{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:58:18Z","timestamp":1790470698574,"version":"4.1.0"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1097\/shk.0b013e3181e7e69e","type":"journal-article","created":{"date-parts":[[2010,6,3]],"date-time":"2010-06-03T07:08:18Z","timestamp":1275548898000},"page":"22-26","source":"Crossref","is-referenced-by-count":68,"title":["THE ROLE OF INNATE IMMUNITY IN SEPTIC ACUTE KIDNEY INJURIES"],"prefix":"10.1097","volume":"34","author":[{"given":"Giselle Martins","family":"Gon\u00e7alves","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dario S.","family":"Zamboni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels Olsen Saraiva","family":"C\u00e2mara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-4-20210213","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1097\/00003246-200107000-00002","article-title":"Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care.","volume":"29","author":"Angus","year":"2001","journal-title":"Crit Care Med"},{"key":"R2-4-20210213","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/s00134-001-1143-z","article-title":"Epidemiology of sepsis and infection in ICU patients from an international multicentre cohort study.","volume":"28","author":"Alberti","year":"2002","journal-title":"Intensive Care Med"},{"key":"R3-4-20210213","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1001\/jama.294.7.813","article-title":"Acute renal failure in critically ill patients: a multinational, multicenter study.","volume":"294","author":"Uchino","year":"2005","journal-title":"JAMA"},{"key":"R4-4-20210213","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1097\/00075198-200212000-00005","article-title":"Developing a consensus classification system for acute renal failure.","volume":"8","author":"Kellum","year":"2002","journal-title":"Curr Opin Crit Care"},{"key":"R5-4-20210213","doi-asserted-by":"crossref","first-page":"S198","DOI":"10.1097\/CCM.0b013e318168ccd5","article-title":"Pathophysiology of septic acute kidney injury: what do we really know?","volume":"36","author":"Wan","year":"2008","journal-title":"Crit Care Med"},{"key":"R6-4-20210213","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-4804(80)90037-2","article-title":"Sepsis and septic shock-a review of laboratory models and a proposal.","volume":"29","author":"Wichterman","year":"1980","journal-title":"J Surg Res"},{"key":"R7-4-20210213","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1078\/1438-4221-00232","article-title":"Staphylococcal and streptococcal superantigens: molecular, biological and clinical aspects.","volume":"292","author":"Alouf","year":"2003","journal-title":"Int J Med Microbiol"},{"issue":"Suppl 1","key":"R8-4-20210213","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1097\/01.shk.0000191414.94461.7e","article-title":"Cecal ligation and puncture.","volume":"24","author":"Hubbard","year":"2005","journal-title":"Shock"},{"key":"R9-4-20210213","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1378\/chest.98.1.170","article-title":"Detection of renal blood flow abnormalities in septic and critically ill patients using a newly designed indwelling thermodilution renal vein catheter.","volume":"98","author":"Brenner","year":"1990","journal-title":"Chest"},{"key":"R10-4-20210213","doi-asserted-by":"crossref","first-page":"5817","DOI":"10.4049\/jimmunol.168.11.5817","article-title":"Acute renal failure in endotoxemia is caused by TNF acting directly on TNF receptor-1 in kidney.","volume":"168","author":"Cunningham","year":"2002","journal-title":"J Immunol"},{"key":"R11-4-20210213","doi-asserted-by":"crossref","first-page":"2011","DOI":"10.1046\/j.1523-1755.2000.00051.x","article-title":"Lipopolysaccharide-induced MCP-1 gene expression in rat tubular epithelial cells is nuclear factor-kappaB dependent.","volume":"57","author":"Wang","year":"2000","journal-title":"Kidney Int"},{"key":"R12-4-20210213","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1126\/science.282.5396.2085","article-title":"Defective LPS signaling in C3H\/HeJ and C57BL\/10ScCr mice: mutations in Tlr4 gene.","volume":"282","author":"Poltorak","year":"1998","journal-title":"Science"},{"key":"R13-4-20210213","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1189\/jlb.0304127","article-title":"Endogenous ligands of Toll-like receptors.","volume":"76","author":"Tsan","year":"2004","journal-title":"J Leukoc Biol"},{"key":"R14-4-20210213","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev.immunol.21.120601.141126","article-title":"Toll-like receptors.","volume":"21","author":"Takeda","year":"2003","journal-title":"Annu Rev Immunol"},{"key":"R15-4-20210213","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.coi.2005.11.012","article-title":"How Toll-like receptors signal: what we know and what we don't know.","volume":"18","author":"O'Neill","year":"2006","journal-title":"Curr Opin Immunol"},{"key":"R16-4-20210213","doi-asserted-by":"crossref","first-page":"15416","DOI":"10.1073\/pnas.0406933101","article-title":"Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling.","volume":"101","author":"Honda","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R17-4-20210213","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s00281-007-0081-4","article-title":"Inflammasomes in inflammatory disorders: the role of TLRs and their interactions with NLRs.","volume":"29","author":"Becker","year":"2007","journal-title":"Semin Immunopathol"},{"key":"R18-4-20210213","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/j.1365-2249.2004.02433.x","article-title":"Differential expression of Toll-like receptor (TLR)-2 and TLR-4 on monocytes in human sepsis.","volume":"136","author":"Armstrong","year":"2004","journal-title":"Clin Exp Immunol"},{"key":"R19-4-20210213","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1203\/01.PDR.0000180544.02537.FD","article-title":"Expression of toll-like receptors in neonatal sepsis.","volume":"58","author":"Viemann","year":"2005","journal-title":"Pediatr Res"},{"key":"R20-4-20210213","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1126\/science.1087262","article-title":"Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway.","volume":"301","author":"Yamamoto","year":"2003","journal-title":"Science"},{"key":"R21-4-20210213","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/nature736","article-title":"Severe impairment of interleukin-1 and Toll-like receptor signalling in mice lacking IRAK-4.","volume":"416","author":"Suzuki","year":"2002","journal-title":"Nature"},{"key":"R22-4-20210213","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1172\/JCI20762","article-title":"Antagonistic antibody prevents toll-like receptor 2-driven lethal shock-like syndromes.","volume":"113","author":"Meng","year":"2004","journal-title":"J Clin Invest"},{"key":"R23-4-20210213","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/01.shk.0000145936.31967.d7","article-title":"Neutrophil elastase, MIP-2, and TLR-4 expression during human and experimental sepsis.","volume":"23","author":"Tsujimoto","year":"2005","journal-title":"Shock"},{"key":"R24-4-20210213","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1097\/01.CCM.0000069343.27691.F3","article-title":"Modulation of tissue Toll-like receptor 2 and 4 during the early phases of polymicrobial sepsis correlates with mortality.","volume":"31","author":"Williams","year":"2003","journal-title":"Crit Care Med"},{"key":"R25-4-20210213","doi-asserted-by":"crossref","first-page":"7271","DOI":"10.1128\/IAI.69.12.7172-7276.2001","article-title":"Differences in innate defense mechanisms in endotoxemia and polymicrobial septic peritonitis.","volume":"69","author":"Echtenacher","year":"2001","journal-title":"Infect Immun"},{"key":"R26-4-20210213","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.4049\/jimmunol.168.3.1286","article-title":"In vivo expression of Toll-like receptor 2 and 4 by renal epithelial cells: IFN-gamma and TNF-alpha mediated up-regulation during inflammation.","volume":"168","author":"Wolfs","year":"2002","journal-title":"J Immunol"},{"key":"R27-4-20210213","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.1172\/JCI22832","article-title":"Renal-associated TLR2 mediates ischemia\/reperfusion injury in the kidney.","volume":"115","author":"Leemans","year":"2005","journal-title":"J Clin Invest"},{"key":"R28-4-20210213","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1038\/sj.ki.5000165","article-title":"Sepsis-induced organ failure is mediated by different pathways in the kidney and liver: acute renal failure is dependent on MyD88 but not renal cell apoptosis.","volume":"69","author":"Dear","year":"2006","journal-title":"Kidney Int"},{"key":"R29-4-20210213","doi-asserted-by":"crossref","first-page":"F1050","DOI":"10.1152\/ajprenal.00461.2007","article-title":"Chloroquine and inhibition of Toll-like receptor 9 protect from sepsis-induced acute kidney injury.","volume":"294","author":"Yasuda","year":"2008","journal-title":"Am J Physiol Renal Physiol"},{"key":"R30-4-20210213","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1093\/intimm\/dxp017","article-title":"The roles of TLRs, RLRs and NLRs in pathogen recognition.","volume":"21","author":"Kawai","year":"2009","journal-title":"Int Immunol"},{"key":"R31-4-20210213","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1093\/embo-reports\/kve155","article-title":"CARD4\/Nod1 mediates NF-kappaB and JNK activation by invasive Shigella flexneri.","volume":"2","author":"Girardin","year":"2001","journal-title":"EMBO Rep"},{"key":"R32-4-20210213","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nature02664","article-title":"Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf.","volume":"430","author":"Mariathasan","year":"2004","journal-title":"Nature"},{"key":"R33-4-20210213","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1038\/sj.cdd.4402195","article-title":"Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration.","volume":"14","author":"Petrilli","year":"2007","journal-title":"Cell Death Differ"},{"key":"R34-4-20210213","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.it.2005.06.004","article-title":"NLRs join TLRs as innate sensors of pathogens.","volume":"26","author":"Martinon","year":"2005","journal-title":"Trends Immunol"},{"key":"R35-4-20210213","doi-asserted-by":"crossref","first-page":"24035","DOI":"10.1074\/jbc.M109.014266","article-title":"Biglycan, a danger signal that activates the NLRP3 inflammasome via toll-like and P2X receptors.","volume":"284","author":"Babelova","year":"2009","journal-title":"J Biol Cheml"},{"key":"R36-4-20210213","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1182\/blood-2008-09-178038","article-title":"Caspase-7 deficiency protects from endotoxin-induced lymphocyte apoptosis and improves survival.","volume":"113","author":"Lamkanfi","year":"2009","journal-title":"Blood"},{"key":"R37-4-20210213","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1038\/nature04656","article-title":"Enhanced bacterial clearance and sepsis resistance in caspase-12-deficient mice.","volume":"440","author":"Saleh","year":"2006","journal-title":"Nature"},{"key":"R38-4-20210213","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1164\/rccm.200703-418OC","article-title":"Inflammasome mRNA expression in human monocytes during early septic shock.","volume":"177","author":"Fahy","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"R39-4-20210213","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1038\/ni.1633","article-title":"Superoxide dismutase 1 regulates caspase-1 and endotoxic shock.","volume":"9","author":"Meissner","year":"2008","journal-title":"Nat Immunol"},{"key":"R40-4-20210213","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1164\/rccm.200604-546OC","article-title":"Caspase-1 regulates Escherichia coli sepsis and splenic B cell apoptosis independently of interleukin-1beta and interleukin-18.","volume":"174","author":"Sarkar","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"R41-4-20210213","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.immuni.2006.02.004","article-title":"Critical role for NALP3\/CIAS1\/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1.","volume":"24","author":"Sutterwala","year":"2006","journal-title":"Immunity"},{"key":"R42-4-20210213","doi-asserted-by":"crossref","first-page":"F997","DOI":"10.1152\/ajprenal.00130.2004","article-title":"W, Faubel S, Ljubanovic D, Mitra A, Falk SA, Kim J, Tao Y, Soloviev A, Reznikov LL, Dinarello, et al: Endotoxemic acute renal failure is attenuated in caspase-1-deficient mice.","volume":"288","year":"2005","journal-title":"Am J Physiol Renal Physiol"}],"container-title":["Shock"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00024382-201009001-00004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:21:45Z","timestamp":1786040505000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00024382-201009001-00004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":42,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1097\/shk.0b013e3181e7e69e","relation":{},"ISSN":["1073-2322"],"issn-type":[{"value":"1073-2322","type":"print"}],"subject":[],"published":{"date-parts":[[2010,9]]}}}