{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:31:42Z","timestamp":1786120302852,"version":"build-2736575974"},"reference-count":51,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,11]]},"DOI":"10.1097\/ta.0b013e318232e782","type":"journal-article","created":{"date-parts":[[2011,11,10]],"date-time":"2011-11-10T05:07:36Z","timestamp":1320901656000},"page":"S456-S461","source":"Crossref","is-referenced-by-count":9,"title":["Recombinant Human Erythropoietin Improves Gut Barrier Function in a Hemorrhagic Shock and Resuscitation Rat Model"],"prefix":"10.1097","volume":"71","author":[{"given":"Capt(N) Raymond L. C.","family":"Kao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anargyros","family":"Xenocostas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David K.","family":"Driman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Rui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixiong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiujun","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio M.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-12-20210211","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.surg.2007.12.013","article-title":"Erythropoietin and its derivatives protect the intestine from severe ischemia\/reperfusion injury in the rat.","volume":"143","author":"Mori","year":"2008","journal-title":"Surgery"},{"key":"R2-12-20210211","doi-asserted-by":"crossref","first-page":"509","DOI":"10.2119\/2007-00032.Guneli","article-title":"Erythropoietin protects the intestine against ischemia\/reperfusion injury in rats.","volume":"13","author":"Guneli","year":"2007","journal-title":"Mol Med"},{"key":"R3-12-20210211","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1159\/000201353","article-title":"Erythropoietin stimulates proliferation of rat-cultured gastric mucosal cells.","volume":"57","author":"Okada","year":"1996","journal-title":"Digestion"},{"key":"R4-12-20210211","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1203\/00006450-199909000-00003","article-title":"Why is erythropoietin present in human milk? Studies of erythropoietin receptors on enterocytes of human and rat neonates.","volume":"46","author":"Juul","year":"1999","journal-title":"Pediatr Res"},{"key":"R5-12-20210211","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/S0039-6109(16)43689-3","article-title":"Special problems in the diagnosis and treatment of surgical sepsis.","volume":"65","author":"Wilson","year":"1985","journal-title":"Surg Clin North Am"},{"key":"R6-12-20210211","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1001\/archsurg.1986.01400020082010","article-title":"Multiple-organ-failure syndrome.","volume":"121","author":"Carrico","year":"1986","journal-title":"Arch Surg"},{"key":"R7-12-20210211","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1001\/archsurg.1985.01390340007001","article-title":"Multiple-organ failure. Generalized autodestructive inflammation?","volume":"120","author":"Goris","year":"1985","journal-title":"Arch Surg"},{"key":"R8-12-20210211","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/00000658-199208000-00002","article-title":"Multiple organ failure. Pathophysiology and potential future therapy.","volume":"216","author":"Deitch","year":"1992","journal-title":"Ann Surg"},{"key":"R9-12-20210211","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1097\/01.CCM.0000162952.14590.EC","article-title":"A free radical scavenger, edaravone (MCI-186), diminishes intestinal neutrophil lipid peroxidation and bacterial translocation in a rat hemorrhagic shock model.","volume":"33","author":"Mori","year":"2005","journal-title":"Crit Care Med"},{"key":"R10-12-20210211","first-page":"212","article-title":"Reevaluation of the linkage between acute hemorrhagic shock and bacterial translocation in the rat.","volume":"40","author":"LaRocco","year":"1993","journal-title":"Circ Shock"},{"key":"R11-12-20210211","first-page":"1342","article-title":"The effect of erythropoietin on microcirculation perfusion and tissue bioenergetics of the small intestine in a hemorrhagic shock and resuscitation rat model.","volume":"68","author":"Kao","year":"2010","journal-title":"J Trauma"},{"key":"R12-12-20210211","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1111\/j.1432-2277.2006.00366.x","article-title":"Recombinant human erythropoietin protects the liver from hepatic ischemia-reperfusion injury in the rat.","volume":"19","author":"Sepodes","year":"2006","journal-title":"Transpl Int"},{"key":"R13-12-20210211","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.surg.2006.03.003","article-title":"Amiloride moderates increased gut permeability and diminishes mesenteric lymph-mediated priming of neutrophils in trauma\/hemorrhagic shock.","volume":"140","author":"Fujiyoshi","year":"2006","journal-title":"Surgery"},{"key":"R14-12-20210211","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1097\/00005373-199801000-00024","article-title":"The presence of hemorrhagic shock increases the rate of bacterial translocation in blunt abdominal trauma.","volume":"44","author":"Kale","year":"1998","journal-title":"J Trauma"},{"key":"R15-12-20210211","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/00024382-200116030-00003","article-title":"PGE2 suppresses intestinal T cell function in thermal injury: a cause of enhanced bacterial translocation.","volume":"16","author":"Choudhry","year":"2001","journal-title":"Shock"},{"key":"R16-12-20210211","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/00003246-200201000-00012","article-title":"Elevation of plasma peptidoglycan and peripheral blood neutrophil activation during hemorrhagic shock: plasma peptidoglycan reflects bacterial translocation and may affect neutrophil activation.","volume":"30","author":"Shimizu","year":"2002","journal-title":"Crit Care Med"},{"key":"R17-12-20210211","doi-asserted-by":"crossref","first-page":"3705","DOI":"10.1097\/00003246-200011000-00028","article-title":"Bacterial translocation and tumor necrosis factor-alpha gene expression in experimental hemorrhagic shock.","volume":"28","author":"Tani","year":"2000","journal-title":"Crit Care Med"},{"key":"R18-12-20210211","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1097\/00005373-198807000-00002","article-title":"Hemorrhagic shock induces bacterial translocation from the gut.","volume":"28","author":"Baker","year":"1988","journal-title":"J Trauma"},{"key":"R19-12-20210211","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1128\/IAI.25.3.820-827.1979","article-title":"Inhibition of translocation of viable Escherichia coli from the gastrointestinal tract of mice by bacterial antagonism.","volume":"25","author":"Berg","year":"1979","journal-title":"Infect Immun"},{"key":"R20-12-20210211","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1097\/00003246-199706000-00021","article-title":"Monoclonal antibody to endotoxin attenuates hemorrhage-induced lung injury and mortality in rats.","volume":"25","author":"Bahrami","year":"1997","journal-title":"Crit Care Med"},{"key":"R21-12-20210211","first-page":"197","article-title":"Significance of translocation\/endotoxin in the development of systemic sepsis following trauma and\/or haemorrhage.","volume":"392","author":"Bahrami","year":"1995","journal-title":"Prog Clin Biol Res"},{"key":"R22-12-20210211","first-page":"27","article-title":"Effect of anti-tumor necrosis factor alpha on leukocyte adhesion in the liver after hemorrhagic shock: an intravital microscopic study in the rat.","volume":"3","author":"Marzi","year":"1995","journal-title":"Shock"},{"key":"R23-12-20210211","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1097\/00024382-199507000-00008","article-title":"Hemorrhagic shock increases gut macromolecular permeability in the rat.","volume":"4","author":"Russell","year":"1995","journal-title":"Shock"},{"key":"R24-12-20210211","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1001\/archsurg.1970.01340280030009","article-title":"Intestinal mucosal lesion in low-flow states. I. A morphological, hemodynamic, and metabolic reappraisal.","volume":"101","author":"Chiu","year":"1970","journal-title":"Arch Surg"},{"key":"R25-12-20210211","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1016\/j.injury.2009.12.006","article-title":"Erythropoietin protects severe haemorrhagic shock-induced organ damage in conscious rats.","volume":"41","author":"Wu","year":"2010","journal-title":"Injury"},{"key":"R26-12-20210211","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1097\/00000658-199501000-00012","article-title":"Kinetics of endotoxin and tumor necrosis factor appearance in portal and systemic circulation after hemorrhagic shock in rats.","volume":"221","author":"Jiang","year":"1995","journal-title":"Ann Surg"},{"key":"R27-12-20210211","first-page":"266","article-title":"[Role of intestinal lymphatic pathway in pathogenesis of intestine-derived bacteria\/endotoxin translocation in rats in shock].","volume":"19","author":"Niu","year":"2007","journal-title":"Zhongguo Wei Zhong Bing Ji Jiu Yi Xue"},{"key":"R28-12-20210211","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1097\/00054725-200102000-00014","article-title":"Mechanisms and modulation of intestinal epithelial repair.","volume":"7","author":"Dignass","year":"2001","journal-title":"Inflamm Bowel Dis"},{"key":"R29-12-20210211","first-page":"G495","article-title":"Mucosal immunity and inflammation. V. Innate mechanisms of mucosal defense and repair: the best offense is a good defense.","volume":"277","author":"Podolsky","year":"1999","journal-title":"Am J Physiol"},{"key":"R30-12-20210211","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1097\/00005373-200108000-00023","article-title":"Mesenteric and renal oxygen transport during hemorrhage and reperfusion: evaluation of optimal goals for resuscitation.","volume":"51","author":"Chiara","year":"2001","journal-title":"J Trauma"},{"key":"R31-12-20210211","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1002\/bjs.1800810504","article-title":"Ischaemia-reperfusion injury.","volume":"81","author":"Grace","year":"1994","journal-title":"Br J Surg"},{"key":"R32-12-20210211","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.surg.2003.12.012","article-title":"A study of the biologic activity of trauma-hemorrhagic shock mesenteric lymph over time and the relative role of cytokines.","volume":"136","author":"Davidson","year":"2004","journal-title":"Surgery"},{"key":"R33-12-20210211","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1097\/01.shk.0000133592.55400.83","article-title":"The role of lymph factors in lung injury, bone marrow suppression, and endothelial cell dysfunction in a primate model of trauma-hemorrhagic shock.","volume":"22","author":"Deitch","year":"2004","journal-title":"Shock"},{"key":"R34-12-20210211","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1139\/y98-049","article-title":"The gut as a potential trigger of exercise-induced inflammatory responses.","volume":"76","author":"Marshall","year":"1998","journal-title":"Can J Physiol Pharmacol"},{"key":"R35-12-20210211","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1056\/NEJM198501173120305","article-title":"Oxygen-derived free radicals in post-ischemic tissue injury.","volume":"312","author":"McCord","year":"1985","journal-title":"N Engl J Med"},{"key":"R36-12-20210211","doi-asserted-by":"crossref","first-page":"4217","DOI":"10.1016\/S0041-1345(98)01397-9","article-title":"The nature of ischemia\/reperfusion injury.","volume":"30","author":"Massberg","year":"1998","journal-title":"Transplant Proc"},{"key":"R37-12-20210211","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1146\/annurev.ph.57.030195.001523","article-title":"Physiologic mechanisms of post-ischemic tissue injury.","volume":"57","author":"Granger","year":"1995","journal-title":"Annu Rev Physiol"},{"key":"R38-12-20210211","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1016\/S0024-3205(02)01966-5","article-title":"Alterations of intestinal motor responsiveness in a model of mild mesenteric ischemia\/reperfusion in rats.","volume":"71","author":"Ballabeni","year":"2002","journal-title":"Life Sci"},{"key":"R39-12-20210211","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/j.lfs.2004.08.031","article-title":"Protective effect of melatonin on contractile activity and oxidative injury induced by ischemia and reperfusion of rat ileum.","volume":"76","author":"Ozacmak","year":"2005","journal-title":"Life Sci"},{"key":"R40-12-20210211","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0002-9610(99)00231-7","article-title":"The role of the gastrointestinal tract in post-injury multiple organ failure.","volume":"178","author":"Moore","year":"1999","journal-title":"Am J Surg"},{"key":"R41-12-20210211","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00024382-200115010-00001","article-title":"Post-injury multiple organ failure: the role of the gut.","volume":"15","author":"Hassoun","year":"2001","journal-title":"Shock"},{"key":"R42-12-20210211","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1365-2796.2008.02024.x","article-title":"Erythropoietin-mediated tissue protection: reducing collateral damage from the primary injury response.","volume":"264","author":"Brines","year":"2008","journal-title":"J Intern Med"},{"key":"R43-12-20210211","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s00381-002-0680-2","article-title":"Erythropoietin prevents ischemia-reperfusion from inducing oxidative damage in fetal rat brain.","volume":"19","author":"Solaroglu","year":"2003","journal-title":"Childs Nerv Syst"},{"key":"R44-12-20210211","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.ehj.2003.11.017","article-title":"Erythropoietin in cardiovascular diseases.","volume":"25","author":"van der meer","year":"2004","journal-title":"Eur Heart J"},{"key":"R45-12-20210211","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/ki.1991.31","article-title":"Direct vasopressor effect of recombinant human erythropoietin on renal resistance vessels.","volume":"39","author":"Heidenreich","year":"1991","journal-title":"Kidney Int"},{"key":"R46-12-20210211","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1365-2362.2008.01968.x","article-title":"Erythropoietin and the endothelium-a promising link?","volume":"38","author":"Fliser","year":"2008","journal-title":"Eur J Clin Invest"},{"key":"R47-12-20210211","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.ghir.2007.05.006","article-title":"High-dose erythropoietin inhibits apoptosis and stimulates proliferation in neonatal rat intestine.","volume":"17","author":"McPherson","year":"2007","journal-title":"Growth Horm IGF Res"},{"key":"R48-12-20210211","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1111\/j.1365-2141.2008.07014.x","article-title":"The non-haematopoietic biological effects of erythropoietin.","volume":"141","author":"Arcasoy","year":"2008","journal-title":"Br J Haematol"},{"key":"R49-12-20210211","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1097\/00001503-200310000-00002","article-title":"Ischemic preconditioning in the brain.","volume":"16","author":"Davis","year":"2003","journal-title":"Curr Opin Anaesthesiol"},{"key":"R50-12-20210211","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.vph.2005.02.004","article-title":"Erythropoietin mimics ischemic preconditioning.","volume":"42","author":"Baker","year":"2005","journal-title":"Vascul Pharmacol"},{"key":"R51-12-20210211","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.lfs.2008.12.025","article-title":"Pharmacological preconditioning with erythropoietin reduces ischemia-reperfusion injury in the small intestine of rats.","volume":"84","author":"Sayan","year":"2009","journal-title":"Life Sci"}],"container-title":["Journal of Trauma: Injury, Infection &amp; Critical Care"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/TA.0b013e318232e782","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T20:28:27Z","timestamp":1786048107000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00005373-201111001-00012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":51,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1097\/ta.0b013e318232e782","relation":{},"ISSN":["0022-5282"],"issn-type":[{"value":"0022-5282","type":"print"}],"subject":[],"published":{"date-parts":[[2011,11]]}}}