{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:44:36Z","timestamp":1792089876906,"version":"4.4.0"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,7]]},"DOI":"10.1097\/ta.0b013e3181fc93a2","type":"journal-article","created":{"date-parts":[[2011,2,18]],"date-time":"2011-02-18T09:15:46Z","timestamp":1298020546000},"page":"175-185","source":"Crossref","is-referenced-by-count":71,"title":["Early Appropriate Care: Definitive Stabilization of Femoral Fractures Within 24 Hours of Injury Is Safe in Most Patients With Multiple Injuries"],"prefix":"10.1097","volume":"71","author":[{"given":"Nickolas J.","family":"Nahm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Como","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H.","family":"Wilber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather A.","family":"Vallier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-28-20210211","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1097\/00005373-197702000-00005","article-title":"Primary operative fixation of long bone fractures in patients with multiple injuries.","volume":"17","author":"Riska","year":"1977","journal-title":"J Trauma"},{"key":"R2-28-20210211","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1097\/00005373-198211000-00002","article-title":"Early osteosynthesis and prophylactic mechanical ventilation in the multitrauma patient.","volume":"22","author":"Goris","year":"1982","journal-title":"J Trauma"},{"key":"R3-28-20210211","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1097\/00000658-198509000-00003","article-title":"Blunt multiple trauma (ISS 36), femur traction, and the pulmonary failure-septic state.","volume":"202","author":"Seibel","year":"1985","journal-title":"Ann Surg"},{"key":"R4-28-20210211","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/0020-1383(86)90003-3","article-title":"Comparison of mortality of patients with multiple injuries according to type of fracture treatment\u2014a retrospective age- and injury-matched series.","volume":"17","author":"Meek","year":"1986","journal-title":"Injury"},{"key":"R6-28-20210211","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1097\/00005373-199712000-00008","article-title":"The impact of the quantity of skeletal injury on mortality and pulmonary morbidity.","volume":"43","author":"Ziran","year":"1997","journal-title":"J Trauma"},{"key":"R7-28-20210211","doi-asserted-by":"crossref","first-page":"336","DOI":"10.2106\/00004623-198971030-00004","article-title":"Early versus delayed stabilization of femoral fractures. A prospective randomized study.","volume":"71","author":"Bone","year":"1989","journal-title":"J Bone Joint Surg Am"},{"issue":"suppl 3","key":"R9-28-20210211","doi-asserted-by":"crossref","first-page":"S82","DOI":"10.1016\/0020-1383(93)90012-U","article-title":"Influence of thoracic trauma and primary femoral intramedullary nailing on the incidence of ARDS in multiple trauma patients.","volume":"24","author":"Pape","year":"1993","journal-title":"Injury"},{"key":"R13-28-20210211","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1097\/00005373-199410000-00023","article-title":"Delayed surgical fixation of femur fractures is a risk factor for pulmonary failure independent of thoracic trauma.","volume":"37","author":"Charash","year":"1994","journal-title":"J Trauma"},{"key":"R14-28-20210211","doi-asserted-by":"crossref","first-page":"799","DOI":"10.2106\/00004623-199706000-00001","article-title":"Adult respiratory distress syndrome, pneumonia, and mortality following thoracic injury and a femoral fracture treated either with intramedullary nailing with reaming or with a plate. A comparative study.","volume":"79","author":"Bosse","year":"1997","journal-title":"J Bone Joint Surg Am"},{"key":"R15-28-20210211","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/00005131-199801000-00007","article-title":"Treatment of femur fracture with associated head injury.","volume":"12","author":"Starr","year":"1998","journal-title":"J Orthop Trauma"},{"key":"R16-28-20210211","first-page":"299","article-title":"Timing of femur fracture fixation: effect on outcome in patients with thoracic and head injuries.","volume":"52","author":"Brundage","year":"2002","journal-title":"J Trauma"},{"key":"R17-28-20210211","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2106\/JBJS.H.00338","article-title":"Delayed internal fixation of femoral shaft fracture reduces mortality among patients with multisystem trauma.","volume":"91","author":"Morshed","year":"2009","journal-title":"J Bone Joint Surg Am"},{"key":"R18-28-20210211","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1097\/00005373-199905000-00012","article-title":"Early fracture fixation may be \u201cjust fine\u201d after head injury: no difference in central nervous system outcomes.","volume":"46","author":"Scalea","year":"1999","journal-title":"J Trauma"},{"key":"R19-28-20210211","first-page":"692","article-title":"Early unreamed intramedullary nailing of femoral fractures is safe in patients with severe thoracic trauma.","volume":"62","author":"Weninger","year":"2007","journal-title":"J Trauma"},{"key":"R20-28-20210211","first-page":"602","article-title":"Safety and efficacy of damage control external fixation versus early definitive stabilization for femoral shaft fractures in the multiple-injured patient.","volume":"67","author":"Tuttle","year":"2009","journal-title":"J Trauma"},{"key":"R22-28-20210211","doi-asserted-by":"crossref","first-page":"781","DOI":"10.2106\/00004623-200006000-00004","article-title":"Conversion of external fixation to intramedullary nailing for fractures of the shaft of the femur in multiply injured patients.","volume":"82","author":"Nowotarski","year":"2000","journal-title":"J Bone Joint Surg Am"},{"key":"R24-28-20210211","first-page":"1013","article-title":"Resuscitation before stabilization of femoral fractures limits acute respiratory distress syndrome in patients with multiple traumatic injuries despite low use of damage control orthopedics.","volume":"67","author":"O'Toole","year":"2009","journal-title":"J Trauma"},{"key":"R26-28-20210211","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/01.TA.0000075787.69695.4E","article-title":"Impact of intramedullary instrumentation versus damage control for femoral fractures on immunoinflammatory parameters: prospective randomized analysis by the EPOFF Study Group.","volume":"55","author":"Pape","year":"2003","journal-title":"J Trauma"},{"key":"R27-28-20210211","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1097\/01.CCM.0000145586.23276.0F","article-title":"Epidemiology of sepsis in patients with traumatic injury.","volume":"32","author":"Osborn","year":"2004","journal-title":"Crit Care Med"},{"key":"R28-28-20210211","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1046\/j.1365-2168.1998.00770.x","article-title":"Stimulation of inflammatory markers after blunt trauma.","volume":"85","author":"Giannoudis","year":"1998","journal-title":"Br J Surg"},{"key":"R30-28-20210211","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1302\/0301-620X.81B2.0810356","article-title":"Stimulation of the inflammatory system by reamed and unreamed nailing of femoral fractures. An analysis of the second hit.","volume":"81","author":"Giannoudis","year":"1999","journal-title":"J Bone Joint Surg Br"},{"issue":"suppl 1","key":"R32-28-20210211","first-page":"v","article-title":"Fracture and dislocation compendium. Orthopaedic Trauma Association Committee for Coding and Classification.","volume":"10","year":"1996","journal-title":"J Orthop Trauma"},{"key":"R33-28-20210211","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/00005373-197403000-00001","article-title":"The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care.","volume":"14","author":"Baker","year":"1974","journal-title":"J Trauma"},{"key":"R34-28-20210211","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1164\/rccm.200405-644ST","article-title":"Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia.","volume":"171","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"R35-28-20210211","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1164\/ajrccm.149.3.7509706","article-title":"The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination.","volume":"149","author":"Bernard","year":"1994","journal-title":"Am J Respir Crit Care Med"},{"key":"R36-28-20210211","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.jamcollsurg.2007.09.011","article-title":"Natural history and outcomes of renal failure after trauma.","volume":"206","author":"Brown","year":"2008","journal-title":"J Am Coll Surg"},{"key":"R37-28-20210211","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1097\/00003246-199206000-00025","article-title":"American College of Chest Physicians\/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis.","volume":"20","year":"1992","journal-title":"Crit Care Med"},{"key":"R38-28-20210211","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1097\/01.TA.0000092378.10660.D1","article-title":"Multiple organ failure in trauma patients.","volume":"55","author":"Durham","year":"2003","journal-title":"J Trauma"},{"key":"R39-28-20210211","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1097\/01.bot.0000161712.87129.80","article-title":"Timing of fixation of major fractures in blunt polytrauma: role of conventional indicators in clinical decision making.","volume":"19","author":"Pape","year":"2005","journal-title":"J Orthop Trauma"},{"key":"R40-28-20210211","first-page":"735","article-title":"Variation in diagnosis of compartment syndrome by surgeons treating tibial shaft fractures.","volume":"67","author":"O'Toole","year":"2009","journal-title":"J Trauma"},{"key":"R41-28-20210211","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.2106\/00004623-200411000-00002","article-title":"The epidemiology of posttraumatic adult respiratory distress syndrome.","volume":"86","author":"White","year":"2004","journal-title":"J Bone Joint Surg Am"},{"key":"R42-28-20210211","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1097\/00005373-198505000-00001","article-title":"Incidence of adult respiratory distress syndrome in patients with multiple musculoskeletal injuries: effect of early operative stabilization of fractures.","volume":"25","author":"Johnson","year":"1985","journal-title":"J Trauma"},{"key":"R43-28-20210211","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1097\/00005373-199707000-00008","article-title":"Thoracic trauma and early intramedullary nailing of femur fractures: are we doing harm?","volume":"43","author":"Boulanger","year":"1997","journal-title":"J Trauma"},{"key":"R44-28-20210211","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1097\/00005131-199803000-00005","article-title":"Femur fractures in chest-injured patients: is reaming contraindicated?","volume":"12","author":"Carlson","year":"1998","journal-title":"J Orthop Trauma"},{"key":"R45-28-20210211","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1097\/00005373-199404000-00006","article-title":"Is early osteosynthesis safe in multiple trauma patients with severe thoracic trauma and pulmonary contusion?","volume":"36","author":"van Os","year":"1994","journal-title":"J Trauma"},{"key":"R46-28-20210211","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1056\/NEJMoa022139","article-title":"The epidemiology of sepsis in the United States from 1979 through 2000.","volume":"348","author":"Martin","year":"2003","journal-title":"N Engl J Med"},{"key":"R47-28-20210211","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1097\/01.CCM.0000261890.41311.E9","article-title":"Rapid increase in hospitalization and mortality rates for severe sepsis in the United States: a trend analysis from 1993 to 2003.","volume":"35","author":"Dombrovskiy","year":"2007","journal-title":"Crit Care Med"},{"key":"R48-28-20210211","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/0002-9610(82)90612-2","article-title":"Clinical predictors of the adult respiratory distress syndrome.","volume":"144","author":"Pepe","year":"1982","journal-title":"Am J Surg"},{"issue":"2","key":"R49-28-20210211","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1164\/ajrccm.151.2.7842182","article-title":"Clinical risks for development of the acute respiratory distress syndrome.","volume":"151","author":"Hudson","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"R50-28-20210211","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1002\/bjs.1800810619","article-title":"Increased gut permeability after multiple trauma.","volume":"81","author":"Pape","year":"1994","journal-title":"Br J Surg"},{"key":"R51-28-20210211","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1002\/bjs.1800770505","article-title":"Gut barrier function and the surgeon.","volume":"77","author":"Saadia","year":"1990","journal-title":"Br J Surg"},{"key":"R52-28-20210211","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1136\/gut.45.2.223","article-title":"Gut origin of sepsis: a prospective study investigating associations between bacterial translocation, gastric microflora, and septic morbidity.","volume":"45","author":"MacFie","year":"1999","journal-title":"Gut"},{"key":"R53-28-20210211","first-page":"1037","article-title":"Intestinal permeability increases with the severity of abdominal trauma: a comparison between gas liquid chromatographic and enzymatic method.","volume":"47","author":"Liverani","year":"2000","journal-title":"Hepatogastroenterology"},{"key":"R55-28-20210211","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1097\/00003246-199710000-00026","article-title":"Effect of mechanical ventilation strategy on dissemination of intratracheally instilled Escherichia coli in dogs.","volume":"25","author":"Nahum","year":"1997","journal-title":"Crit Care Med"}],"container-title":["Journal of Trauma: Injury, Infection &amp; Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/TA.0b013e3181fc93a2","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T07:15:24Z","timestamp":1620976524000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00005373-201107000-00028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,7]]},"references-count":44,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1097\/ta.0b013e3181fc93a2","relation":{},"ISSN":["0022-5282"],"issn-type":[{"value":"0022-5282","type":"print"}],"subject":[],"published":{"date-parts":[[2011,7]]}}}