{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T07:22:45Z","timestamp":1775546565767,"version":"3.50.1"},"reference-count":30,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1097\/shk.0b013e318235331e","type":"journal-article","created":{"date-parts":[[2011,11,11]],"date-time":"2011-11-11T18:11:11Z","timestamp":1321035071000},"page":"553-559","source":"Crossref","is-referenced-by-count":10,"title":["Duration and Magnitude of Hypotension and Monocyte Deactivation in Patients With Community-Acquired Pneumonia"],"prefix":"10.1097","volume":"36","author":[{"given":"Peter M.","family":"Simon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russell L.","family":"Delude","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"MinJae","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan","family":"Kong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynda J.","family":"Guzik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David T.","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derek C.","family":"Angus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Kellum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"issue":"7","key":"R1-5-20210213","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1097\/00003246-200107000-00002","article-title":"Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care.","volume":"29","author":"Angus","year":"2001","journal-title":"Crit Care Med"},{"issue":"5","key":"R2-5-20210213","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1177\/09680519050110050901","article-title":"Reprogramming of circulatory cells in sepsis and SIRS.","volume":"11","author":"Cavaillon","year":"2005","journal-title":"J Endotoxin Res"},{"issue":"15","key":"R3-5-20210213","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1001\/archinte.167.15.1655","article-title":"Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study.","volume":"167","author":"Kellum","year":"2007","journal-title":"Arch Intern Med"},{"issue":"5","key":"R4-5-20210213","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1097\/00003246-200205000-00010","article-title":"Coincidence of pro- and anti-inflammatory responses in the early phase of severe sepsis: longitudinal study of mononuclear histocompatibility leukocyte antigen-DR expression, procalcitonin, C-reactive protein, and changes in T-cell subsets in septic and postoperative patients.","volume":"30","author":"Tschaikowsky","year":"2002","journal-title":"Crit Care Med"},{"issue":"1-2","key":"R5-5-20210213","doi-asserted-by":"crossref","first-page":"64","DOI":"10.2119\/2007-00102.Monneret","article-title":"Monitoring immune dysfunctions in the septic patient: a new skin for the old ceremony.","volume":"14","author":"Monneret","year":"2008","journal-title":"Mol Med"},{"issue":"2","key":"R6-5-20210213","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.imlet.2004.07.009","article-title":"The anti-inflammatory response dominates after septic shock: association of low monocyte HLA-DR expression and high interleukin-10 concentration.","volume":"95","author":"Monneret","year":"2004","journal-title":"Immunol Lett"},{"issue":"7","key":"R7-5-20210213","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s001340051277","article-title":"Leukocyte activation in sepsis; correlations with disease state and mortality.","volume":"26","author":"Muller Kobold","year":"2000","journal-title":"Intensive Care Med"},{"issue":"6-7","key":"R8-5-20210213","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1080\/00365540701199808","article-title":"Monocyte CD14 and soluble CD14 in predicting mortality of patients with severe community acquired infection.","volume":"39","author":"Aalto","year":"2007","journal-title":"Scand J Infect Dis"},{"issue":"8","key":"R9-5-20210213","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1007\/s00134-006-0204-8","article-title":"Persisting low monocyte human leukocyte antigen-DR expression predicts mortality in septic shock.","volume":"32","author":"Monneret","year":"2006","journal-title":"Intensive Care Med"},{"issue":"6","key":"R10-5-20210213","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/0022-4804(89)90019-X","article-title":"Mechanism of immunosuppression following hemorrhage: defective antigen presentation by macrophages.","volume":"46","author":"Stephan","year":"1989","journal-title":"J Surg Res"},{"issue":"1","key":"R12-5-20210213","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1001\/archsurg.1987.01400130068010","article-title":"Hemorrhage without tissue trauma produces immunosuppression and enhances susceptibility to sepsis.","volume":"122","author":"Stephan","year":"1987","journal-title":"Arch Surg"},{"issue":"2","key":"R13-5-20210213","first-page":"138","article-title":"An experimental study of susceptibility to infection after hemorrhagic shock.","volume":"168","author":"Livingston","year":"1989","journal-title":"Surg Gynecol Obstet"},{"issue":"5","key":"R14-5-20210213","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1038\/nm0509-496","article-title":"The sepsis seesaw: tilting toward immunosuppression.","volume":"15","author":"Hotchkiss","year":"2009","journal-title":"Nat Med"},{"issue":"3","key":"R15-5-20210213","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1034\/j.1399-3062.1999.010302.x","article-title":"Low HLA-DR expression on peripheral blood monocytes predicts bacterial sepsis after liver transplantation: relation with prednisolone intake.","volume":"1","author":"Haveman","year":"1999","journal-title":"Transpl Infect Dis"},{"issue":"1","key":"R17-5-20210213","doi-asserted-by":"crossref","first-page":"R15","DOI":"10.1186\/cc8872","article-title":"Sepsis biomarkers: a review.","volume":"14","author":"Pierrakos","year":"2010","journal-title":"Crit Care"},{"issue":"4","key":"R18-5-20210213","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1056\/NEJM199701233360402","article-title":"A prediction rule to identify low-risk patients with community-acquired pneumonia.","volume":"336","author":"Fine","year":"1997","journal-title":"N Engl J Med"},{"issue":"4","key":"R19-5-20210213","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1097\/00003246-200104000-00039","article-title":"New strategies for clinical trials in patients with sepsis and septic shock.","volume":"29","author":"Cohen","year":"2001","journal-title":"Crit Care Med"},{"issue":"3","key":"R20-5-20210213","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/s00134-002-1624-8","article-title":"Surviving intensive care: a report from the 2002 Brussels Roundtable.","volume":"29","author":"Angus","year":"2003","journal-title":"Intensive Care Med"},{"issue":"1","key":"R21-5-20210213","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/1746-1596-4-12","article-title":"Mortality in human sepsis is associated with downregulation of Toll-like receptor 2 and CD14 expression on blood monocytes.","volume":"4","author":"Schaaf","year":"2009","journal-title":"Diagn Pathol"},{"issue":"11","key":"R23-5-20210213","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1097\/00003246-199811000-00016","article-title":"Use of the SOFA score to assess the incidence of organ dysfunctionfailure in intensive care units: results of a multicenter, prospective study. Working group on sepsis-related problems of the European Society of Intensive Care Medicine.","volume":"26","author":"Vincent","year":"1998","journal-title":"Crit Care Med"},{"issue":"14","key":"R24-5-20210213","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1001\/jama.286.14.1754","article-title":"Serial evaluation of the SOFA score to predict outcome in critically ill patients.","volume":"286","author":"Ferreira","year":"2001","journal-title":"JAMA"},{"issue":"6","key":"R25-5-20210213","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1097\/CCM.0b013e31819ffea6","article-title":"Active cytomegalovirus infection is common in mechanically ventilated medical intensive care unit patients.","volume":"37","author":"Chiche","year":"2009","journal-title":"Crit Care Med"},{"issue":"6","key":"R26-5-20210213","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1186\/cc2879","article-title":"Clinical review: immunomodulatory effects of dopamine in general inflammation.","volume":"8","author":"Beck","year":"2004","journal-title":"Crit Care"},{"issue":"1","key":"R27-5-20210213","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1128\/CDLI.11.1.161-167.2004","article-title":"Cytokine production and monocyte HLA-DR expression as predictors of outcome for patients with community-acquired severe infections.","volume":"11","author":"Lekkou","year":"2004","journal-title":"Clin Diagn Lab Immunol"},{"issue":"2","key":"R29-5-20210213","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1023\/A:1009717806924","article-title":"Neutrophils: function and role in sepsis syndrome.","volume":"2","author":"Gaviria","year":"1998","journal-title":"Sepsis"},{"issue":"2","key":"R30-5-20210213","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1189\/jlb.0105017","article-title":"Leukocyte apoptosis and its significance in sepsis and shock.","volume":"78","author":"Wesche","year":"2005","journal-title":"J Leukoc Biol"},{"issue":"1","key":"R31-5-20210213","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/(SICI)1098-1128(199601)16:1<87::AID-MED3>3.0.CO;2-Q","article-title":"The biological effects of interleukin 6.","volume":"16","author":"Barton","year":"1996","journal-title":"Med Res Rev"},{"issue":"3","key":"R33-5-20210213","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.4049\/jimmunol.177.3.1941","article-title":"Hypoxia modifies the transcriptome of primary human monocytes: modulation of novel immune-related genes and identification of CC-chemokine ligand 20 as a new hypoxia-inducible gene.","volume":"177","author":"Bosco","year":"2006","journal-title":"J Immunol"},{"issue":"1","key":"R34-5-20210213","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1001\/archsurg.1992.01420010084012","article-title":"Chloroquine attenuates hemorrhagic shock-induced immunosuppression and decreases susceptibility to sepsis.","volume":"127","author":"Ertel","year":"1992","journal-title":"Arch Surg"},{"issue":"12","key":"R35-5-20210213","doi-asserted-by":"crossref","first-page":"5748","DOI":"10.4049\/jimmunol.157.12.5748","article-title":"Prolactin administration following hemorrhagic shock improves macrophage cytokine release capacity and decreases mortality from subsequent sepsis.","volume":"157","author":"Zellweger","year":"1996","journal-title":"J Immunol"}],"container-title":["Shock"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/SHK.0b013e318235331e","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,6,11]],"date-time":"2023-06-11T02:34:06Z","timestamp":1686450846000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00024382-201112000-00005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1097\/shk.0b013e318235331e","relation":{},"ISSN":["1073-2322"],"issn-type":[{"value":"1073-2322","type":"print"}],"subject":[],"published":{"date-parts":[[2011,12]]}}}