{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T09:36:49Z","timestamp":1791193009296,"version":"4.1.0"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,3]]},"DOI":"10.1097\/sla.0b013e31819a0486","type":"journal-article","created":{"date-parts":[[2009,5,21]],"date-time":"2009-05-21T10:21:00Z","timestamp":1242901260000},"page":"420-425","source":"Crossref","is-referenced-by-count":200,"title":["Long-Term Outcome of Initially Unresectable Metastatic Colorectal Cancer Patients Treated with 5-Fluorouracil\/Leucovorin, Oxaliplatin, and Irinotecan (FOLFOXIRI) Followed by Radical Surgery of Metastases"],"prefix":"10.1097","volume":"249","author":[{"given":"Gianluca","family":"Masi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fotios","family":"Loupakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Pollina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Vasile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samanta","family":"Cupini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Ricci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isa Maura","family":"Brunetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Ferraldeschi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Naso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Filipponi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Pietrabissa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orlando","family":"Goletti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Baldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Fornaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Andreuccetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Falcone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"issue":"4","key":"R1-12-20210203","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1097\/00000658-199610000-00009","article-title":"Resection of nonresectable liver metastases from colorectal cancer after neoadjuvant chemotherapy.","volume":"224","author":"Bismuth","year":"1996","journal-title":"Ann Surg"},{"issue":"29","key":"R2-12-20210203","doi-asserted-by":"crossref","first-page":"4575","DOI":"10.1200\/JCO.2007.11.0833","article-title":"Actual 10-year survival after resection of colorectal liver metastases defines cure.","volume":"25","author":"Tomlinson","year":"2007","journal-title":"J Clin Oncol"},{"issue":"3","key":"R3-12-20210203","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.jamcollsurg.2005.11.008","article-title":"Surgical resection of hepatic and pulmonary metastases from colorectal carcinoma.","volume":"202","author":"Shah","year":"2006","journal-title":"J Am Coll Surg"},{"issue":"3","key":"R4-12-20210203","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1245\/ASO.2004.03.085","article-title":"Results of R0 resection for colorectal liver metastases associated with extrahepatic disease.","volume":"11","author":"Elias","year":"2004","journal-title":"Ann Surg Oncol"},{"issue":"4","key":"R5-12-20210203","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s10434-001-0347-3","article-title":"Five-year survival following hepatic resection after neoadjuvant therapy for nonresectable colorectal.","volume":"8","author":"Adam","year":"2001","journal-title":"Ann Surg Oncol"},{"issue":"5","key":"R6-12-20210203","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1093\/annonc\/mdi246","article-title":"Neoadjuvant treatment of unresectable colorectal liver metastases: correlation between tumour response and resection rates.","volume":"16","author":"Folprecht","year":"2005","journal-title":"Ann Oncol"},{"issue":"19","key":"R7-12-20210203","doi-asserted-by":"crossref","first-page":"4006","DOI":"10.1200\/JCO.2002.12.075","article-title":"Biweekly chemotherapy with oxaliplatin, irinotecan, infusional Fluorouracil, and leucovorin: a pilot study in patients with metastatic colorectal cancer.","volume":"20","author":"Falcone","year":"2002","journal-title":"J Clin Oncol"},{"key":"R8-12-20210203","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1093\/annonc\/mdh470","article-title":"First line treatment of metastatic colorectal cancer with irinotecan, oxaliplatin and 5-fluorouracil\/leucovorin (FOLFOXIRI): results of phase II study with a simplified biweekly schedule.","volume":"15","author":"Masi","year":"2004","journal-title":"Ann Oncol"},{"issue":"1","key":"R9-12-20210203","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1245\/ASO.2006.03.094","article-title":"Treatment with 5-fluorouracil\/folinic acid, oxaliplatin and irinotecan (FOLFOXIRI) enables surgical resection of metastases in patients with initially unresectable metastatic colorectal cancer.","volume":"13","author":"Masi","year":"2006","journal-title":"Ann Surg Oncol"},{"issue":"13","key":"R10-12-20210203","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1200\/JCO.2006.09.0928","article-title":"Phase III trial of infusional fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI) compared with infusional fluorouracil, leucovorin, and irinotecan (FOLFIRI) as first-line treatment for metastatic colorectal cancer: the Gruppo Oncologico Nord Ovest.","volume":"25","author":"Falcone","year":"2007","journal-title":"J Clin Oncol"},{"issue":"31","key":"R11-12-20210203","doi-asserted-by":"crossref","first-page":"4954","DOI":"10.1200\/JCO.2006.07.9244","article-title":"Benefits and risks of neoadjuvant therapy for liver metastases.","volume":"24","author":"Nordlinger","year":"2006","journal-title":"J Clin Oncol"},{"issue":"3","key":"R12-12-20210203","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1093\/annonc\/mdh095","article-title":"Severe hepatic sinusoidal obstruction associated with oxaliplatin-based chemotherapy in patients with metastatic colorectal cancer.","volume":"15","author":"Rubbia-Brandt","year":"2004","journal-title":"Ann Oncol"},{"issue":"6","key":"R13-12-20210203","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1002\/hep.20701","article-title":"Design and validation of a histological scoring system for nonalcoholic fatty liver disease.","volume":"41","author":"Kleiner","year":"2005","journal-title":"Hepatology"},{"issue":"28","key":"R14-12-20210203","doi-asserted-by":"crossref","first-page":"7125","DOI":"10.1200\/JCO.2005.08.722","article-title":"OncoSurge: a strategy for improving resectability with curative intent in metastatic colorectal cancer.","volume":"23","author":"Poston","year":"2005","journal-title":"J Clin Oncol"},{"issue":"6","key":"R15-12-20210203","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1023\/A:1008347829017","article-title":"Long-term survival of patients with unresectable colorectal cancer liver metastases following infusional chemotherapy with 5-fluorouracil, leucovorin, oxaliplatin and surgery.","volume":"10","author":"Giacchetti","year":"1999","journal-title":"Ann Oncol"},{"issue":"8","key":"R16-12-20210203","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1038\/sj.bjc.6603988","article-title":"Final analysis of colorectal cancer patients treated with irinotecan and 5-fluorouracil plus folinic acid neoadjuvant chemotherapy for unresectable liver metastases.","volume":"97","author":"Barone","year":"2007","journal-title":"Br J Cancer"},{"issue":"9","key":"R17-12-20210203","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1200\/JCO.2005.00.349","article-title":"Neoadjuvant chemotherapy before liver resection for patients with unresectable liver metastases from colorectal carcinoma.","volume":"23","author":"Leonard","year":"2005","journal-title":"J Clin Oncol"},{"issue":"10","key":"R18-12-20210203","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1200\/JCO.2007.13.7471","article-title":"Complete pathologic response after preoperative chemotherapy for colorectal liver metastases: myth or realty?","volume":"26","author":"Adam","year":"2008","journal-title":"J Clin Oncol"},{"issue":"24","key":"R19-12-20210203","doi-asserted-by":"crossref","first-page":"3939","DOI":"10.1200\/JCO.2006.05.8727","article-title":"Complete response of colorectal liver metastases after chemotherapy: does it mean cure?","volume":"24","author":"Benoist","year":"2006","journal-title":"J Clin Oncol"},{"issue":"3","key":"R21-12-20210203","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/bjs.5719","article-title":"Chemotherapy-associated hepatotoxicity and surgery for colorectal liver metastases.","volume":"94","author":"Zorzi","year":"2007","journal-title":"Br J Surg"},{"issue":"13","key":"R22-12-20210203","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1200\/JCO.2005.05.3074","article-title":"Chemotherapy regimen predicts steatohepatitis and an increase in 90-day mortality after surgery for hepatic colorectal metastases.","volume":"24","author":"Vauthey","year":"2006","journal-title":"J Clin Oncol"},{"issue":"31","key":"R23-12-20210203","doi-asserted-by":"crossref","first-page":"4983","DOI":"10.1200\/JCO.2006.05.8156","article-title":"Liver histology and surgical outcomes after preoperative chemotherapy with fluorouracil plus oxaliplatin in colorectal cancer liver metastases.","volume":"24","author":"Aloia","year":"2006","journal-title":"J Clin Oncol"},{"issue":"1","key":"R24-12-20210203","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.sla.0000193603.26265.c3","article-title":"Influence of preoperative chemotherapy on the risk of major hepatectomy for colorectal liver metastases.","volume":"243","author":"Karoui","year":"2006","journal-title":"Ann Surg"},{"issue":"8","key":"R25-12-20210203","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.gassur.2003.09.012","article-title":"Impact of steatosis on perioperative outcome following hepatic resection.","volume":"7","author":"Kooby","year":"2003","journal-title":"J Gastrointest Surg"},{"issue":"3","key":"R26-12-20210203","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1097\/00000658-199909000-00004","article-title":"Clinical score for predicting recurrence after hepatic resection for metastatic colorectal cancer: analysis of 1001 consecutive cases.","volume":"230","author":"Fong","year":"1999","journal-title":"Ann Surg"},{"issue":"4","key":"R27-12-20210203","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1097\/01.sla.0000141198.92114.f6","article-title":"Rescue surgery for unresectable colorectal liver metastases downstaged by chemotherapy: a model to predict long-term survival.","volume":"240","author":"Adam","year":"2004","journal-title":"Ann Surg"},{"issue":"12","key":"R28-12-20210203","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1200\/JCO.2007.14.9930","article-title":"Bevacizumab in combination with oxaliplatin-based chemotherapy as first-line therapy in metastatic colorectal cancer: a randomized phase III study.","volume":"26","author":"Saltz","year":"2008","journal-title":"J Clin Oncol"}],"container-title":["Annals of Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.lww.com\/00000658-200903000-00012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T07:30:47Z","timestamp":1618039847000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00000658-200903000-00012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1097\/sla.0b013e31819a0486","relation":{},"ISSN":["0003-4932"],"issn-type":[{"value":"0003-4932","type":"print"}],"subject":[],"published":{"date-parts":[[2009,3]]}}}