{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:20:38Z","timestamp":1791228038556,"version":"4.1.0"},"reference-count":40,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1097\/shk.0b013e31825d1ed0","type":"journal-article","created":{"date-parts":[[2012,5,10]],"date-time":"2012-05-10T08:57:37Z","timestamp":1336640257000},"page":"177-185","source":"Crossref","is-referenced-by-count":30,"title":["Dietary Phosphatidylcholine Supplementation Attenuates Inflammatory Mucosal Damage in a Rat Model of Experimental Colitis"],"prefix":"10.1097","volume":"38","author":[{"given":"Tam\u00e1s","family":"Kov\u00e1cs","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella","family":"Varga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e1niel","family":"\u00c9rces","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00fcnde","family":"T\u0151k\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e1szl\u00f3","family":"Tiszlavicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikl\u00f3s","family":"Ghyczy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mih\u00e1ly","family":"Boros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f3zsef","family":"Kaszaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-10-20210213","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.clim.2009.02.006","article-title":"Advances in the pathogenesis and treatment of IBD.","volume":"132","author":"Braus","year":"2009","journal-title":"Clin Immunol"},{"key":"R3-10-20210213","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1053\/gast.1996.v110.pm8612998","article-title":"Polyunsaturated phosphatidylcholine prevents stricture formation in a rat model of colitis.","volume":"110","author":"Mourelle","year":"1996","journal-title":"Gastroenterology"},{"key":"R4-10-20210213","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1136\/gut.2004.052316","article-title":"Retarded release phosphatidylcholine benefits patients with chronic active ulcerative colitis.","volume":"54","author":"Stremmel","year":"2005","journal-title":"Gut"},{"key":"R5-10-20210213","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3748\/wjg.v12.i2.271","article-title":"Systemic phosphatidylcholine pretreatment protects canine esophageal mucosa during acute experimental biliary reflux.","volume":"12","author":"Eros","year":"2006","journal-title":"World J Gastroenterol"},{"key":"R6-10-20210213","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/ar2651","article-title":"Oral phosphatidylcholine pretreatment alleviates the signs of experimental rheumatoid arthritis.","volume":"11","author":"Eros","year":"2009","journal-title":"Arthritis Res Ther"},{"key":"R7-10-20210213","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jss.2006.08.004","article-title":"Beneficial effects of phosphatidylcholine during hindlimb reperfusion.","volume":"139","author":"Gera","year":"2007","journal-title":"J Surg Res"},{"key":"R8-10-20210213","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1097\/SHK.0b013e31816f204a","article-title":"Oral phosphatidylcholine pretreatment decreases ischaemia-reperfusion-induced methane generation and the inflammatory response in the small intestine.","volume":"30","author":"Ghyczy","year":"2008","journal-title":"Shock"},{"key":"R9-10-20210213","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1097\/SHK.0b013e31822f36b0","article-title":"Protective effects of a phosphatidylcholine-enriched diet in lipopolysaccharide-induced experimental neuroinflammation in the rat.","volume":"36","author":"Tokes","year":"2011","journal-title":"Shock"},{"key":"R10-10-20210213","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1080\/00365520410006233","article-title":"Phosphatidylcholine and lysophosphatidylcholine in intestinal mucus of ulcerative colitis patients. A quantitative approach by nanoelectrospray-tandem mass spectrometry.","volume":"39","author":"Ehehalt","year":"2004","journal-title":"Scand J Gastroenterol"},{"key":"R11-10-20210213","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1002\/eji.1830270722","article-title":"Predominant pathogenic role of tumor necrosis factor in experimental colitis in mice.","volume":"27","author":"Neurath","year":"1997","journal-title":"Eur J Immunol"},{"key":"R12-10-20210213","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0014-2999(97)01246-6","article-title":"Time-dependent actions of nitric oxide synthase inhibition on colonic inflammation induced by trinitrobenzene sulphonic acid in rats.","volume":"336","author":"Kiss","year":"1997","journal-title":"Eur J Pharmacol"},{"key":"R13-10-20210213","first-page":"915","article-title":"Colon epithelial cell death in 2,4,6-trinitrobenzenesulfonic acid-induced colitis is associated with increased inducible nitric-oxide synthase expression and peroxynitrite production.","volume":"297","author":"Yue","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"R14-10-20210213","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/0016-5085(89)90904-9","article-title":"Hapten-induced model of chronic inflammation and ulceration in the rat colon.","volume":"96","author":"Morris","year":"1989","journal-title":"Gastroenterology"},{"key":"R15-10-20210213","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1053\/gast.1996.v110.pm8608888","article-title":"Molecular association of trinitrobenzenesulfonic acid and surface phospholipids in the development of colitis in rats.","volume":"110","author":"Tatsumi","year":"1996","journal-title":"Gastroenterology"},{"key":"R16-10-20210213","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.2353\/ajpath.2008.070593","article-title":"Multiple pathogenic roles of microvasculature in inflammatory bowel disease: a jack of all trades.","volume":"172","author":"Deban","year":"2008","journal-title":"Am J Pathol"},{"key":"R17-10-20210213","first-page":"304","article-title":"The use of colonoscopy to follow the inflammatory time course of TNBS colitis in rats.","volume":"74","author":"Vermeulen","year":"2011","journal-title":"Acta Gastroenterol Belg"},{"key":"R18-10-20210213","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.1023\/A:1020631220599","article-title":"In vivo detection of morphological and microvascular changes of the colon in association with colitis using fiberoptic confocal imaging (FOCI).","volume":"47","author":"McLaren","year":"2002","journal-title":"Dig Dis Sci"},{"key":"R19-10-20210213","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1053\/j.gastro.2007.09.011","article-title":"Identification of epithelial gaps in human small and large intestine by confocal endomicroscopy.","volume":"133","author":"Kiesslich","year":"2007","journal-title":"Gastroenterology"},{"key":"R20-10-20210213","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1136\/gut.32.2.174","article-title":"Microscopic activity in ulcerative colitis: what does it mean","volume":"32","author":"Riley","year":"1991","journal-title":"Gut"},{"key":"R21-10-20210213","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1146\/annurev.ph.57.030195.003025","article-title":"The hydrophobic barrier properties of gastrointestinal mucus.","volume":"57","author":"Lichtenberger","year":"1995","journal-title":"Annu Rev Physiol"},{"key":"R22-10-20210213","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000200969","article-title":"Effects of phosphatidylcholine and phosphatidylinositol on acetic-acid-induced colitis in the rat.","volume":"53","author":"Fabia","year":"1992","journal-title":"Digestion"},{"key":"R23-10-20210213","first-page":"132","article-title":"Do different animal models of IBD serve different purposes Inflamm Bowel Dis","volume":"2","author":"Grisham","year":"2008","journal-title":"Suppl"},{"key":"R24-10-20210213","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/S0016-5085(03)00699-1","article-title":"Acquired microvascular dysfunction in inflammatory bowel disease: loss of nitric oxide-mediated vasodilation.","volume":"125","author":"Hatoum","year":"2003","journal-title":"Gastroenterology"},{"key":"R25-10-20210213","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/j.bbalip.2010.05.014","article-title":"Phosphatidylcholine as a constituent in the colonic mucosal barrierphysiological and clinical relevance.","volume":"1801","author":"Ehehalt","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"R26-10-20210213","first-page":"490","article-title":"Phosphatidylcholine (Lecithin) and the mucus layer: evidence of therapeutic efficacy in ulcerative colitis Dig","volume":"28","author":"Stremmel","year":"2010","journal-title":"Dis"},{"key":"R27-10-20210213","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1002\/ibd.20993","article-title":": Alterations of phospholipid concentration and species composition of the intestinal mucus barrier in ulcerative colitis: a clue to pathogenesis.","volume":"15","author":"Braun","year":"2009","journal-title":"Inflamm Bowel Dis"},{"key":"R28-10-20210213","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1053\/gast.2002.30294","article-title":": Mucosal flora in inflammatory bowel disease.","volume":"122","author":"Swidsinski","year":"2002","journal-title":"Gastroenterology"},{"key":"R29-10-20210213","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1097\/SHK.0b013e318173e8d4","article-title":"Oral phosphatidylcholine preserves the gastrointestinal mucosal barrier during LPS-induced inflammation.","volume":"30","author":"Dial","year":"2008","journal-title":"Shock"},{"key":"R30-10-20210213","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1016\/0016-5085(93)91065-P","article-title":"F, Bode G, Ditschuneit H, Malfertheiner P; Demonstration of a phospholipid-rich zone in the human gastric epithelium damaged by Helicobacter pylori.","volume":"105","year":"1993","journal-title":"Gastroenterology"},{"key":"R31-10-20210213","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1097\/00042737-200207000-00008","article-title":"Role of mucins in inflammatory bowel disease: important lessons from experimental models.","volume":"14","author":"Einerhand","year":"2002","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"R32-10-20210213","doi-asserted-by":"crossref","first-page":"27155","DOI":"10.1074\/jbc.M704408200","article-title":": Anti-inflammatory effects of phosphatidylcholine.","volume":"282","author":"Treede","year":"2007","journal-title":"J Biol Chem"},{"key":"R33-10-20210213","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1172\/JCI30555","article-title":"Physiology and immunology of the cholinergic antiinflammatory pathway.","volume":"117","author":"Tracey","year":"2007","journal-title":"J Clin Invest"},{"key":"R34-10-20210213","first-page":"1124","article-title":"Simultaneous generation of methane, carbon dioxide, and carbon monoxide from choline and ascorbic acida defensive mechanism against reductive stress FASEB","volume":"17","author":"Ghyczy","year":"2003","journal-title":"J"},{"key":"R35-10-20210213","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1002\/cbf.1517","article-title":"Soy lecithin supplementation alters macrophage phagocytosis and lymphocyte response to concanavalin A: a study in alloxan-induced diabetic rats.","volume":"26","author":"Miranda","year":"2008","journal-title":"Cell Biochem Funct"},{"key":"R36-10-20210213","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1046\/j.1365-2249.2001.01479.x","article-title":"Dipalmitoylphosphatidylcholine modulates inflammatory functions of monocytic cells independently of mitogen activated protein kinases.","volume":"124","author":"Tonks","year":"2001","journal-title":"Clin Exp Immunol"},{"key":"R37-10-20210213","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1172\/JCI118331","article-title":"Inhibitory effect of porcine surfactant on the respiratory burst oxidase in human neutrophils. Attenuation of p47phox and p67phox membrane translocation as the mechanism.","volume":"96","author":"Chao","year":"1995","journal-title":"J Clin Invest"},{"key":"R38-10-20210213","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1046\/j.1365-2567.1998.00479.x","article-title":"Immunization of mice with phosphatidylcholine drastically reduces the parasitaemia of subsequent Plasmodium chabaudi blood-stage infections.","volume":"94","author":"Bordmann","year":"1998","journal-title":"Immunology"},{"key":"R39-10-20210213","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1471-230X-9-53","article-title":"TNF-alpha-induced up-regulation of pro-inflammatory cytokines is reduced by phosphatidylcholine in intestinal epithelial cells.","volume":"9","author":"Treede","year":"2009","journal-title":"BMC Gastroenterol"},{"key":"R40-10-20210213","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.atherosclerosis.2009.01.010","article-title":"Soy phosphatidylcholine inhibited TLR4-mediated MCP-1 expression in vascular cells.","volume":"205","author":"Ishikado","year":"2009","journal-title":"Atherosclerosis"},{"key":"R41-10-20210213","doi-asserted-by":"crossref","first-page":"e25058","DOI":"10.1371\/journal.pone.0025058","article-title":"Tumor necrosis factor- and Muc2 mucin play major roles in disease onset and progression in dextran sodium sulphate-induced colitis.","volume":"6","author":"Dharmani","year":"2011","journal-title":"PLoS One"}],"container-title":["Shock"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.lww.com\/00024382-201208000-00010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T07:23:41Z","timestamp":1618039421000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00024382-201208000-00010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.1097\/shk.0b013e31825d1ed0","relation":{},"ISSN":["1073-2322"],"issn-type":[{"value":"1073-2322","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8]]}}}