{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T02:02:48Z","timestamp":1790128968177,"version":"4.0.1"},"reference-count":52,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,9]]},"DOI":"10.1097\/spc.0b013e32833d303b","type":"journal-article","created":{"date-parts":[[2010,7,23]],"date-time":"2010-07-23T06:02:02Z","timestamp":1279864922000},"page":"200-206","source":"Crossref","is-referenced-by-count":25,"title":["Updates on osteonecrosis of the jaw"],"prefix":"10.1097","volume":"4","author":[{"given":"Junro","family":"Yamashita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie K","family":"McCauley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Van Poznak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-16-20211004","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.bone.2008.09.012","article-title":"Osteonecrosis of the jaw: who gets it, and why?","volume":"44","author":"Reid","year":"2009","journal-title":"Bone"},{"key":"R2-16-20211004","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/07357900802208608","article-title":"Higher incidence of osteonecrosis of the jaw (ONJ) in patients with metastatic castration resistant prostate cancer treated with antiangiogenic agents","volume":"27","author":"Aragon-Ching","year":"2009","journal-title":"Cancer Invest"},{"key":"R3-16-20211004","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1359\/jbmr.0707onj","article-title":"Bisphosphonate-associated osteonecrosis of the jaw: report of a Task Force of the American Society for Bone and Mineral Research","volume":"22","author":"Khosla","year":"2007","journal-title":"J Bone Min Res"},{"key":"R4-16-20211004","doi-asserted-by":"crossref","first-page":"864","DOI":"10.14219\/jada.archive.2009.0280","article-title":"Bisphosphonate and nonbisphosphonate-associated osteonecrosis of the jaw: a review","volume":"140","author":"Almazrooa","year":"2009","journal-title":"J Am Dent Assoc"},{"issue":"Suppl 5","key":"R5-16-20211004","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.joms.2009.01.005","article-title":"Epidemiology of bisphosphonate-related osteonecrosis of the jaws: the utility of a national registry","volume":"67","author":"Gliklich","year":"2009","journal-title":"J Oral Maxillofac Surg"},{"issue":"Suppl 5","key":"R6-16-20211004","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.joms.2009.01.007","article-title":"The pathogenesis of bisphosphonate-related osteonecrosis of the jaw: so many hypotheses, so few data","volume":"67","author":"Allen","year":"2009","journal-title":"J Oral Maxillofac Surg"},{"key":"R7-16-20211004","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S1359-6349(09)72028-2","article-title":"Denosumab versus zoledronic acid for the treatment of breast cancer patients with bone metastases: results of a randomized phase 3 study","volume":"7","author":"Stopeck","year":"2009","journal-title":"Eur J Cancer Suppl"},{"key":"R8-16-20211004","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S1359-6349(09)72055-5","article-title":"A double-blind, randomized study of denosumab versus zoledronic acid for the treatment of bone metastases in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma","volume":"7","author":"Henry","year":"2009","journal-title":"Eur J Cancer Suppl"},{"key":"R9-16-20211004","doi-asserted-by":"crossref","first-page":"590","DOI":"10.4158\/EP09115.RA","article-title":"Is Vitamin D the fountain of youth?","volume":"15","author":"Binkley","year":"2009","journal-title":"Endocr Pract"},{"key":"R10-16-20211004","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/j.1365-2141.2008.07214.x","article-title":"Prevalence and significance of vitamin D deficiency in multiple myeloma patients","volume":"142","author":"Badros","year":"2008","journal-title":"Br J Haemat"},{"key":"R11-16-20211004","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1210\/jc.2009-1773","article-title":"Update in Vitamin D","volume":"95","author":"Adams","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"R12-16-20211004","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1634\/theoncologist.2008-0013","article-title":"Evaluation of vitamin D deficiency in breast cancer patients on bisphosphonates","volume":"13","author":"Wang-Gillam","year":"2008","journal-title":"Oncologist"},{"key":"R13-16-20211004","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1200\/JCO.2008.19.6162","article-title":"High prevalence of vitamin D deficiency despite supplementation in premenopausal women with breast cancer undergoing adjuvant chemotherapy","volume":"27","author":"Crew","year":"2009","journal-title":"J Clin Oncol"},{"key":"R14-16-20211004","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/ajh.21412","article-title":"Impact of vitamin D deficiency on the clinical presentation and prognosis of patients with newly diagnosed multiple myeloma","volume":"84","author":"Ng","year":"2009","journal-title":"Am J Hematol"},{"key":"R15-16-20211004","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1111\/j.1464-410X.2009.08531.x","article-title":"Vitamin D deficiency and insufficiency among patients with prostate cancer.","volume":"104","author":"Trump","year":"2009","journal-title":"BJU Int"},{"key":"R16-16-20211004","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1016\/j.joms.2009.09.052","article-title":"Osteonecrosis or metastases of the jaw or both? Case report and review of the literature","volume":"68","author":"Otto","year":"2010","journal-title":"J Oral Maxillofac Surg"},{"key":"R17-16-20211004","doi-asserted-by":"crossref","first-page":"5356","DOI":"10.1200\/JCO.2009.21.9584","article-title":"Longitudinal cohort study of risk factors in cancer patients of bisphosphonate-related osteonecrosis of the jaw","volume":"27","author":"Vahtsevanos","year":"2009","journal-title":"J Clin Oncol"},{"key":"R19-16-20211004","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1056\/NEJM199512283332608","article-title":"Clinical applications of research on angiogenesis","volume":"333","author":"Folkman","year":"1995","journal-title":"N Engl J Med"},{"key":"R20-16-20211004","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/nrclinonc.2009.52","article-title":"Anticancer strategies involving the vasculature","volume":"6","author":"Heath","year":"2009","journal-title":"Nat Rev Clin Oncol"},{"key":"R21-16-20211004","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1093\/annonc\/mdn653","article-title":"Bevacizumab-associated osteonecrosis of the jaw","volume":"19","author":"Greuter","year":"2008","journal-title":"Ann Oncol"},{"key":"R22-16-20211004","doi-asserted-by":"crossref","first-page":"4037","DOI":"10.1200\/JCO.2007.15.5424","article-title":"Osteonecrosis of the jaw related to bevacizumab","volume":"26","author":"Estilo","year":"2008","journal-title":"J Clin Oncol"},{"key":"R23-16-20211004","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1093\/annonc\/mdn788","article-title":"Osteonecrosis of the jaw under bisphosphonate and antiangiogenic therapies: cumulative toxicity profile?","volume":"20","author":"Ayllon","year":"2009","journal-title":"Ann Oncol"},{"key":"R24-16-20211004","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.bone.2008.08.132","article-title":"Worsening of osteonecrosis of the jaw during treatment with sunitinib in a patient with metastatic renal cell carcinoma","volume":"44","author":"Brunello","year":"2009","journal-title":"Bone"},{"key":"R25-16-20211004","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s10549-010-0866-3","article-title":"Bevacizumab and osteonecrosis of the jaw: incidence and association with bisphosphonate therapy in three large prospective trials in advanced breast cancer.","volume":"122","author":"Guarneri","year":"2010","journal-title":"Breast Cancer Res Treat"},{"key":"R26-16-20211004","doi-asserted-by":"crossref","first-page":"9588","DOI":"10.1200\/jco.2008.26.15_suppl.9588","article-title":"Osteonecrosis of the jaw (ONJ) among intravenous (IV) bisphosphonate- and\/or bevacizumab-treated patients (pts) at Memorial Sloan-Kettering Cancer Center (MSKCC)","volume":"26","author":"McArthur","year":"2008","journal-title":"J Clin Oncol"},{"key":"R27-16-20211004","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1182\/blood-2008-04-147884","article-title":"Bisphosphonate-related osteonecrosis of the jaw is associated with polymorphisms of the cytochrome P450 CYP2C8 in multiple myeloma: a genome-wide single nucleotide polymorphism analysis","volume":"112","author":"Sarasquete","year":"2008","journal-title":"Blood"},{"key":"R28-16-20211004","doi-asserted-by":"crossref","first-page":"5489","DOI":"10.1242\/jcs.02674","article-title":"Cytochrome P450 epoxygenases 2C8 and 2C9 are implicated in hypoxia-induced endothelial cell migration and angiogenesis","volume":"118","author":"Michaelis","year":"2005","journal-title":"J Cell Sci"},{"issue":"Suppl 1","key":"R29-16-20211004","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.joms.2008.12.003","article-title":"Utility of hyperbaric oxygen in treatment of bisphosphonate-related osteonecrosis of the jaws","volume":"67","author":"Freiberger","year":"2009","journal-title":"J Oral Maxillofac Surg"},{"key":"R30-16-20211004","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1359\/jbmr.081210","article-title":"Osteocyte apoptosis controls activation of intracortical resorption in response to bone fatigue","volume":"24","author":"Cardoso","year":"2009","journal-title":"J Bone Miner Res"},{"key":"R32-16-20211004","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1359\/jbmr.091009","article-title":"Fluorescent risedronate analogs reveal bisphosphonate uptake by bone marrow monocytes and localization around osteocytes in vivo","volume":"25","author":"Roelofs","year":"2010","journal-title":"J Bone Miner Res"},{"key":"R33-16-20211004","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.joms.2008.01.038","article-title":"Mandible matrix necrosis in beagle dogs after 3 years of daily oral bisphosphonate treatment","volume":"66","author":"Allen","year":"2008","journal-title":"J Oral Maxillofac Surg"},{"key":"R34-16-20211004","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ar.20619","article-title":"Bone remodeling in maxilla, mandible, and femur of young dogs","volume":"291","author":"Huja","year":"2008","journal-title":"Anat Rec (Hoboken)"},{"key":"R35-16-20211004","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1359\/jbmr.090713","article-title":"Cancer treatment dosing regimens of zoledronic acid result in near complete suppression of mandible intra-cortical bone remodeling in beagle dogs","volume":"25","author":"Allen","year":"2010","journal-title":"J Bone Miner Res"},{"key":"R36-16-20211004","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1749-6632.2009.05210.x","article-title":"Effects of antiresorptive agents on osteomyelitis: novel insights into the pathogenesis of osteonecrosis of the jaw","volume":"1192","author":"Li","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"R37-16-20211004","doi-asserted-by":"crossref","first-page":"6800","DOI":"10.1021\/jm801003y","article-title":"Design, synthesis, and biological evaluation of novel aminobisphosphonates possessing an in vivo antitumor activity through a gammadelta-T lymphocytes-mediated activation mechanism","volume":"51","author":"Simoni","year":"2008","journal-title":"J Med Chem"},{"key":"R38-16-20211004","doi-asserted-by":"crossref","first-page":"522","DOI":"10.4049\/jimmunol.182.1.522","article-title":"Activated V gamma 9V delta 2 T cells trigger granulocyte functions via MCP-2 release","volume":"182","author":"Agrati","year":"2009","journal-title":"J Immunol"},{"key":"R39-16-20211004","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.bone.2007.12.225","article-title":"Visualizing mineral binding and uptake of bisphosphonate by osteoclasts and nonresorbing cells","volume":"42","author":"Coxon","year":"2008","journal-title":"Bone"},{"key":"R40-16-20211004","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.intimp.2009.05.010","article-title":"Mouse macrophages primed with alendronate down-regulate monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1alpha (MIP-1alpha) production in response to Toll-like receptor (TLR) 2 and TLR4 agonist via Smad3 activation","volume":"9","author":"Masuda","year":"2009","journal-title":"Int Immunopharmacol"},{"key":"R41-16-20211004","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1080\/08923970902814103","article-title":"Zoledronic acid, an aminobisphosphonate, modulates differentiation and maturation of human dendritic cells","volume":"31","author":"Chen","year":"2009","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"R42-16-20211004","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.oraloncology.2008.04.013","article-title":"Bony changes in the jaws of rats treated with zoledronic acid and dexamethasone before dental extractions mimic bisphosphonate-related osteonecrosis in cancer patients","volume":"45","author":"Sonis","year":"2009","journal-title":"Oral Oncol"},{"key":"R43-16-20211004","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1111\/j.1365-2141.2007.06705.x","article-title":"Immunodeficiency and immunotherapy in multiple myeloma","volume":"138","author":"Pratt","year":"2007","journal-title":"Br J Haematol"},{"key":"R45-16-20211004","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1002\/jbmr.23","article-title":"Increased prevalence of bisphosphonate-related osteonecrosis of the jaw with vitamin D deficiency in rats.","volume":"25","author":"Hokugo","year":"2010","journal-title":"J Bone Miner Res"},{"key":"R46-16-20211004","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D deficiency","volume":"357","author":"Holick","year":"2007","journal-title":"N Engl J Med"},{"key":"R47-16-20211004","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00774-009-0128-9","article-title":"Zoledronic acid delays wound healing of the tooth extraction socket, inhibits oral epithelial cell migration, and promotes proliferation and adhesion to hydroxyapatite of oral bacteria, without causing osteonecrosis of the jaw, in mice","volume":"28","author":"Kobayashi","year":"2010","journal-title":"J Bone Miner Metab"},{"key":"R48-16-20211004","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s00774-009-0090-6","article-title":"Bisphosphonate administration prior to tooth extraction delays initial healing of the extraction socket in rats","volume":"27","author":"Hikita","year":"2009","journal-title":"J Bone Miner Metab"},{"key":"R49-16-20211004","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1182\/blood-2009-08-237628","article-title":"Osteoclasts are important for bone angiogenesis","volume":"115","author":"Cackowski","year":"2010","journal-title":"Blood"},{"key":"R50-16-20211004","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.bone.2009.01.010","article-title":"The bisphosphonate zoledronic acid decreases tumor growth in bone in mice with defective osteoclasts","volume":"44","author":"Hirbe","year":"2009","journal-title":"Bone"},{"key":"R51-16-20211004","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.coi.2010.01.009","article-title":"Macrophages, innate immunity and cancer: balance, tolerance, and diversity.","volume":"22","author":"Mantovani","year":"2010","journal-title":"Curr Opin Immunol"},{"key":"R52-16-20211004","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.bone.2009.07.011","article-title":"Bisphosphonate-associated osteonecrosis of the jaw: a key role of inflammation?","volume":"45","author":"Lesclous","year":"2009","journal-title":"Bone"},{"key":"R53-16-20211004","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.14219\/jada.archive.2009.0049","article-title":"Microbial biofilms in osteomyelitis of the jaw and osteonecrosis of the jaw secondary to bisphosphonate therapy","volume":"140","author":"Sedghizadeh","year":"2009","journal-title":"J Am Dent Assoc"},{"key":"R54-16-20211004","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1034\/j.1600-051X.2003.00366.x","article-title":"Dynamics of bone tissue formation in tooth extraction sites: an experimental study in dogs","volume":"30","author":"Cardaropoli","year":"2003","journal-title":"J Clin Periodontol"},{"key":"R55-16-20211004","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1148\/radiol.2413051858","article-title":"Vertebral marrow fat content and diffusion and perfusion indexes in women with varying bone density: MR evaluation","volume":"241","author":"Griffith","year":"2006","journal-title":"Radiology"}],"container-title":["Current Opinion in Supportive & Palliative Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/01263393-201009000-00016","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:32:34Z","timestamp":1786041154000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/01263393-201009000-00016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,9]]},"references-count":52,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1097\/spc.0b013e32833d303b","relation":{},"ISSN":["1751-4258"],"issn-type":[{"value":"1751-4258","type":"print"}],"subject":[],"published":{"date-parts":[[2010,9]]}}}