3181ae8155","relation":{},"ISSN":["1073-2322"],"issn-type":[{"value":"1073-2322","type":"print"}],"subject":[],"published":{"date-parts":[[2010,2]]}}}