{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:31:27Z","timestamp":1786120287261,"version":"build-2736575974"},"reference-count":32,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,8]]},"DOI":"10.1097\/ta.0b013e31822556f4","type":"journal-article","created":{"date-parts":[[2011,8,3]],"date-time":"2011-08-03T17:13:36Z","timestamp":1312391616000},"page":"S171-S175","source":"Crossref","is-referenced-by-count":3,"title":["Poly-N-Acetylglucosamine Fibers Amplify the Effectiveness of Recombinant Factor VIIA on Clot Formation in Hemophilia B Canine Blood"],"prefix":"10.1097","volume":"71","author":[{"given":"Thomas H.","family":"Fischer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy C.","family":"Nichols","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Scull","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carr J.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Demcheva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-4-20210211","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1016\/S0140-6736(88)90259-0","article-title":"Successful use of recombinant factor VIIa in patient with severe haemophilia A during synovectomy.","volume":"2","author":"Hedner","year":"1988","journal-title":"Lancet"},{"key":"R2-4-20210211","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1097\/00001721-199008000-00009","article-title":"Factor VIIa in the treatment of haemophilia.","volume":"1","author":"Hedner","year":"1990","journal-title":"Blood Coagul Fibrinolysis"},{"key":"R3-4-20210211","first-page":"S38","article-title":"Evaluation of poly-N-acetyl glucosamine as a hemostatic agent in patients undergoing cardiac catherization: a double-blind, randomized study.","volume":"57","author":"Najjar","year":"2004","journal-title":"J Trauma"},{"key":"R4-4-20210211","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1097\/01.TA.0000147501.64610.AFS","article-title":"Modified rapid deployment hemostat bandage terminates bleeding in coagulopathic patients with severe visceral injuries.","volume":"57","author":"King","year":"2004","journal-title":"J Trauma"},{"issue":"Suppl 1","key":"R5-4-20210211","first-page":"S15","article-title":"A possible mechanism of action of activated factor VII independent of tissue factor.","volume":"9","author":"Monroe","year":"1998","journal-title":"Blood Coagul Fibrinolysis"},{"key":"R6-4-20210211","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1055\/s-2000-8455","article-title":"The factor VII-platelet interplay: effectiveness of recombinant factor VIIa in the treatment of bleeding in severe thrombocytopenia.","volume":"26","author":"Monroe","year":"2000","journal-title":"Semin Thromb Hemost"},{"key":"R7-4-20210211","doi-asserted-by":"crossref","first-page":"884","DOI":"10.7326\/0003-4819-137-11-200212030-00009","article-title":"Reversal of warfarin-induced excessive anticoagulation with recombinant human Factor VIIa concentrate.","volume":"137","author":"Deveras","year":"2002","journal-title":"Ann Intern Med"},{"issue":"Suppl 1","key":"R8-4-20210211","first-page":"159","article-title":"Clinical experience with recombinant factor VIIa in patients with thrombocytopenia.","volume":"26","author":"Kristensen","year":"1996","journal-title":"Haemostasis"},{"key":"R9-4-20210211","doi-asserted-by":"crossref","first-page":"3951","DOI":"10.1182\/blood.V94.11.3951","article-title":"Recombinant factor VIIa is effective for bleeding and surgery in patients with Glanzmann thrombasthenia.","volume":"94","author":"Poon","year":"1999","journal-title":"Blood"},{"key":"R10-4-20210211","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/sj.bmt.1703157","article-title":"Off-label use of recombinant Factor VIIa in patients following bone marrow transplantation.","volume":"28","author":"Blatt","year":"2001","journal-title":"Bone Marrow Transplant"},{"issue":"Suppl 1","key":"R11-4-20210211","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1159\/000057301","article-title":"The use of recombinant Factor VIIa in controlling surgical bleeding in non-haemophiliac patients.","volume":"32","author":"Aldouri","year":"2002","journal-title":"Pathophysiol Haemost Thromb"},{"key":"R12-4-20210211","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1097\/00000542-200306000-00034","article-title":"Treatment of excessive bleeding in Jehovah's Witness patients after cardiac surgery with recombinant Factor VIIa (NovoSeven).","volume":"98","author":"Tanaka","year":"2003","journal-title":"Anesthesiology"},{"key":"R13-4-20210211","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S0952-8180(03)00034-5","article-title":"Recombinant factor VIIa for control of hemorrhage: early experience in critically ill trauma patients.","volume":"15","author":"Dutton","year":"2003","journal-title":"J Clin Anesth"},{"key":"R14-4-20210211","first-page":"9","article-title":"The use of rFVIIa as an adjunct treatment for hemorrhage control in trauma and surgery.","volume":"1","author":"Martinowitz","year":"2001","journal-title":"Bloodline Rev"},{"key":"R15-4-20210211","first-page":"S13","article-title":"Mechanisms of poly-N-acetyl glucosamine polymer-mediated hemostasis: platelet interactions.","volume":"57","author":"Thatte","year":"2004","journal-title":"J Trauma"},{"key":"R16-4-20210211","first-page":"S2","article-title":"Isolation, purification and characterization of poly-N-acetyl glucosamine for use as a hemostatic agent.","volume":"57","author":"Vournakis","year":"2004","journal-title":"J Trauma"},{"key":"R17-4-20210211","doi-asserted-by":"crossref","first-page":"5433","DOI":"10.1016\/j.biomaterials.2005.01.023","article-title":"Platelet integrin signaling and factor XII activation are synergistic mechanisms for poly-n-acetyl glucosamine fiber mediated hemostasis.","volume":"26","author":"Fischer","year":"2004","journal-title":"Biomaterials"},{"key":"R18-4-20210211","first-page":"S22","article-title":"In vitro effects of poly-N-acetyl glucosamine on activation of platelets in rich plasma with and without RBCs.","volume":"57","author":"Valeri","year":"2004","journal-title":"J Trauma"},{"key":"R19-4-20210211","first-page":"S7","article-title":"Poly-N-acetylglucosamine mediated red blood cell interactions.","volume":"57","author":"Thatte","year":"2004","journal-title":"J Trauma"},{"key":"R20-4-20210211","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1006\/jsre.2001.6323","article-title":"Vascular effects of poly-N-acetylglucosamine in isolated rat aortic rings.","volume":"102","author":"Ikeda","year":"2002","journal-title":"J Surg Res"},{"key":"R21-4-20210211","first-page":"1","article-title":"Non-classical processes in surface hemostasis: mechanisms for the poly-N-acetyl glucosamine-induced alteration of red blood cell morphology and prothrombogenicity.","volume":"3","author":"Fischer","year":"2008","journal-title":"J Biomed Mater"},{"key":"R22-4-20210211","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1002\/jemt.20612","article-title":"Differential effect of materials for surface hemostasis on red blood cell morphology.","volume":"71","author":"Smith","year":"2008","journal-title":"Microsc Res Tech"},{"key":"R23-4-20210211","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1093\/ndt\/gfh622","article-title":"Red blood cells may contribute to hypercoagulability in uraemia via enhanced surface exposure of phosphatidylserine.","volume":"20","author":"Bonomini","year":"2005","journal-title":"Nephrol Dial Transplant"},{"key":"R24-4-20210211","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.1182\/blood.V98.12.3228","article-title":"Thrombophilia in sickle cell disease: the red cell connection.","volume":"98","author":"Setty","year":"2001","journal-title":"Blood"},{"key":"R25-4-20210211","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1055\/s-0038-1650577","article-title":"Increased procoagulant activity of red blood cells from patients with homozygous sickle cell disease and beta-thalassemia.","volume":"76","author":"Helley","year":"1996","journal-title":"Thromb Haemost"},{"key":"R26-4-20210211","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1182\/blood.V89.4.1121","article-title":"Pathophysiologic implications of membrane phospholipid asymmetry in blood cells.","volume":"89","author":"Zwaal","year":"1997","journal-title":"Blood"},{"key":"R27-4-20210211","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/jbm.a.30877","article-title":"Hemostatic properties of glucosamine-based materials.","volume":"80","author":"Fischer","year":"2007","journal-title":"J Biomed Mater Res A"},{"key":"R28-4-20210211","first-page":"1382","article-title":"Effect of recombinant factor VIIa on the hemostatic defect in dogs with hemophilia A, hemophilia B, and von Willebrand disease.","volume":"86","author":"Brinkhous","year":"1989","journal-title":"In: Proceedings of the National Academy of Sciences of the United States of America"},{"key":"R29-4-20210211","doi-asserted-by":"crossref","first-page":"3432","DOI":"10.1182\/blood.V88.9.3432.bloodjournal8893432","article-title":"Blood clotting in minimally altered whole blood.","volume":"88","author":"Rand","year":"1996","journal-title":"Blood"},{"key":"R30-4-20210211","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/jemt.20017","article-title":"Comparison of structural and hemostatic properties of the poly-N-acetyl glucosamine Syvek Patch with products containing chitosan.","volume":"63","author":"Fischer","year":"2004","journal-title":"Microsc Res Tech"},{"key":"R31-4-20210211","first-page":"450","article-title":"J Trauma.","volume":"67","author":"Kheirabadi","year":"2009","journal-title":""},{"key":"R32-4-20210211","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1111\/j.1538-7836.2004.01015.x","article-title":"Recombinant human factor VIIa (rFVIIa) can activate factor FIX on activated platelets.","volume":"2","author":"Gabriel","year":"2004","journal-title":"J Thromb Haemost"}],"container-title":["Journal of Trauma: Injury, Infection &amp; Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/TA.0b013e31822556f4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T20:22:31Z","timestamp":1786047751000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00005373-201108001-00004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1097\/ta.0b013e31822556f4","relation":{},"ISSN":["0022-5282"],"issn-type":[{"value":"0022-5282","type":"print"}],"subject":[],"published":{"date-parts":[[2011,8]]}}}