{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:20:24Z","timestamp":1786119624787,"version":"build-2736575974"},"reference-count":25,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,12]]},"DOI":"10.1097\/ta.0b013e3181dc59e4","type":"journal-article","created":{"date-parts":[[2010,12,11]],"date-time":"2010-12-11T02:29:24Z","timestamp":1292034564000},"page":"1473-1480","source":"Crossref","is-referenced-by-count":14,"title":["Short-Term Application of Dexamethasone Enhances Bone Morphogenetic Protein-7-Induced Ectopic Bone Formation In Vivo"],"prefix":"10.1097","volume":"69","author":[{"given":"Alexander S.","family":"Spiro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Timo Beil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten","family":"Schinke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arndt F.","family":"Schilling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Eulenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes M.","family":"Rueger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Amling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-24-20210211","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0889-857X(05)70196-4","article-title":"An update on glucocorticoid-induced osteoporosis.","volume":"27","author":"Lane","year":"2001","journal-title":"Rheum Dis Clin North Am"},{"key":"R2-24-20210211","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1001\/archinte.159.9.941","article-title":"Systemic adverse effects of inhaled corticosteroid therapy: a systematic review and meta-analysis.","volume":"159","author":"Lipworth","year":"1999","journal-title":"Arch Intern Med"},{"key":"R3-24-20210211","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1172\/JCI2799","article-title":"Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone.","volume":"102","author":"Weinstein","year":"1998","journal-title":"J Clin Invest"},{"key":"R4-24-20210211","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1002\/jcb.20836","article-title":"Osteogenic growth peptide effects on primary human osteoblast cultures: potential relevance for the treatment of glucocorticoid-induced osteoporosis.","volume":"98","author":"Spreafico","year":"2006","journal-title":"J Cell Biochem"},{"key":"R5-24-20210211","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1002\/jcb.240500411","article-title":"Glucocorticoids promote development of the osteoblast phenotype by selectively modulating expression of cell growth and differentiation associated genes.","volume":"50","author":"Shalhoub","year":"1992","journal-title":"J Cell Biochem"},{"key":"R6-24-20210211","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1023\/B:HIJO.0000020883.33256.fe","article-title":"Inductive effects of dexamethasone on the gene expression of Cbfa1, Osterix and bone matrix proteins during differentiation of cultured primary rat osteoblasts.","volume":"35","author":"Igarashi","year":"2004","journal-title":"J Mol Histol"},{"key":"R7-24-20210211","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1002\/jor.20838","article-title":"In vitro dexamethasone pretreatment enhances bone formation of human mesenchymal stem cells in vivo.","volume":"27","author":"Song","year":"2009","journal-title":"J Orthop Res"},{"key":"R8-24-20210211","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1007\/s10856-007-0134-1","article-title":"In vitro models of periodontal cells: a comparative study of long-term gingival, periodontal ligament and alveolar bone cell cultures in the presence of beta-glycerophosphate and dexamethasone.","volume":"18","author":"Cabral","year":"2007","journal-title":"J Mater Sci Mater Med"},{"key":"R9-24-20210211","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.bone.2003.11.014","article-title":"Differential growth factor control of bone formation through osteoprogenitor differentiation.","volume":"34","author":"Chaudhary","year":"2004","journal-title":"Bone"},{"key":"R10-24-20210211","first-page":"689","article-title":"Selection and amplification of a bone marrow cell population and its induction to the chondro-osteogenic lineage by rhOP-1: an in vitro and in vivo study.","volume":"45","author":"Andrades","year":"2001","journal-title":"Int J Dev Biol"},{"key":"R11-24-20210211","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1002\/jor.20565","article-title":"Dexamethasone modulates BMP-2 effects on mesenchymal stem cells in vitro.","volume":"26","author":"J\u00e4ger","year":"2008","journal-title":"J Orthop Res"},{"key":"R12-24-20210211","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.bone.2004.04.017","article-title":"Glucocorticoid regulation of human BMP-6 transcription.","volume":"35","author":"Liu","year":"2004","journal-title":"Bone"},{"key":"R13-24-20210211","doi-asserted-by":"crossref","first-page":"20352","DOI":"10.1016\/S0021-9258(19)88709-4","article-title":"Recombinant human osteogenic protein-1 (hOP-1) induces new bone formation in vivo with a specific activity comparable with natural bovine osteogenic protein and stimulates osteoblast proliferation and differentiation in vitro.","volume":"267","author":"Sampath","year":"1992","journal-title":"J Biol Chem"},{"key":"R14-24-20210211","doi-asserted-by":"crossref","first-page":"803","DOI":"10.2106\/00004623-200106000-00001","article-title":"The effect of osteogenic protein-1 on the healing of segmental bone defects treated with autograft or allograft bone.","volume":"83","author":"Salkeld","year":"2001","journal-title":"J Bone Joint Surg Am"},{"key":"R15-24-20210211","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/S8756-3282(03)00191-1","article-title":"BMP signaling components are expressed in human fracture callus.","volume":"33","author":"Kloen","year":"2003","journal-title":"Bone"},{"key":"R16-24-20210211","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3109\/08977199609003228","article-title":"Complete regeneration of bone in the baboon by recombinant human osteogenic protein-1 (hOP-1, bone morphogenetic protein-7).","volume":"13","author":"Ripamonti","year":"1996","journal-title":"Growth Factors"},{"key":"R17-24-20210211","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1302\/0301-620X.81B4.0810710","article-title":"Osteogenic activity of OP-1 bone morphogenetic protein (BMP-7) in a human fibular defect.","volume":"81","author":"Geesink","year":"1999","journal-title":"J Bone Joint Surg Br"},{"key":"R18-24-20210211","doi-asserted-by":"crossref","first-page":"151","DOI":"10.2106\/00004623-200100002-00010","article-title":"Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions.","volume":"83","author":"Friedlaender","year":"2001","journal-title":"J Bone Joint Surg Am"},{"key":"R19-24-20210211","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/s00264-007-0422-x","article-title":"Clinical applications of BMP-7\/OP-1 in fractures, nonunions and spinal fusion.","volume":"31","author":"White","year":"2007","journal-title":"Int Orthop"},{"key":"R20-24-20210211","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1016\/S8756-3282(02)00737-8","article-title":"Glucocorticoid-induced osteopenia in the mouse as assessed by histomorphometry, microcomputed tomography, and biochemical markers.","volume":"30","author":"McLaughlin","year":"2002","journal-title":"Bone"},{"key":"R21-24-20210211","doi-asserted-by":"crossref","first-page":"4982","DOI":"10.1210\/endo.140.11.7110","article-title":"Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: formal histomorphometric and biomechanical analyses.","volume":"140","author":"Amling","year":"1999","journal-title":"Endocrinology"},{"key":"R22-24-20210211","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1002\/jbmr.5650020617","article-title":"Bone histomorphometry: standardization of nomenclature, symbols and units.","volume":"6","author":"Parfitt","year":"1987","journal-title":"J Bone Miner Res"},{"key":"R23-24-20210211","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1359\/JBMR.041101","article-title":"Increased bone formation in mice lacking apolipoprotein E.","volume":"20","author":"Schilling","year":"2005","journal-title":"J Bone Miner Res"},{"key":"R24-24-20210211","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1677\/jme.0.0330175","article-title":"Gene expression profiling of glucocorticoid-inhibited osteoblasts.","volume":"33","author":"Leclerc","year":"2004","journal-title":"J Mol Endocrinol"},{"key":"R25-24-20210211","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1359\/jbmr.2003.18.7.1186","article-title":"Bone morphogenetic protein-2 restores mineralization in glucocorticoid-inhibited MC3T3\u2013E1 osteoblast cultures.","volume":"18","author":"Luppen","year":"2003","journal-title":"J Bone Miner Res"}],"container-title":["Journal of Trauma: Injury, Infection & Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/TA.0b013e3181dc59e4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:45:56Z","timestamp":1786041956000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00005373-201012000-00024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1097\/ta.0b013e3181dc59e4","relation":{},"ISSN":["0022-5282"],"issn-type":[{"value":"0022-5282","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12]]}}}