{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:31:55Z","timestamp":1786120315283,"version":"build-2736575974"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1097\/shk.0b013e31822c7380","type":"journal-article","created":{"date-parts":[[2011,10,4]],"date-time":"2011-10-04T14:57:18Z","timestamp":1317740238000},"page":"361-369","source":"Crossref","is-referenced-by-count":9,"title":["Activated Protein C Restores Hepatic Microcirculation During Sepsis by Modulating Vasoregulator Expression"],"prefix":"10.1097","volume":"36","author":[{"given":"Steve A.","family":"Keller","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy C.","family":"Moore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark G.","family":"Clemens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain H.","family":"McKillop","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toan","family":"Huynh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"19","key":"R1-8-20210213","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.2174\/138161208784980590","article-title":"The epidemiology of sepsis.","volume":"14","author":"Hodgin","year":"2008","journal-title":"Curr Pharm Des"},{"issue":"Suppl 4","key":"R2-8-20210213","doi-asserted-by":"crossref","first-page":"S13","DOI":"10.1186\/cc3753","article-title":"The microcirculation is the motor of sepsis.","volume":"9","author":"Ince","year":"2005","journal-title":"Crit Care"},{"issue":"2","key":"R3-8-20210213","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1056\/NEJMra021333","article-title":"The pathophysiology and treatment of sepsis.","volume":"348","author":"Hotchkiss","year":"2003","journal-title":"N Engl J Med"},{"issue":"Suppl","key":"R4-8-20210213","first-page":"149","article-title":"Inflammation and the activated protein C anticoagulant pathway.","volume":"32","author":"Esmon","year":"2006","journal-title":"Semin Thromb Hemost"},{"issue":"5","key":"R5-8-20210213","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1055\/s-0038-1650653","article-title":"Interleukin-6 stimulates coagulation, not fibrinolysis, in humans.","volume":"76","author":"Stouthard","year":"1996","journal-title":"Thrombosis and haemostasis"},{"issue":"19","key":"R6-8-20210213","first-page":"5604","article-title":"Clinical trials with human tumor necrosis factor: in vivo and in vitro effects on human mononuclear phagocyte function.","volume":"48","author":"Conkling","year":"1988","journal-title":"Cancer research"},{"issue":"4","key":"R7-8-20210213","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1073\/pnas.0507700103","article-title":"Activation of protein C by the thrombin-thrombomodulin complex: cooperative roles of Arg-35 of thrombin and Arg-67 of protein C.","volume":"103","author":"Yang","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"R8-8-20210213","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1152\/physrev.00027.2008","article-title":"The hepatic microcirculation: mechanistic contributions and therapeutic targets in liver injury and repair.","volume":"89","author":"Vollmar","year":"2009","journal-title":"Physiol Rev"},{"issue":"4","key":"R9-8-20210213","first-page":"222","article-title":"Elevated plasma levels of endothelin in patients with sepsis syndrome.","volume":"33","author":"Weitzberg","year":"1991","journal-title":"Circ Shock"},{"issue":"3","key":"R10-8-20210213","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/00024382-199903000-00004","article-title":"Patterns of vasoregulatory gene expression in the liver response to ischemia\/reperfusion and endotoxemia.","volume":"11","author":"Sonin","year":"1999","journal-title":"Shock"},{"issue":"6","key":"R11-8-20210213","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1172\/JCI3428","article-title":"Protective role of endogenous carbon monoxide in hepatic microcirculatory dysfunction after hemorrhagic shock in rats.","volume":"102","author":"Pannen","year":"1998","journal-title":"J Clin Invest"},{"issue":"2","key":"R12-8-20210213","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/shk.0b013e3180ca9ef3","article-title":"Microcirculatory alterations of hepatic and mesenteric microcirculation in endotoxin tolerance.","volume":"29","author":"Lendemans","year":"2008","journal-title":"Shock"},{"issue":"27","key":"R13-8-20210213","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1056\/NEJMct0808063","article-title":"Activated protein C for sepsis.","volume":"361","author":"Toussaint","year":"2009","journal-title":"N Engl J Med"},{"issue":"2","key":"R14-8-20210213","first-page":"360","article-title":"Reducing leukocyte trafficking preserves hepatic function after sepsis.","volume":"69","author":"Huynh","year":"2010","journal-title":"J Trauma"},{"issue":"3","key":"R15-8-20210213","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/BF03016089","article-title":"Effects of activated protein C on the mesenteric microcirculation and cytokine release during experimental endotoxemia.","volume":"55","author":"Lehmann","year":"2008","journal-title":"Can J Anaesth"},{"issue":"2","key":"R16-8-20210213","first-page":"205","article-title":"Effect of sepsis on tissue adenine nucleotide levels.","volume":"85","author":"Chaudry","year":"1979","journal-title":"Surgery"},{"issue":"2","key":"R18-8-20210213","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/cc2167","article-title":"Safety assessment of drotrecogin alfa (activated) in the treatment of adult patients with severe sepsis.","volume":"7","author":"Bernard","year":"2003","journal-title":"Crit Care"},{"issue":"3","key":"R19-8-20210213","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1097\/00024382-200115030-00005","article-title":"In vivo assessment of endothelin-induced heterogeneity of hepatic tissue perfusion.","volume":"15","author":"Baveja","year":"2001","journal-title":"Shock"},{"issue":"4","key":"R20-8-20210213","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1097\/01.shk.0000180618.98692.ee","article-title":"Induction of biphasic changes in perfusion heterogeneity of rat liver after sequential stress in vivo.","volume":"24","author":"Kamoun","year":"2005","journal-title":"Shock"},{"issue":"1","key":"R22-8-20210213","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.canlet.2009.10.004","article-title":"Silibinin inhibits ethanol metabolism and ethanol-dependent cell proliferation in an in vitro model of hepatocellular carcinoma.","volume":"291","author":"Brandon-Warner","year":"2010","journal-title":"Cancer Lett"},{"issue":"5","key":"R23-8-20210213","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1097\/00024382-200014050-00010","article-title":"Proinflammatory Kupffer cell alterations after femur fracture trauma and sepsis in rats.","volume":"14","author":"Huynh","year":"2000","journal-title":"Shock"},{"issue":"24","key":"R25-8-20210213","doi-asserted-by":"crossref","first-page":"9797","DOI":"10.1073\/pnas.85.24.9797","article-title":"Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor.","volume":"85","author":"de Nucci","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"R26-8-20210213","doi-asserted-by":"crossref","first-page":"G652","DOI":"10.1152\/ajpgi.00143.2003","article-title":"Influence of caveolin on constitutively activated recombinant eNOS: insights into eNOS dysfunction in BDL rat liver.","volume":"285","author":"Hendrickson","year":"2003","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"25","key":"R27-8-20210213","doi-asserted-by":"crossref","first-page":"15583","DOI":"10.1074\/jbc.272.25.15583","article-title":"Reciprocal regulation of endothelial nitric-oxide synthase by Ca2+-calmodulin and caveolin.","volume":"272","author":"Michel","year":"1997","journal-title":"J Biol Chem"},{"issue":"5","key":"R28-8-20210213","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1155\/S1064744994000190","article-title":"Group a streptococcal puerperal sepsis: historical review and 1990s resurgence.","volume":"1","author":"Nathan","year":"1994","journal-title":"Infect Dis Obstet Gynecol"},{"issue":"11","key":"R29-8-20210213","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nrneph.2009.155","article-title":"Selective iNOS inhibition for the treatment of sepsis-induced acute kidney injury.","volume":"5","author":"Heemskerk","year":"2009","journal-title":"Nat Rev Nephrol"},{"issue":"8","key":"R30-8-20210213","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1097\/00003246-198908000-00001","article-title":"Early hemodynamic correlates of survival in patients with septic shock.","volume":"17","author":"Tuchschmidt","year":"1989","journal-title":"Crit Care Med"},{"issue":"1","key":"R32-8-20210213","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0168-8278(01)00076-9","article-title":"Altered endothelin receptor expression in prehepatic portal hypertension predisposes the liver to microcirculatory dysfunction in rats.","volume":"35","author":"Yokoyama","year":"2001","journal-title":"J Hepatol"},{"issue":"2","key":"R34-8-20210213","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1161\/CIRCRESAHA.110.227496","article-title":"The art of microRNA research.","volume":"108","author":"van Rooij","year":"2011","journal-title":"Circ Res"},{"issue":"10","key":"R36-8-20210213","doi-asserted-by":"crossref","first-page":"e7405","DOI":"10.1371\/journal.pone.0007405","article-title":"MicroRNA fingerprints identify miR-150 as a plasma prognostic marker in patients with sepsis.","volume":"4","author":"Vasilescu","year":"2009","journal-title":"PLoS One"},{"issue":"8","key":"R37-8-20210213","doi-asserted-by":"crossref","first-page":"5232","DOI":"10.4049\/jimmunol.0901084","article-title":"Ethanol-induced expression of ET-1 and ET-BR in liver sinusoidal endothelial cells and human endothelial cells involves hypoxia-inducible factor-1alpha and microrNA-199.","volume":"183","author":"Yeligar","year":"2009","journal-title":"J Immunol"}],"container-title":["Shock"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00024382-201110000-00008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T20:30:27Z","timestamp":1786048227000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00024382-201110000-00008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1097\/shk.0b013e31822c7380","relation":{},"ISSN":["1073-2322"],"issn-type":[{"value":"1073-2322","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]}}}