{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T01:21:14Z","timestamp":1769563274544,"version":"3.49.0"},"reference-count":59,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,12]]},"DOI":"10.1097\/sla.0b013e31811f4467","type":"journal-article","created":{"date-parts":[[2009,3,5]],"date-time":"2009-03-05T02:51:00Z","timestamp":1236221460000},"page":"1075-1082","source":"Crossref","is-referenced-by-count":82,"title":["Is Total Parathyroidectomy the Treatment of Choice for Hyperparathyroidism in Multiple Endocrine Neoplasia Type 1?"],"prefix":"10.1097","volume":"246","author":[{"given":"Francesco","family":"Tonelli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tommaso","family":"Marcucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geri","family":"Fratini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Silvia","family":"Tommasi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Falchetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Luisa","family":"Brandi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-23-20210203","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1245\/ASO.2006.12.009","article-title":"Primary hyperparathyroidism in multiple endocrine neoplasia type 1: individualized management with low recurrence rates.","volume":"13","author":"Lee","year":"2006","journal-title":"Ann Surg Oncol"},{"key":"R2-23-20210203","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1001\/archsurg.141.3.235","article-title":"Subtotal parathyroidectomy as an adequate treatment for primary hyperparathyroidism in multiple endocrine neoplasia type 1.","volume":"141","author":"Hubbard","year":"2006","journal-title":"Arch Surg"},{"key":"R3-23-20210203","doi-asserted-by":"crossref","first-page":"5658","DOI":"10.1210\/jcem.86.12.8070","article-title":"Guidelines for diagnosis and therapy of MEN type 1 and type 2.","volume":"86","author":"Brandi","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"R4-23-20210203","first-page":"943","article-title":"The Metabolic and Molecular Bases of Inherited Disease. 8th ed.","author":"Marx","year":"2001"},{"key":"R5-23-20210203","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1093\/qjmed\/89.9.653","article-title":"Clinical studies of multiple endocrine neoplasia type 1 (MEN1).","volume":"89","author":"Tramp","year":"1996","journal-title":"Q J Med"},{"key":"R6-23-20210203","doi-asserted-by":"crossref","first-page":"484","DOI":"10.7326\/0003-4819-129-6-199809150-00011","article-title":"Clinical expressions of multiple endocrine neoplasia type 1 at the National Institutes of Health.","volume":"129","author":"Skarulis","year":"1998","journal-title":"Ann Intern Med"},{"key":"R7-23-20210203","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1365-2796.2004.01428.x","article-title":"Parathyroid surgery in familial hyperparathyroid disorders.","volume":"257","author":"Carling","year":"2005","journal-title":"J Intern Med"},{"key":"R8-23-20210203","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/S0039-6060(03)00406-9","article-title":"Results of initial operation for hyperparathyroidism in patients with multiple endocrine neoplasia type 1.","volume":"134","author":"Elaraj","year":"2003","journal-title":"Surgery"},{"key":"R9-23-20210203","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1097\/00000658-198010000-00003","article-title":"Long term evaluation of patients with primary parathyroid hyperplasia managed by total parathyroidectomy and heterotopic autotransplantation.","volume":"192","author":"Wells","year":"1980","journal-title":"Ann Surg"},{"key":"R10-23-20210203","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1007\/BF02067367","article-title":"Findings and long-term results of parathyroid surgery in multiple endocrine neoplasia type 1.","volume":"16","author":"Hellman","year":"1992","journal-title":"World J Surg"},{"key":"R11-23-20210203","first-page":"23","article-title":"Total parathyroidectomy and parathyroid transplantation into subcutaneous fat tissue in the treatment of hyperparathyroidism in multiple endocrine neoplasia type 1.","volume":"26","author":"Jansson","year":"1994","journal-title":"Acta Chir Austriaca"},{"key":"R12-23-20210203","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1365-2265.1991.tb00938.x","article-title":"Heterogeneous size of the parathyroid glands in familial multiple endocrine neoplasia type 1.","volume":"35","author":"Marx","year":"1991","journal-title":"Clin Endocrinol"},{"key":"R13-23-20210203","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1177\/172460089501000403","article-title":"Intraoperative fall in plasma levels of intact parathyroid hormone in patients undergoing parathyroid adenomectomy.","volume":"10","author":"Tommasi","year":"1995","journal-title":"Int J Biol Markers"},{"key":"R14-23-20210203","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1097\/00000658-197610000-00001","article-title":"Recurrent hyperparathyroidism.","volume":"184","author":"Clark","year":"1976","journal-title":"Ann Surg"},{"key":"R15-23-20210203","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1056\/NEJM198605153142004","article-title":"Parathyroid mitogenic activity in plasma from patients with familial multiple endocrine neoplasia type 1.","volume":"314","author":"Brandi","year":"1986","journal-title":"N Engl J Med"},{"key":"R16-23-20210203","first-page":"1080","article-title":"Hyperparathyroidism in multiple endocrine neoplasia syndrome.","volume":"112","author":"Kraimps","year":"1992","journal-title":"Surgery"},{"key":"R17-23-20210203","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1067\/msy.2002.128607","article-title":"Long-term results of less than total parathyroidectomy for hyperparathyroidism in multiple endocrine neoplasia type 1.","volume":"132","author":"Arnalsteen","year":"2002","journal-title":"Surgery"},{"key":"R18-23-20210203","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1097\/01.sla.0000124383.98416.8d","article-title":"Clinical genetic testing and early surgical intervention in patients with multiple endocrine neoplasia type 1.","volume":"239","author":"Lairmore","year":"2004","journal-title":"Ann Surg"},{"key":"R19-23-20210203","first-page":"591","article-title":"The Parathyroids. Basic and Clinical Concepts.","author":"Metz","year":"1994"},{"key":"R20-23-20210203","first-page":"2621","article-title":"Mutation analysis of the MEN 1 gene in multiple endocrine neoplasia type 1, familial acromegaly and familial isolated hyperparathyroidism.","volume":"83","author":"Teh","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"R21-23-20210203","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1086\/301729","article-title":"Characterization of mutations in patients with multiple endocrine neoplasia type 1.","volume":"62","author":"Bassett","year":"1998","journal-title":"Am J Hum Genet"},{"key":"R22-23-20210203","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/(SICI)1098-1004(1999)13:3<175::AID-HUMU1>3.0.CO;2-R","article-title":"Germline mutations in the multiple endocrine neoplasia type 1 gene: evidence for frequent splicing defects.","volume":"13","author":"Mutch","year":"1999","journal-title":"Hum Mutat"},{"key":"R23-23-20210203","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1038\/ng0897-375","article-title":"Somatic mutation of the MEN1 gene in parathyroid tumors.","volume":"16","author":"Heppner","year":"1997","journal-title":"Nat Genet"},{"key":"R24-23-20210203","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0889-8529(05)70150-X","article-title":"Multiple endocrine neoplasia type 1.","volume":"29","author":"Thakker","year":"2000","journal-title":"Endocrinol Metab Clin North Am"},{"key":"R25-23-20210203","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1006\/geno.1996.0570","article-title":"Definition of the minimal MEN 1 candidate area based on a 5-Mb integrated map of proximal 11q13.","volume":"37","author":"Courseaux","year":"1996","journal-title":"Genomics"},{"key":"R26-23-20210203","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1046\/j.1365-2265.2000.00966.x","article-title":"Clinical features of multiple endocrine neoplasia type 1 (MEN1) phenocopy without germline MEN1 gene mutations: analysis of 20 Japanese sporadic cases without MEN 1.","volume":"52","author":"Hai","year":"2000","journal-title":"Clin Endocrinol (Oxf)"},{"key":"R27-23-20210203","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1365-2265.2005.02190.x","article-title":"Detection of an MEN1 gene mutation depends on clinical features and supports current referral criteria for diagnostic molecular genetic testing.","volume":"62","author":"Ellard","year":"2005","journal-title":"Clin Endocrinol"},{"key":"R28-23-20210203","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1210\/mend.15.10.0717","article-title":"Molecular and genetic mechanisms of tumorigenesis in multiple endocrine neoplasia type-1.","volume":"15","author":"Guo","year":"2001","journal-title":"Mol Endocrinol"},{"key":"R29-23-20210203","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1530\/eje.0.1420131","article-title":"MEN1 gene mutation analysis in Italian patients with multiple endocrine neoplasia type 1.","volume":"142","author":"Morelli","year":"2000","journal-title":"Eur J Endocrinol"},{"key":"R30-23-20210203","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1093\/hmg\/6.7.1169","article-title":"Germline mutations of the MEN1 gene in familial multiple endocrine neoplasia type 1 and related states.","volume":"6","author":"Agarwal","year":"1997","journal-title":"Hum Mol Genet"},{"key":"R31-23-20210203","doi-asserted-by":"crossref","first-page":"e72","DOI":"10.1136\/jmg.40.5.e72","article-title":"Mutational and gross deletion study of the MEN1 gene and correlation with clinical features in Spanish patients.","volume":"40","author":"Cebrian","year":"2003","journal-title":"J Med Genet"},{"key":"R32-23-20210203","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1001\/archsurg.137.6.641","article-title":"Genotype\u2013phenotype analysis in multiple endocrine neoplasia type 1.","volume":"137","author":"Kouvaraki","year":"2002","journal-title":"Arch Surg"},{"key":"R33-23-20210203","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1210\/jcem.87.6.8607","article-title":"Frequent occurrence of an intron 4 mutation in multiple endocrine neoplasia type 1.","volume":"87","author":"Turner","year":"2002","journal-title":"J Clin Endocrinol Metab"},{"key":"R34-23-20210203","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/humu.10092","article-title":"Germline mutation profile of MEN1 in multiple endocrine neoplasia type 1: search for correlation between phonotype and the functional domains of the MEN1 protein.","volume":"20","author":"Wautot","year":"2002","journal-title":"Hum Mutat"},{"key":"R35-23-20210203","first-page":"13","article-title":"Histologic features of parathyroid hyperplasia in multiple endocrine neoplasia type 1 (MEN-1). Diagnostic and surgical implications.","volume":"26","author":"Amorosi","year":"1994","journal-title":"Acta Chir Austriaca"},{"key":"R36-23-20210203","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/00000658-197603000-00010","article-title":"The anatomic basis of parathyroid surgery.","volume":"183","author":"Wang","year":"1976","journal-title":"Ann Surg"},{"key":"R37-23-20210203","first-page":"14","article-title":"Surgical anatomy of human parathyroid glands.","volume":"95","author":"Akerstrom","year":"1984","journal-title":"Surgery"},{"key":"R38-23-20210203","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1016\/S0039-6060(98)70040-6","article-title":"Primary and reoperative parathyroid operations in hyperparathyroidism of multiple endocrine neoplasia type 1.","volume":"124","author":"Hellman","year":"1998","journal-title":"Surgery"},{"key":"R39-23-20210203","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1001\/archsurg.134.10.1119","article-title":"Osteoporosis multiple endocrine neoplasia type 1.","volume":"134","author":"Burgess","year":"1999","journal-title":"Arch Surg"},{"key":"R40-23-20210203","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1007\/s002689910091","article-title":"Intraoperative parathormone measurement in patients with multiple endocrine neoplasia type 1 syndrome and hyperparathyroidism.","volume":"24","author":"Tonelli","year":"2000","journal-title":"World J Surg"},{"key":"R41-23-20210203","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1067\/msy.2001.118379","article-title":"Reoperation for hyperparathyroidism in multiple endocrine neoplasia type 1.","volume":"130","author":"Kivlen","year":"2001","journal-title":"Surgery"},{"key":"R42-23-20210203","first-page":"1031","article-title":"Surgical management of primary hyperparathyroidism in multiple endocrine neoplasia type 1 and 2.","volume":"114","author":"O' Riordain","year":"1993","journal-title":"Surgery"},{"key":"R43-23-20210203","first-page":"32","article-title":"Hyperparathyroidism and multiple endocrine neoplasia type 1 (MEN-1).","volume":"26","author":"Cougard","year":"1994","journal-title":"Acta Chir Austriaca"},{"key":"R44-23-20210203","first-page":"35","article-title":"How to handle the parathyroid glands in multiple endocrine neoplasia type 1 (MEN-1) and type 2 (MEN-2)? Surgical approach to uniglandular vs multiglandular disease in hereditary primary hyperparathyroidism.","volume":"26","author":"Dralle","year":"1994","journal-title":"Acta Chir Austriaca"},{"key":"R45-23-20210203","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1007\/s00268-001-0046-z","article-title":"Hyperparathyroidism in multiple endocrine neoplasia type 1: surgical trends and results of a 256-patient series from group d'etude des n\u00e8oplasies endocriniennes multiples study group.","volume":"25","author":"Goudet","year":"2001","journal-title":"World J Surg"},{"key":"R46-23-20210203","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1080\/110241501750099294","article-title":"Long-term biochemical results after operative treatment of primary hyperparathyroidism associated with multiple endocrine neoplasia types I and IIa: is a more or less extended operation essential?","volume":"167","author":"Dotzenrath","year":"2001","journal-title":"Eur J Surg"},{"key":"R47-23-20210203","first-page":"456","article-title":"Recurrent hyperparathyroidism from benign neoplastic seeding: a review with recommendations for management.","volume":"113","author":"Sokol","year":"1993","journal-title":"Surgery"},{"key":"R48-23-20210203","first-page":"462","article-title":"Results of sub-total parathyroidectomy for primary chief cell hyperplasia.","volume":"86","author":"Edis","year":"1979","journal-title":"Surgery"},{"key":"R49-23-20210203","first-page":"26","article-title":"Subtotal parathyroidectomy for primary chief cell hyperplasia of the multiple endocrine neoplasia type 1 syndrome.","volume":"193","author":"Prinz","year":"1981","journal-title":"Surgery"},{"key":"R50-23-20210203","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1001\/archsurg.1983.01390050017003","article-title":"Primary hyperparathyroidism in patients with multiple endocrine neoplasia syndroms. Surgical experience.","volume":"118","author":"Van Heerden","year":"1983","journal-title":"Arch Surg"},{"key":"R51-23-20210203","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1007\/BF01665302","article-title":"Management of primary hyperparathyroidism caused by multiglandular disease.","volume":"15","author":"Goretzki","year":"1991","journal-title":"World J Surg"},{"key":"R52-23-20210203","first-page":"16","article-title":"Technical considerations in the surgical management of primary hyperparathyroidism caused by multiple gland disease (hyperplasia).","volume":"26","author":"Thompson","year":"1994","journal-title":"Acta Chir Austriaca"},{"key":"R53-23-20210203","first-page":"41","article-title":"Treatment of primary parathyroid hyperplasia: representative experience at Mayo Clinic.","volume":"26","author":"Grant","year":"1994","journal-title":"Acta Chir Austriaca"},{"key":"R54-23-20210203","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1007\/BF01655552","article-title":"Parathyroid surgery in the multiple endocrine neoplasia type 1 syndrome: choice of surgical procedure.","volume":"10","author":"Malmaeus","year":"1986","journal-title":"World J Surg"},{"key":"R55-23-20210203","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1111\/j.1365-2796.2006.01619.x","article-title":"Thymic carcinoid in multiple endocrine neoplasia 1: genotype\u2013phonotype correlation and prevention.","volume":"259","author":"Lim","year":"2006","journal-title":"J Int Med"},{"key":"R56-23-20210203","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1046\/j.1365-2265.2001.01348.x","article-title":"Malignant thymic carcinoid is not prevented by transcervical thymectomy in multiple endocrine neoplasia type 1.","volume":"55","author":"Burgess","year":"2001","journal-title":"Clin Endocrinol"},{"key":"R57-23-20210203","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/BF01665310","article-title":"Replantation of cryopreserved human parathyroid tissue.","volume":"15","author":"Wagner","year":"1991","journal-title":"World J Surg"},{"key":"R58-23-20210203","first-page":"588","article-title":"Parathyroid autotransplantation to the time of reoperation for persistent hyperparathyroidism.","volume":"88","author":"Edis","year":"1980","journal-title":"Surgery"},{"key":"R59-23-20210203","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1067\/msy.2099.101580","article-title":"Results of heterotopic parathyroid autotransplantation: a 13-year experience.","volume":"126","author":"Feldman","year":"1999","journal-title":"Surgery"}],"container-title":["Annals of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.lww.com\/00000658-200712000-00023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T07:27:18Z","timestamp":1618039638000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00000658-200712000-00023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12]]},"references-count":59,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007]]}},"URL":"https:\/\/doi.org\/10.1097\/sla.0b013e31811f4467","relation":{},"ISSN":["0003-4932"],"issn-type":[{"value":"0003-4932","type":"print"}],"subject":[],"published":{"date-parts":[[2007,12]]}}}