{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:16:04Z","timestamp":1793038564862,"version":"4.5.0"},"reference-count":44,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,12]]},"DOI":"10.1097\/ta.0b013e3182782641","type":"journal-article","created":{"date-parts":[[2012,11,27]],"date-time":"2012-11-27T10:43:34Z","timestamp":1354013014000},"page":"1461-1470","source":"Crossref","is-referenced-by-count":63,"title":["Pharmacologic resuscitation for hemorrhagic shock combined with traumatic brain injury"],"prefix":"10.1097","volume":"73","author":[{"given":"Guang","family":"Jin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Duggan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayesha","family":"Imam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc A.","family":"deMoya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Sillesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Hwabejire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilie H.","family":"Jepsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali Y.","family":"Mejaddam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William Michael","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George C.","family":"Velmahos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Socrate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan B.","family":"Alam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-20-20210210","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1742-2094-7-5","article-title":"Prehospital resuscitation with hypertonic saline-dextran modulates inflammatory, coagulation and endothelial activation marker profiles in severe traumatic brain injured patients.","volume":"7","author":"Rhind","year":"2010","journal-title":"J Neuroinflammation"},{"key":"R2-20-20210210","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1097\/00005373-199302000-00006","article-title":"The role of secondary brain injury in determining outcome from severe head injury.","volume":"34","author":"Chesnut","year":"1993","journal-title":"J Trauma"},{"key":"R3-20-20210210","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0006-8993(89)91409-1","article-title":". Increased vulnerability of the mildly traumatized rat brain to cerebral ischemia: the use of controlled secondary ischemia as a research tool to identify common or different mechanisms contributing to mechanical and ischemic brain injury.","volume":"477","author":"Jenkins","year":"1989","journal-title":"Brain Res"},{"key":"R4-20-20210210","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1097\/00004647-200107000-00010","article-title":"Delayed hemorrhagic hypotension exacerbates the hemodynamic and histopathologic consequences of traumatic brain injury in rats.","volume":"21","author":"Matsushita","year":"2001","journal-title":"J Cereb Blood Flow Metab"},{"key":"R5-20-20210210","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1056\/NEJMoa067514","article-title":"Saline or albumin for fluid resuscitation in patients with traumatic brain injury.","volume":"357","author":"Myburgh","year":"2007","journal-title":"N Engl J Med"},{"key":"R6-20-20210210","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1097\/01.TA.0000135162.85859.4C","article-title":"Building a better fluid for emergency resuscitation of traumatic brain injury.","volume":"57","author":"Crookes","year":"2004","journal-title":"J Trauma"},{"key":"R7-20-20210210","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.surg.2004.05.011","article-title":"Changes in intracranial pressure, coagulation, and neurologic outcome after resuscitation from experimental traumatic brain injury with hetastarch.","volume":"136","author":"King","year":"2004","journal-title":"Surgery"},{"key":"R8-20-20210210","doi-asserted-by":"crossref","first-page":"R68","DOI":"10.1186\/cc10048","article-title":"Balanced massive transfusion ratios in multiple injury patients with traumatic brain injury.","volume":"15","author":"Peiniger","year":"2011","journal-title":"Crit Care"},{"key":"R10-20-20210210","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1097\/TA.0b013e31820d0dcc","article-title":"Hemostatic and pharmacologic resuscitation: results of a long-term survival study in a swine polytrauma model.","volume":"70","author":"Alam","year":"2011","journal-title":"J Trauma"},{"key":"R11-20-20210210","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1097\/TA.0b013e31818233ef","article-title":"Hepatoprotection and lethality rescue by histone deacetylase inhibitor valproic acid in fatal hemorrhagic shock.","volume":"65","author":"Gonzales","year":"2008","journal-title":"J Trauma"},{"key":"R13-20-20210210","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.surg.2009.04.007","article-title":"Surviving blood loss without blood transfusion in a swine poly-trauma model.","volume":"146","author":"Alam","year":"2009","journal-title":"Surgery"},{"key":"R14-20-20210210","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/S0006-8993(99)02439-7","article-title":"Sodium valproate inhibits production of TNF-alpha and IL-6 and activation of NF-kappaB.","volume":"857","author":"Ichiyama","year":"2000","journal-title":"Brain Res"},{"key":"R15-20-20210210","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.resuscitation.2011.07.029","article-title":"Effect of valproic acid on acute lung injury in a rodent model of intestinal ischemia reperfusion.","volume":"83","author":"Kim","year":"2012","journal-title":"Resuscitation"},{"key":"R16-20-20210210","doi-asserted-by":"crossref","first-page":"4055","DOI":"10.1007\/s00018-008-8521-4","article-title":"Valproic acid attenuates inflammation in experimental autoimmune neuritis.","volume":"65","author":"Zhang","year":"2008","journal-title":"Cell Mol Life Sci"},{"key":"R17-20-20210210","doi-asserted-by":"crossref","first-page":"299","DOI":"10.4142\/jvs.2011.12.3.299","article-title":"Pro- and anti-inflammatory cytokine expression and histopathological characteristics in canine brain with traumatic brain injury.","volume":"12","author":"Yu","year":"2011","journal-title":"J Vet Sci"},{"key":"R21-20-20210210","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1001\/archsurg.133.4.390","article-title":"Delayed fluid resuscitation of head injury and uncontrolled hemorrhagic shock.","volume":"133","author":"Bourguignon","year":"1998","journal-title":"Arch Surg"},{"key":"R22-20-20210210","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.expneurol.2009.02.004","article-title":"CD47 gene knockout protects against transient focal cerebral ischemia in mice.","volume":"217","author":"Jin","year":"2009","journal-title":"Exp Neurol"},{"key":"R24-20-20210210","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s12975-009-0009-5","article-title":"First-order mathematical modeling of brain swelling in focal cerebral ischemia.","volume":"1","author":"Jin","year":"2010","journal-title":"Transl Stroke Res"},{"key":"R25-20-20210210","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1080\/01616412.1999.11741008","article-title":"The impact-acceleration model of head injury: injury severity predicts motor and cognitive performance after trauma.","volume":"21","author":"Beaumont","year":"1999","journal-title":"Neurol Res"},{"key":"R26-20-20210210","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1089\/neu.1999.16.487","article-title":"Neuroprotective effect of hypothermia on neuronal injury in diffuse traumatic brain injury coupled with hypoxia and hypotension.","volume":"16","author":"Yamamoto","year":"1999","journal-title":"J Neurotrauma"},{"key":"R27-20-20210210","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1089\/neu.2011.1979","article-title":"Histopathological and behavioral effects of immediate and delayed hemorrhagic shock after mild traumatic brain injury in rats.","volume":"29","author":"Navarro","year":"2012","journal-title":"J Neurotrauma"},{"key":"R28-20-20210210","doi-asserted-by":"crossref","first-page":"2403","DOI":"10.1089\/neu.2009.0980","article-title":". Resuscitation of traumatic brain injury and hemorrhagic shock with polynitroxylated albumin, hextend, hypertonic saline, and lactated Ringers: effects on acute hemodynamics, survival, and neuronal death in mice.","volume":"26","author":"Exo","year":"2009","journal-title":"J Neurotrauma"},{"key":"R29-20-20210210","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1089\/neu.2006.0032","article-title":"Prognostic value of admission blood pressure in traumatic brain injury: results from the IMPACT study.","volume":"24","author":"Butcher","year":"2007","journal-title":"J Neurotrauma"},{"issue":"suppl 5","key":"R30-20-20210210","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1097\/00005373-199705001-00005","article-title":"Physiologic principles for volume regulation of a tissue enclosed in a rigid shell with application to the injured brain.","volume":"42","author":"Grande","year":"1997","journal-title":"J Trauma"},{"key":"R31-20-20210210","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3171\/jns.1988.69.1.0072","article-title":"Isovolemic hemodilution in experimental focal cerebral ischemia. Part 1: effects on hemodynamics, hemorheology, and intracranial pressure.","volume":"69","author":"Tu","year":"1988","journal-title":"J Neurosurg"},{"key":"R32-20-20210210","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/0090-3019(93)90068-C","article-title":"Role of hypervolemic hemodilution in focal cerebral ischemia of rats.","volume":"40","author":"Ohtaki","year":"1993","journal-title":"Surg Neurol"},{"key":"R33-20-20210210","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jss.2010.04.013","article-title":". Pharmacologic resuscitation promotes survival and attenuates hemorrhage-induced activation of extracellular signal-regulated kinase 12.","volume":"163","author":"Fukudome","year":"2010","journal-title":"J Surg Res"},{"key":"R34-20-20210210","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/978-1-4419-5638-5_11","article-title":"Creating a pro-survival and anti-inflammatory phenotype by modulation of acetylation in models of hemorrhagic and septic shock.","volume":"710","author":"Li","year":"2012","journal-title":"Adv Exp Med Biol"},{"key":"R35-20-20210210","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1017\/S0265021507003390","article-title":"Central nervous system inflammation.","volume":"42","author":"Soriano","year":"2008","journal-title":"Eur J Anaesthesiol Suppl"},{"key":"R36-20-20210210","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.jns.2008.05.019","article-title":"Immune cell entry into the central nervous system: involvement of adhesion molecules and chemokines.","volume":"274","author":"Engelhardt","year":"2008","journal-title":"J Neurol Sci"},{"key":"R37-20-20210210","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1097\/00005373-199803000-00007","article-title":"Effects of trauma and sepsis on soluble L-selectin and cell surface expression of L-selectin and CD11b.","volume":"44","author":"Maekawa","year":"1998","journal-title":"J Trauma"},{"key":"R38-20-20210210","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.injury.2007.10.005","article-title":"Modulation of immune response by head injury.","volume":"38","author":"Morganti-Kossmann","year":"2007","journal-title":"Injury"},{"key":"R39-20-20210210","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1177\/0885066608318458","article-title":"Cytokines and brain injury: invited review.","volume":"23","author":"Kadhim","year":"2008","journal-title":"J Intensive Care Med"},{"key":"R40-20-20210210","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/bja\/80.1.77","article-title":"Cytokines and adhesion molecules in acute brain injury.","volume":"80","author":"McKeating","year":"1998","journal-title":"Br J Anaesth"},{"key":"R41-20-20210210","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0165-5728(90)90105-V","article-title":"Elevation of tumor necrosis factor in head injury.","volume":"30","author":"Goodman","year":"1990","journal-title":"J Neuroimmunol"},{"key":"R42-20-20210210","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1097\/00024382-200115060-00002","article-title":"Differential release of interleukines 6, 8, and 10 in cerebrospinal fluid and plasma after traumatic brain injury.","volume":"15","author":"Maier","year":"2001","journal-title":"Shock"},{"key":"R43-20-20210210","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1196\/annals.1391.022","article-title":"Interleukin-1 system in CNS stress: seizures, fever, and neurotrauma.","volume":"1113","author":"Bartfai","year":"2007","journal-title":"Ann N Y Acad Sci"},{"key":"R44-20-20210210","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.cnr.2006.09.004","article-title":"The cellular response in neuroinflammation: the role of leukocytes, microglia and astrocytes in neuronal death and survival.","volume":"6","author":"Carson","year":"2006","journal-title":"Clin Neurosci Res"},{"key":"R45-20-20210210","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.surg.2011.07.001","article-title":"Histone deacetylase inhibitors enhance endothelial cell sprouting angiogenesis in vitro.","volume":"150","author":"Jin","year":"2011","journal-title":"Surgery"},{"key":"R46-20-20210210","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/jcbfm.2010.195","article-title":"Valproic acid attenuates blood-brain barrier disruption in a rat model of transient focal cerebral ischemia: the roles of HDAC and MMP-9 inhibition.","volume":"31","author":"Wang","year":"2011","journal-title":"J Cereb Blood Flow Metab"},{"key":"R47-20-20210210","doi-asserted-by":"crossref","first-page":"e11383","DOI":"10.1371\/journal.pone.0011383","article-title":"Valproate administered after traumatic brain injury provides neuroprotection and improves cognitive function in rats.","volume":"5","author":"Dash","year":"2010","journal-title":"PLoS One"},{"key":"R48-20-20210210","doi-asserted-by":"crossref","first-page":"4266","DOI":"10.1096\/fj.09-134700","article-title":"Histone deacetylase inhibitor ITF2357 is neuroprotective, improves functional recovery, and induces glial apoptosis following experimental traumatic brain injury.","volume":"23","author":"Shein","year":"2009","journal-title":"FASEB J"},{"key":"R49-20-20210210","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/sj.bjc.6603851","article-title":". Valproic acid (VPA) in patients with refractory advanced cancer: a dose escalating phase I clinical trial.","volume":"97","author":"Atmaca","year":"2007","journal-title":"Br J Cancer"},{"key":"R50-20-20210210","first-page":"431","article-title":"Science review: carnitine in the treatment of valproic acid-induced toxicitywhat is the evidence Crit Care.","volume":"9","author":"Lheureux","year":"2005","journal-title":""}],"container-title":["Journal of Trauma and Acute Care Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.lww.com\/01586154-201212000-00020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T01:28:56Z","timestamp":1618277336000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01586154-201212000-00020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12]]},"references-count":44,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2012]]}},"URL":"https:\/\/doi.org\/10.1097\/ta.0b013e3182782641","relation":{},"ISSN":["2163-0755"],"issn-type":[{"value":"2163-0755","type":"print"}],"subject":[],"published":{"date-parts":[[2012,12]]}}}