{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T18:24:10Z","timestamp":1786991050189,"version":"build-2736575974"},"reference-count":48,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1097\/ta.0b013e318232e5ab","type":"journal-article","created":{"date-parts":[[2011,11,10]],"date-time":"2011-11-10T10:07:36Z","timestamp":1320919656000},"page":"S427-S434","source":"Crossref","is-referenced-by-count":54,"title":["Clotting Factor Deficiency in Early Trauma-Associated Coagulopathy"],"prefix":"10.1097","volume":"71","author":[{"given":"Sandro B.","family":"Rizoli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Scarpelini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannie","family":"Callum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bartolomeu","family":"Nascimento","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth G.","family":"Mann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruxandra","family":"Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Jansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Homer C.","family":"Tien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-8-20210211","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1097\/00005373-199409000-00016","article-title":"Death in the operating room: an analysis of a multi-center experience.","volume":"37","author":"Hoyt","year":"1994","journal-title":"J Trauma"},{"key":"R2-8-20210211","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1097\/01.ta.0000251558.38388.47","article-title":"Preventable deaths from hemorrhage at a level I Canadian trauma center.","volume":"62","author":"Tien","year":"2007","journal-title":"J Trauma"},{"key":"R3-8-20210211","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1097\/SLA.0b013e318185a9ad","article-title":"Increased plasma and platelet to red blood cell ratios improves outcome in 466 massively transfused civilian trauma patients.","volume":"248","author":"Holcomb","year":"2008","journal-title":"Ann Surg"},{"key":"R4-8-20210211","first-page":"748","article-title":"The coagulopathy of trauma: a review of mechanisms.","volume":"65","author":"Hess","year":"2008","journal-title":"J Trauma"},{"key":"R5-8-20210211","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1007\/BF03022247","article-title":"From normal to pathological hemostasis.","volume":"53","author":"Lasne","year":"2006","journal-title":"Can J Anaesth"},{"key":"R6-8-20210211","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.tmrv.2009.06.002","article-title":"Controversy in trauma resuscitation: do ratios of plasma to red blood cells matter?","volume":"23","author":"Stansbury","year":"2009","journal-title":"Transfus Med Rev"},{"key":"R7-8-20210211","first-page":"401","article-title":"Management of massive operative blood loss.","volume":"73","author":"Kozek-Langenecker","year":"2007","journal-title":"Minerva Anestesiol"},{"key":"R8-8-20210211","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.beha.2005.01.026","article-title":"Plasma and plasma products in the treatment of massive haemorrhage.","volume":"19","author":"Erber","year":"2006","journal-title":"Best Pract Res Clin Haematol"},{"key":"R9-8-20210211","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/01.TA.0000075338.21177.EF","article-title":"Early coagulopathy predicts mortality in trauma.","volume":"55","author":"MacLeod","year":"2003","journal-title":"J Trauma"},{"key":"R10-8-20210211","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1097\/01.TA.0000069184.82147.06","article-title":"Acute traumatic coagulopathy.","volume":"54","author":"Brohi","year":"2003","journal-title":"J Trauma"},{"key":"R11-8-20210211","first-page":"1211","article-title":"Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis.","volume":"64","author":"Brohi","year":"2008","journal-title":"J Trauma"},{"key":"R12-8-20210211","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1097\/MCC.0b013e3282f1e78f","article-title":"Acute coagulopathy of trauma: mechanism, identification and effect.","volume":"13","author":"Brohi","year":"2007","journal-title":"Curr Opin Crit Care"},{"key":"R13-8-20210211","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1097\/01.sla.0000256862.79374.31","article-title":"Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway?","volume":"245","author":"Brohi","year":"2007","journal-title":"Ann Surg"},{"key":"R14-8-20210211","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.amjsurg.2008.12.014","article-title":"A high ratio of plasma and platelets to packed red blood cells in the first 6 hours of massive transfusion improves outcomes in a large multicenter study.","volume":"197","author":"Zink","year":"2009","journal-title":"Am J Surg"},{"key":"R15-8-20210211","first-page":"693","article-title":"Impact of plasma transfusion in massively transfused trauma patients.","volume":"66","author":"Teixeira","year":"2009","journal-title":"J Trauma"},{"key":"R16-8-20210211","first-page":"358","article-title":"The relationship of blood product ratio to mortality: survival benefit or survival bias?","volume":"66","author":"Snyder","year":"2009","journal-title":"J Trauma"},{"key":"R17-8-20210211","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1186\/cc8205","article-title":"Clinical review: fresh frozen plasma in massive bleedings\u2014more questions than answers.","volume":"14","author":"Nascimento","year":"2010","journal-title":"Crit Care"},{"key":"R18-8-20210211","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1423-0410.2009.01265.x","article-title":"Should we increase the ratio of plasma\/platelets to red blood cells in massive transfusion: what is the evidence?","volume":"98","author":"Phan","year":"2010","journal-title":"Vox Sang"},{"key":"R19-8-20210211","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1016\/j.amjsurg.2008.07.043","article-title":"Is there a role for aggressive use of fresh frozen plasma in massive transfusion of civilian trauma patients?","volume":"196","author":"Moore","year":"2008","journal-title":"Am J Surg"},{"key":"R20-8-20210211","doi-asserted-by":"crossref","first-page":"R178","DOI":"10.1186\/cc5133","article-title":"Recombinant activated factor VII as an adjunctive therapy for bleeding control in severe trauma patients with coagulopathy: subgroup analysis from two randomized trials.","volume":"10","author":"Rizoli","year":"2006","journal-title":"Crit Care"},{"key":"R21-8-20210211","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1182\/blood-2002-01-0290","article-title":"a combination of Dr Jekyll and Mr Hyde.","volume":"101","author":"Mann","year":"2003","journal-title":"Blood"},{"key":"R22-8-20210211","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1213\/ane.0b013e31819bcc9c","article-title":"Blood coagulation: hemostasis and thrombin regulation.","volume":"108","author":"Tanaka","year":"2009","journal-title":"Anesth Analg"},{"key":"R23-8-20210211","first-page":"1","article-title":"Transfusion Therapy: Clinical Principles and Practice.","author":"Dzik","year":"2005"},{"key":"R24-8-20210211","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/j.1365-3148.2007.00795.x","article-title":"The James Blundell Award Lecture 2006: transfusion and the treatment of haemorrhage: past, present and future.","volume":"17","author":"Dzik","year":"2007","journal-title":"Transfus Med"},{"key":"R25-8-20210211","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1111\/j.1365-2141.1987.tb02359.x","article-title":"Clotting factor levels and the risk of diffuse microvascular bleeding in the massively transfused patient.","volume":"67","author":"Ciavarella","year":"1987","journal-title":"Br J Haematol"},{"key":"R26-8-20210211","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1365-2141.2004.04868.x","article-title":"Efficacy of standard dose and 30 ml\/kg fresh frozen plasma in correcting laboratory parameters of haemostasis in critically ill patients.","volume":"125","author":"Chowdhury","year":"2004","journal-title":"Br J Haematol"},{"key":"R27-8-20210211","doi-asserted-by":"crossref","first-page":"18322","DOI":"10.1074\/jbc.M201173200","article-title":"A model for the stoichiometric regulation of blood coagulation.","volume":"277","author":"Hockin","year":"2002","journal-title":"J Biol Chem"},{"key":"R28-8-20210211","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1097\/00005373-199704000-00023","article-title":"Usefulness of thrombelastography in assessment of trauma patient coagulation.","volume":"42","author":"Kaufmann","year":"1997","journal-title":"J Trauma"},{"key":"R29-8-20210211","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.bcmd.2005.12.034","article-title":"Models of blood coagulation.","volume":"36","author":"Mann","year":"2006","journal-title":"Blood Cells Mol Dis"},{"key":"R30-8-20210211","doi-asserted-by":"crossref","first-page":"6648","DOI":"10.1074\/jbc.M708036200","article-title":"Effects of prothrombin on the individual activated protein C-mediated cleavages of coagulation factor Va.","volume":"283","author":"Tran","year":"2008","journal-title":"J Biol Chem"},{"key":"R31-8-20210211","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1365-2141.2004.04972.x","article-title":"Guidelines for the use of fresh-frozen plasma, cryoprecipitate and cryosupernatant.","volume":"126","author":"O'Shaughnessy","year":"2004","journal-title":"Br J Haematol"},{"key":"R32-8-20210211","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/j.1537-2995.1961.tb00017.x","article-title":"Physiological basis for transfusion therapy in hemorrhagic disorders: a critical review.","volume":"1","author":"Aggeler","year":"1961","journal-title":"Transfusion"},{"key":"R33-8-20210211","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1160\/TH07-07-0448","article-title":"Stability of coagulation assays performed in plasma from citrated whole blood transported at ambient temperature.","volume":"99","author":"Z\u00fcrcher","year":"2008","journal-title":"Thromb Haemost"},{"key":"R34-8-20210211","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1097\/00001721-200106000-00002","article-title":"Stability of coagulation proteins in frozen plasma.","volume":"12","author":"Woodhams","year":"2001","journal-title":"Blood Coagul Fibrinolysis"},{"key":"R35-8-20210211","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1172\/JCI111531","article-title":"Factor V (Quebec): a bleeding diathesis associated with a qualitative platelet Factor V deficiency.","volume":"74","author":"Tracy","year":"1984","journal-title":"J Clin Invest"},{"key":"R36-8-20210211","first-page":"S68","article-title":"A review of studies on the effects of hemorrhagic shock and resuscitation on the coagulation profile.","volume":"54","author":"Ledgerwood","year":"2003","journal-title":"J Trauma"},{"key":"R37-8-20210211","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1097\/00000658-198510000-00010","article-title":"Fresh frozen plasma supplement to massive red blood cell transfusion.","volume":"202","author":"Martin","year":"1985","journal-title":"Ann Surg"},{"key":"R38-8-20210211","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1213\/00000539-196207000-00022","article-title":"Problems related to massive blood replacement.","volume":"41","author":"Boyan","year":"1962","journal-title":"Anesth Analg"},{"key":"R39-8-20210211","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1097\/00005373-198910000-00020","article-title":"The effect of hemorrhagic shock on the clotting cascade in injured patients.","volume":"29","author":"Harrigan","year":"1989","journal-title":"J Trauma"},{"key":"R40-8-20210211","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1097\/00000658-198208000-00013","article-title":"Altered coagulation protein content after albumin resuscitation.","volume":"196","author":"Lucas","year":"1982","journal-title":"Ann Surg"},{"key":"R41-8-20210211","first-page":"307","article-title":"Damage control resuscitation: directly addressing the early coagulopathy of trauma.","volume":"62","author":"Holcomb","year":"2007","journal-title":"J Trauma"},{"key":"R42-8-20210211","first-page":"1352","article-title":"In vivo bleeding time and in vitro thrombelastography measurements are better indicators of dilutional hypothermic coagulopathy than prothrombin time.","volume":"62","author":"Kheirabadi","year":"2007","journal-title":"J Trauma"},{"key":"R43-8-20210211","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.trsl.2009.04.001","article-title":"Early evaluation of acute traumatic coagulopathy by thrombelastography.","volume":"154","author":"Carroll","year":"2009","journal-title":"Transl Res"},{"key":"R44-8-20210211","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1590\/S0100-879X2009001200015","article-title":"Normal range values for thromboelastography in healthy adult volunteers.","volume":"42","author":"Scarpelini","year":"2009","journal-title":"Braz J Med Biol Res"},{"key":"R45-8-20210211","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/j.1399-6576.2005.00602.x","article-title":"Effects of coagulation factor deficiency on plasma coagulation kinetics determined via thrombelastography: critical roles of fibrinogen and factors II, VII, X and XII.","volume":"49","author":"Nielsen","year":"2005","journal-title":"Acta Anaesthesiol Scand"},{"key":"R46-8-20210211","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.1365-2141.2004.04973.x","article-title":"Is fresh frozen plasma clinically effective? A systematic review of randomized controlled trials.","volume":"126","author":"Stanworth","year":"2004","journal-title":"Br J Haematol"},{"key":"R47-8-20210211","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1160\/TH07-07-0438","article-title":"Increased thrombin generation and fibrinogen level after therapeutic plasma transfusion: relation to bleeding.","volume":"99","author":"Schols","year":"2008","journal-title":"Thromb Haemost"},{"key":"R48-8-20210211","first-page":"1539","article-title":"Prospective audit of the use of fresh-frozen plasma, based on Canadian Medical Association transfusion guidelines.","volume":"166","author":"Luk","year":"2002","journal-title":"CMAJ"}],"container-title":["Journal of Trauma: Injury, Infection & Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/TA.0b013e318232e5ab","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T07:21:05Z","timestamp":1620976865000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00005373-201111001-00008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":48,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1097\/ta.0b013e318232e5ab","relation":{},"ISSN":["0022-5282"],"issn-type":[{"value":"0022-5282","type":"print"}],"subject":[],"published":{"date-parts":[[2011,11]]}}}