{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:17:02Z","timestamp":1786119422811,"version":"build-2736575974"},"reference-count":52,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1097\/sla.0b013e3181d50299","type":"journal-article","created":{"date-parts":[[2010,3,19]],"date-time":"2010-03-19T04:47:38Z","timestamp":1268974058000},"page":"692-700","source":"Crossref","is-referenced-by-count":34,"title":["Inchinkoto, an Herbal Medicine, Exerts Beneficial Effects in the Rat Liver Under Stress With Hepatic Ischemia-Reperfusion and Subsequent Hepatectomy"],"prefix":"10.1097","volume":"251","author":[{"given":"Kiyotaka","family":"Kawai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukihiro","family":"Yokoyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshio","family":"Kokuryo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsutaka","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomomi","family":"Kitagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Nagino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-18-20210203","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1007\/s005340050064","article-title":"Mechanisms of reperfusion injury after warm ischemia of the liver.","volume":"5","author":"Jaeschke","year":"1998","journal-title":"J Hepatobiliary Pancreat Surg"},{"key":"R2-18-20210203","first-page":"G1137","article-title":"Prevention of Kupffer cell-induced oxidant injury in rat liver by atrial natriuretic peptide.","volume":"276","author":"Bilzer","year":"1999","journal-title":"Am J Physiol"},{"key":"R3-18-20210203","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jhep.2004.09.018","article-title":"Free radical scavenger (edaravone) prevents endotoxin-induced liver injury after partial hepatectomy in rats.","volume":"42","author":"Tsuji","year":"2005","journal-title":"J Hepatol"},{"key":"R4-18-20210203","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1111\/j.1432-2277.2005.00094.x","article-title":"MCI-186 (edaravone), a free radical scavenger, attenuates hepatic warm ischemia-reperfusion injury in rats.","volume":"18","author":"Suzuki","year":"2005","journal-title":"Transpl Int"},{"key":"R5-18-20210203","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1067\/msy.2002.121097","article-title":"P38 mitogen-activated protein kinase inhibition attenuates ischemia-reperfusion injury of the rat liver.","volume":"131","author":"Kobayashi","year":"2002","journal-title":"Surgery"},{"key":"R6-18-20210203","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/hep.1840130226","article-title":"Effects of cytokines on the liver.","volume":"13","author":"Andus","year":"1991","journal-title":"Hepatology"},{"key":"R7-18-20210203","first-page":"H2976","article-title":"Ischemia\/reperfusion-induced microvascular dysfunction: role of oxidants and lipid mediators.","volume":"272","author":"Kurose","year":"1997","journal-title":"Am J Physiol"},{"key":"R8-18-20210203","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1172\/JCI112990","article-title":"Conversion of xanthine dehydrogenase to oxidase in ischemic rat tissues.","volume":"79","author":"Engerson","year":"1987","journal-title":"J Clin Invest"},{"key":"R9-18-20210203","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1124\/pr.58.1.6","article-title":"Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol.","volume":"58","author":"Pacher","year":"2006","journal-title":"Pharmacol Rev"},{"key":"R10-18-20210203","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/0016-5085(95)90075-6","article-title":"Endotoxin-stimulated nitric oxide production increases injury and reduces rat liver chemiluminescence during reperfusion.","volume":"108","author":"Ma","year":"1995","journal-title":"Gastroenterology"},{"key":"R11-18-20210203","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1152\/physrev.00029.2006","article-title":"Nitric oxide and peroxynitrite in health and disease.","volume":"87","author":"Pacher","year":"2007","journal-title":"Physiol Rev"},{"key":"R12-18-20210203","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1002\/hep.510250514","article-title":"Reperfusion after liver transplantation in rats differentially activates the mitogen-activated protein kinases.","volume":"25","author":"Bradham","year":"1997","journal-title":"Hepatology"},{"key":"R13-18-20210203","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1016\/j.jhep.2005.01.030","article-title":"JNK mediates hepatic ischemia reperfusion injury.","volume":"42","author":"Uehara","year":"2005","journal-title":"J Hepatol"},{"key":"R14-18-20210203","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.2353\/ajpath.2006.050645","article-title":"Heat shock proteins and mitogen-activated protein kinases in steatotic livers undergoing ischemia-reperfusion: some answers.","volume":"168","author":"Massip-Salcedo","year":"2006","journal-title":"Am J Pathol"},{"key":"R15-18-20210203","doi-asserted-by":"crossref","first-page":"21256","DOI":"10.1074\/jbc.M510644200","article-title":"JNK- and p38 kinase-mediated phosphorylation of Bax leads to its activation and mitochondrial translocation and to apoptosis of human hepatoma HepG2 cells.","volume":"281","author":"Kim","year":"2006","journal-title":"J Biol Chem"},{"key":"R16-18-20210203","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/S0016-5085(00)70220-4","article-title":"Genipin, a metabolite derived from the herbal medicine Inchin-ko-to, and suppression of Fas-induced lethal liver apoptosis in mice.","volume":"118","author":"Yamamoto","year":"2000","journal-title":"Gastroenterology"},{"key":"R17-18-20210203","first-page":"552","article-title":"The herbal medicine Inchin-ko-to inhibits liver cell apoptosis induced by transforming growth factor beta 1.","volume":"23","author":"Yamamoto","year":"1996","journal-title":"Hepatology"},{"key":"R18-18-20210203","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1007\/s003830000561","article-title":"Beneficial effect of a traditional herbal medicine (inchin-ko-to) in postoperative biliary atresia patients.","volume":"17","author":"Kobayashi","year":"2001","journal-title":"Pediatr Surg Int"},{"key":"R19-18-20210203","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/hep.20003","article-title":"Genipin enhances Mrp2 (Abcc2)-mediated bile formation and organic anion transport in rat liver.","volume":"39","author":"Shoda","year":"2004","journal-title":"Hepatology"},{"key":"R20-18-20210203","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1872-034X.2008.00453.x","article-title":"Choleretic effect of inchinkoto, a herbal medicine, on livers of patients with biliary obstruction due to bile duct carcinoma.","volume":"39","author":"Watanabe","year":"2009","journal-title":"Hepatol Res"},{"key":"R21-18-20210203","doi-asserted-by":"crossref","first-page":"G1450","DOI":"10.1152\/ajpgi.00302.2006","article-title":"Inchinkoto, a herbal medicine, and its ingredients dually exert Mrp2\/MRP2-mediated choleresis and Nrf2-mediated antioxidative action in rat livers.","volume":"292","author":"Okada","year":"2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"R22-18-20210203","doi-asserted-by":"crossref","first-page":"G582","DOI":"10.1152\/ajpgi.00374.2006","article-title":"Does estrogen contribute to the hepatic regeneration following portal branch ligation in rats?","volume":"292","author":"Kawai","year":"2007","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"R23-18-20210203","doi-asserted-by":"crossref","first-page":"8380","DOI":"10.1074\/jbc.M211086200","article-title":"Lack of tyrosine nitration by hypochlorous acid in the presence of physiological concentrations of nitrite. Implications for the role of nitryl chloride in tyrosine nitration in vivo.","volume":"278","author":"Whiteman","year":"2003","journal-title":"J Biol Chem"},{"key":"R24-18-20210203","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.canlet.2008.01.035","article-title":"MEK inhibitor enhances the inhibitory effect of imatinib on pancreatic cancer cell growth.","volume":"264","author":"Takayama","year":"2008","journal-title":"Cancer Lett"},{"key":"R25-18-20210203","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1600-065X.1992.tb01407.x","article-title":"IL-6 and NF-IL6 in acute-phase response and viral infection.","volume":"127","author":"Akira","year":"1992","journal-title":"Immunol Rev"},{"key":"R26-18-20210203","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s00726-004-0078-4","article-title":"Arginine pathways and the inflammatory response: interregulation of nitric oxide and polyamines: review article.","volume":"26","author":"Satriano","year":"2004","journal-title":"Amino Acids"},{"key":"R27-18-20210203","doi-asserted-by":"crossref","first-page":"2073","DOI":"10.1016\/S0024-3205(97)00585-7","article-title":"Nitric oxide and inflammatory arthritides.","volume":"61","author":"Miyasaka","year":"1997","journal-title":"Life Sci"},{"key":"R28-18-20210203","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.niox.2008.04.010","article-title":"Tumoricidal activity of endothelium-derived NO and the survival of metastatic cells with high GSH and Bcl-2 levels.","volume":"19","author":"Ortega","year":"2008","journal-title":"Nitric Oxide"},{"key":"R29-18-20210203","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0165-6147(00)01499-1","article-title":"The dual personality of NO.","volume":"21","author":"Colasanti","year":"2000","journal-title":"Trends Pharmacol Sci"},{"key":"R30-18-20210203","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1006\/bbrc.1999.1143","article-title":"Hepatic ischemia\/reperfusion in rats induces iNOS gene transcription by activation of NF-kappaB.","volume":"261","author":"Hur","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"R31-18-20210203","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1248\/bpb.17.1573","article-title":"Enzymic studies on the animal and intestinal bacterial metabolism of geniposide.","volume":"17","author":"Akao","year":"1994","journal-title":"Biol Pharm Bull"},{"key":"R32-18-20210203","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/372739a0","article-title":"A protein kinase involved in the regulation of inflammatory cytokine biosynthesis.","volume":"372","author":"Lee","year":"1994","journal-title":"Nature"},{"key":"R33-18-20210203","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1002\/bjs.5329","article-title":"Involvement of protein kinase B and mitogen-activated protein kinases in experimental normothermic liver ischaemia-reperfusion injury.","volume":"93","author":"Cursio","year":"2006","journal-title":"Br J Surg"},{"key":"R34-18-20210203","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1053\/jhep.2000.9323","article-title":"Inflammatory mechanisms and therapeutic strategies for warm hepatic ischemia\/reperfusion injury.","volume":"32","author":"Lentsch","year":"2000","journal-title":"Hepatology"},{"key":"R35-18-20210203","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1016\/j.freeradbiomed.2005.02.004","article-title":"Lipid peroxidation during ischemia depends on ischemia time in warm ischemia and reperfusion of rat liver.","volume":"38","author":"Fukai","year":"2005","journal-title":"Free Radic Biol Med"},{"key":"R36-18-20210203","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1097\/00007890-200205150-00013","article-title":"A novel inhibitor of inducible nitric oxide synthase (ONO-1714) prevents critical warm ischemia-reperfusion injury in the pig liver.","volume":"73","author":"Meguro","year":"2002","journal-title":"Transplantation"},{"key":"R37-18-20210203","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1189\/jlb.71.6.1005","article-title":"Regulation of cyclooxygenase-2 by nitric oxide in activated hepatic macrophages during acute endotoxemia.","volume":"71","author":"Ahmad","year":"2002","journal-title":"J Leukoc Biol"},{"key":"R38-18-20210203","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1023\/A:1005498402659","article-title":"Calcium-channel blocker attenuates Kupffer cell production of cytokine-induced neutrophil chemoattractant following ischemia-reperfusion in rat liver.","volume":"45","author":"Liang","year":"2000","journal-title":"Dig Dis Sci"},{"key":"R39-18-20210203","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/S0002-9610(00)00573-0","article-title":"Hepatic ischemia-reperfusion injury.","volume":"181","author":"Serracino-Inglott","year":"2001","journal-title":"Am J Surg"},{"key":"R40-18-20210203","doi-asserted-by":"crossref","first-page":"G15","DOI":"10.1152\/ajpgi.00342.2002","article-title":"Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning.","volume":"284","author":"Jaeschke","year":"2003","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"R41-18-20210203","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1097\/00000658-199010000-00009","article-title":"Multiple cytokines are required to induce hepatocyte nitric oxide production and inhibit total protein synthesis.","volume":"212","author":"Curran","year":"1990","journal-title":"Ann Surg"},{"key":"R42-18-20210203","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1084\/jem.176.1.261","article-title":"Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin.","volume":"176","author":"Nussler","year":"1992","journal-title":"J Exp Med"},{"key":"R43-18-20210203","doi-asserted-by":"crossref","first-page":"4890","DOI":"10.4049\/jimmunol.155.10.4890","article-title":"A central role for IL-1 beta in the in vitro and in vivo regulation of hepatic inducible nitric oxide synthase. IL-1 beta induces hepatic nitric oxide synthesis.","volume":"155","author":"Geller","year":"1995","journal-title":"J Immunol"},{"key":"R44-18-20210203","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.cyto.2006.04.009","article-title":"Mechanisms of interleukin-6 protection against ischemia-reperfusion injury in rat liver.","volume":"34","author":"Tiberio","year":"2006","journal-title":"Cytokine"},{"key":"R45-18-20210203","first-page":"415","article-title":"Role of oxygen-derived free radicals in digestive tract diseases.","volume":"94","author":"Parks","year":"1983","journal-title":"Surgery"},{"key":"R46-18-20210203","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1053\/jhep.2001.23073","article-title":"Subcellular site of superoxide dismutase expression differentially controls AP-1 activity and injury in mouse liver following ischemia\/reperfusion.","volume":"33","author":"Zhou","year":"2001","journal-title":"Hepatology"},{"key":"R47-18-20210203","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1172\/JCI117607","article-title":"Quantitation of nitrotyrosine levels in lung sections of patients and animals with acute lung injury.","volume":"94","author":"Haddad","year":"1994","journal-title":"J Clin Invest"},{"key":"R48-18-20210203","first-page":"3607","article-title":"Lipid peroxidation and peroxynitrite in retinal ischemia-reperfusion injury.","volume":"41","author":"Shibuki","year":"2000","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R49-18-20210203","doi-asserted-by":"crossref","first-page":"C341","DOI":"10.1152\/ajpcell.2000.279.2.C341","article-title":"Peroxynitrite-induced apoptosis involves activation of multiple caspases in HL-60 cells.","volume":"279","author":"Zhuang","year":"2000","journal-title":"Am J Physiol Cell Physiol"},{"key":"R50-18-20210203","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s10620-006-3172-5","article-title":"Inhibition of inducible nitric oxide synthase prevents hepatic, but not pulmonary, injury following ischemia-reperfusion of rat liver.","volume":"51","author":"Takamatsu","year":"2006","journal-title":"Dig Dis Sci"},{"key":"R51-18-20210203","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1172\/JCI200418385","article-title":"A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR.","volume":"113","author":"Huang","year":"2004","journal-title":"J Clin Invest"},{"key":"R52-18-20210203","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s002040050615","article-title":"Protective effects of capillarisin on tert-butylhydroperoxide-induced oxidative damage in rat primary hepatocytes.","volume":"73","author":"Chu","year":"1999","journal-title":"Arch Toxicol"}],"container-title":["Annals of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/SLA.0b013e3181d50299","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:15:53Z","timestamp":1786040153000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000658-201004000-00018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1097\/sla.0b013e3181d50299","relation":{},"ISSN":["0003-4932"],"issn-type":[{"value":"0003-4932","type":"print"}],"subject":[],"published":{"date-parts":[[2010,4]]}}}