{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T17:18:53Z","timestamp":1786295933104,"version":"build-2736575974"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1097\/ta.0b013e31825ab11f","type":"journal-article","created":{"date-parts":[[2012,8,21]],"date-time":"2012-08-21T14:17:43Z","timestamp":1345558663000},"page":"861-868","source":"Crossref","is-referenced-by-count":6,"title":["Role of p38 mitogen-activated protein kinase in posttraumatic immunosuppression in mice"],"prefix":"10.1097","volume":"73","author":[{"given":"Nadine","family":"Ding","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Dahlke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann-Kathrin","family":"Janze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petra C.","family":"Mailer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"Maus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Bohling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Welte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels C.","family":"Riedemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich A.","family":"Maus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-11-20210210","doi-asserted-by":"crossref","first-page":"R662","DOI":"10.1186\/cc3826","article-title":"Circulating immune parameters predicting the progression from hospital-acquired pneumonia to septic shock in surgical patients.","volume":"9","author":"von Dossow","year":"2005","journal-title":"Crit Care"},{"key":"R2-11-20210210","first-page":"79","article-title":"Systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), multiple organ failure (MOF): are we winning the battle Shock.","volume":"10","author":"Baue","year":"1998","journal-title":""},{"key":"R3-11-20210210","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1186\/cc1514","article-title":"Clinical review: immunodepression in the surgical patient and increased susceptibility to infection.","volume":"6","author":"Angele","year":"2002","journal-title":"Crit Care"},{"key":"R4-11-20210210","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1097\/00003246-200102000-00015","article-title":"Risk factors for nosocomial pneumonia in critically ill trauma patients.","volume":"29","author":"Tejada Artigas","year":"2001","journal-title":"Crit Care Med"},{"key":"R5-11-20210210","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0272-5231(21)00988-6","article-title":"Epidemic nosocomial pneumonia in the intensive care unit.","volume":"16","author":"Maloney","year":"1995","journal-title":"Clin Chest Med"},{"key":"R7-11-20210210","doi-asserted-by":"crossref","first-page":"L799","DOI":"10.1152\/ajplung.00465.2001","article-title":"3rd, Matalon S, Wang P, Bland KI, Chaudry IH. Alveolar macrophage activation after trauma-hemorrhage and sepsis is dependent on NF-kappaB and MAPKERK mechanisms.","volume":"283","author":"Jarrar","year":"2002","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"R8-11-20210210","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1067\/msy.2002.126096","article-title":"Impaired activation of mitogen-activated protein kinases after hemorrhagic shock.","volume":"132","author":"Khadaroo","year":"2002","journal-title":"Surgery"},{"key":"R9-11-20210210","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1001\/archsurg.139.8.896","article-title":"The effect of inhibition of a major cell signaling pathway following trauma hemorrhage on hepatic injury and interleukin 6 levels.","volume":"139","author":"Jarrar","year":"2004","journal-title":"Arch Surg"},{"key":"R11-11-20210210","doi-asserted-by":"crossref","first-page":"C662","DOI":"10.1152\/ajpcell.2001.281.2.C662","article-title":"MAPK p38 antagonism as a novel method of inhibiting lymphoid immune suppression in polymicrobial sepsis.","volume":"281","author":"Song","year":"2001","journal-title":"Am J Physiol Cell Physiol"},{"key":"R12-11-20210210","doi-asserted-by":"crossref","first-page":"C476","DOI":"10.1152\/ajpcell.00076.2006","article-title":"Src family kinases regulate p38 MAPK-mediated IL-6 production in Kupffer cells following hypoxia.","volume":"291","author":"Thobe","year":"2006","journal-title":"Am J Physiol Cell Physiol"},{"key":"R13-11-20210210","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.4049\/jimmunol.179.5.3099","article-title":"FMS-like tyrosine kinase 3 ligand aggravates the lung inflammatory response to Streptococcus pneumoniae infection in mice: role of dendritic cells.","volume":"179","author":"Winter","year":"2007","journal-title":"J Immunol"},{"key":"R14-11-20210210","doi-asserted-by":"crossref","first-page":"4931","DOI":"10.4049\/jimmunol.0804096","article-title":"Important role for CC chemokine ligand 2-dependent lung mononuclear phagocyte recruitment to inhibit sepsis in mice infected with Streptococcus pneumoniae.","volume":"182","author":"Winter","year":"2009","journal-title":"J Immunol"},{"key":"R15-11-20210210","doi-asserted-by":"crossref","first-page":"5828","DOI":"10.4049\/jimmunol.178.9.5828","article-title":". Lung-specific overexpression of CC chemokine ligand (CCL) 2 enhances the host defense to Streptococcus pneumoniae infection in mice: role of the CCL2-CCR2 axis.","volume":"178","author":"Winter","year":"2007","journal-title":"J Immunol"},{"key":"R16-11-20210210","doi-asserted-by":"crossref","first-page":"L1245","DOI":"10.1152\/ajplung.00453.2001","article-title":". Role of resident alveolar macrophages in leukocyte traffic into the alveolar air space of intact mice.","volume":"282","author":"Maus","year":"2002","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"R17-11-20210210","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1165\/rcmb.2007-0132OC","article-title":"Macrophage turnover kinetics in the lungs of mice infected with Streptococcus pneumoniae.","volume":"38","author":"Taut","year":"2008","journal-title":"Am J Respir Cell Mol Biol"},{"key":"R18-11-20210210","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1164\/rccm.200610-1533OC","article-title":". Importance of phosphoinositide 3-kinase gamma in the host defense against pneumococcal infection.","volume":"175","author":"Maus","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"R19-11-20210210","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1086\/376571","article-title":"Immunizations with pneumococcal surface protein A and pneumolysin are protective against pneumonia in a murine model of pulmonary infection with Streptococcus pneumoniae.","volume":"188","author":"Briles","year":"2003","journal-title":"J Infect Dis"},{"key":"R20-11-20210210","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1165\/rcmb.2005-0241OC","article-title":"Resident alveolar macrophages are replaced by recruited monocytes in response to endotoxin-induced lung inflammation.","volume":"35","author":"Maus","year":"2006","journal-title":"Am J Respir Cell Mol Biol"},{"key":"R21-11-20210210","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.bcp.2008.10.032","article-title":". Inhibition of pro-inflammatory cytokine production by the dual p38JNK2 inhibitor BIRB796 correlates with the inhibition of p38 signaling.","volume":"77","author":"Gruenbaum","year":"2009","journal-title":"Biochem Pharmacol"},{"key":"R22-11-20210210","doi-asserted-by":"crossref","first-page":"4070","DOI":"10.4049\/jimmunol.168.8.4070","article-title":". Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia.","volume":"168","author":"Branger","year":"2002","journal-title":"J Immunol"},{"key":"R23-11-20210210","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.1021\/jm020057r","article-title":". Pyrazole urea-based inhibitors of p38 MAP kinase: from lead compound to clinical candidate.","volume":"45","author":"Regan","year":"2002","journal-title":"J Med Chem"},{"key":"R24-11-20210210","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1001\/archsurg.1988.01400270021002","article-title":"Alteration of monocyte function following major injury.","volume":"123","author":"Faist","year":"1988","journal-title":"Arch Surg"},{"key":"R25-11-20210210","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1001\/archsurg.1986.01400090026004","article-title":"Depression of cellular immunity after major injury. Its association with posttraumatic complications and its reversal with immunomodulation.","volume":"121","author":"Faist","year":"1986","journal-title":"Arch Surg"},{"key":"R26-11-20210210","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1128\/IAI.65.6.2283-2291.1997","article-title":"Distinct mechanisms of immunosuppres-sion as a consequence of major surgery.","volume":"65","author":"Hensler","year":"1997","journal-title":"Infect Immun"},{"key":"R27-11-20210210","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1097\/00000658-197709000-00002","article-title":"Delayed hypersensitivity: indicator of acquired failure of host defenses in sepsis and trauma.","volume":"186","author":"Meakins","year":"1977","journal-title":"Ann Surg"},{"key":"R28-11-20210210","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1001\/archsurg.1988.01400270027003","article-title":"Mechanisms of altered monocyte prostaglandin E2 production in severely injured patients.","volume":"123","author":"Miller-Graziano","year":"1988","journal-title":"Arch Surg"},{"key":"R29-11-20210210","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1128\/CDLI.11.4.742-751.2004","article-title":"Bacterial clearance and cytokine profiles in a murine model of postsurgical nosocomial pneumonia.","volume":"11","author":"Manderscheid","year":"2004","journal-title":"Clin Diagn Lab Immunol"},{"key":"R30-11-20210210","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1164\/rccm.200606-763OC","article-title":"Effect of laparotomy on clearance and cytokine induction in Staphylococcus aureus infected lungs.","volume":"176","author":"Olszewski","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"R31-11-20210210","doi-asserted-by":"crossref","first-page":"e8406","DOI":"10.1371\/journal.pone.0008406","article-title":". An adequately robust early TNF-alpha response is a hallmark of survival following traumahemorrhage.","volume":"4","author":"Namas","year":"2009","journal-title":"PLoS One"},{"key":"R32-11-20210210","first-page":"R167","article-title":"Differential alterations in plasma IL-6 and TNF levels after trauma and hemorrhage.","volume":"260","author":"Ayala","year":"1991","journal-title":"Am J Physiol"},{"key":"R33-11-20210210","first-page":"H2219","article-title":"Significance of TNF in hemorrhage-related hemodynamic alterations, organ injury, and mortality in rats.","volume":"272","author":"Bahrami","year":"1997","journal-title":"Am J Physiol"},{"key":"R34-11-20210210","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s000110050318","article-title":"The inflammatory basis of traumashock-associated multiple organ failure.","volume":"47","author":"Yao","year":"1998","journal-title":"Inflamm Res"},{"key":"R35-11-20210210","first-page":"647","article-title":"Interleukin-6 in the injured patient.","volume":"224","author":"Biffl","year":"1996","journal-title":"Marker of injury or mediator of inflammation Ann Surg"},{"key":"R36-11-20210210","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1042\/BJ20070797","article-title":"The selectivity of protein kinase inhibitors: a further update.","volume":"408","author":"Bain","year":"2007","journal-title":"Biochem J"},{"key":"R37-11-20210210","doi-asserted-by":"crossref","first-page":"19472","DOI":"10.1074\/jbc.M414221200","article-title":"BIRB796 inhibits all p38 MAPK isoforms in vitro and in vivo.","volume":"280","author":"Kuma","year":"2005","journal-title":"J Biol Chem"},{"key":"R38-11-20210210","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1097\/01.CCM.0000280568.61217.26","article-title":"Attenuating burn wound inflammation improves pulmonary function and survival in a burn-pneumonia model.","volume":"35","author":"Ipaktchi","year":"2007","journal-title":"Crit Care Med"},{"key":"R39-11-20210210","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1097\/TA.0b013e3181bb9cd3","article-title":"SB203580, a p38 inhibitor, improved cardiac function but worsened lung injury and survival during Escherichia coli pneumonia in mice.","volume":"68","author":"Su","year":"2010","journal-title":"J Trauma"},{"issue":"Suppl 7","key":"R40-11-20210210","doi-asserted-by":"crossref","first-page":"S459","DOI":"10.1086\/431997","article-title":"Alterations in cell signaling in sepsis.","volume":"41","author":"Abraham","year":"2005","journal-title":"Clin Infect Dis"}],"container-title":["Journal of Trauma and Acute Care Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/TA.0b013e31825ab11f","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:42:07Z","timestamp":1643244127000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01586154-201210000-00011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.1097\/ta.0b013e31825ab11f","relation":{},"ISSN":["2163-0755"],"issn-type":[{"value":"2163-0755","type":"print"}],"subject":[],"published":{"date-parts":[[2012,10]]}}}