{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:19:23Z","timestamp":1786119563391,"version":"build-2736575974"},"reference-count":21,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,11]]},"DOI":"10.1097\/sla.0b013e3181fdc54c","type":"journal-article","created":{"date-parts":[[2010,10,29]],"date-time":"2010-10-29T05:07:21Z","timestamp":1288328841000},"page":"869-875","source":"Crossref","is-referenced-by-count":27,"title":["Bacterial Colonization of Colonic Crypt Mucous Gel and Disease Activity in Ulcerative Colitis"],"prefix":"10.1097","volume":"252","author":[{"given":"Fiachra","family":"Rowan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil G.","family":"Docherty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madeline","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. Brendan","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Calvin","family":"Coffey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. Ronan","family":"O'Connell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20-20210203","first-page":"9","article-title":"Intestinal bacteria and ulcerative colitis.","volume":"41","author":"Cummings","year":"2003","journal-title":"Curr Issues Intest Microbiol"},{"key":"R2-20-20210203","doi-asserted-by":"crossref","first-page":"1690","DOI":"10.1086\/420823","article-title":"Chemotaxonomic analysis of bacterial populations colonizing the rectal mucosa in patients with ulcerative colitis.","volume":"3812","author":"Macfarlane","year":"2004","journal-title":"Clin Infect Dis"},{"key":"R3-20-20210203","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1126\/science.1124234","article-title":"Metagenomic analysis of the human distal gut microbiome.","volume":"3125778","author":"Gill","year":"2006","journal-title":"Science"},{"key":"R5-20-20210203","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1126\/science.1106442","article-title":"Immunity, inflammation, and allergy in the gut.","volume":"3075717","author":"Macdonald","year":"2005","journal-title":"Science"},{"key":"R6-20-20210203","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.3748\/wjg.v11.i8.1131","article-title":"Spatial organization of bacterial flora in normal and inflamed intestine: a fluorescence in situ hybridization study in mice.","volume":"118","author":"Swidsinski","year":"2005","journal-title":"World J Gastroenterol"},{"key":"R7-20-20210203","doi-asserted-by":"crossref","first-page":"3380","DOI":"10.1128\/JCM.43.7.3380-3389.2005","article-title":"Spatial organization and composition of the mucosal flora in patients with inflammatory bowel disease.","volume":"437","author":"Swidsinski","year":"2005","journal-title":"J Clin Microbiol"},{"key":"R9-20-20210203","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1128\/IAI.23.1.128-132.1979","article-title":"Adhesion of commensal bacteria to the large intestine wall in humans.","volume":"231","author":"Hartley","year":"1979","journal-title":"Infect Immun"},{"key":"R10-20-20210203","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1002\/path.2006","article-title":"Validation of 16s DNA sequencing in microdissected bowel biopsies from Crohns disease patients to assess bacterial flora diversity.","volume":"2094","author":"De Hertogh","year":"2006","journal-title":"J Pathol"},{"key":"R12-20-20210203","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1136\/gut.2003.031245","article-title":"Identification and quantitation of mucosal and faecal desulfovibrios using real time polymerase chain reaction.","volume":"534","author":"Fite","year":"2004","journal-title":"Gut"},{"key":"R13-20-20210203","doi-asserted-by":"crossref","first-page":"963","DOI":"10.2307\/2529876","article-title":"Random-effects models for longitudinal data.","volume":"384","author":"Laird","year":"1982","journal-title":"Biometrics"},{"key":"R14-20-20210203","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1002\/(SICI)1097-0258(19971030)16:20<2349::AID-SIM667>3.0.CO;2-E","article-title":"Using the general linear mixed model to analyse unbalanced repeated measures and longitudinal data.","volume":"1620","author":"Cnaan","year":"1997","journal-title":"Stat Med"},{"key":"R15-20-20210203","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1136\/gut.2006.098160","article-title":"Comparative study of the intestinal mucus barrier in normal and inflamed colon.","volume":"563","author":"Swidsinski","year":"2007","journal-title":"Gut"},{"key":"R16-20-20210203","doi-asserted-by":"crossref","first-page":"2629","DOI":"10.1128\/JB.186.9.2629-2635.2004","article-title":"Divergence and redundancy of 16S rRNA sequences in genomes with multiple rrn operons.","volume":"1869","author":"Acinas","year":"2004","journal-title":"J Bacteriol"},{"key":"R17-20-20210203","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/dnares\/dsn033","article-title":"The human intestinal microbiome: a new frontier of human biology.","volume":"161","author":"Hattori","year":"2009","journal-title":"DNA Res"},{"key":"R18-20-20210203","doi-asserted-by":"crossref","first-page":"15064","DOI":"10.1073\/pnas.0803124105","article-title":"The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria.","volume":"10539","author":"Johansson","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R19-20-20210203","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.femsec.2005.03.001","article-title":"Characterisation of intestinal bacteria in infant stools using real-time PCR and northern hybridisation analyses.","volume":"541","author":"Hopkins","year":"2005","journal-title":"FEMS Microbiol Ecol"},{"key":"R20-20-20210203","doi-asserted-by":"crossref","first-page":"6113","DOI":"10.1128\/AEM.70.10.6113-6122.2004","article-title":"Comparison of compositions and metabolic activities of fecal microbiotas in young adults and in antibiotic-treated and non-antibiotic-treated elderly subjects.","volume":"7010","author":"Woodmansey","year":"2004","journal-title":"Appl Environ Microbiol"},{"key":"R21-20-20210203","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/S0016-5085(99)70393-8","article-title":"The intestinal mucus layer from patients with inflammatory bowel disease harbors high numbers of bacteria compared with controls.","volume":"1175","author":"Schultsz","year":"1999","journal-title":"Gastroenterology"},{"key":"R22-20-20210203","doi-asserted-by":"crossref","first-page":"2566","DOI":"10.1128\/JCM.42.6.2566-2572.2004","article-title":"Quantification of intestinal bacterial populations by real-time PCR with a universal primer set and minor groove binder probes: a global approach to the enteric flora.","volume":"426","author":"Ott","year":"2004","journal-title":"J Clin Microbiol"},{"key":"R23-20-20210203","doi-asserted-by":"crossref","first-page":"2820","DOI":"10.1111\/j.1572-0241.2002.07029.x","article-title":"Cytokine profile in colonic mucosa of ulcerative colitis correlates with disease activity and response to granulocytapheresis.","volume":"9711","author":"Tsukada","year":"2002","journal-title":"Am J Gastroenterol"},{"key":"R24-20-20210203","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/nature06005","article-title":"Unravelling the pathogenesis of inflammatory bowel disease.","volume":"4487152","author":"Xavier","year":"2007","journal-title":"Nature"}],"container-title":["Annals of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00000658-201011000-00020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:34:59Z","timestamp":1786041299000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000658-201011000-00020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1097\/sla.0b013e3181fdc54c","relation":{},"ISSN":["0003-4932"],"issn-type":[{"value":"0003-4932","type":"print"}],"subject":[],"published":{"date-parts":[[2010,11]]}}}