{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:17:35Z","timestamp":1791839855214,"version":"4.3.4"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplantation"],"published-print":{"date-parts":[[2019,1]]},"abstract":"\n Background<\/jats:title>\n Malignancy after liver transplant (LT) is a leading cause of mortality, but data is limited. The aim of this study was to identify patients at higher risk for de novo malignancies after LT in a large multicenter database.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n The Scientific Registry of Transplant Recipients database comprising all 108 412 LT recipients across the United States between 1987 and March 2015 was analyzed with a median follow-up of 6.95 years. Potential risk factors for malignancies after LT were assessed using Cox regression analysis for the outcome of time to first malignancy.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Mean age 51.9 \u00b1 10.8 years, 64.6% male, 74.5% white, and 15.8% with previous malignancy. Malignancies during follow-up were 4,483 (41.3%) skin, 1519 (14.0%) hematologic, and 4842 (44.7%) solid organ. The 10-year probability of de novo malignancy was 11.5% (11.3-11.8%). On multivariable analysis, age by decade (hazard ratio [HR], 1.52; P<\/jats:italic> < 0.001), male sex (HR, 1.28; P<\/jats:italic> < 0.001), white race (compared with other races: HR, 1.45-2.04; P<\/jats:italic> < 0.001), multiorgan transplant (HR, 1.35; P<\/jats:italic> < 0.001), previous malignancy (HR, 1.34; P<\/jats:italic> < 0.001), and alcoholic liver disease, autoimmune, nonalcoholic steatohepatitis (HR, 1.35; P<\/jats:italic> < 0.001), and primary sclerosing cholangitis pre-LT (compared with hepatitis C virus, P<\/jats:italic> < 0.001) were associated with higher risk of post-LT malignancy, but type of immunosuppression was not (P<\/jats:italic> = NS).<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n This large data set demonstrates the effects of ethnicity\/race and etiologies of liver disease, particularly nonalcoholic steatohepatitis as additional risk factors for cancer after LT. Patients with these high-risk characteristics should be more regularly and diligently screened.<\/jats:p>\n <\/jats:sec>","DOI":"10.1097\/tp.0000000000002113","type":"journal-article","created":{"date-parts":[[2018,1,28]],"date-time":"2018-01-28T18:36:27Z","timestamp":1517164587000},"page":"91-100","source":"Crossref","is-referenced-by-count":42,"title":["Gender, Race and Disease Etiology Predict De Novo Malignancy Risk After Liver Transplantation: Insights for Future Individualized Cancer Screening Guidance"],"prefix":"10.1097","volume":"103","author":[{"given":"Mamatha","family":"Bhat","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Mara","sequence":"additional","affiliation":[{"name":"Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross","family":"Dierkhising","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kymberly D.","family":"Watt","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"bib1-20231002","doi-asserted-by":"crossref","first-page":"2010","DOI":"10.1053\/j.gastro.2009.08.070","article-title":"Long-term probability of and mortality from de novo malignancy after liver transplantation","volume":"137","year":"2009","journal-title":"Gastroenterology"},{"key":"bib2-20231002","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.transproceed.2004.12.077","article-title":"Tacrolimus for primary liver transplantation: 12 to 15 years actual follow-up with safety profile","volume":"37","year":"2005","journal-title":"Transplant 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