{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T15:44:51Z","timestamp":1776872691980,"version":"3.51.2"},"reference-count":69,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transplantation"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec>\n            <jats:title>Background<\/jats:title>\n            <jats:p>Airway epithelium is the primary target of trachea and lung transplant rejection, the degree of epithelial injury is closely correlated with obliterative bronchiolitis development. In this study, we investigated the cellular and molecular mechanisms of IL-17A-mediated airway epithelial injury after transplantation.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Methods<\/jats:title>\n            <jats:p>Murine orthotopic allogeneic trachea or lung transplants were implemented in wild type or ROR\u03b3t<jats:sup>\u2212\/\u2212<\/jats:sup> mice. Recipients received anti-IL-17A or anti-IFN\u03b3 for cytokine neutralization, anti-CD8 for CD8<jats:sup>+<\/jats:sup> T-cell depletion, or STAT3 inhibitor to suppress type 17 CD4<jats:sub>+<\/jats:sub>\/CD8<jats:sub>+<\/jats:sub> T cell development. Airway injury and graft inflammatory cell infiltration were examined by histopathology and immunohistochemistry. Gene expression of IL-17A, IFN\u03b3, perforin, granzyme B, and chemokines in grafts was quantitated by real-time RT-PCR.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Results<\/jats:title>\n            <jats:p>IL-17A and IFN\u03b3 were rapidly expressed and associated with epithelial injury and CD8<jats:sup>+<\/jats:sup> T-cell accumulation after allotransplantation. Depletion of CD8<jats:sup>+<\/jats:sup> T cells prevented airway epithelial injury. Neutralization of IL-17A or devoid of IL-17A production by ROR\u03b3t deficiency improved airway epithelial integrity of the trachea allografts. Anti\u2013IL-17A reduced the expression of CXCL9, CXCL10, CXCL11, and CCL20, and abolished CD8<jats:sup>+<\/jats:sup> T-cell accumulation in the trachea allografts. Inhibition of STAT3 activation significantly reduced IL-17A expression in both trachea and lung allografts; however, it increased IFN\u03b3 expression and cytotoxic activities, which resulted in the failure of airway protection.<\/jats:p>\n          <\/jats:sec>\n          <jats:sec>\n            <jats:title>Conclusions<\/jats:title>\n            <jats:p>Our data reveal the critical role of IL-17A in mediating CD8<jats:sup>+<\/jats:sup> T effector response that causes airway epithelial injury and lung allograft rejection, and indicate that inhibition of STAT3 signals could drive CD8<jats:sup>+<\/jats:sup> T cells from Tc17 toward Tc1 development.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1097\/tp.0000000000002452","type":"journal-article","created":{"date-parts":[[2018,9,29]],"date-time":"2018-09-29T07:06:42Z","timestamp":1538204802000},"page":"e483-e493","source":"Crossref","is-referenced-by-count":17,"title":["IL-17A Is Critical for CD8+ T Effector Response in Airway Epithelial Injury After Transplantation"],"prefix":"10.1097","volume":"102","author":[{"given":"Ruochan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Immunology, Capital Medical University, Beijing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huihui","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Immunology, Capital Medical University, Beijing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongjuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Immunology, Capital Medical University, Beijing, China."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordi C.","family":"Ochando","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaozhong","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Immunology, Capital Medical University, Beijing, 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innate immune response required for responses to antigen skin challenge","volume":"182","year":"2009","journal-title":"J Immunol"},{"key":"bib46-20231002","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nri3365","article-title":"Innate lymphoid cells\u2014a proposal for uniform nomenclature","volume":"13","year":"2013","journal-title":"Nat Rev Immunol"},{"key":"bib47-20231002","doi-asserted-by":"crossref","first-page":"7268","DOI":"10.4049\/jimmunol.1000600","article-title":"Cytokine requirements for the differentiation and expansion of IL-17A- and IL-22-producing human Vgamma2Vdelta2 T cells","volume":"184","year":"2010","journal-title":"J Immunol"},{"key":"bib48-20231002","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.immuni.2011.08.001","article-title":"Pivotal role of dermal IL-17-producing \u03b3\u03b4 T cells in skin inflammation","volume":"35","year":"2011","journal-title":"Immunity"},{"key":"bib49-20231002","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.4049\/jimmunol.162.4.2347","article-title":"Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways","volume":"162","year":"1999","journal-title":"J Immunol"},{"key":"bib50-20231002","doi-asserted-by":"crossref","first-page":"4844","DOI":"10.4049\/jimmunol.171.9.4844","article-title":"Role of CXCL9\/CXCR3 chemokine biology during pathogenesis of acute lung allograft rejection","volume":"171","year":"2003","journal-title":"J Immunol"},{"key":"bib51-20231002","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1097\/TP.0000000000000269","article-title":"Differential cytokine, chemokine and growth factor expression in phenotypes of chronic lung allograft 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