{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:11:49Z","timestamp":1790975509116,"version":"4.1.0"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1097\/shk.0b013e3182279868","type":"journal-article","created":{"date-parts":[[2011,6,23]],"date-time":"2011-06-23T07:43:49Z","timestamp":1308815029000},"page":"370-380","source":"Crossref","is-referenced-by-count":32,"title":["Nonhematopoietic Toll-Like Receptor 2 Contributes to Neutrophil and Cardiac Function Impairment During Polymicrobial Sepsis"],"prefix":"10.1097","volume":"36","author":[{"given":"Lin","family":"Zou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"19","key":"R1-9-20210213","first-page":"1","article-title":"Deaths: final data for 2004.","volume":"55","author":"Minino","year":"2007","journal-title":"Natl Vital Stat Rep"},{"issue":"7","key":"R2-9-20210213","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1097\/00003246-200107000-00002","article-title":"Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care.","volume":"29","author":"Angus","year":"2001","journal-title":"Crit Care Med"},{"issue":"5","key":"R3-9-20210213","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1097\/01.CCM.0000261890.41311.E9","article-title":"Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003.","volume":"35","author":"Dombrovskiy","year":"2007","journal-title":"Crit Care Med"},{"issue":"4","key":"R4-9-20210213","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1097\/ALN.0b013e3181cea3d0","article-title":"Temporal trends in the epidemiology of severe postoperative sepsis after elective surgery: a large, nationwide sample.","volume":"112","author":"Bateman","year":"2010","journal-title":"Anesthesiology"},{"issue":"6917","key":"R5-9-20210213","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nature01326","article-title":"The immunopathogenesis of sepsis.","volume":"420","author":"Cohen","year":"2002","journal-title":"Nature"},{"issue":"2","key":"R6-9-20210213","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1056\/NEJMra021333","article-title":"The pathophysiology and treatment of sepsis.","volume":"348","author":"Hotchkiss","year":"2003","journal-title":"N Engl J Med"},{"issue":"10","key":"R7-9-20210213","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/nri2402","article-title":"Harmful molecular mechanisms in sepsis.","volume":"8","author":"Rittirsch","year":"2008","journal-title":"Nat Rev Immunol"},{"issue":"1","key":"R8-9-20210213","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/01.shk.0000170353.80318.d5","article-title":"Harmful and protective roles of neutrophils in sepsis.","volume":"24","author":"Hoesel","year":"2005","journal-title":"Shock"},{"key":"R9-9-20210213","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1146\/annurev.immunol.23.021704.115653","article-title":"How neutrophils kill microbes.","volume":"23","author":"Segal","year":"2005","journal-title":"Annu Rev Immunol"},{"issue":"4","key":"R10-9-20210213","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.cell.2006.02.015","article-title":"Pathogen recognition and innate immunity.","volume":"124","author":"Akira","year":"2006","journal-title":"Cell"},{"issue":"1","key":"R11-9-20210213","doi-asserted-by":"crossref","first-page":"H1","DOI":"10.1152\/ajpheart.00995.2008","article-title":"Toll-like receptor signaling: a critical modulator of cell survival and ischemic injury in the heart.","volume":"296","author":"Chao","year":"2009","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"3","key":"R12-9-20210213","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1189\/jlb.0607374","article-title":"Early events in the recognition of danger signals after tissue injury.","volume":"83","author":"Kaczorowski","year":"2008","journal-title":"J Leukoc Biol"},{"issue":"4","key":"R13-9-20210213","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S1074-7613(00)80119-3","article-title":"Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.","volume":"11","author":"Takeuchi","year":"1999","journal-title":"Immunity"},{"issue":"6","key":"R14-9-20210213","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1086\/427815","article-title":"Bacterial peptidoglycan-associated lipoprotein: a naturally occurring toll-like receptor 2 agonist that is shed into serum and has synergy with lipopolysaccharide.","volume":"191","author":"Liang","year":"2005","journal-title":"J Infect Dis"},{"issue":"10","key":"R15-9-20210213","doi-asserted-by":"crossref","first-page":"4018","DOI":"10.1073\/pnas.0900196106","article-title":"Regulation of chemokine receptor by toll-like receptor 2 is critical to neutrophil migration and resistance to polymicrobial sepsis.","volume":"106","author":"Alves-Filho","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"R16-9-20210213","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1097\/CCM.0b013e3181d99e67","article-title":"Toll-like receptor 2 plays a critical role in cardiac dysfunction during polymicrobial sepsis.","volume":"38","author":"Zou","year":"2010","journal-title":"Crit Care Med"},{"issue":"4","key":"R17-9-20210213","doi-asserted-by":"crossref","first-page":"C760","DOI":"10.1152\/ajpcell.00155.2010","article-title":"Bone marrow MyD88 signaling modulates neutrophil function and ischemic myocardial injury.","volume":"299","author":"Feng","year":"2010","journal-title":"Am J Physiol Cell Physiol"},{"issue":"5","key":"R18-9-20210213","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.jhep.2010.04.037","article-title":"Characterization of two F4\/80-positive Kupffer cell subsets by their function and phenotype in mice.","volume":"53","author":"Kinoshita","year":"2010","journal-title":"J Hepatol"},{"issue":"23","key":"R20-9-20210213","doi-asserted-by":"crossref","first-page":"21997","DOI":"10.1074\/jbc.M413676200","article-title":"Lipopolysaccharide improves cardiomyocyte survival and function after serum deprivation.","volume":"280","author":"Chao","year":"2005","journal-title":"J Biol Chem"},{"issue":"4","key":"R21-9-20210213","doi-asserted-by":"crossref","first-page":"H1900","DOI":"10.1152\/ajpheart.00112.2006","article-title":"MyD88 and NOS2 are essential for toll-like receptor 4-mediated survival effect in cardiomyocytes.","volume":"291","author":"Zhu","year":"2006","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"2","key":"R22-9-20210213","doi-asserted-by":"crossref","first-page":"R298","DOI":"10.1152\/ajpregu.00659.2003","article-title":"Role for CD14, TLR2, and TLR4 in bacterial product-induced anorexia.","volume":"287","author":"von Meyenburg","year":"2004","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"3","key":"R23-9-20210213","doi-asserted-by":"crossref","first-page":"H1311","DOI":"10.1152\/ajpheart.00119.2008","article-title":"Innate immune adaptor MyD88 mediates neutrophil recruitment and myocardial injury after ischemia-reperfusion in mice.","volume":"295","author":"Feng","year":"2008","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"5","key":"R24-9-20210213","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1161\/ATVBAHA.107.140723","article-title":"Toll-like receptors 2-deficient mice are protected against postischemic coronary endothelial dysfunction.","volume":"27","author":"Favre","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"2","key":"R25-9-20210213","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1084\/jem.20091959","article-title":"Type I interferon signaling in hematopoietic cells is required for survival in mouse polymicrobial sepsis by regulating CXCL10.","volume":"207","author":"Kelly-Scumpia","year":"2010","journal-title":"J Exp Med"},{"issue":"10","key":"R26-9-20210213","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1038\/nrd1854","article-title":"Animal models of sepsis: setting the stage.","volume":"4","author":"Buras","year":"2005","journal-title":"Nat Rev Drug Discov"},{"issue":"2","key":"R27-9-20210213","doi-asserted-by":"crossref","first-page":"722","DOI":"10.4049\/jimmunol.155.2.722","article-title":"Neutralization of IL-10 increases survival in a murine model of Klebsiella pneumoniae.","volume":"155","author":"Greenberger","year":"1995","journal-title":"J Immunol"},{"issue":"5","key":"R28-9-20210213","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1093\/infdis\/174.5.994","article-title":"Interleukin-10 impairs host defense in murine pneumococcal pneumonia.","volume":"174","author":"van der Poll","year":"1996","journal-title":"J Infect Dis"},{"issue":"11","key":"R29-9-20210213","doi-asserted-by":"crossref","first-page":"5397","DOI":"10.4049\/jimmunol.155.11.5397","article-title":"Endogenous IL-10 protects mice from death during septic peritonitis.","volume":"155","author":"van der Poll","year":"1995","journal-title":"J Immunol"},{"issue":"3","key":"R30-9-20210213","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1084\/jem.20102049","article-title":"Mitochondrial reactive oxygen species promote production of proinflammatory cytokines and are elevated in TNFR1-associated periodic syndrome (TRAPS).","volume":"208","author":"Bulua","year":"2011","journal-title":"J Exp Med"},{"issue":"4","key":"R31-9-20210213","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1172\/JCI28111","article-title":"Oxidative stress in sepsis: a redox redux.","volume":"116","author":"Kolls","year":"2006","journal-title":"J Clin Invest"},{"issue":"3","key":"R32-9-20210213","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1084\/jem.20110367","article-title":"Mitochondrial reactive oxygen species drive proinflammatory cytokine production.","volume":"208","author":"Naik","year":"2011","journal-title":"J Exp Med"},{"issue":"2","key":"R33-9-20210213","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/00075197-200203000-00009","article-title":"Reactive oxygen species as mediators of organ dysfunction caused by sepsis, acute respiratory distress syndrome, or hemorrhagic shock: potential benefits of resuscitation with Ringer's ethyl pyruvate solution.","volume":"5","author":"Fink","year":"2002","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"11","key":"R34-9-20210213","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1164\/rccm.200410-1346OC","article-title":"Polyethylene glycol-superoxide dismutase prevents endotoxin-induced cardiac dysfunction.","volume":"173","author":"Supinski","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"R35-9-20210213","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1161\/01.RES.0000253888.09574.7a","article-title":"Cardiomyocyte-specific overexpression of nitric oxide synthase 3 prevents myocardial dysfunction in murine models of septic shock.","volume":"100","author":"Ichinose","year":"2007","journal-title":"Circ Res"},{"key":"R36-9-20210213","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1146\/annurev.bioeng.7.060804.100423","article-title":"Molecular mechanics and dynamics of leukocyte recruitment during inflammation.","volume":"7","author":"Simon","year":"2005","journal-title":"Annu Rev Biomed Eng"},{"key":"R37-9-20210213","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1146\/annurev.immunol.20.103001.114744","article-title":"Phagocytosis of microbes: complexity in action.","volume":"20","author":"Underhill","year":"2002","journal-title":"Annu Rev Immunol"},{"issue":"1-2","key":"R38-9-20210213","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.imlet.2010.09.007","article-title":"TLR2 enhances NADPH oxidase activity and killing of Staphylococcus aureus by PMN.","volume":"135","author":"Jann","year":"2010","journal-title":"Immunol Lett"},{"issue":"4","key":"R39-9-20210213","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1189\/jlb.0807528","article-title":"Deletion of MyD88 markedly attenuates sepsis-induced T and B lymphocyte apoptosis but worsens survival.","volume":"83","author":"Peck-Palmer","year":"2008","journal-title":"J Leukoc Biol"},{"issue":"5","key":"R40-9-20210213","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1097\/CCM.0b013e3181da4662","article-title":"Does polymicrobial sepsis exert cardiac dysfunction directly through toll-like receptor 2?","volume":"38","author":"Mersmann","year":"2010","journal-title":"Crit Care Med"},{"issue":"5-6","key":"R41-9-20210213","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2119\/2007-00130.Flierl","article-title":"Molecular events in the cardiomyopathy of sepsis.","volume":"14","author":"Flierl","year":"2008","journal-title":"Mol Med"},{"issue":"3","key":"R42-9-20210213","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1097\/01.CCM.0000256723.37586.A2","article-title":"Toll-like receptor 2 activation by bacterial peptidoglycan-associated lipoprotein activates cardiomyocyte inflammation and contractile dysfunction.","volume":"35","author":"Zhu","year":"2007","journal-title":"Crit Care Med"},{"issue":"24","key":"R43-9-20210213","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1161\/01.CIR.0000143081.13042.04","article-title":"Toll-like receptor 2 mediates Staphylococcus aureus-induced myocardial dysfunction and cytokine production in the heart.","volume":"110","author":"Knuefermann","year":"2004","journal-title":"Circulation"},{"issue":"1","key":"R44-9-20210213","doi-asserted-by":"crossref","first-page":"569","DOI":"10.4049\/jimmunol.0902315","article-title":"NADPH oxidase-dependent reactive oxygen species mediate amplified TLR4 signaling and sepsis-induced mortality in Nrf2-deficient mice.","volume":"185","author":"Kong","year":"2010","journal-title":"J Immunol"}],"container-title":["Shock"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00024382-201110000-00009","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T19:30:14Z","timestamp":1786044614000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00024382-201110000-00009"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1097\/shk.0b013e3182279868","relation":{},"ISSN":["1073-2322"],"issn-type":[{"value":"1073-2322","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]}}}