{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:14:51Z","timestamp":1786119291391,"version":"build-2736575974"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,11]]},"DOI":"10.1097\/ta.0b013e3181c6619d","type":"journal-article","created":{"date-parts":[[2010,3,25]],"date-time":"2010-03-25T02:29:20Z","timestamp":1269484160000},"page":"1196-1202","source":"Crossref","is-referenced-by-count":2,"title":["rFVIIa and NN1731 Reduce Bleeding in Hydroxyethyl Starch Hemodiluted Rabbits"],"prefix":"10.1097","volume":"69","author":[{"given":"Brian","family":"Lauritzen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorthe","family":"Viuff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael","family":"Tranholm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirella","family":"Ezban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-27-20210211","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1136\/bmj.296.6632.1305","article-title":"Retrospective study of 1000 deaths from injury in England and Wales.","volume":"296","author":"Anderson","year":"1988","journal-title":"BMJ (Clin Res Ed)"},{"key":"R2-27-20210211","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/00005373-199502000-00006","article-title":"Epidemiology of trauma deaths: a reassessment.","volume":"38","author":"Sauaia","year":"1995","journal-title":"J Trauma"},{"issue":"suppl 2","key":"R3-27-20210211","doi-asserted-by":"crossref","first-page":"S241","DOI":"10.1007\/s00134-002-1471-7","article-title":"Updates in the management of severe coagulopathy in trauma patients.","volume":"28","author":"Lynn","year":"2002","journal-title":"Intensive Care Med"},{"key":"R4-27-20210211","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1007\/s00268-006-0653-9","article-title":"Coagulopathy: its pathophysiology and treatment in the injured patient.","volume":"31","author":"Tieu","year":"2007","journal-title":"World J Surg"},{"key":"R5-27-20210211","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1177\/000313480206800702","article-title":"Blood transfusions correlate with infections in trauma patients in a dose-dependent manner.","volume":"68","author":"Claridge","year":"2002","journal-title":"Am Surg"},{"key":"R6-27-20210211","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1001\/archsurg.1997.01430300062013","article-title":"Blood transfusion. An independent risk factor for postinjury multiple organ failure.","volume":"132","author":"Moore","year":"1997","journal-title":"Arch Surg"},{"key":"R7-27-20210211","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.jbiotec.2006.03.042","article-title":"Mechanism of action, development and clinical experience of recombinant FVIIa.","volume":"124","author":"Hedner","year":"2006","journal-title":"J Biotechnol"},{"key":"R8-27-20210211","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1046\/j.1365-2141.1997.4463256.x","article-title":"Platelet activity of high-dose factor VIIa is independent of tissue factor.","volume":"99","author":"Monroe","year":"1997","journal-title":"Br J Haematol"},{"issue":"suppl 1","key":"R9-27-20210211","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/S0268-960X(03)90000-2","article-title":"A cell-based model of coagulation and the role of factor VIIa.","volume":"17","author":"Hoffman","year":"2003","journal-title":"Blood Rev"},{"key":"R10-27-20210211","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1056\/NEJMoa042991","article-title":"Recombinant activated factor VII for acute intracerebral hemorrhage.","volume":"352","author":"Mayer","year":"2005","journal-title":"N Engl J Med"},{"key":"R11-27-20210211","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1056\/NEJMoa0707534","article-title":"Efficacy and safety of recombinant activated factor VII for acute intracerebral hemorrhage.","volume":"358","author":"Mayer","year":"2008","journal-title":"N Engl J Med"},{"key":"R12-27-20210211","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/01.TA.0000171453.37949.B7","article-title":"Recombinant factor VIIa as adjunctive therapy for bleeding control in severely injured trauma patients: two parallel randomized, placebo-controlled, double-blind clinical trials.","volume":"59","author":"Boffard","year":"2005","journal-title":"J Trauma"},{"key":"R13-27-20210211","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1007\/s00018-007-7480-5","article-title":"Cofactor-induced and mutational activity enhancement of coagulation factor VIIa.","volume":"65","author":"Olsen","year":"2008","journal-title":"Cell Mol Life Sci"},{"key":"R14-27-20210211","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1538-7836.2008.03253.x","article-title":"Evaluation of the safety and pharmacokinetics of a fast-acting recombinant FVIIa analogue, NN1731, in healthy male subjects.","volume":"7","author":"Moss","year":"2009","journal-title":"J Thromb Haemost"},{"key":"R15-27-20210211","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1111\/j.1538-7836.2009.03532.x","article-title":"Faster onset of effect and higher efficacy of NN1731, compared to rFVIIa, aPCC & FVIII in tail-bleeding in haemophilic mice.","volume":"7","author":"Holmberg","year":"2009","journal-title":"J Thromb Haemost"},{"key":"R16-27-20210211","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1097\/00005373-200104000-00021","article-title":"Intravenous rFVIIa administered for hemorrhage control in hypothermic coagulopathic swine with grade V liver injuries.","volume":"50","author":"Martinowitz","year":"2001","journal-title":"J Trauma"},{"key":"R17-27-20210211","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1097\/00005373-200208000-00011","article-title":"The effect of recombinant factor VIIa on coagulopathic pigs with grade V liver injuries.","volume":"53","author":"Schreiber","year":"2002","journal-title":"J Trauma"},{"key":"R18-27-20210211","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/01.TA.0000174557.89804.A2","article-title":"Effect of recombinant FVIIa in hypothermic, coagulopathic pigs with liver injuries.","volume":"59","author":"Klemcke","year":"2005","journal-title":"J Trauma"},{"key":"R19-27-20210211","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1093\/bja\/aen175","article-title":"Effect of haemodilution, acidosis, and hypothermia on the activity of recombinant factor VIIa (NovoSeven(R)).","volume":"101","author":"Viuff","year":"2008","journal-title":"Br J Anaesth"},{"key":"R20-27-20210211","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1182\/blood.V80.1.25.25","article-title":"Measurement of basal levels of factor VIIa in hemophilia A and B patients.","volume":"80","author":"Wildgoose","year":"1992","journal-title":"Blood"},{"key":"R21-27-20210211","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1055\/s-2007-1000370","article-title":"Clinical relevance of the effects of plasma expanders on coagulation.","volume":"33","author":"Levi","year":"2007","journal-title":"Semin Thromb Hemost"},{"key":"R22-27-20210211","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1097\/00000542-200011000-00016","article-title":"Low- and medium-molecular-weight hydroxyethyl starches: comparison of their effect on blood coagulation.","volume":"93","author":"Jamnicki","year":"2000","journal-title":"Anesthesiology"},{"key":"R23-27-20210211","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1213\/01.ane.0000197694.48429.94","article-title":"A head-to-head comparison of the in vitro coagulation effects of saline-based and balanced electrolyte crystalloid and colloid intravenous fluids.","volume":"102","author":"Roche","year":"2006","journal-title":"Anesth Analg"},{"key":"R24-27-20210211","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1093\/bja\/ael019","article-title":"Molar substitution and C2\/C6 ratio of hydroxyethyl starch: influence on blood coagulation.","volume":"96","author":"von Roten","year":"2006","journal-title":"Br J Anaesth"},{"key":"R25-27-20210211","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1161\/01.ATV.0000257204.82396.2b","article-title":"A variant of recombinant factor VIIa with enhanced procoagulant and antifibrinolytic activities in an in vitro model of hemophilia.","volume":"27","author":"Allen","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"R26-27-20210211","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1093\/bja\/aei557","article-title":"Recombinant factor VIIa fails to correct coagulopathy induced by haemodilution with colloid.","volume":"94","author":"Sorensen","year":"2005","journal-title":"Br J Anaesth"},{"key":"R27-27-20210211","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1111\/j.1538-7836.2005.01203.x","article-title":"Guidelines for the use of recombinant activated factor VII (rFVIIa) in uncontrolled bleeding: a report by the Israeli Multidisciplinary rFVIIa Task Force.","volume":"3","author":"Martinowitz","year":"2005","journal-title":"J Thromb Haemost"},{"key":"R28-27-20210211","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/j.1538-7836.2009.03287.x","article-title":"rFVIIa and a new enhanced rFVIIa-analogue, NN1731, reduce bleeding in clopidogrel-treated and in thrombocytopenic rats.","volume":"7","author":"Lauritzen","year":"2009","journal-title":"J Thromb Haemost"},{"key":"R29-27-20210211","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0049-3848(03)00146-4","article-title":"Recombinant factor VIIa reduces bleeding in severely thrombocytopenic rabbits.","volume":"109","author":"Tranholm","year":"2003","journal-title":"Thromb Res"},{"key":"R30-27-20210211","doi-asserted-by":"crossref","first-page":"3615","DOI":"10.1182\/blood-2003-05-1369","article-title":"Improved hemostasis with superactive analogs of factor VIIa in a mouse model of hemophilia A.","volume":"102","author":"Tranholm","year":"2003","journal-title":"Blood"},{"key":"R31-27-20210211","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1111\/j.1538-7836.2008.02933.x","article-title":"Recombinant human factor VIIa and a factor VIIa-analogue reduces heparin and low molecular weight heparin (LMWH)-induced bleeding in rats.","volume":"6","author":"Lauritzen","year":"2008","journal-title":"J Thromb Haemost"},{"key":"R32-27-20210211","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1365-2141.2007.06534.x","article-title":"Factor VIIa analogue (V158D\/E296V\/M298Q-FVIIa) normalizes clot formation in whole blood from patients with severe haemophilia A.","volume":"137","author":"Sorensen","year":"2007","journal-title":"Br J Haematol"},{"key":"R33-27-20210211","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/j.1365-2516.2007.01524.x","article-title":"Effect of recombinant factor VIIa variant (NN1731) on platelet function, clot structure and force onset time in whole blood from healthy volunteers and haemophilia patients.","volume":"13","author":"Brophy","year":"2007","journal-title":"Haemophilia"},{"key":"R34-27-20210211","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.thromres.2004.11.003","article-title":"Characterization of recombinant murine factor VIIa and recombinant murine tissue factor: a human-murine species compatibility study.","volume":"116","author":"Petersen","year":"2005","journal-title":"Thromb Res"}],"container-title":["Journal of Trauma: Injury, Infection &amp; Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/TA.0b013e3181c6619d","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:12:00Z","timestamp":1786039920000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00005373-201011000-00027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":34,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1097\/ta.0b013e3181c6619d","relation":{},"ISSN":["0022-5282"],"issn-type":[{"value":"0022-5282","type":"print"}],"subject":[],"published":{"date-parts":[[2010,11]]}}}