{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:08:14Z","timestamp":1793210894970,"version":"4.5.0"},"reference-count":60,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,5]]},"DOI":"10.1097\/shk.0b013e31820e2152","type":"journal-article","created":{"date-parts":[[2011,1,25]],"date-time":"2011-01-25T01:15:51Z","timestamp":1295918151000},"page":"440-448","source":"Crossref","is-referenced-by-count":32,"title":["Genetic Predisposition for Development of Complications in Multiple Trauma Patients"],"prefix":"10.1097","volume":"35","author":[{"given":"Frank","family":"Hildebrand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Mommsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Frink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn","family":"van Griensven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Krettek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"5","key":"R1-2-20210213","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1097\/01.ccx.0000140942.42247.7e","article-title":"Genetic determinants of the inflammatory response.","volume":"10","author":"Imahara","year":"2004","journal-title":"Curr Opin Crit Care"},{"issue":"2","key":"R2-2-20210213","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0378-1119(99)00219-X","article-title":"The essence of SNPs.","volume":"234","author":"Brookes","year":"1999","journal-title":"Gene"},{"key":"R3-2-20210213","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/1471-2105-5-92","article-title":"Target SNP selection in complex disease association studies.","volume":"5","author":"Wjst","year":"2004","journal-title":"BMC Bioinformatics"},{"issue":"9426","key":"R4-2-20210213","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1016\/S0140-6736(04)16460-X","article-title":"Injury research in the genomic era.","volume":"363","author":"Cobb","year":"2004","journal-title":"Lancet"},{"issue":"10","key":"R5-2-20210213","first-page":"2759","article-title":"A common haplotype of the LBP gene predisposes to severe sepsis.","volume":"37","author":"Flores","year":"2009","journal-title":"Crit Care Med"},{"issue":"4","key":"R6-2-20210213","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1182\/blood-2007-09-101709","article-title":"Lipopolysaccharide binding protein promoter variants influence the risk for gram-negative bacteremia and mortality after allogeneic hematopoietic cell transplantation.","volume":"111","author":"Chien","year":"2008","journal-title":"Blood"},{"issue":"10","key":"R7-2-20210213","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1164\/rccm.200209-1064OC","article-title":"Characterization of a single nucleotide polymorphism in the lipopolysaccharide binding protein and its association with sepsis.","volume":"167","author":"Barber","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"R8-2-20210213","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1097\/00003246-200103000-00015","article-title":"Gene variants of the bactericidal\/permeability increasing protein and lipopolysaccharide binding protein in sepsis patients: gender-specific genetic predisposition to sepsis.","volume":"29","author":"Hubacek","year":"2001","journal-title":"Crit Care Med"},{"issue":"8","key":"R9-2-20210213","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1097\/CCM.0b013e318180b1ed","article-title":"Functional significance of CD14 promoter polymorphisms and their clinical relevance in a Chinese Han population.","volume":"36","author":"Gu","year":"2008","journal-title":"Crit Care Med"},{"issue":"11","key":"R10-2-20210213","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1007\/s001340101106","article-title":"Lack of association between the -260 C-T promoter polymorphism of the endotoxin receptor CD14 gene and the CD14 density of unstimulated human monocytes and soluble CD14 plasma levels.","volume":"27","author":"Heesen","year":"2001","journal-title":"Intensive Care Med"},{"issue":"8","key":"R11-2-20210213","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1007\/s00134-002-1389-0","article-title":"The -260 C-T promoter polymorphism of the lipopolysaccharide receptor CD14 and severe sepsis in trauma patients.","volume":"28","author":"Heesen","year":"2002","journal-title":"Intensive Care Med"},{"key":"R12-2-20210213","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1741-7015-4-10","article-title":"IL-10, IL-6 and CD14 polymorphisms and sepsis outcome in ventilated very low birth weight infants.","volume":"4","author":"Baier","year":"2006","journal-title":"BMC Med"},{"issue":"5","key":"R13-2-20210213","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1165\/ajrcmb.20.5.3494","article-title":"A polymorphism in the 5 flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E.","volume":"20","author":"Baldini","year":"1999","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"5","key":"R14-2-20210213","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1097\/00003246-200205000-00003","article-title":"Association between a genomic polymorphism within the CD14 locus and septic shock susceptibility and mortality rate.","volume":"30","author":"Gibot","year":"2002","journal-title":"Crit Care Med"},{"issue":"4","key":"R15-2-20210213","doi-asserted-by":"crossref","first-page":"250","DOI":"10.3121\/cmr.4.4.250","article-title":"Innate immunity SNPs are associated with risk for severe sepsis after burn injury.","volume":"4","author":"Barber","year":"2006","journal-title":"Clin Med Res"},{"issue":"3","key":"R16-2-20210213","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1097\/01.CCM.0000156242.44356.C5","article-title":"Polymorphisms in CD14, mannose-binding lectin, and Toll-like receptor-2 are associated with increased prevalence of infection in critically ill adults.","volume":"33","author":"Sutherland","year":"2005","journal-title":"Crit Care Med"},{"issue":"3","key":"R17-2-20210213","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1097\/01.shk.0000239770.10528.9a","article-title":"CD14-159 C allele is associated with increased risk of mortality after burn injury.","volume":"27","author":"Barber","year":"2007","journal-title":"Shock"},{"key":"R18-2-20210213","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1097\/SHK.0b013e3181eb45b3","article-title":"Identification of haplotype tag Snps within the entire TLR2 gene and their clinical relevance in patients with major trauma.","volume":"35","author":"Chen","year":"2011","journal-title":"Shock"},{"issue":"1","key":"R19-2-20210213","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1574-695X.2001.tb01586.x","article-title":"Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients.","volume":"31","author":"Kang","year":"2001","journal-title":"FEMS Immunol Med Microbiol"},{"issue":"5","key":"R20-2-20210213","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1038\/sj.gene.6364405","article-title":"A polymorphism in human TLR2 is associated with increased susceptibility to tuberculous meningitis.","volume":"8","author":"Thuong","year":"2007","journal-title":"Genes Immun"},{"issue":"11","key":"R21-2-20210213","doi-asserted-by":"crossref","first-page":"6398","DOI":"10.1128\/IAI.68.11.6398-6401.2000","article-title":"A novel polymorphism in the Toll-like receptor 2 gene and its potential association with staphylococcal infection.","volume":"68","author":"Lorenz","year":"2000","journal-title":"Infect Immun"},{"issue":"6","key":"R23-2-20210213","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1128\/CDLI.11.6.1194-1197.2004","article-title":"Lack of association between Toll-like receptor 2 polymorphisms and susceptibility to severe disease caused by Staphylococcus aureus.","volume":"11","author":"Moore","year":"2004","journal-title":"Clin Diagn Lab Immunol"},{"issue":"5","key":"R24-2-20210213","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1097\/CCM.0b013e3181d8ad12","article-title":"Functional significance of the Toll-like receptor 4 promoter gene polymorphisms in the Chinese Han population.","volume":"38","author":"Chen","year":"2010","journal-title":"Crit Care Med"},{"issue":"2","key":"R25-2-20210213","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/76048","article-title":"TLR4 mutations are associated with endotoxin hyporesponsiveness in humans.","volume":"25","author":"Arbour","year":"2000","journal-title":"Nat Genet"},{"issue":"10","key":"R26-2-20210213","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1086\/344893","article-title":"Human Toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections.","volume":"186","author":"Agnese","year":"2002","journal-title":"J Infect Dis"},{"issue":"9","key":"R27-2-20210213","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1001\/archinte.162.9.1028","article-title":"Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock.","volume":"162","author":"Lorenz","year":"2002","journal-title":"Arch Intern Med"},{"issue":"2","key":"R28-2-20210213","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1097\/SHK.0b013e31803df782","article-title":"Functional significance of the TLR4\/11367 polymorphism identified in Chinese Han population.","volume":"28","author":"Duan","year":"2007","journal-title":"Shock"},{"issue":"2","key":"R29-2-20210213","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/cc7702","article-title":"Bench-to-bedside review: association of genetic variation with sepsis.","volume":"13","author":"Sutherland","year":"2009","journal-title":"Crit Care"},{"issue":"9158","key":"R30-2-20210213","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/S0140-6736(98)08350-0","article-title":"Association of variants of the gene for mannose-binding lectin with susceptibility to meningococcal disease. Meningococcal Research Group.","volume":"353","author":"Hibberd","year":"1999","journal-title":"Lancet"},{"issue":"10","key":"R31-2-20210213","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1001\/jama.285.10.1316","article-title":"Acute respiratory tract infections and mannose-binding lectin insufficiency during early childhood.","volume":"285","author":"Koch","year":"2001","journal-title":"JAMA"},{"issue":"4","key":"R32-2-20210213","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1097\/01.shk.0000180621.52058.e1","article-title":"Genetic polymorphisms and sepsis.","volume":"24","author":"Arcaroli","year":"2005","journal-title":"Shock"},{"issue":"1","key":"R33-2-20210213","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/00003246-200301000-00011","article-title":"Heat shock protein 70 genotypes HSPA1B and HSPA1L influence cytokine concentrations and interfere with outcome after major injury.","volume":"31","author":"Schroder","year":"2003","journal-title":"Crit Care Med"},{"issue":"7","key":"R34-2-20210213","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1097\/00003246-199907000-00006","article-title":"Analysis of two human leukocyte antigen-linked polymorphic heat shock protein 70 genes in patients with severe sepsis.","volume":"27","author":"Schroeder","year":"1999","journal-title":"Crit Care Med"},{"issue":"2","key":"R35-2-20210213","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/01.shk.0000190826.36406.27","article-title":"Polymorphisms of heat shock protein-70 (HSPA1B and HSPA1L loci) do not influence infection or outcome risk in critically ill surgical patients.","volume":"25","author":"Bowers","year":"2006","journal-title":"Shock"},{"issue":"9","key":"R36-2-20210213","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1007\/s00134-004-2359-5","article-title":"The septic shock associated HSPA1B1267 polymorphism influences production of HSPA1A and HSPA1B.","volume":"30","author":"Temple","year":"2004","journal-title":"Intensive Care Med"},{"issue":"1","key":"R37-2-20210213","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.cyto.2009.04.002","article-title":"No association between CALCA polymorphisms and clinical outcome or serum procalcitonin levels in German polytrauma patients.","volume":"47","author":"Hildebrand","year":"2009","journal-title":"Cytokine"},{"issue":"6","key":"R38-2-20210213","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1007\/s00134-009-1413-8","article-title":"Genetic variants in the angiopoietin-2 gene are associated with increased risk of ARDS.","volume":"35","author":"Su","year":"2009","journal-title":"Intensive Care Med"},{"issue":"10","key":"R39-2-20210213","doi-asserted-by":"crossref","first-page":"2794","DOI":"10.1097\/CCM.0b013e318186b843","article-title":"Variation in the myosin light chain kinase gene is associated with development of acute lung injury after major trauma.","volume":"36","author":"Christie","year":"2008","journal-title":"Crit Care Med"},{"issue":"1","key":"R42-2-20210213","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1097\/SHK.0b013e3181a99508","article-title":"Association of mitochondrial allele 4216C with increased risk for sepsis-related organ dysfunction and shock after burn injury.","volume":"33","author":"Huebinger","year":"2010","journal-title":"Shock"},{"issue":"1","key":"R43-2-20210213","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1001\/archinte.165.1.75","article-title":"The association of interleukin 6 haplotype clades with mortality in critically ill adults.","volume":"165","author":"Sutherland","year":"2005","journal-title":"Arch Intern Med"},{"issue":"38","key":"R44-2-20210213","doi-asserted-by":"crossref","first-page":"23310","DOI":"10.1074\/jbc.271.38.23310","article-title":"CD14 is a cell-activating receptor for bacterial peptidoglycan.","volume":"271","author":"Gupta","year":"1996","journal-title":"J Biol Chem"},{"issue":"3","key":"R45-2-20210213","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1093\/infdis\/173.3.661","article-title":"Function of soluble CD14 in serum from patients with septic shock.","volume":"173","author":"Landmann","year":"1996","journal-title":"J Infect Dis"},{"issue":"3","key":"R46-2-20210213","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1093\/infdis\/171.3.639","article-title":"Increased circulating soluble CD14 is associated with high mortality in gram-negative septic shock.","volume":"171","author":"Landmann","year":"1995","journal-title":"J Infect Dis"},{"issue":"6","key":"R47-2-20210213","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/sj.gene.6363691","article-title":"The common functional C(-159)T polymorphism within the promoter region of the lipopolysaccharide receptor CD14 is not associated with sepsis development or mortality.","volume":"1","author":"Hubacek","year":"2000","journal-title":"Genes Immun"},{"issue":"1","key":"R48-2-20210213","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1093\/infdis\/141.1.55","article-title":"The primary role of lymphoreticular cells in the mediation of host responses to bacterial endotoxin.","volume":"141","author":"Michalek","year":"1980","journal-title":"J Infect Dis"},{"issue":"5160","key":"R49-2-20210213","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1038\/2191253a0","article-title":"Genetic control of leucocyte responses to endotoxin.","volume":"219","author":"Sultzer","year":"1968","journal-title":"Nature"},{"issue":"1","key":"R50-2-20210213","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1128\/IAI.73.1.532-545.2005","article-title":"Central role of Toll-like receptor 4 signaling and host defense in experimental pneumonia caused by gram-negative bacteria.","volume":"73","author":"Schurr","year":"2005","journal-title":"Infect Immun"},{"issue":"3","key":"R52-2-20210213","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1046\/j.1365-2567.2003.01674.x","article-title":"Effects of functional Toll-like receptor-4 mutations on the immune response to human and experimental sepsis.","volume":"109","author":"Feterowski","year":"2003","journal-title":"Immunology"},{"issue":"6","key":"R53-2-20210213","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/sj.gene.6363784","article-title":"Mannan-binding lectin (MBL) gene polymorphisms in ulcerative colitis and Crohn's disease.","volume":"2","author":"Rector","year":"2001","journal-title":"Genes Immun"},{"issue":"1-2","key":"R54-2-20210213","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0022-1759(00)00198-8","article-title":"Detection of structural gene mutations and promoter polymorphisms in the mannan-binding lectin (MBL) gene by polymerase chain reaction with sequence-specific primers.","volume":"241","author":"Steffensen","year":"2000","journal-title":"J Immunol Methods"},{"issue":"5230","key":"R55-2-20210213","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1126\/science.7545313","article-title":"A mechanism for the specific immunogenicity of heat shock protein-chaperoned peptides.","volume":"269","author":"Suto","year":"1995","journal-title":"Science"},{"issue":"6","key":"R56-2-20210213","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1744-313X.2008.00812.x","article-title":"Genetic variation in heat shock protein 70 is associated with septic shock: narrowing the association to a specific haplotype.","volume":"35","author":"Kee","year":"2008","journal-title":"Int J Immunogenet"},{"issue":"41-42","key":"R57-2-20210213","first-page":"595","article-title":"Procalcitonin: how a hormone became a marker and mediator of sepsis.","volume":"131","author":"Muller","year":"2001","journal-title":"Swiss Med Wkly"},{"issue":"1","key":"R58-2-20210213","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/em.20134","article-title":"Calcitonin gene polymorphism CALCA-624 (T\/C) and ovarian cancer.","volume":"46","author":"Goodman","year":"2005","journal-title":"Environ Mol Mutagen"},{"issue":"12","key":"R59-2-20210213","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1359\/jbmr.040915","article-title":"Decreased bone formation and osteopenia in mice lacking alpha-calcitonin gene-related peptide.","volume":"19","author":"Schinke","year":"2004","journal-title":"J Bone Miner Res"},{"issue":"3","key":"R60-2-20210213","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1097\/CCM.0B013E318165BABB","article-title":"Procalcitonin assay in systemic inflammation, infection, and sepsis: clinical utility and limitations.","volume":"36","author":"Becker","year":"2008","journal-title":"Crit Care Med"},{"issue":"3","key":"R61-2-20210213","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1002\/jcp.1041630311","article-title":"Regulation of endothelial cell gap formation and barrier dysfunction: role of myosin light chain phosphorylation.","volume":"163","author":"Garcia","year":"1995","journal-title":"J Cell Physiol"},{"issue":"4","key":"R62-2-20210213","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1165\/rcmb.2005-0404OC","article-title":"Novel polymorphisms in the myosin light chain kinase gene confer risk for acute lung injury.","volume":"34","author":"Gao","year":"2006","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"11","key":"R63-2-20210213","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1007\/s00134-006-0327-y","article-title":"A systematic review of the quality of genetic association studies in human sepsis.","volume":"32","author":"Clark","year":"2006","journal-title":"Intensive Care Med"},{"issue":"2","key":"R64-2-20210213","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/00125817-200203000-00002","article-title":"A comprehensive review of genetic association studies.","volume":"4","author":"Hirschhorn","year":"2002","journal-title":"Genet Med"}],"container-title":["Shock"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00024382-201105000-00002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:46:40Z","timestamp":1786042000000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00024382-201105000-00002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,5]]},"references-count":60,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1097\/shk.0b013e31820e2152","relation":{},"ISSN":["1073-2322"],"issn-type":[{"value":"1073-2322","type":"print"}],"subject":[],"published":{"date-parts":[[2011,5]]}}}