{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:36:26Z","timestamp":1791203786090,"version":"4.2.0"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,5]]},"DOI":"10.1097\/shk.0b013e31820b2e1c","type":"journal-article","created":{"date-parts":[[2011,4,16]],"date-time":"2011-04-16T15:32:54Z","timestamp":1302967974000},"page":"492-498","source":"Crossref","is-referenced-by-count":49,"title":["A Monoclonal Antibody Against RAGE Alters Gene Expression and is Protective in Experimental Models of Sepsis and Pneumococcal Pneumonia"],"prefix":"10.1097","volume":"35","author":[{"given":"Eirini","family":"Christaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Opal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James C.","family":"Keith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nubar","family":"Kessimian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John E.","family":"Palardy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas A.","family":"Parejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang Yang","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Piche-Nicholas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lioudmila","family":"Tchistiakova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George P.","family":"Vlasuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M.","family":"Shields","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Feldman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward R.","family":"LaVallie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya","family":"Arai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Mounts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debra D.","family":"Pittman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"16","key":"R1-10-20210213","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1056\/NEJMoa022139","article-title":"The epidemiology of sepsis in the United States from 1979 through 2000.","volume":"348","author":"Martin","year":"2003","journal-title":"N Engl J Med"},{"issue":"6","key":"R2-10-20210213","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nri1372","article-title":"Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses.","volume":"4","author":"Seong","year":"2004","journal-title":"Nat Rev Immunol"},{"issue":"7","key":"R3-10-20210213","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1172\/JCI200114002","article-title":"The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses.","volume":"108","author":"Schmidt","year":"2001","journal-title":"J Clin Invest"},{"issue":"21","key":"R4-10-20210213","doi-asserted-by":"crossref","first-page":"14987","DOI":"10.1016\/S0021-9258(18)42137-0","article-title":"Isolation and characterization of two binding proteins for advanced glycosylation end products from bovine lung which are present on the endothelial cell surface.","volume":"267","author":"Schmidt","year":"1992","journal-title":"J Biol Chem"},{"issue":"21","key":"R5-10-20210213","doi-asserted-by":"crossref","first-page":"14998","DOI":"10.1016\/S0021-9258(18)42138-2","article-title":"Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins.","volume":"267","author":"Neeper","year":"1992","journal-title":"J Biol Chem"},{"issue":"2-3","key":"R6-10-20210213","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0167-4889(00)00087-2","article-title":"The biology of the receptor for advanced glycation end products and its ligands.","volume":"1498","author":"Schmidt","year":"2000","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"R7-10-20210213","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/cc6164","article-title":"Bench-to-bedside review: the inflammation-perpetuating pattern-recognition receptor RAGE as a therapeutic target in sepsis.","volume":"12","author":"Bopp","year":"2008","journal-title":"Crit Care"},{"issue":"7","key":"R8-10-20210213","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1161\/hc0702.104183","article-title":"Advanced glycation end products activate endothelium through signal-transduction receptor RAGE: a mechanism for amplification of inflammatory responses.","volume":"105","author":"Basta","year":"2002","journal-title":"Circulation"},{"issue":"7","key":"R9-10-20210213","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1007\/s00018-002-8491-x","article-title":"RAGE is a multiligand receptor of the immunoglobulin superfamily: implications for homeostasis and chronic disease.","volume":"59","author":"Bucciarelli","year":"2002","journal-title":"Cell Mol Life Sci"},{"issue":"7","key":"R10-10-20210213","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0092-8674(00)80801-6","article-title":"RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100\/calgranulin polypeptides.","volume":"97","author":"Hofmann","year":"1999","journal-title":"Cell"},{"issue":"11","key":"R11-10-20210213","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1007\/s00109-005-0688-7","article-title":"Understanding RAGE, the receptor for advanced glycation end products.","volume":"83","author":"Bierhaus","year":"2005","journal-title":"J Mol Med"},{"issue":"9","key":"R12-10-20210213","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1517\/14656566.8.9.1193","article-title":"Antibodies against RAGE in sepsis and inflammation: implications for therapy.","volume":"8","author":"Lutterloh","year":"2007","journal-title":"Expert Opin Pharmacother"},{"issue":"16","key":"R13-10-20210213","doi-asserted-by":"crossref","first-page":"3868","DOI":"10.1038\/sj.emboj.7601805","article-title":"Structural and functional insights into RAGE activation by multimeric S100B.","volume":"26","author":"Ostendorp","year":"2007","journal-title":"EMBO J"},{"issue":"26","key":"R14-10-20210213","doi-asserted-by":"crossref","first-page":"16498","DOI":"10.1074\/jbc.272.26.16498","article-title":"Characterization and functional analysis of the promoter of RAGE, the receptor for advanced glycation end products.","volume":"272","author":"Li","year":"1997","journal-title":"J Biol Chem"},{"issue":"28","key":"R15-10-20210213","doi-asserted-by":"crossref","first-page":"17810","DOI":"10.1074\/jbc.272.28.17810","article-title":"Activation of the receptor for advanced glycation end products triggers a p21(ras)-dependent mitogen-activated protein kinase pathway regulated by oxidant stress.","volume":"272","author":"Lander","year":"1997","journal-title":"J Biol Chem"},{"issue":"9","key":"R16-10-20210213","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1681\/ASN.V1191656","article-title":"Expression of advanced glycation end products and their cellular receptor RAGE in diabetic nephropathy and nondiabetic renal disease.","volume":"11","author":"Tanji","year":"2000","journal-title":"J Am Soc Nephrol"},{"issue":"5","key":"R17-10-20210213","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1055\/s-2000-13204","article-title":"RAGE: a multiligand receptor contributing to the cellular response in diabetic vasculopathy and inflammation.","volume":"26","author":"Schmidt","year":"2000","journal-title":"Semin Thromb Hemost"},{"issue":"10","key":"R18-10-20210213","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1084\/jem.20030800","article-title":"The pattern recognition receptor (RAGE) is a counterreceptor for leukocyte integrins: a novel pathway for inflammatory cell recruitment.","volume":"198","author":"Chavakis","year":"2003","journal-title":"J Exp Med"},{"issue":"11","key":"R19-10-20210213","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1172\/JCI200418704","article-title":"Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response.","volume":"113","author":"Liliensiek","year":"2004","journal-title":"J Clin Invest"},{"issue":"6","key":"R20-10-20210213","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/cc6184","article-title":"Inhibition of the RAGE products increases survival in experimental models of severe sepsis and systemic infection.","volume":"11","author":"Lutterloh","year":"2007","journal-title":"Crit Care"},{"issue":"3","key":"R21-10-20210213","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.jmb.2009.03.019","article-title":"Affinity maturation of a humanized rat antibody for anti-RAGE therapy: comprehensive mutagenesis reveals a high level of mutational plasticity both inside and outside the complementarity-determining regions.","volume":"388","author":"Finlay","year":"2009","journal-title":"J Mol Biol"},{"issue":"34","key":"R22-10-20210213","doi-asserted-by":"crossref","first-page":"24124","DOI":"10.1074\/jbc.M601905200","article-title":"Protein kinase Czeta is up-regulated in osteoarthritic cartilage and is required for activation of NF-kappaB by tumor necrosis factor and interleukin-1 in articular chondrocytes.","volume":"281","author":"LaVallie","year":"2006","journal-title":"J Biol Chem"},{"issue":"1-2","key":"R23-10-20210213","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0166-4328(01)00297-2","article-title":"Controlling the false discovery rate in behavior genetics research.","volume":"125","author":"Benjamini","year":"2001","journal-title":"Behav Brain Res"},{"issue":"5","key":"R24-10-20210213","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1007\/s00134-003-1699-x","article-title":"Streptococcus pneumoniae strain-dependent lung inflammatory responses in a murine model of pneumococcal pneumonia.","volume":"29","author":"Mohler","year":"2003","journal-title":"Intensive Care Med"},{"issue":"7","key":"R25-10-20210213","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1097\/00003246-200107000-00002","article-title":"Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care.","volume":"29","author":"Angus","year":"2001","journal-title":"Crit Care Med"},{"issue":"8","key":"R26-10-20210213","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1038\/nm1269","article-title":"Intracellular protein therapy with SOCS3 inhibits inflammation and apoptosis.","volume":"11","author":"Jo","year":"2005","journal-title":"Nat Med"},{"issue":"13","key":"R27-10-20210213","doi-asserted-by":"crossref","first-page":"8217","DOI":"10.1074\/jbc.R800032200","article-title":"A20: central gatekeeper in inflammation and immunity.","volume":"284","author":"Coornaert","year":"2009","journal-title":"J Biol Chem"},{"issue":"2","key":"R28-10-20210213","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.4049\/jimmunol.0900163","article-title":"A20 attenuates allergic airway inflammation in mice.","volume":"183","author":"Kang","year":"2009","journal-title":"J Immunol"},{"issue":"3","key":"R29-10-20210213","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.ejphar.2006.03.073","article-title":"An inhibitory effect of A20 on NF-kappaB activation in airway epithelium upon influenza virus infection.","volume":"541","author":"Onose","year":"2006","journal-title":"Eur J Pharmacol"},{"issue":"11","key":"R30-10-20210213","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1016\/j.peptides.2007.08.012","article-title":"Mice heterozygous for adrenomedullin exhibit a more extreme inflammatory response to endotoxin-induced septic shock.","volume":"28","author":"Dackor","year":"2007","journal-title":"Peptides"},{"issue":"3","key":"R31-10-20210213","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.cellsig.2007.11.010","article-title":"hSef potentiates EGF-mediated MAPK signaling through affecting EGFR trafficking and degradation.","volume":"20","author":"Ren","year":"2008","journal-title":"Cell Signal"},{"issue":"7","key":"R32-10-20210213","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/labinvest.3780116","article-title":"Interaction of the receptor for advanced glycation end products (RAGE) with transthyretin triggers nuclear transcription factor kB (NF-kB) activation.","volume":"80","author":"Sousa","year":"2000","journal-title":"Lab Invest"},{"issue":"13","key":"R33-10-20210213","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1016\/j.micinf.2004.08.004","article-title":"RAGE (receptor for advanced glycation end products): a central player in the inflammatory response.","volume":"6","author":"Chavakis","year":"2004","journal-title":"Microbes Infect"},{"issue":"7","key":"R34-10-20210213","doi-asserted-by":"crossref","first-page":"4349","DOI":"10.4049\/jimmunol.0801199","article-title":"The receptor for advanced glycation end products impairs host defense in pneumococcal pneumonia.","volume":"182","author":"van Zoelen","year":"2009","journal-title":"J Immunol"},{"issue":"5","key":"R35-10-20210213","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1086\/604730","article-title":"Receptor for advanced glycation end products facilitates host defense during Escherichia coli-induced abdominal sepsis in mice.","volume":"200","author":"van Zoelen","year":"2009","journal-title":"J Infect Dis"}],"container-title":["Shock"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/SHK.0b013e31820b2e1c","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T19:17:57Z","timestamp":1786043877000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00024382-201105000-00010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1097\/shk.0b013e31820b2e1c","relation":{},"ISSN":["1073-2322"],"issn-type":[{"value":"1073-2322","type":"print"}],"subject":[],"published":{"date-parts":[[2011,5]]}}}