{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:18:10Z","timestamp":1786119490327,"version":"build-2736575974"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1097\/shk.0b013e3181d8e4f5","type":"journal-article","created":{"date-parts":[[2010,3,23]],"date-time":"2010-03-23T02:46:42Z","timestamp":1269312402000},"page":"412-419","source":"Crossref","is-referenced-by-count":16,"title":["ANESTHESIA AGGRAVATES LUNG DAMAGE AND PRECIPITATES HYPOTENSION IN ENDOTOXEMIC SHEEP"],"prefix":"10.1097","volume":"34","author":[{"given":"Oliver","family":"Soehnlein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Eriksson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Hjelmqvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"M\u00f6rgelin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lennart","family":"Lindbom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats","family":"Rundgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Frithiof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-15-20210213","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.it.2009.06.006","article-title":"Neutrophil granule proteins tune monocytic cell function.","volume":"30","author":"Soehnlein","year":"2009","journal-title":"Trends Immunol"},{"issue":"suppl 30","key":"R2-15-20210213","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1097\/SHK.0b013e3181818466","article-title":"The role of neutrophils in severe sepsis.","volume":"1","author":"Alves-Filho","year":"2008","journal-title":"Shock"},{"key":"R3-15-20210213","first-page":"1195","article-title":"Neutrophil margination and extravasation in sinusoids and venules of liver during endotoxin-induced injury.","volume":"272","author":"Chosay","year":"1997","journal-title":"Am J Physiol"},{"key":"R4-15-20210213","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/jlb.53.2.144","article-title":"Inhibition of Corynebacterium parvum-primed and lipopolysaccharide-induced hepatic necrosis in rats by selective depletion of neutrophils using a monoclonal antibody.","volume":"53","author":"Sato","year":"1993","journal-title":"J Leukoc Biol"},{"key":"R5-15-20210213","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1183\/09031936.00173207","article-title":"Neutrophil degranulation mediates severe lung damage triggered by streptococcal M1 protein.","volume":"32","author":"Soehnlein","year":"2008","journal-title":"Eur Respir J"},{"key":"R6-15-20210213","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1056\/NEJM198902093200606","article-title":"Tissue destruction by neutrophils.","volume":"320","author":"Weiss","year":"1989","journal-title":"N Engl J Med"},{"key":"R7-15-20210213","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/nm1001-1123","article-title":"Heparin-binding protein (HBP\/CAP37): a missing link in neutrophil-evoked alteration of vascular permeability.","volume":"7","author":"Gautam","year":"2001","journal-title":"Nat Med"},{"key":"R8-15-20210213","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/01.moh.0000190113.31027.d5","article-title":"Neutrophil granule contents in the pathogenesis of lung injury.","volume":"13","author":"Moraes","year":"2006","journal-title":"Curr Opin Hematol"},{"key":"R9-15-20210213","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/00003246-199502000-00011","article-title":"Microvascular function and rheologic changes in hyperdynamic sepsis.","volume":"23","author":"Astiz","year":"1995","journal-title":"Crit Care Med"},{"key":"R10-15-20210213","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s00134-001-1205-2","article-title":"Mechanisms of organ dysfunction in critical illness: report from a Round Table Conference held in Brussels.","volume":"28","author":"Fink","year":"2002","journal-title":"Intensive Care Med"},{"key":"R11-15-20210213","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000107614","article-title":"Isoflurane inhalation after induction of endotoxemia in rats attenuates the systemic cytokine response.","volume":"40","author":"Flondor","year":"2008","journal-title":"Eur Surg Res"},{"key":"R12-15-20210213","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1128\/CVI.13.2.281-288.2006","article-title":"General anesthesia delays the inflammatory response and increases survival for mice with endotoxic shock.","volume":"13","author":"Fuentes","year":"2006","journal-title":"Clin Vaccine Immunol"},{"key":"R13-15-20210213","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1097\/01.shk.0000248595.17130.24","article-title":"Isoflurane improves survival and protects against renal and hepatic injury in murine septic peritonitis.","volume":"27","author":"Lee","year":"2007","journal-title":"Shock"},{"key":"R14-15-20210213","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1097\/00000542-200301000-00017","article-title":"Isoflurane pretreatment inhibits lipopolysaccharide-induced inflammation in rats.","volume":"98","author":"Plachinta","year":"2003","journal-title":"Anesthesiology"},{"key":"R15-15-20210213","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1097\/00000542-200004000-00028","article-title":"Volatile anesthetics differentially affect immunostimulated expression of inducible nitric oxide synthase: role of intracellular calcium.","volume":"92","author":"Tschaikowsky","year":"2000","journal-title":"Anesthesiology"},{"key":"R16-15-20210213","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1097\/00000542-200603000-00019","article-title":"Protective effects of isoflurane pretreatment in endotoxin-induced lung injury.","volume":"104","author":"Reutershan","year":"2006","journal-title":"Anesthesiology"},{"key":"R17-15-20210213","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1213\/ANE.0b013e3181baf506","article-title":"Isoflurane preconditioning ameliorates endotoxin-induced acute lung injury and mortality in rats.","volume":"109","author":"Li","year":"2009","journal-title":"Anesth Analg"},{"key":"R18-15-20210213","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/01.shk.0000215314.76370.c3","article-title":"Comparison between the effects on hemodynamic responses of central and peripheral infusions of hypertonic NaCl during hemorrhage in conscious and isoflurane-anesthetized sheep.","volume":"26","author":"Frithiof","year":"2006","journal-title":"Shock"},{"key":"R19-15-20210213","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1097\/00000542-200205000-00026","article-title":"Isoflurane depresses baroreflex control of heart rate in decerebrate rats.","volume":"96","author":"Lee","year":"2002","journal-title":"Anesthesiology"},{"key":"R20-15-20210213","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1097\/00005344-199610000-00006","article-title":"Effects of isoflurane on cardiovascular system and sympathovagal balance in New Zealand white rabbits.","volume":"28","author":"Marano","year":"1996","journal-title":"J Cardiovasc Pharmacol"},{"key":"R21-15-20210213","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1097\/00000542-199504000-00015","article-title":"A comparison of baroreflex sensitivity during isoflurane and desflurane anesthesia in humans.","volume":"82","author":"Muzi","year":"1995","journal-title":"Anesthesiology"},{"key":"R22-15-20210213","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1097\/ALN.0b013e318167af9a","article-title":"Isoflurane differentially modulates inhibitory and excitatory synaptic transmission to the solitary tract nucleus.","volume":"108","author":"Peters","year":"2008","journal-title":"Anesthesiology"},{"key":"R23-15-20210213","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1213\/00000539-199203000-00003","article-title":"Comparative hemodynamic depression of halothane versus isoflurane in neonates and infants: an echocardiographic study.","volume":"74","author":"Murray","year":"1992","journal-title":"Anesth Analg"},{"key":"R24-15-20210213","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1467-2995.2007.00370.x","article-title":"Effects of isoflurane on echocardiographic parameters in healthy dogs.","volume":"35","author":"Sousa","year":"2008","journal-title":"Vet Anaesth Analg"},{"key":"R25-15-20210213","first-page":"17","article-title":"Cardiovascular and respiratory actions of desflurane: is desflurane different from isoflurane?","volume":"75","author":"Warltier","year":"1992","journal-title":"Anesth Analg"},{"key":"R26-15-20210213","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1097\/01.CCM.0000145951.76082.77","article-title":"Prolonged isoflurane sedation of intensive care unit patients with the anesthetic conserving device.","volume":"32","author":"Sackey","year":"2004","journal-title":"Crit Care Med"},{"key":"R27-15-20210213","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1113\/jphysiol.2007.139592","article-title":"Intravenous hypertonic NaCl acts via cerebral sodium-sensitive and angiotensinergic mechanisms to improve cardiac function in haemorrhaged conscious sheep.","volume":"583","author":"Frithiof","year":"2007","journal-title":"J Physiol"},{"key":"R28-15-20210213","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0165-2427(93)90190-F","article-title":"Cross-reactivity of workshop antibodies with cells from domestic and wild ruminants.","volume":"39","author":"Naessens","year":"1993","journal-title":"Vet Immunol Immunopathol"},{"key":"R29-15-20210213","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0092-8674(04)00057-1","article-title":"M protein, a classical bacterial virulence determinant, forms complexes with fibrinogen that induce vascular leakage.","volume":"116","author":"Herwald","year":"2004","journal-title":"Cell"},{"issue":"suppl 30","key":"R30-15-20210213","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/SHK.0b013e318181a343","article-title":"Experimental models of sepsis and their clinical relevance.","volume":"1","author":"Poli-de-Figueiredo","year":"2008","journal-title":"Shock"},{"key":"R31-15-20210213","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/nri2402","article-title":"Harmful molecular mechanisms in sepsis.","volume":"8","author":"Rittirsch","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"R32-15-20210213","doi-asserted-by":"crossref","first-page":"3503","DOI":"10.1182\/blood.V89.10.3503","article-title":"Granules of the human neutrophilic polymorphonuclear leukocyte.","volume":"89","author":"Borregaard","year":"1997","journal-title":"Blood"},{"key":"R33-15-20210213","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1160\/TH07-02-0156","article-title":"Neutrophil activation via beta2 integrins (CD11\/CD18): molecular mechanisms and clinical implications.","volume":"98","author":"Schymeinsky","year":"2007","journal-title":"Thromb Haemost"},{"key":"R35-15-20210213","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1097\/00000542-200109000-00023","article-title":"Desflurane, sevoflurane, and isoflurane affect left atrial active and passive mechanical properties and impair left atrial-left ventricular coupling in vivo: analysis using pressure-volume relations.","volume":"95","author":"Gare","year":"2001","journal-title":"Anesthesiology"},{"key":"R36-15-20210213","doi-asserted-by":"crossref","first-page":"R1247","DOI":"10.1152\/ajpregu.00437.2009","article-title":"Septic shock induces distinct changes in sympathetic nerve activity to the heart and kidney in conscious sheep.","volume":"297","author":"Ramchandra","year":"2009","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"R37-15-20210213","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1097\/00003643-200005000-00007","article-title":"Comparison of the effects of inhalational anaesthetic agents on sympathetic activity in rabbits.","volume":"17","author":"Pac-Soo","year":"2000","journal-title":"Eur J Anaesthesiol"},{"key":"R38-15-20210213","first-page":"342","article-title":"The effects of sevoflurane, enflurane, and isoflurane on baroreceptor-sympathetic reflex in rabbits.","volume":"82","author":"Saeki","year":"1996","journal-title":"Anesth Analg"},{"key":"R39-15-20210213","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1213\/00000539-200209000-00017","article-title":"The effect of isoflurane on neutrophil selectin and beta(2)-integrin activation in vitro.","volume":"95","author":"de Rossi","year":"2002","journal-title":"Anesth Analg"},{"key":"R40-15-20210213","first-page":"141","article-title":"Alterations in the course of acid-induced lung injury in rats after general anesthesia: volatile anesthetics versus ketamine.","volume":"86","author":"Nader-Djalal","year":"1998","journal-title":"Anesth Analg"},{"key":"R41-15-20210213","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1111\/j.1399-6576.2004.00266.x","article-title":"Pulmonary inflammatory mediators after sevoflurane and thiopentone anaesthesia in pigs.","volume":"48","author":"Takala","year":"2004","journal-title":"Acta Anaesthesiol Scand"},{"key":"R42-15-20210213","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1165\/rcmb.2005-0170OC","article-title":"Apoptosis of airway epithelial cells: human serum sensitive induction by the cathelicidin LL-37.","volume":"34","author":"Lau","year":"2006","journal-title":"Am J Respir Cell Mol Biol"},{"key":"R43-15-20210213","doi-asserted-by":"crossref","first-page":"3491","DOI":"10.1172\/JCI35740","article-title":"Neutrophil primary granule proteins HBP and HNP1-3 boost bacterial phagocytosis by human and murine macrophages.","volume":"118","author":"Soehnlein","year":"2008","journal-title":"J Clin Invest"},{"key":"R44-15-20210213","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1189\/jlb.0808495","article-title":"Neutrophil-derived azurocidin alarms the immune system.","volume":"85","author":"Soehnlein","year":"2009","journal-title":"J Leukoc Biol"},{"key":"R45-15-20210213","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1378\/chest.128.5_suppl_2.592S","article-title":"Cardiovascular issues in respiratory care.","volume":"128","author":"Pinsky","year":"2005","journal-title":"Chest"},{"key":"R46-15-20210213","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/labinvest.3700440","article-title":"Mechanical ventilation induces inflammation, lung injury, and extra-pulmonary organ dysfunction in experimental pneumonia.","volume":"86","author":"Dhanireddy","year":"2006","journal-title":"Lab Invest"},{"key":"R47-15-20210213","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/s00134-003-2147-7","article-title":"Infectious and inflammatory dissemination are affected by ventilation strategy in rats with unilateral pneumonia.","volume":"30","author":"Schortgen","year":"2004","journal-title":"Intensive Care Med"},{"key":"R48-15-20210213","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1186\/cc5050","article-title":"Mechanical ventilation interacts with endotoxemia to induce extrapulmonary organ dysfunction.","volume":"10","author":"O'Mahony","year":"2006","journal-title":"Crit Care"}],"container-title":["Shock"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/SHK.0b013e3181d8e4f5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:17:17Z","timestamp":1786040237000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00024382-201010000-00015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":47,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1097\/shk.0b013e3181d8e4f5","relation":{},"ISSN":["1073-2322"],"issn-type":[{"value":"1073-2322","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]}}}