{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T12:23:08Z","timestamp":1790166188954,"version":"4.1.0"},"reference-count":47,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1097\/sla.0b013e31818584c7","type":"journal-article","created":{"date-parts":[[2008,10,21]],"date-time":"2008-10-21T07:17:26Z","timestamp":1224573446000},"page":"821-828","source":"Crossref","is-referenced-by-count":76,"title":["Single Administration of Thrombopoietin Prevents Progression of Liver Fibrosis and Promotes Liver Regeneration After Partial Hepatectomy in Cirrhotic Rats"],"prefix":"10.1097","volume":"248","author":[{"given":"Soichiro","family":"Murata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuka","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoritaka","family":"Nakano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andriy","family":"Myronovych","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motonobu","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiro","family":"Ohkohchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-18-20210203","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.dld.2004.01.003","article-title":"Liver fibrosis: from the bench to clinical targets.","volume":"36","author":"Pinzani","year":"2004","journal-title":"Dig Liver Dis"},{"key":"R2-18-20210203","first-page":"277","article-title":"Primary liver cancer in Japan. Clinicopathologic features and results of surgical treatment.","volume":"211","year":"1990","journal-title":"Ann Surg"},{"key":"R3-18-20210203","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S1089-3261(05)70168-9","article-title":"Hepatic fibrosis. Pathogenesis and principles of therapy.","volume":"5","author":"Albanis","year":"2001","journal-title":"Clin Liver Dis"},{"key":"R4-18-20210203","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/S0002-9440(10)65034-1","article-title":"The development and compensation of biliary cirrhosis in interleukin-6-deficient mice.","volume":"156","author":"Ezure","year":"2000","journal-title":"Am J Pathol"},{"key":"R5-18-20210203","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1126\/science.276.5309.60","article-title":"Liver regeneration.","volume":"276","author":"Michalopoulos","year":"1997","journal-title":"Science"},{"key":"R6-18-20210203","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0168-8278(00)80412-2","article-title":"Liver regeneration.","volume":"32","author":"Fausto","year":"2000","journal-title":"J Hepatol"},{"key":"R7-18-20210203","first-page":"186","article-title":"Experimental pathology of the liver.","volume":"12","author":"Higgins","year":"1931","journal-title":"Arch Pathol"},{"key":"R8-18-20210203","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1097\/00000658-198707000-00005","article-title":"Human liver regeneration after major hepatic resection: a study of normal liver and livers with chronic hepatitis and cirrhosis.","volume":"206","author":"Nagasue","year":"1987","journal-title":"Ann Surg"},{"key":"R9-18-20210203","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1097\/00000658-200011000-00008","article-title":"Percutaneous portal vein embolization increases the feasibility and safety of major liver resection for hepatocellular carcinoma in injured livers.","volume":"232","author":"Azoulay","year":"2000","journal-title":"Ann Surg"},{"key":"R10-18-20210203","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0168-3659(02)00463-7","article-title":"A trial on regeneration therapy of rat liver cirrhosis by controlled release of hepatocyte growth factor.","volume":"88","author":"Oe","year":"2003","journal-title":"J Control Release"},{"key":"R11-18-20210203","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S0006-2952(99)00359-7","article-title":"The decrease in total collagen fibers in the liver by hepatocyte growth factor after formation of cirrhosis induced by thioacetamine.","volume":"59","author":"Sato","year":"2000","journal-title":"Biochem Pharmacol"},{"key":"R12-18-20210203","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.surg.2005.10.003","article-title":"Combination gene therapy of HGF and truncated type II TGF-\u03b2 receptor for rat liver cirrhosis after partial hepatectomy.","volume":"139","author":"Ozawa","year":"2006","journal-title":"Surgery"},{"key":"R13-18-20210203","first-page":"177","article-title":"Increased level of serum hepatocyte growth factor\/scatter factor in liver cancer is associated with tumor metastasis.","volume":"13","author":"Junbo","year":"1999","journal-title":"In Vivo"},{"key":"R14-18-20210203","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.ejso.2006.12.007","article-title":"Significance of serum hepatocyte growth factor levels in patients with hepatocellular carcinoma undergoing hepatic resection.","volume":"34","author":"Chau","year":"2007","journal-title":"Eur J Surg Oncol"},{"key":"R15-18-20210203","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1007\/s00268-006-0772-3","article-title":"Platelets promote liver regeneration in early period after hepatectomy.","volume":"31","author":"Murata","year":"2007","journal-title":"World J Surg"},{"key":"R16-18-20210203","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.jss.2007.02.035","article-title":"Platelets strongly induce hepatocyte proliferation with IGF-1 and HGF in vitro.","volume":"145","author":"Matsuo","year":"2008","journal-title":"J Surg Res"},{"key":"R17-18-20210203","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.cryobiol.2007.08.007","article-title":"Freeze dried platelets promote hepatocyte proliferation in mice.","volume":"55","author":"Hoshi","year":"2007","journal-title":"Cryobiology"},{"key":"R18-18-20210203","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1126\/science.1123842","article-title":"Platelet-derived serotonin mediates liver regeneration.","volume":"312","author":"Lesurtel","year":"2006","journal-title":"Science"},{"key":"R19-18-20210203","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1007\/s00268-008-9493-0","article-title":"Platelets promote liver regeneration under conditions of Kupffer cell depletion after hepatectomy in mice.","volume":"32","author":"Murata","year":"2008","journal-title":"World J Surg"},{"key":"R20-18-20210203","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1182\/blood.V91.1.37","article-title":"Multilineage hematopoietic recovery by a single injection of pegylated recombinant human megakaryocyte growth and development factor in myelosuppressed mice.","volume":"91","author":"Shibuya","year":"1998","journal-title":"Blood"},{"key":"R21-18-20210203","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1046\/j.1365-2141.2003.04696.x","article-title":"New TPO treatment schedules of increased safety and efficacy: pre-clinical validation of a thrombopoiesis simulation model.","volume":"123","author":"Skomorovski","year":"2003","journal-title":"Br J Haematol"},{"key":"R22-18-20210203","doi-asserted-by":"crossref","first-page":"19673","DOI":"10.1074\/jbc.270.34.19673","article-title":"Thrombopoietin induces megakaryocyte differentiation in hematopoietic progenitor FDC-P2 cells.","volume":"270","author":"Nagata","year":"1995","journal-title":"J Biol Chem"},{"key":"R23-18-20210203","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1055\/s-0038-1656057","article-title":"Serum thrombopoietin level is not regulated by transcription but by the total counts of both megakaryocytes and platelets during thrombocytopenia and thrombocytosis.","volume":"77","author":"Nagata","year":"1997","journal-title":"Thromb Haemost"},{"key":"R24-18-20210203","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1056\/NEJMoa073255","article-title":"Eltrombopag for thrombocytopenia in patients with cirrhosis associated with hepatitis C.","volume":"357","author":"McHutchinson","year":"2007","journal-title":"N Engl J Med"},{"key":"R25-18-20210203","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S0168-8278(87)80570-6","article-title":"A morphological study of the early stages of hepatic fibrosis induced by low doses of dimethylnitrosamine in the rat.","volume":"5","author":"J\u00e9z\u00e9quel","year":"1987","journal-title":"J Hepatol"},{"key":"R26-18-20210203","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1006\/jsre.1997.5243","article-title":"Perioperative continuous hepatocytes growth factor supply prevents postoperative liver failure in rats with liver cirrhosis.","volume":"74","author":"Kaido","year":"1998","journal-title":"J Surg Res"},{"issue":"suppl 2","key":"R27-18-20210203","first-page":"111","article-title":"Perspectives in the treatment of liver fibrosis.","volume":"22","author":"Mavier","year":"1995","journal-title":"J Hepatol"},{"key":"R28-18-20210203","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1023\/A:1009645015601","article-title":"Differential expression of apoptosis-associated genes post-hepatectomy in cirrhotic vs. normal rats.","volume":"5","author":"Masson","year":"2000","journal-title":"Apoptosis"},{"key":"R29-18-20210203","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0168-8278(97)80185-7","article-title":"Stimulation of liver regeneration and function after partial hepatectomy in cirrhotic rats by continuous infusion of recombinant human hepatocytes growth factor.","volume":"27","author":"Kaibori","year":"1997","journal-title":"J Hepatol"},{"key":"R30-18-20210203","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0168-8278(02)00164-2","article-title":"Halofuginone, a collagen type I inhibitor improves liver regeneration in cirrhotic rats.","volume":"37","author":"Spira","year":"2002","journal-title":"J Hepatol"},{"key":"R31-18-20210203","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.jss.2005.08.002","article-title":"Administration of rhHGF-activator via portal vein stimulates the regeneration of cirrhotic liver after partial hepatectomy in rats.","volume":"130","author":"Yanagida","year":"2006","journal-title":"J Surg Res"},{"key":"R32-18-20210203","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1182\/blood.V89.1.101","article-title":"Localization and regulation of thrombopoietin mRNA expression in human kidney, liver, bone marrow, and spleen using in situ hybridization.","volume":"89","author":"Sungaran","year":"1997","journal-title":"Blood"},{"key":"R33-18-20210203","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1097\/00042737-200107000-00006","article-title":"The role of the liver in the production of thrombopoietin compared with erythropoietin.","volume":"13","author":"Jelkmann","year":"2001","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"R34-18-20210203","doi-asserted-by":"crossref","first-page":"285","DOI":"10.7326\/0003-4819-127-4-199708150-00005","article-title":"Thrombopoietin levels in patients with cirrhosis before and after orthopic liver transplantation.","volume":"127","author":"Martin","year":"1997","journal-title":"Ann Intern Med"},{"key":"R35-18-20210203","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1111\/j.1440-1746.1998.tb00760.x","article-title":"Reduced expression of thrombopoietin is involved in thrombocytopenia in human and rat liver cirrhosis.","volume":"13","author":"Ishikawa","year":"1998","journal-title":"J Gastroenterol Hepatol"},{"key":"R36-18-20210203","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1002\/hep.510290627","article-title":"Hepatic thrombopoietin mRNA levels in acute and chronic liver failure of childhood.","volume":"29","author":"Wolber","year":"1999","journal-title":"Hepatology"},{"key":"R37-18-20210203","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/MEG.0b013e3282f246e6","article-title":"Thrombopoietin is a growth factor for rat hepatic progenitors.","volume":"20","author":"Schmelzer","year":"2008","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"R38-18-20210203","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/hep.21516","article-title":"Platelets and platelet-derived serotonin promote tissue repair after normothermic hepatic ischemia in mice.","volume":"45","author":"Nocito","year":"2007","journal-title":"Hepatology"},{"key":"R39-18-20210203","doi-asserted-by":"crossref","first-page":"2345","DOI":"10.1073\/pnas.96.5.2345","article-title":"Blockade of type beta transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat.","volume":"96","author":"Qi","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R40-18-20210203","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1053\/jhep.2000.9109","article-title":"Inhibition of transforming growth factor beta prevents progression of liver fibrosis and enhances hepatocytes regeneration in dimethylnitrosamine-treated rats.","volume":"32","author":"Nakamura","year":"2000","journal-title":"Hepatology"},{"key":"R41-18-20210203","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/5593","article-title":"Hepatocyte growth factor gene therapy of liver cirrhosis in rats.","volume":"5","author":"Ueki","year":"1999","journal-title":"Nat Med"},{"key":"R42-18-20210203","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1053\/jhep.2001.27949","article-title":"Adenosine reverses a preestablished CCl4-induced micronodular cirrhosis through enhancing collagenolytic activity and stimulating hepatocyte cell proliferation in rats.","volume":"34","author":"Hernandez-Munoz","year":"2001","journal-title":"Hepatology"},{"key":"R43-18-20210203","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1002\/hep.20452","article-title":"Transdifferentiation of bone marrow cells reduces CCl4-induced liver fibrosis in mice.","volume":"40","author":"Sakaida","year":"2004","journal-title":"Hepatology"},{"key":"R44-18-20210203","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.bbrc.2003.12.044","article-title":"A subpopulation of bone marrow cells depleted by a novel antibody, anti Liv8, is useful for cell therapy to repair damaged liver.","volume":"313","author":"Yamamoto","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"R45-18-20210203","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1053\/j.gastro.2007.03.110","article-title":"Significance and therapeutic potential of endothelial progenitor cell transplantation in a cirrhotic liver rat model.","volume":"133","author":"Nakamura","year":"2007","journal-title":"Gastroenterology"},{"key":"R46-18-20210203","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.bbrc.2005.07.127","article-title":"Dual effects of adenovirus-mediated thrombopoietin gene transfer on hepatic oval cell proliferation and platelet counts.","volume":"335","author":"Ichiba","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"R47-18-20210203","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1160\/TH07-02-0147","article-title":"Platelet interaction with progenitor cells: potential implications for regenerative medicine.","volume":"98","author":"Stellos","year":"2007","journal-title":"Thromb Haemost"}],"container-title":["Annals of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.lww.com\/00000658-200811000-00018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T07:30:02Z","timestamp":1618039802000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00000658-200811000-00018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.1097\/sla.0b013e31818584c7","relation":{},"ISSN":["0003-4932"],"issn-type":[{"value":"0003-4932","type":"print"}],"subject":[],"published":{"date-parts":[[2008,11]]}}}