{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T07:57:46Z","timestamp":1789891066132,"version":"4.0.1"},"reference-count":27,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,3]]},"DOI":"10.1097\/sla.0b013e3181cc939f","type":"journal-article","created":{"date-parts":[[2010,2,19]],"date-time":"2010-02-19T03:20:11Z","timestamp":1266549611000},"page":"499-505","source":"Crossref","is-referenced-by-count":574,"title":["Circulating microRNAs as Novel Minimally Invasive Biomarkers for Breast Cancer"],"prefix":"10.1097","volume":"251","author":[{"given":"Helen M.","family":"Heneghan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aoife J.","family":"Lowery","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karl J.","family":"Sweeney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Newell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Kerin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-19-20210203","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1093\/jnci\/djn172","article-title":"Mammography facility characteristics associated with interpretive accuracy of screening mammography.","volume":"100","author":"Taplin","year":"2008","journal-title":"J Natl Cancer Inst"},{"key":"R2-19-20210203","doi-asserted-by":"crossref","first-page":"R26","DOI":"10.1186\/bcr1983","article-title":"Evaluation of the current knowledge limitations in breast cancer research: a gap analysis.","volume":"10","author":"Thompson","year":"2008","journal-title":"Breast Cancer Res"},{"key":"R3-19-20210203","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1056\/NEJMoa052306","article-title":"Trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer.","volume":"353","author":"Piccart-Gebhart","year":"2005","journal-title":"N Engl J Med"},{"key":"R4-19-20210203","doi-asserted-by":"crossref","first-page":"5287","DOI":"10.1200\/JCO.2007.14.2364","article-title":"American Society of Clinical Oncology 2007 update of recommendations for the use of tumor markers in breast cancer.","volume":"25","author":"Harris","year":"2007","journal-title":"J Clin Oncol"},{"key":"R5-19-20210203","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1038\/bjc.1995.249","article-title":"An evaluation of preoperative CA 15\u20133 measurement in primary breast carcinoma.","volume":"71","author":"O'Hanlon","year":"1995","journal-title":"Br J Cancer"},{"key":"R6-19-20210203","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s10147-008-0773-3","article-title":"Long-term prognostic study of carcinoembryonic antigen (CEA) and carbohydrate antigen 15\u20133 (CA 15\u20133) in breast cancer.","volume":"13","author":"Uehara","year":"2007","journal-title":"Int J Clin Oncol"},{"key":"R7-19-20210203","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/nature03702","article-title":"MicroRNA expression profiles classify human cancers.","volume":"435","author":"Lu","year":"2005","journal-title":"Nature"},{"key":"R8-19-20210203","doi-asserted-by":"crossref","first-page":"7065","DOI":"10.1158\/0008-5472.CAN-05-1783","article-title":"MicroRNA gene expression deregulation in human breast cancer.","volume":"65","author":"Iorio","year":"2005","journal-title":"Cancer Res"},{"key":"R9-19-20210203","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1476-4598-5-24","article-title":"Optimized high-throughput microRNA expression profiling provides novel biomarker assessment of clinical prostate and breast cancer biopsies.","volume":"5","author":"Mattie","year":"2006","journal-title":"Mol Cancer"},{"key":"R10-19-20210203","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1472-6750-7-36","article-title":"Comparison of miRNA expression patterns using total RNA extracted from matched samples of formalin-fixed paraffin-embedded (FFPE) cells and snap frozen cells.","volume":"29","author":"Li","year":"2007","journal-title":"BMC Biotechnol"},{"key":"R11-19-20210203","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1111\/j.1365-2141.2008.07077.x","article-title":"Detection of elevated levels of tumor-associated microRNAs in serum of patients with diffuse large B-cell lymphoma.","volume":"141","author":"Lawrie","year":"2008","journal-title":"Br J Haematol"},{"key":"R12-19-20210203","doi-asserted-by":"crossref","first-page":"10513","DOI":"10.1073\/pnas.0804549105","article-title":"Circulating microRNAs as stable blood-based markers for cancer detection.","volume":"105","author":"Mitchell","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R13-19-20210203","doi-asserted-by":"crossref","first-page":"e3148","DOI":"10.1371\/journal.pone.0003148","article-title":"Serum MicroRNAs are promising novel biomarkers.","volume":"3","author":"Gilad","year":"2008","journal-title":"PLoS One"},{"key":"R14-19-20210203","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1038\/cr.2008.282","article-title":"Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases.","volume":"18","author":"Chen","year":"2008","journal-title":"Cell Res"},{"key":"R15-19-20210203","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ygyno.2008.08.036","article-title":"The detection of differentially expressed microRNAs from the serum of ovarian cancer patients using a novel real-time PCR platform.","volume":"112","author":"Resnick","year":"2009","journal-title":"Gynecol Oncol"},{"key":"R16-19-20210203","doi-asserted-by":"crossref","first-page":"4402","DOI":"10.1073\/pnas.0813371106","article-title":"Circulating microRNAs, potential biomarkers for drug-induced liver injury.","volume":"106","author":"Wang","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R17-19-20210203","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1158\/1078-0432.CCR-07-0992","article-title":"MicroRNAs as prognostic indicators and therapeutic targets: potential effect on breast cancer management.","volume":"14","author":"Lowery","year":"2008","journal-title":"Clin Cancer Res"},{"key":"R18-19-20210203","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/1471-2199-9-76","article-title":"Identification of suitable endogenous control genes for microRNA gene expression analysis in human breast cancer.","volume":"9","author":"Davoren","year":"2008","journal-title":"BMC Mol Biol"},{"key":"R19-19-20210203","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.tcb.2008.07.007","article-title":"The let-7 family of microRNAs.","volume":"18","author":"Roush","year":"2008","journal-title":"Trends Cell Biol"},{"key":"R20-19-20210203","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ccr.2006.01.025","article-title":"Unique microRNA molecular profiles in lung cancer diagnosis and prognosis.","volume":"9","author":"Yanaihara","year":"2006","journal-title":"Cancer Cell"},{"key":"R21-19-20210203","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1158\/0008-5472.CAN-06-4074","article-title":"The human let-7a-3 locus contains an epigenetically regulated microRNA gene with oncogenic function.","volume":"67","author":"Brueckner","year":"2007","journal-title":"Cancer Res"},{"key":"R22-19-20210203","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/cr.2008.290","article-title":"A truth serum for cancer\u2014microRNAs have major potential as cancer biomarkers.","volume":"18","author":"Chin","year":"2008","journal-title":"Cell Res"},{"key":"R23-19-20210203","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1261\/rna.1034808","article-title":"MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis.","volume":"14","author":"Yan","year":"2008","journal-title":"RNA"},{"key":"R24-19-20210203","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.1093\/nar\/gkp117","article-title":"Estradiol downregulates miR-21 expression and increases miR-21 target gene expression in MCF-7 breast cancer cells.","volume":"37","author":"Wickramasinghe","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"R25-19-20210203","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nature06174","article-title":"Tumor invasion and metastasis initiated by microRNA-10b in breast cancer.","volume":"449","author":"Ma","year":"2007","journal-title":"Nature"},{"key":"R26-19-20210203","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s10549-008-0219-7","article-title":"High miR-21 expression in breast cancer associated with poor disease-free survival in early stage disease and high TGF-beta1.","volume":"117","author":"Qian","year":"2008","journal-title":"Breast Cancer Res Treat"},{"key":"R27-19-20210203","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1002\/cncr.22618","article-title":"Descriptive analysis of estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER2-negative invasive breast cancer, the so-called triple-negative phenotype: a population-based study from the California cancer registry.","volume":"109","author":"Bauer","year":"2007","journal-title":"Cancer"}],"container-title":["Annals of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00000658-201003000-00019","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:14:36Z","timestamp":1786040076000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000658-201003000-00019"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1097\/sla.0b013e3181cc939f","relation":{},"ISSN":["0003-4932"],"issn-type":[{"value":"0003-4932","type":"print"}],"subject":[],"published":{"date-parts":[[2010,3]]}}}