{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:17:33Z","timestamp":1786119453287,"version":"build-2736575974"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,7]]},"DOI":"10.1097\/shk.0b013e3181cd8d05","type":"journal-article","created":{"date-parts":[[2010,3,23]],"date-time":"2010-03-23T02:50:14Z","timestamp":1269312614000},"page":"46-54","source":"Crossref","is-referenced-by-count":20,"title":["SIMVASTATIN REDUCES MORTALITY AND HEPATIC INJURY AFTER HEMORRHAGE\/RESUSCITATION IN RATS"],"prefix":"10.1097","volume":"34","author":[{"given":"Borna","family":"Relja","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Lehnert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Korbinian","family":"Seyboth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Bormann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"H\u00f6hn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Czerny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dirk","family":"Henrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingo","family":"Marzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"7346","key":"R1-9-20210213","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1136\/bmj.324.7346.1153","article-title":"Road traffic injuries are a global public health problem.","volume":"324","author":"Peden","year":"2002","journal-title":"BMJ"},{"issue":"7","key":"R2-9-20210213","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1186\/2047-783X-14-7-284","article-title":"Very early posttraumatic serum alterations are significantly associated to initial massive RBC substitution, injury severity, multiple organ failure and adverse clinical outcome in multiple injured patients.","volume":"14","author":"Bogner","year":"2009","journal-title":"Eur J Med Res"},{"issue":"2","key":"R3-9-20210213","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1097\/00024382-199808000-00001","article-title":"Systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), multiple organ failure (MOF): are we winning the battle?","volume":"10","author":"Baue","year":"1998","journal-title":"Shock"},{"issue":"2","key":"R4-9-20210213","first-page":"194","article-title":"Neutrophil priming and activation in the pathogenesis of postinjury multiple organ failure.","volume":"4","author":"Partrick","year":"1996","journal-title":"New Horiz"},{"issue":"5","key":"R5-9-20210213","doi-asserted-by":"crossref","first-page":"G1219","DOI":"10.1152\/ajpgi.00527.2007","article-title":"Differential mechanisms of hepatic vascular dysregulation with mild vs. moderate ischemia-reperfusion.","volume":"294","author":"Lee","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"2","key":"R6-9-20210213","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/SHK.0b013e31815dd623","article-title":"A peptide inhibitor of C-jun N-terminal kinase modulates hepatic damage and the inflammatory response after hemorrhagic shock and resuscitation.","volume":"30","author":"Lehnert","year":"2008","journal-title":"Shock"},{"issue":"6","key":"R7-9-20210213","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1172\/JCI3428","article-title":"Protective role of endogenous carbon monoxide in hepatic microcirculatory dysfunction after hemorrhagic shock in rats.","volume":"102","author":"Pannen","year":"1998","journal-title":"J Clin Invest"},{"issue":"22","key":"R8-9-20210213","doi-asserted-by":"crossref","first-page":"7505","DOI":"10.1093\/nar\/gkm893","article-title":"DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?","volume":"35","author":"Passos","year":"2007","journal-title":"Nucleic Acids Res"},{"issue":"6","key":"R10-9-20210213","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1084\/jem.187.6.917","article-title":"Essential role of induced nitric oxide in the initiation of the inflammatory response after hemorrhagic shock.","volume":"187","author":"Hierholzer","year":"1998","journal-title":"J Exp Med"},{"issue":"5","key":"R11-9-20210213","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1080\/08941930390230379","article-title":"The attenuation of hemorrhage-induced liver injury by exogenous nitric oxide, l-arginine, and inhibition of inducible nitric oxide synthase.","volume":"16","author":"Anaya-Prado","year":"2003","journal-title":"J Invest Surg"},{"issue":"11","key":"R12-9-20210213","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1172\/JCI119842","article-title":"Liver sinusoidal endothelial cells are responsible for nitric oxide modulation of resistance in the hepatic sinusoids.","volume":"100","author":"Shah","year":"1997","journal-title":"J Clin Invest"},{"issue":"6257","key":"R13-9-20210213","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/343425a0","article-title":"Regulation of the mevalonate pathway.","volume":"343","author":"Goldstein","year":"1990","journal-title":"Nature"},{"issue":"10","key":"R14-9-20210213","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1161\/01.STR.0000181077.84981.11","article-title":"Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection.","volume":"36","author":"Rikitake","year":"2005","journal-title":"Stroke"},{"issue":"1","key":"R15-9-20210213","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1161\/01.CIR.0000020682.73694.AB","article-title":"Rho-kinase mediates hypoxia-induced downregulation of endothelial nitric oxide synthase.","volume":"106","author":"Takemoto","year":"2002","journal-title":"Circulation"},{"issue":"2","key":"R16-9-20210213","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1161\/01.STR.0000054055.28435.BF","article-title":"Withdrawal of statin treatment abrogates stroke protection in mice.","volume":"34","author":"Gertz","year":"2003","journal-title":"Stroke"},{"issue":"12","key":"R17-9-20210213","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1161\/01.RES.0000196564.18314.23","article-title":"Rho GTPases, statins, and nitric oxide.","volume":"97","author":"Rikitake","year":"2005","journal-title":"Circ Res"},{"issue":"1","key":"R18-9-20210213","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1172\/JCI9639","article-title":"Neuroprotection mediated by changes in the endothelial actin cytoskeleton.","volume":"106","author":"Laufs","year":"2000","journal-title":"J Clin Invest"},{"issue":"6","key":"R19-9-20210213","doi-asserted-by":"crossref","first-page":"3686","DOI":"10.1128\/IAI.73.6.3686-3692.2005","article-title":"Strain-specific effects of probiotics on gut barrier integrity following hemorrhagic shock.","volume":"73","author":"Luyer","year":"2005","journal-title":"Infect Immun"},{"issue":"10","key":"R20-9-20210213","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1161\/01.CIR.0000140694.67251.9C","article-title":"Simvastatin induces heme oxygenase-1: a novel mechanism of vessel protection.","volume":"110","author":"Lee","year":"2004","journal-title":"Circulation"},{"issue":"2","key":"R21-9-20210213","doi-asserted-by":"crossref","first-page":"C343","DOI":"10.1152\/ajpcell.2001.280.2.C343","article-title":"Essential role for IL-6 in postresuscitation inflammation in hemorrhagic shock.","volume":"280","author":"Meng","year":"2001","journal-title":"Am J Physiol Cell Physiol"},{"issue":"4","key":"R22-9-20210213","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1097\/00024382-200304000-00009","article-title":"Dependence of liver injury after hemorrhage\/resuscitation in mice on NADPH oxidase-derived superoxide.","volume":"19","author":"Lehnert","year":"2003","journal-title":"Shock"},{"issue":"9","key":"R23-9-20210213","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1096\/fj.02-0624com","article-title":"Recovery of hepatocellular ATP and \"pericentral apoptosis\" after hemorrhage and resuscitation.","volume":"17","author":"Paxian","year":"2003","journal-title":"FASEB J"},{"issue":"1","key":"R24-9-20210213","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/00000441-200501000-00003","article-title":"Simvastatin and l-arginine preserve renal function after ischemia\/reperfusion injury.","volume":"329","author":"Inman","year":"2005","journal-title":"Am J Med Sci"},{"issue":"5","key":"R25-9-20210213","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1097\/TP.0b013e3181664e70","article-title":"Pharmacological preconditioning with simvastatin protects liver from ischemia-reperfusion injury by heme oxygenase-1 induction.","volume":"85","author":"Lai","year":"2008","journal-title":"Transplantation"},{"issue":"1","key":"R26-9-20210213","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2005.01.105","article-title":"Simvastatin reduced ischemic brain injury and perfusion deficits in an embolic model of stroke.","volume":"1042","author":"Shabanzadeh","year":"2005","journal-title":"Brain Res"},{"issue":"2","key":"R27-9-20210213","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1007\/s00380-005-0868-y","article-title":"Effects of simvastatin on cardiohemodynamic responses to ischemia-reperfusion in isolated rat hearts.","volume":"21","author":"Zheng","year":"2006","journal-title":"Heart Vessels"},{"issue":"3","key":"R28-9-20210213","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/j.resuscitation.2008.12.003","article-title":"Fluvastatin attenuates severe hemorrhagic shock-induced organ damage in rats.","volume":"80","author":"Lee","year":"2009","journal-title":"Resuscitation"},{"issue":"4","key":"R29-9-20210213","doi-asserted-by":"crossref","first-page":"309","DOI":"10.2174\/1570161043385475","article-title":"Non-lipid effects of statins: emerging new indications.","volume":"2","author":"Yildirir","year":"2004","journal-title":"Curr Vasc Pharmacol"},{"issue":"6","key":"R30-9-20210213","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.jhep.2005.01.030","article-title":"JNK mediates hepatic ischemia reperfusion injury.","volume":"42","author":"Uehara","year":"2005","journal-title":"J Hepatol"},{"issue":"6","key":"R31-9-20210213","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s00228-006-0097-z","article-title":"Antioxidant effects of simvastatin in primary and secondary prevention of coronary heart disease.","volume":"62","author":"Tavridou","year":"2006","journal-title":"Eur J Clin Pharmacol"},{"issue":"2-3","key":"R32-9-20210213","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0167-5273(02)00577-6","article-title":"A comparative study of the in vitro antioxidant activity of statins.","volume":"90","author":"Franzoni","year":"2003","journal-title":"Int J Cardiol"},{"issue":"2","key":"R33-9-20210213","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1152\/physrev.00011.2005","article-title":"Heme oxygenase-1\/carbon monoxide: from basic science to therapeutic applications.","volume":"86","author":"Ryter","year":"2006","journal-title":"Physiol Rev"},{"issue":"2","key":"R34-9-20210213","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1189\/jlb.0705363","article-title":"Mechanism of the salutary effects of flutamide on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of estrogen receptor-{beta}-dependent HO-1.","volume":"79","author":"Yu","year":"2006","journal-title":"J Leukoc Biol"},{"issue":"12","key":"R35-9-20210213","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1097\/00003246-199912000-00027","article-title":"Differential expression pattern of heme oxygenase-1\/heat shock protein 32 and nitric oxide synthase-II and their impact on liver injury in a rat model of hemorrhage and resuscitation.","volume":"27","author":"Rensing","year":"1999","journal-title":"Crit Care Med"},{"issue":"4","key":"R36-9-20210213","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1097\/00024382-199910000-00009","article-title":"Role of reactive oxygen species for hepatocellular injury and heme oxygenase-1 gene expression after hemorrhage and resuscitation.","volume":"12","author":"Rensing","year":"1999","journal-title":"Shock"},{"issue":"6","key":"R37-9-20210213","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1002\/hep.1840360623","article-title":"Endothelin-1 and heme oxygenase-1 as modulators of sinusoidal tone in the stress-exposed rat liver.","volume":"36","author":"Rensing","year":"2002","journal-title":"Hepatology"},{"issue":"6","key":"R38-9-20210213","doi-asserted-by":"crossref","first-page":"3553","DOI":"10.4049\/jimmunol.172.6.3553","article-title":"Heme oxygenase-1 modulates the expression of adhesion molecules associated with endothelial cell activation.","volume":"172","author":"Soares","year":"2004","journal-title":"J Immunol"},{"issue":"6","key":"R39-9-20210213","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1152\/japplphysiol.00499.2004","article-title":"Insights into the role of interleukin-6 in the induction of hepatic injury after trauma-hemorrhagic shock.","volume":"97","author":"Toth","year":"2004","journal-title":"J Appl Physiol"},{"issue":"15","key":"R40-9-20210213","doi-asserted-by":"crossref","first-page":"8880","DOI":"10.1073\/pnas.95.15.8880","article-title":"Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase.","volume":"95","author":"Endres","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"R41-9-20210213","doi-asserted-by":"crossref","first-page":"C661","DOI":"10.1152\/ajpcell.00459.2005","article-title":"Physiological role of ROCKs in the cardiovascular system.","volume":"290","author":"Noma","year":"2006","journal-title":"Am J Physiol Cell Physiol"},{"issue":"6","key":"R42-9-20210213","doi-asserted-by":"crossref","first-page":"H2598","DOI":"10.1152\/ajpheart.01393.2006","article-title":"Rho kinase activation plays a major role as a mediator of irreversible injury in reperfused myocardium.","volume":"292","author":"Hamid","year":"2007","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"37","key":"R43-9-20210213","doi-asserted-by":"crossref","first-page":"24266","DOI":"10.1074\/jbc.273.37.24266","article-title":"Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase.","volume":"273","author":"Laufs","year":"1998","journal-title":"J Biol Chem"},{"issue":"3","key":"R44-9-20210213","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1083\/jcb.140.3.627","article-title":"Apoptotic membrane blebbing is regulated by myosin light chain phosphorylation.","volume":"140","author":"Mills","year":"1998","journal-title":"J Cell Biol"}],"container-title":["Shock"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/SHK.0b013e3181cd8d05","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:17:25Z","timestamp":1786040245000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00024382-201007000-00009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,7]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1097\/shk.0b013e3181cd8d05","relation":{},"ISSN":["1073-2322"],"issn-type":[{"value":"1073-2322","type":"print"}],"subject":[],"published":{"date-parts":[[2010,7]]}}}