{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T15:50:03Z","timestamp":1790437803005,"version":"4.1.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1097\/shk.0b013e3181b2b0f4","type":"journal-article","created":{"date-parts":[[2010,2,6]],"date-time":"2010-02-06T01:56:21Z","timestamp":1265421381000},"page":"315-321","source":"Crossref","is-referenced-by-count":31,"title":["EXOU-INDUCED VASCULAR HYPERPERMEABILITY AND PLATELET ACTIVATION IN THE COURSE OF EXPERIMENTAL PSEUDOMONAS AERUGINOSA PNEUMOSEPSIS"],"prefix":"10.1097","volume":"33","author":[{"given":"Gloria-Beatriz S.","family":"Machado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Cristina","family":"de Assis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robson","family":"Le\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra M.","family":"Saliba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio C. A.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose H.","family":"Suassuna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albanita V.","family":"de Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Cristina","family":"Plotkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-14-20210213","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1001\/archinte.1996.00440170139015","article-title":"Epidemiology and outcome of Pseudomonas aeruginosa bacteremia, with special emphasis on the influence of antibiotic treatment. Analysis of 189 episodes.","volume":"156","author":"Vidal","year":"1996","journal-title":"Arch Intern Med"},{"key":"R2-14-20210213","doi-asserted-by":"crossref","first-page":"8484","DOI":"10.1073\/pnas.0832438100","article-title":"Conservation of genome content and virulence determinants among clinical and environmental isolates of Pseudomonas aeruginosa.","volume":"100","author":"Wolfgang","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R3-14-20210213","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1099\/00221287-147-10-2659","article-title":"Prevalence of type III secretion genes in clinical and environmental isolates of Pseudomonas aeruginosa.","volume":"147","author":"Feltman","year":"2001","journal-title":"Microbiology"},{"key":"R4-14-20210213","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1111\/j.1365-2958.2004.04194.x","article-title":"ExoU is a potent intracellular phospholipase.","volume":"53","author":"Sato","year":"2004","journal-title":"Mol Microbiol"},{"key":"R5-14-20210213","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1111\/j.1462-5822.2005.00635.x","article-title":"Eicosanoid-mediated proinflammatory activity of Pseudomonas aeruginosa ExoU.","volume":"7","author":"Saliba","year":"2005","journal-title":"Cell Microbiol"},{"key":"R6-14-20210213","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.micpath.2008.01.008","article-title":"Lipid body mobilization in the ExoU-induced release of inflammatory mediators by airway epithelial cells.","volume":"45","author":"Plotkowski","year":"2008","journal-title":"Microb Pathog"},{"key":"R7-14-20210213","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1172\/JCI7124","article-title":"Pathogenesis of septic shock in Pseudomonas aeruginosa pneumonia.","volume":"104","author":"Kurahashi","year":"1999","journal-title":"J Clin Invest"},{"key":"R8-14-20210213","doi-asserted-by":"crossref","first-page":"5880","DOI":"10.4049\/jimmunol.167.10.5880","article-title":"Therapeutic administration of anti-PcrV F(ab)(2) is sepsis associated with Pseudomonas aeruginosa.","volume":"167","author":"Shime","year":"2001","journal-title":"J Immunol"},{"key":"R9-14-20210213","doi-asserted-by":"crossref","first-page":"6969","DOI":"10.1128\/IAI.72.12.6969-6977.2004","article-title":"Relative contribution of Pseudomonas aeruginosa ExoU, ExoS, ExoT to virulence in the lung.","volume":"72","author":"Shaver","year":"2004","journal-title":"Infect Immun"},{"key":"R10-14-20210213","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1086\/377000","article-title":"P, Attree I, Plesiat P, Chabert J, de Bentzmann S, Pozzetto B, Grattard F, Groupe d'etudes des septicemias a Pseudomonas aeruginosa: Genotypic and phenotypic analysis of the type III secretion system in a cohort of Pseudomonas aeruginosa bacteremia isolates: evidence for a possible association between O serotypes and exo genes.","volume":"188","year":"2003","journal-title":"J Infect Dis"},{"key":"R11-14-20210213","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1086\/379372","article-title":"Secretion of the toxin ExoU is a marker for highly virulent Pseudomonas aeruginosa isolates obtained from patients with hospital-acquired pneumonia.","volume":"188","author":"Schulert","year":"2003","journal-title":"J Infect Dis"},{"issue":"suppl A","key":"R12-14-20210213","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1093\/jac\/41.suppl_1.17","article-title":"The haematological manifestations of sepsis.","volume":"41","author":"Mammen","year":"1998","journal-title":"J Antimicrob Chemother"},{"key":"R13-14-20210213","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/S0008-6363(02)00857-X","article-title":"Infection and inflammation and the coagulation system.","volume":"60","author":"Levi","year":"2003","journal-title":"Cardiovasc Res"},{"issue":"suppl 4","key":"R14-14-20210213","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1186\/cc3751","article-title":"The microcirculation as a functional system.","volume":"9","author":"Ellis","year":"2005","journal-title":"Crit Care"},{"issue":"6","key":"R15-14-20210213","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1097\/SHK.0b013e3181a4fd01","article-title":"Cardiovascular collapse and vascular permeability changes in an ovine model of methicillin-resistant Staphylococcus aureus sepsis.","volume":"32","author":"Jonkam","year":"2009","journal-title":"Shock"},{"key":"R16-14-20210213","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1183\/09031936.00086708","article-title":"ExoU-induced procoagulant activity in Pseudomonas aeruginosa-infected airway cells.","volume":"32","author":"Plotkowski","year":"2008","journal-title":"Eur Respir J"},{"key":"R17-14-20210213","doi-asserted-by":"crossref","first-page":"4925","DOI":"10.1182\/blood.V87.12.4925.bloodjournal87124925","article-title":"Flow cytometry: a clinical test of platelet function.","volume":"12","author":"Michelson","year":"1996","journal-title":"Blood"},{"key":"R18-14-20210213","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1046\/j.1538-7836.2003.00309.x","article-title":"Cellular microparticles: what are they bad or good for?","volume":"1","author":"Freyssinet","year":"2003","journal-title":"J Thromb Haemost"},{"key":"R19-14-20210213","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/0160-5402(89)90068-5","article-title":"Plasma exudation: correlation between Evans blue and radiolabeled albumin in guinea-pig airways in vivo.","volume":"21","author":"Rogers","year":"1989","journal-title":"J Pharmacol Methods"},{"key":"R20-14-20210213","doi-asserted-by":"crossref","first-page":"e1527","DOI":"10.1371\/journal.pone.0001527","article-title":"Anti-human tissue-factor antibody ameliorated intestinal ischemia reperfusion-induced acute lung injury in human tissue factor knock-in mice.","volume":"3","author":"He","year":"2008","journal-title":"PLoS ONE"},{"key":"R21-14-20210213","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.thromres.2008.06.006","article-title":"Function and role of microparticles in various clinical settings.","volume":"123","author":"Nomura","year":"2008","journal-title":"Thromb Res"},{"key":"R22-14-20210213","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1007\/BF03022837","article-title":"Organ perfusion\/permeability-related effects of norepinephrine and vasopressin in sepsis.","volume":"53","author":"Farand","year":"2006","journal-title":"Can J Anaesth"},{"key":"R23-14-20210213","doi-asserted-by":"crossref","first-page":"266","DOI":"10.2174\/157016107782023389","article-title":"Microcirculatory endothelial dysfunction during endotoxemia-insights into pathophysiology, pathologic mechanisms and clinical relevance.","volume":"5","author":"Czabanka","year":"2007","journal-title":"Curr Vasc Pharmacol"},{"issue":"suppl","key":"R24-14-20210213","doi-asserted-by":"crossref","first-page":"S302","DOI":"10.1097\/00003246-200205001-00021","article-title":"Markers of endothelial damage in organ dysfunction and sepsis.","volume":"30","author":"Reinhart","year":"2002","journal-title":"Crit Care Med"},{"key":"R25-14-20210213","first-page":"1181","article-title":"Direct effects of endotoxin on the endothelium: barrier function and injury.","volume":"79","author":"Bannerman","year":"1999","journal-title":"Lab Invest"},{"key":"R26-14-20210213","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1161\/01.RES.0000134922.25721.d9","article-title":"Paradoxical cAMP-induced lung endothelial hyperpermeability revealed by Pseudomonas aeruginosa ExoY.","volume":"95","author":"Sayner","year":"2004","journal-title":"Circ Res"},{"key":"R27-14-20210213","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s00418-006-0174-5","article-title":"Perturbation of endothelial junction proteins by Staphylococcus aureus alpha-toxin: inhibition of endothelial gap formation by adrenomedullin.","volume":"126","author":"Hocke","year":"2006","journal-title":"Histochem Cell Biol"},{"key":"R28-14-20210213","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.micinf.2005.07.011","article-title":"Implications of oxidative stress in the cytotoxicity of Pseudomonas aeruginosa ExoU.","volume":"8","author":"Saliba","year":"2006","journal-title":"Microbes Infect"},{"key":"R29-14-20210213","first-page":"367","article-title":"Platelet interaction with bacteria. I. Reaction phases and effects of inhibitors.","volume":"65","author":"Clawson","year":"1971","journal-title":"Am J Pathol"},{"key":"R30-14-20210213","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.micpath.2004.10.006","article-title":"Bovine platelets activated by Haemophilus somnus and its LOS induce apoptosis in bovine endothelial cells.","volume":"38","author":"Kuckleburg","year":"2005","journal-title":"Microb Pathog"},{"key":"R31-14-20210213","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1080\/09537100220122448","article-title":"Platelet-platelet and platelet-leukocyte interactions induced by outer vesicles from N. meningitidis.","volume":"13","author":"Mirlashari","year":"2002","journal-title":"Platelets"},{"key":"R32-14-20210213","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1182\/blood-2005-03-0916","article-title":"Platelets express functional Toll-like receptor 4.","volume":"106","author":"Andonegui","year":"2005","journal-title":"Blood"},{"key":"R33-14-20210213","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1182\/blood-2005-06-2202","article-title":"Platelet Toll-like receptor expression modulates lipopolysaccharide-induced thrombocytopenia and tumor necrosis factor-alpha production in vivo.","volume":"107","author":"Aslam","year":"2006","journal-title":"Blood"},{"key":"R34-14-20210213","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1006\/jaut.2000.0449","article-title":"Anti-beta2 glycoprotein I antibodies prevent the de-activation of platelets and sustain their phagocytic clearance.","volume":"15","author":"Bondanza","year":"2000","journal-title":"J Autoimmun"},{"key":"R35-14-20210213","doi-asserted-by":"crossref","first-page":"11877","DOI":"10.1073\/pnas.93.21.11877","article-title":"In vivo tracking of platelets: circulating degranulated platelets rapidly lose surface P-selectin but continue to circulate and function.","volume":"93","author":"Michelson","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R36-14-20210213","first-page":"133","article-title":"Overview of physiological and pathophysiological effects of thromboxane A2.","volume":"46","author":"Ogletree","year":"1987","journal-title":"FASEB J"},{"key":"R37-14-20210213","doi-asserted-by":"crossref","first-page":"2358","DOI":"10.1097\/01.ASN.0000136300.72480.86","article-title":"Thromboxane receptor mediates renal vasoconstriction and contributes to acute renal failure in endotoxemic mice.","volume":"15","author":"Boffa","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"R38-14-20210213","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1182\/blood.V95.3.930.003k46_930_935","article-title":"Cellular origin and procoagulant properties of microparticles in meningococcal sepsis.","volume":"95","author":"Nieuwland","year":"2000","journal-title":"Blood"}],"container-title":["Shock"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00024382-201003000-00014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:12:10Z","timestamp":1786039930000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00024382-201003000-00014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1097\/shk.0b013e3181b2b0f4","relation":{},"ISSN":["1073-2322"],"issn-type":[{"value":"1073-2322","type":"print"}],"subject":[],"published":{"date-parts":[[2010,3]]}}}